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21. 发明授权

US07214495B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07214495B2
公开(公告)日：2007-05-08
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

22. 发明申请

US20050170461A1 Polypeptides, their production and use 审中-公开
公开(公告)号：US20050170461A1
公开(公告)日：2005-08-04
申请号：US11054211
申请日：2005-02-08
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： A61K38/00 , C07H21/04 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28 , C12N1/21 , C12N15/12
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

23. 发明申请

US20050118639A1 Method of determining ligand 审中-公开
标题翻译：测定配体的方法
公开(公告)号：US20050118639A1
公开(公告)日：2005-06-02
申请号：US10505486
申请日：2003-02-21
申请人： Shuji Hinuma , Ryo Fujii , Kazuhiro Ogi , Hidetoshi Komatsu , Yuji Kawamata , Masaki Hosoya
发明人： Shuji Hinuma , Ryo Fujii , Kazuhiro Ogi , Hidetoshi Komatsu , Yuji Kawamata , Masaki Hosoya
IPC分类号： C07K14/705 , C07K14/72 , G01N33/566 , G01N33/58 , G01N33/74 , G01N33/92 , G01N33/53
CPC分类号： G01N33/582 , G01N33/566 , G01N2333/726
摘要： The present invention aims at providing a method of determining a ligand to an orphan receptor. Specifically, the present invention provides a method of determining a ligand to a receptor protein, to which no ligand has been determined, which comprises using a fusion protein of the receptor protein and a fluorescent protein.
摘要翻译：本发明旨在提供一种测定孤儿受体配体的方法。具体地，本发明提供了确定受体蛋白质的配体的方法，其中没有确定配体，其包括使用受体蛋白质的融合蛋白和荧光蛋白质。

24. 发明申请

US20050089866A1 Novel screening method 失效
标题翻译：新型筛选方法
公开(公告)号：US20050089866A1
公开(公告)日：2005-04-28
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

25. 发明授权

US06881545B1 Polypeptides, their production and use 失效
标题翻译：多肽，其生产和使用
公开(公告)号：US06881545B1
公开(公告)日：2005-04-19
申请号：US09716147
申请日：2000-11-17
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K14/575 , C07K14/705 , G01N33/53 , C07K7/08 , C07K14/72
CPC分类号： C07K14/705 , C07K14/575
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins.The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds.In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物，例如垂体功能调节剂，中枢神经系统功能调节剂和胰功能调节剂，以及（2）开发受体结合测定系统，其使用重组受体蛋白的表达和药物候选化合物的筛选。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

26. 发明授权

US06399325B1 DNA encoding a galanin receptor 失效
标题翻译：编码甘丙肽受体的DNA
公开(公告)号：US06399325B1
公开(公告)日：2002-06-04
申请号：US08540650
申请日：1995-10-11
申请人： Shuji Hinuma , Ryo Fujii , Shoji Fukusumi , Tetsuya Ohtaki , Masaki Hosoya , Kazuhiro Ohgi , Haruo Onda
发明人： Shuji Hinuma , Ryo Fujii , Shoji Fukusumi , Tetsuya Ohtaki , Masaki Hosoya , Kazuhiro Ohgi , Haruo Onda
IPC分类号： C12N1512
CPC分类号： C07K14/723
摘要： Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided. Galanin receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above galanin receptor protein, processes for producing the above receptor protein, methods of screening for a galanin receptor agonist and/or antagonist or screening kits therefor, agonist and/or antagonist compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compound or its salt, and antibodies against the above receptor protein are provided. It is allowable to efficiently screen a galanin receptor agonist or antagonist by using the galanin receptor protein, the partial peptide thereof, the galanin receptor protein-encoding DNA, the receptor protein-containing cell or its membrane fraction. The pharmaceuticals thus screened or characterized permits various applications including prophylactic and/or therapeutic treatments against a variety of diseases, e.g., stomach ulcer, diabetes, Alzheimer's disease, dementia, etc. and a sedative.
摘要翻译：提供了Galanin受体蛋白质，其生产和使用，包括甘露糖素受体激动剂和拮抗剂的筛选。加兰林素受体蛋白等或其盐，其部分肽，编码上述甘丙肽受体蛋白质的DNA，产生上述受体蛋白质的方法，筛选甘丙肽受体激动剂和/或拮抗剂的方法或其筛选试剂盒，激动剂和 /或通过上述筛选方法获得的拮抗剂化合物或其盐或筛选试剂盒，含有上述化合物或其盐的药物组合物和抗上述受体蛋白的抗体。可以通过使用甘丙肽受体蛋白，其部分肽，编码甘露糖素受体蛋白的DNA，含受体蛋白的细胞或其膜部分来有效筛选甘丙肽受体激动剂或拮抗剂。如此筛选或表征的药物允许各种应用，包括针对各种疾病（例如胃溃疡，糖尿病，阿尔茨海默病，痴呆等）和镇静剂的预防和/或治疗性治疗。

27. 发明授权

US07972800B2 Screening method for binding property or signal transduction alterations 有权
标题翻译：结合性质或信号转导改变的筛选方法
公开(公告)号：US07972800B2
公开(公告)日：2011-07-05
申请号：US12428877
申请日：2009-04-23
申请人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

28. 发明申请

US20070117840A1 Receptor antagonist 审中-公开
标题翻译：受体拮抗剂
公开(公告)号：US20070117840A1
公开(公告)日：2007-05-24
申请号：US10549889
申请日：2004-03-16
申请人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Yoshihiro Banno , Hiromi Yoshida , Hirokazu Matsumoto
发明人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Yoshihiro Banno , Hiromi Yoshida , Hirokazu Matsumoto
IPC分类号： A61K31/4704
CPC分类号： A61K31/4704
摘要： A compound represented by the formula (I): wherein ring A represents an aromatic ring; X represents a bond, oxygen, NR4 (R4 represents hydrogen, a hydrocarbon group, or a heterocyclic group), or alkylene; R1 represents a hydrocarbon group, or a heterocyclic group; R2 represents —COYR5 (Y represents a bond, alkylene, oxygen, sulfur, or NR6 (R6 represents hydrogen, a hydrocarbon group, or a heterocyclic group), and R5 represents a hydrocarbon group, or a heterocyclic group), a hydrocarbon group, or a heterocyclic group; and R3 represents a hydrocarbon group, a heterocyclic group, optionally substituted hydroxy, optionally substituted amino, or —S(O)nR7 (R7 represents a hydrocarbon group, or a heterocyclic group, and n is 0 to 2), a salt of the compound, or a prodrug or either is useful as an agent for modulating the function of an RFRP receptor.
摘要翻译：由式（I）表示的化合物：其中环A表示芳环; X表示键，氧，NR 4（R 4表示氢，烃基或杂环基）或亚烷基; R 1表示烃基或杂环基; R 2表示-COYR 5（Y表示键，亚烷基，氧，硫或NR 6（R 6） SUP>表示氢，烃基或杂环基），R 5表示烃基或杂环基），烃基或杂环基; 和R 3表示烃基，杂环基，任选取代的羟基，任选取代的氨基或-S（O）n R 7 （R 7表示烃基或杂环基，n为0〜2），化合物或前药的盐或其可用作调节其功能的试剂 RFRP受体。

29. 发明申请

US20060199795A1 Receptor agonists 失效
标题翻译：受体激动剂
公开(公告)号：US20060199795A1
公开(公告)日：2006-09-07
申请号：US10543997
申请日：2004-01-27
申请人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Takashi Miki , Yuji Kawamata , Satoru Oi , Taisuke Tawaraishi , Yuji Ishichi , Mariko Hirohashi
发明人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Takashi Miki , Yuji Kawamata , Satoru Oi , Taisuke Tawaraishi , Yuji Ishichi , Mariko Hirohashi
IPC分类号： A61K31/554 , A61K31/553 , A61K31/5513
CPC分类号： C07D267/14 , A61K31/4353 , A61K31/5513 , A61K31/553
摘要： The present invention provides a TGR5 receptor agonist comprising a fused ring compound represented by the formula wherein ring A is an optionally substituted aromatic ring; and ring B′ is a 5- to 8-membered ring having one or more substituents or a salt thereof or a prodrug thereof, which is useful for the treatment of various diseases.
摘要翻译：本发明提供一种TGR5受体激动剂，其包含由下式表示的稠环化合物：其中环A为任选取代的芳环; 环B'是具有一个或多个取代基的5-至8-元环或其盐或其前药，其可用于治疗各种疾病。

30. 发明授权

US07045497B1 Use of peptide 失效
标题翻译：使用肽
公开(公告)号：US07045497B1
公开(公告)日：2006-05-16
申请号：US09868885
申请日：1999-12-22
申请人： Hirokazu Matsumoto , Chieko Kitada , Shuji Hinuma
发明人： Hirokazu Matsumoto , Chieko Kitada , Shuji Hinuma
IPC分类号： A61K38/11 , A61K38/16 , C07K14/00 , C07H21/04
CPC分类号： A61K38/2257
摘要： The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserving or treating various diseases related to oxytocin secretion such as uterine inertia, atonic hemorrhage, placental expulsion, subinvolution and the like.
摘要翻译：本发明涉及G蛋白偶联受体蛋白识别为配体的肽的用途。由于本发明的配体多肽对催产素分泌具有刺激作用，因此可用作改善，保存或治疗与催产素分泌相关的各种疾病如子宫惯性，失声性出血，胎盘排出，亚溶解等的药物。

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