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21. 发明授权

US07914656B2 Matrixes, arrays, systems and methods 有权
标题翻译：矩阵，数组，系统和方法
公开(公告)号：US07914656B2
公开(公告)日：2011-03-29
申请号：US11619796
申请日：2007-01-04
申请人： Shmuel Bukshpan , Gleb Zilbertstein
发明人： Shmuel Bukshpan , Gleb Zilbertstein
IPC分类号： G01N27/447
CPC分类号： G01N27/44795 , G01N27/44747
摘要： The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for causing a biomolecule under the influence of an electrical field to accumulate into an buffer that comprises a pH value that is the same as the isoelectric point of the biomolecule. The methods of this invention are useful for, e.g., research and diagnostic purposes.
摘要翻译：本发明涉及用于通过其等电点分析生物分子的基质，阵列，系统和方法，任选地与第二维度分析结合。本文提供的基质，阵列和系统的分类可用于使电场的影响下的生物分子积累到包含与生物分子的等电点相同的pH值的缓冲液中。本发明的方法可用于例如研究和诊断目的。

22. 发明申请

US20070138015A1 Matrixes, Arrays, Systems and Methods 有权
标题翻译：矩阵，数组，系统和方法
公开(公告)号：US20070138015A1
公开(公告)日：2007-06-21
申请号：US11619796
申请日：2007-01-04
申请人： Shmuel Bukshpan , Gleb Zilbertstein
发明人： Shmuel Bukshpan , Gleb Zilbertstein
IPC分类号： B01D57/02
CPC分类号： G01N27/44795 , G01N27/44747
摘要： The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for causing a biomolecule under the influence of an electrical field to accumulate into an IEF buffer that comprises a pH value that is the same as the isoelectric point of the biomolecule. The methods of this invention are useful for, e.g., research and diagnostic purposes.
摘要翻译：本发明涉及用于通过其等电点分析生物分子的基质，阵列，系统和方法，任选地与第二维度分析结合。本文提供的基质，阵列和系统的分类可用于使电场的影响下的生物分子积累到包含与生物分子的等电点相同的pH值的IEF缓冲液中。本发明的方法可用于例如研究和诊断目的。

23. 发明申请

US20060137603A1 Methods and apparatus for rapid crystallization of biomolecules 有权
标题翻译：生物分子快速结晶的方法和装置
公开(公告)号：US20060137603A1
公开(公告)日：2006-06-29
申请号：US10561244
申请日：2005-12-19
申请人： Shmuel Bukshpan
发明人： Shmuel Bukshpan
IPC分类号： C30B7/00 , C30B21/02 , C30B28/06
CPC分类号： C30B7/00 , C07K1/306 , C30B29/58
摘要： The present invention relates to methods and apparatus for promoting rapid formation of biomolecule crystals from a solution of biomolecules, preferably proteins, wherein the protein solution undergoes rapid concentration according to its isoelectric point in an electric field. Protein crystallization according to the methods of the present invention takes place within a period of hours or less.
摘要翻译：本发明涉及用于促进从生物分子（优选蛋白质）溶液快速形成生物分子晶体的方法和装置，其中蛋白质溶液根据其电场中的等电点快速浓缩。根据本发明方法的蛋白质结晶在几小时或更短的时间内进行。

24. 发明授权

US08038792B2 Methods and apparatus for rapid crystallization of biomolecules 有权
标题翻译：生物分子快速结晶的方法和装置
公开(公告)号：US08038792B2
公开(公告)日：2011-10-18
申请号：US12264596
申请日：2008-11-04
申请人： Shmuel Bukshpan
发明人： Shmuel Bukshpan
IPC分类号： C30B7/00
CPC分类号： C30B7/00 , C07K1/306 , C30B29/58
摘要： The present invention relates to methods and apparatus for promoting rapid formation of biomolecule crystals from a solution of biomolecules, preferably proteins, wherein the protein solution undergoes rapid concentration according to its isoelectric point in an electric field. Protein crystallization according to the methods of the present invention takes place within a period of hours or less.
摘要翻译：本发明涉及用于促进从生物分子（优选蛋白质）溶液快速形成生物分子晶体的方法和装置，其中蛋白质溶液根据其电场中的等电点快速浓缩。根据本发明方法的蛋白质结晶在几小时或更短的时间内进行。

25. 发明申请

US20100136143A1 NEW COMPOSITIONS AND METHODS FOR CELL KILLING 审中-公开
标题翻译：新的组合物和细胞杀伤的方法
公开(公告)号：US20100136143A1
公开(公告)日：2010-06-03
申请号：US12594384
申请日：2008-04-03
申请人： Shmuel Bukshpan
发明人： Shmuel Bukshpan
IPC分类号： A61K33/00 , A61K31/16 , C12N5/00
CPC分类号： A01N61/00 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04
摘要： The present invention discloses an insoluble proton sink or source (PSS), useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment. The invention also provides articles of manufacture comprises the PSS and presents an effective method for killing the LTCs.
摘要翻译：本发明公开了一种不溶性质子沉或源（PSS），用于杀死活细胞（LTC），或以其他方式破坏接触后LTC的细胞内过程和/或细胞间相互作用。 PSS包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。本发明还提供包括PSS的制品，并提出了杀死LTC的有效方法。

26. 发明申请

US20090101491A1 METHODS AND APPARATUS FOR RAPID CRYSTALLIZATION OF BIOMOLECULES 有权
标题翻译：用于生物分子快速结晶的方法和装置
公开(公告)号：US20090101491A1
公开(公告)日：2009-04-23
申请号：US12264596
申请日：2008-11-04
申请人： Shmuel Bukshpan
发明人： Shmuel Bukshpan
IPC分类号： C30B7/00
CPC分类号： C30B7/00 , C07K1/306 , C30B29/58
摘要： The present invention relates to methods and apparatus for promoting rapid formation of biomolecule crystals from a solution of biomolecules, preferably proteins, wherein the protein solution undergoes rapid concentration according to its isoelectric point in an electric field. Protein crystallization according to the methods of the present invention takes place within a period of hours or less.
摘要翻译：本发明涉及用于促进从生物分子（优选蛋白质）溶液快速形成生物分子晶体的方法和装置，其中蛋白质溶液根据其电场中的等电点快速浓缩。根据本发明方法的蛋白质结晶在几小时或更短的时间内进行。

27. 发明授权

US07459021B2 Methods and apparatus for rapid crystallization of biomolecules 有权
标题翻译：生物分子快速结晶的方法和装置
公开(公告)号：US07459021B2
公开(公告)日：2008-12-02
申请号：US10561244
申请日：2004-09-02
申请人： Shmuel Bukshpan
发明人： Shmuel Bukshpan
IPC分类号： C30B7/00
CPC分类号： C30B7/00 , C07K1/306 , C30B29/58
摘要： The present invention relates to methods and apparatus for promoting rapid formation of biomolecule crystals from a solution of biomolecules, preferably proteins, wherein the protein solution undergoes rapid concentration according to its isoelectric point in an electric field. Protein crystallization according to the methods of the present invention takes place within a period of hours or less.
摘要翻译：本发明涉及用于促进从生物分子（优选蛋白质）溶液快速形成生物分子晶体的方法和装置，其中蛋白质溶液根据其电场中的等电点快速浓缩。根据本发明方法的蛋白质结晶在几小时或更短的时间内进行。

28. 发明申请

US20050154302A1 System and method of mapping irregularities of hard tissue 失效
公开(公告)号：US20050154302A1
公开(公告)日：2005-07-14
申请号：US10500987
申请日：2005-03-07
申请人： Natan Sela , Shmuel Bukshpan , Michael Kardash , Lior Cohen
发明人： Natan Sela , Shmuel Bukshpan , Michael Kardash , Lior Cohen
IPC分类号： A61B8/00 , A61B8/08
CPC分类号： A61B8/0875 , A61B8/461 , A61B8/467 , A61B8/483
摘要： A system and method of mapping irregularities of hard tissue. The method includes repeatedly transmitting ultra-sonic energy towards the hard tissue at a first angle of incidence, registering the origin of transmission if an echo-reflection the hard tissue is received, defining the origin of transmission in six degrees of freedom, calculating position co-ordinates for a point causing the echo-reflection and changing the origin of transmission. The method further includes compiling position co-ordinates to generate a map of the irregularities in the surface of the hard tissue. The system includes at least one ultrasonic transducer, a central processing unit and a position locator and adjustment mechanism operably connectable and configured to accomplish the disclosed method.

29. 发明授权

US06514203B2 Method for ultrasonic coronary thrombolysis 失效
标题翻译：超声冠状动脉溶栓治疗方法
公开(公告)号：US06514203B2
公开(公告)日：2003-02-04
申请号：US09780511
申请日：2001-02-12
申请人： Shmuel Bukshpan
发明人： Shmuel Bukshpan
IPC分类号： A61B800
CPC分类号： A61B8/12 , A61B8/4483 , A61B8/4488 , G10K11/346
摘要： A method and apparatus for achieving ultrasonic coronary thrombolysis. After intravenous injection of a thrombus-specific ultrasound contrast agent, an array of ultrasonic transducers arranged in a pad placed on the patient's chest transmits ultrasound signals into the patient, from a virtual source. Reflected signals are then analyzed to determine the ratio of the second (or hall) harmonic to first harmonic components in the signals. A high ratio indicates the presence of a thrombus in the field of interrogation Time-of-flight data for each of the receivers is used to calculate a spatial location of the thrombus, and a phased array ultrasonic transmission is then focused on the thrombus, so as to achieve sonoparation.
摘要翻译：用于实现超声冠状动脉溶栓治疗的方法和装置。在静脉注射血栓特异性超声造影剂之后，布置在放置在患者胸部上的垫中的超声波换能器阵列从虚拟源将超声信号传输到患者体内。然后分析反射信号以确定信号中第二（或霍尔）谐波与一次谐波分量的比率。高比例表示在询问领域存在血栓用于每个接收器的飞行时间数据用于计算血栓的空间位置，并且相控阵列超声波传播然后集中在血栓上，因此以获得超声波。

30. 发明授权

US06320935B1 Dosimeter for a miniature energy transducer for emitting X-ray radiation 有权
标题翻译：用于发射X射线辐射的微型能量换能器的剂量计
公开(公告)号：US06320935B1
公开(公告)日：2001-11-20
申请号：US09513959
申请日：2000-02-28
申请人： Guy Shinar , Shmuel Bukshpan
发明人： Guy Shinar , Shmuel Bukshpan
IPC分类号： A61N510
CPC分类号： A61N5/1001 , A61N5/1002 , A61N5/1048 , G01T1/161 , G01T1/201
摘要： A dosimeter for an x-ray brachytherapy system permits in situ monitoring and control of radiation treatment via a miniaturized energy transducer within a human body. The dosimeter comprises a scintillating optical fiber having a distal end which is placed at the treatment site and a proximal end which is coupled to a dosimeter measurement unit. Utilizing energy supplied by an energy source, the miniaturized transducer generates x-ray photons. The scintillating optical fiber absorbs x-ray photons, converts the x-ray photons into light photons, and conveys the light photons to a dosimeter measurement unit. The light photons are converted into an electrical current which is representative of the intensity of the x-ray photons. The dosimeter measurement unit utilizes the electrical current to calculate and display the instantaneous and accumulated radiation dose, and radiation dose parameters are utilized to adjust energy levels, which are sent to the miniature energy transducer. Use of the miniaturized energy transducer in combination with the dosimeter eliminates most of the problems related to the methods based on the use of radioactive sources and offers a method for efficient, accurate, and controllable radiation treatment.
摘要翻译：用于X射线近距离放射治疗系统的剂量计允许通过人体内的小型化能量换能器原位监测和控制辐射治疗。剂量计包括闪烁光纤，其具有放置在治疗部位的远端，以及耦合到剂量计测量单元的近端。利用由能源提供的能量，小型化的换能器产生x射线光子。闪烁光纤吸收x射线光子，将x射线光子转换为光子，并将光子传输到剂量计测量单元。光子被转换为代表x射线光子强度的电流。剂量计测量单元使用电流来计算和显示瞬时和累积的辐射剂量，并且使用辐射剂量参数来调节发送到微型能量换能器的能量水平。将微型能量换能器与剂量计结合使用消除了与基于放射源使用的方法相关的大部分问题，并提供了一种有效，准确和可控的辐射治疗的方法。

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