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21. 发明授权

US08512251B2 Ultrasound transducer and ultrasound diagnostic apparatus 有权
标题翻译：超声波换能器和超声波诊断仪
公开(公告)号：US08512251B2
公开(公告)日：2013-08-20
申请号：US13614168
申请日：2012-09-13
申请人： Kazuya Matsumoto , Katsuhiro Wakabayashi , Jin Hiraoka , Kazuhisa Karaki , Mamoru Hasegawa , Satoshi Yoshida
发明人： Kazuya Matsumoto , Katsuhiro Wakabayashi , Jin Hiraoka , Kazuhisa Karaki , Mamoru Hasegawa , Satoshi Yoshida
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4494 , B06B1/0292
摘要： An ultrasound transducer includes a substrate and a lower electrode layer, a lower insulating layer, an upper insulating layer, and an upper electrode layer. The lower insulating layer and the upper insulating layer are arranged to be opposed to each other via an air gap section. The upper insulating layer and the lower insulating layer are different in a material and thickness and satisfy Equation 1 below. In Equation 1, K1 represents a relative dielectric constant of the lower insulating layer, K2 represents a relative dielectric constant of the upper insulating layer, T1 represents thickness of the lower insulating layer, T2 represents thickness of the upper insulating layer, ρ1(x) represents a charge density distribution in the lower insulating layer, and ρ2(y) represents a charge density distribution in the upper insulating layer. 1 K ⁢ ⁢ 1 ⁢ ∫ 0 T ⁢ ⁢ 1 ⁢ x × ρ ⁢ ⁢ 1 ⁢ ( x ) ⁢ ⁢ ⅆ x = 1 K ⁢ ⁢ 2 ⁢ ∫ 0 T ⁢ ⁢ 2 ⁢ y × ρ ⁢ ⁢ 2 ⁢ ( y ) ⁢ ⁢ ⅆ y ( Equation ⁢ ⁢ 1 )
摘要翻译：超声波换能器包括基板和下电极层，下绝缘层，上绝缘层和上电极层。下绝缘层和上绝缘层经由气隙部分布置成彼此相对。上绝缘层和下绝缘层的材料和厚度不同，满足下面的等式1。在等式1中，K1表示下绝缘层的相对介电常数，K2表示上绝缘层的相对介电常数，T1表示下绝缘层的厚度，T2表示上绝缘层的厚度，rho1（x）表示下绝缘层中的电荷密度分布，并且rho2（y）表示上绝缘层中的电荷密度分布。 1 K·塞尔·∫··············································································· ）⁢ⅆy（方程式1）

22. 发明授权

US08047995B2 Ultrasonic transducer, method of manufacturing ultrasonic transducer, ultrasonic diagnostic apparatus, and ultrasonic microscope 有权
标题翻译：超声波换能器，超声波换能器的制造方法，超声波诊断装置和超声波显微镜
公开(公告)号：US08047995B2
公开(公告)日：2011-11-01
申请号：US12197706
申请日：2008-08-25
申请人： Katsuhiro Wakabayashi , Hideo Adachi , Mamoru Hasegawa , Kazuya Matsumoto , Kazuhisa Karaki , Yoshitaka Kamiya
发明人： Katsuhiro Wakabayashi , Hideo Adachi , Mamoru Hasegawa , Kazuya Matsumoto , Kazuhisa Karaki , Yoshitaka Kamiya
IPC分类号： A61B8/00
CPC分类号： B06B1/0292 , A61B8/483 , H04R19/01 , Y10T29/42
摘要： A ultrasonic transducer of the invention comprises: a transducer cell including a first electrode and a second electrode disposed separated from the first electrode by an air gap portion; and an electret for applying a potential difference between the first electrode and the second electrode. The electret is disposed in a region where at least a part thereof does not overlap with the transducer cell when viewed from a transmitting direction of ultrasonic waves.
摘要翻译：本发明的超声换能器包括：换能器单元，包括第一电极和通过气隙部分与第一电极隔开的第二电极; 以及用于在第一电极和第二电极之间施加电位差的驻极体。当从超声波的发送方向观察时，驻极体设置在至少一部分与换能器单元不重叠的区域。

23. 发明授权

US08026651B2 Ultrasound transducer and electronic device 有权
标题翻译：超声波换能器和电子设备
公开(公告)号：US08026651B2
公开(公告)日：2011-09-27
申请号：US12424118
申请日：2009-04-15
申请人： Katsuhiro Wakabayashi , Hideo Adachi , Kazuya Matsumoto , Mamoru Hasegawa , Kazuhisa Karaki , Yoshitaka Kamiya
发明人： Katsuhiro Wakabayashi , Hideo Adachi , Kazuya Matsumoto , Mamoru Hasegawa , Kazuhisa Karaki , Yoshitaka Kamiya
IPC分类号： H01L41/04 , A61B8/00
CPC分类号： B06B1/0292
摘要： An ultrasound transducer includes a substrate, an ultrasound transducer cell placed on one surface of the substrate and having a lower electrode, a first gap portion placed on the lower electrode and an upper electrode placed on the first gap portion, a first conductive layer placed on the other surface of the substrate and electrically connected to one of the lower electrode and the upper electrode, an electret film placed on the first conductive layer, an insulating layer placed on the electret film, and a second conductive layer placed on the insulating layer and electrically connected to the one of the lower electrode and the upper electrode not electrically connected to the first conductive layer.
摘要翻译：超声波换能器包括基板，放置在基板的一个表面上的超声换能器单元，具有下电极，放置在下电极上的第一间隙部分和放置在第一间隙部分上的上电极，第一导电层置于基板的另一个表面，并且电连接到下电极和上电极中的一个，驻留在第一导电层上的驻极体膜，设置在驻极体膜上的绝缘层和放置在绝缘层上的第二导电层，电连接到未电连接到第一导电层的下电极和上电极之一。

24. 发明申请

US20110162093A1 METHODS FOR PRODUCING ANTIBODIES 审中-公开
标题翻译：生产抗体的方法
公开(公告)号：US20110162093A1
公开(公告)日：2011-06-30
申请号：US11922278
申请日：2006-06-13
申请人： Yasuji Ueda , Hiroto Hara , Tsugumine Shu , Mamoru Hasegawa
发明人： Yasuji Ueda , Hiroto Hara , Tsugumine Shu , Mamoru Hasegawa
IPC分类号： C12P21/00 , C12N5/07
CPC分类号： C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K16/00 , C07K16/1063 , C12N2760/18843
摘要： [Problems to be Solved] The present invention provides methods for producing antibodies and antibody-producing cells.[Means for Solving the Problems] The present invention provides methods for producing antibodies or antibody-producing cells, such methods including the steps of inoculating non-human animals with minus-strand RNA viral vectors carrying nucleic acids which encode foreign polypeptides to be used as antigens, nucleic acids producing the viral vectors, cells into which the vectors or the nucleic acids producing the vectors have been introduced, or lysates of the cells; and collecting the antibodies or antibody-producing cells from the animals. The antibody production can be induced efficiently by the immune activating effect of the minus-strand RNA viral vectors and a high expression of the antigen polypeptides. The antibodies produced by the methods of the present invention can be used in research and development and in the clinical field.
摘要翻译： [待解决的问题]本发明提供了产生抗体和产生抗体的细胞的方法。解决问题的手段本发明提供了产生抗体或抗体产生细胞的方法，包括以下步骤：将携带编码外源多肽的核酸的负链RNA病毒载体接种在非人动物中，以用作为产生病毒载体的核酸，产生载体的载体或核酸的细胞或细胞的裂解物; 并从动物中收集抗体或产生抗体的细胞。可以通过负链RNA病毒载体的免疫激活作用和抗原多肽的高表达来有效诱导抗体产生。通过本发明的方法产生的抗体可用于研究和开发以及临床领域。

25. 发明申请

US20100323428A1 ATTENUATED MINUS-STRANDED RNA VIRUS 审中-公开
标题翻译：衰减的细菌RNA病毒
公开(公告)号：US20100323428A1
公开(公告)日：2010-12-23
申请号：US12526211
申请日：2008-02-07
申请人： Mariko Yoshizaki , Makota Inoue , Mamoru Hasegawa
发明人： Mariko Yoshizaki , Makota Inoue , Mamoru Hasegawa
IPC分类号： C12N7/01 , C12N15/63
CPC分类号： C12N7/00 , A61K48/00 , A61K2039/5254 , C07K14/005 , C12N2760/18822 , C12N2760/18861
摘要： An objective of the present invention is to provide attenuated minus-strand RNA viruses. The present inventors discovered that the amino acid mutation at position 1214 (Y1214F) in the amino acid sequence of L protein of Sendai virus suppressed the viral genome replication activity and/or transcription activity. The inventors also found that the deletion of a particular gene from the viral genome could result in much less cytotoxicity and immune response than conventional. The inventors thus completed the present invention.
摘要翻译：本发明的目的是提供减毒的负链RNA病毒。本发明人发现仙台病毒L蛋白的氨基酸序列中第1214位氨基酸突变（Y1214F）抑制病毒基因组复制活性和/或转录活性。本发明人还发现，从病毒基因组中删除特定基因可导致远低于常规的细胞毒性和免疫应答。本发明人完成了本发明。

26. 发明申请

US20100266633A1 AIDS VIRUS VACCINES USING SENDAI VIRUS VECTOR 有权
标题翻译：艾滋病病毒疫苗使用SENDAI病毒载体
公开(公告)号：US20100266633A1
公开(公告)日：2010-10-21
申请号：US12701303
申请日：2010-02-05
申请人： Munehide KANO , Tetsuro Matano , Atsushi Kato , Yoshiyuki Nagai , Mamoru Hasegawa
发明人： Munehide KANO , Tetsuro Matano , Atsushi Kato , Yoshiyuki Nagai , Mamoru Hasegawa
IPC分类号： A61K39/21
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/57 , C12N2740/15034 , C12N2760/18843 , C12N2760/18871 , C12N2800/30
摘要： The present invention provides a vaccine containing a Sendai virus vector encoding a virus protein of an immunodeficiency virus. By intranasally administering a Sendai virus encoding a virus protein of an immunodeficiency virus to a macaque monkey, the present inventors have succeeded in efficiently inducing protective immunity against an immunodeficiency virus. As a result of intranasal inoculation of vaccine, expression of an antigen protein mediated by Sendai virus vector was detected in intranasal mucous membrane and local lymph nodes and antigen-specific cellular immune response was induced at a significant level. No pathological symptom by vaccination was observed. After vaccination, exposure of simian immunodeficiency virus was performed and the effect was examined. As a result, the amount of virus in plasma significantly decreased, compared with that of the control animal. The present invention provides a promising vaccine as an AIDS vaccine.
摘要翻译：本发明提供含有编码免疫缺陷病毒病毒蛋白质的仙台病毒载体的疫苗。通过将编码免疫缺陷病毒的病毒蛋白的仙台病毒鼻内施用于猕猴，本发明人成功地有效地诱导针对免疫缺陷病毒的保护性免疫。鼻内接种疫苗后，在鼻内粘膜中检测到仙台病毒载体介导的抗原蛋白的表达，局部淋巴结的表达明显升高，抗原特异性细胞免疫应答水平明显升高。未观察到接种疫苗的病理症状。接种疫苗后，进行猿猴免疫缺陷病毒的暴露，并检查其效果。结果，与对照动物相比，血浆中的病毒量显着降低。本发明提供了作为AIDS疫苗的有希望的疫苗。

27. 发明申请

US20080120013A1 Control system for internal combustion engine 失效
标题翻译：内燃机控制系统
公开(公告)号：US20080120013A1
公开(公告)日：2008-05-22
申请号：US11976659
申请日：2007-10-26
申请人： Satoshi Yamaguchi , Mamoru Hasegawa , Hideki Sakamoto , Naoto Kitayama
发明人： Satoshi Yamaguchi , Mamoru Hasegawa , Hideki Sakamoto , Naoto Kitayama
IPC分类号： F02D41/30
CPC分类号： F02D35/023 , F02D35/028 , F02D41/005 , F02D41/008 , F02D41/403 , F02D2041/0067 , F02D2200/0612 , Y02T10/44 , Y02T10/47
摘要： A control system for an internal combustion engine having fuel injectors for injecting fuel into a combustion chamber of the engine. A fuel property is estimated based on a combustion state of the fuel injected into at least one cylinder of the engine. The fuel injectors are controlled so that a specific amount of fuel is injected into the at least one cylinder and an amount of fuel corresponding to an operating condition of the engine is injected into cylinders other than the at least one cylinder. An additional fuel injection is performed after the fuel injection of the specific amount with respect to the at least one cylinder, for example, when a torque difference parameter indicative of a difference between a torque generated by the at least one cylinder and a torque generated by the other cylinders is equal to or greater than a predetermined threshold value.
摘要翻译：一种用于内燃机的控制系统，其具有用于将燃料喷射到发动机的燃烧室中的燃料喷射器。基于喷射到发动机的至少一个气缸中的燃料的燃烧状态来估计燃料特性。控制燃料喷射器，使得特定量的燃料被喷射到至少一个气缸中，并且与发动机的运行状态相对应的燃料量被喷射到除了至少一个气缸之外的气缸中。例如，当指示由至少一个气缸产生的转矩与由至少一个气缸产生的转矩之间的差异的转矩差参数与由至少一个气缸产生的转矩之间的差异时，在相对于至少一个气缸的燃料喷射特定量之后执行额外的燃料喷射，其他气缸等于或大于预定阈值。

28. 发明申请

US20070161110A1 Methods for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken beta-actin promoter 有权
标题翻译：使用包含巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子产生负链rna病毒载体的方法
公开(公告)号：US20070161110A1
公开(公告)日：2007-07-12
申请号：US10586142
申请日：2005-01-20
申请人： Akihiro Iida , Hiroshi Ban , Makoto Inoue , Takahiro Hirata , Mamoru Hasegawa
发明人： Akihiro Iida , Hiroshi Ban , Makoto Inoue , Takahiro Hirata , Mamoru Hasegawa
IPC分类号： C12N15/86 , C07H21/04 , C12N7/00
CPC分类号： C12N15/86 , C12N2770/36143 , C12N2800/108 , C12N2800/30 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/90
摘要： The present invention provides methods for producing a minus-strand RNA viral vector, which comprise using a promoter comprising a cytomegalovirus enhancer and a chicken β-actin promoter, to induce the transcription of the genome RNA of a minus-strand RNA viral vector and the expression of minus-strand RNA viral proteins that form a ribonucleoprotein with the genome RNA. The methods of the present invention enable high efficiency production of highly safe minus-strand RNA viral vectors. The methods of the present invention are particularly useful for producing minus-strand RNA viral vectors that are deficient in envelope-constituting protein genes.
摘要翻译：本发明提供了产生负链RNA病毒载体的方法，其包括使用包含巨细胞病毒增强子和鸡β-肌动蛋白启动子的启动子来诱导负链RNA病毒载体的基因组RNA的转录，表达与基因组RNA形成核糖核蛋白的负链RNA病毒蛋白。本发明的方法能高效生产高度安全的负链RNA病毒载体。本发明的方法特别可用于产生缺失包膜蛋白基因的负链RNA病毒载体。

29. 发明授权

US07241617B2 Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci 失效
标题翻译：包含插入在R1和R2基因座之间的外来基因的仙台病毒载体
公开(公告)号：US07241617B2
公开(公告)日：2007-07-10
申请号：US09843922
申请日：2001-04-30
申请人： Masayuki Fukumura , Makoto Asakawa , Mamoru Hasegawa , Masayuki Shirakura
发明人： Masayuki Fukumura , Makoto Asakawa , Mamoru Hasegawa , Masayuki Shirakura
IPC分类号： C12N15/00 , C07H21/02 , C07H21/04 , A01N63/00 , A01N65/00 , A01N43/04 , A61K31/70
CPC分类号： C07K14/50 , A61K38/00 , A61K38/185 , A61K48/00 , A61K48/0075 , C12N9/2402 , C12N15/86 , C12N2760/18832 , C12N2760/18843 , C12Y302/01031
摘要： Use of a negative-sense RNA virus vector has enabled transfer of nucleic acid into nerve cells. The method of this invention can be used for introducing a gene efficiently into nerve cells including the central nerve tissue in gene therapy, etc.
摘要翻译：使用负义RNA病毒载体使核酸能够转移到神经细胞中。本发明的方法可用于将基因有效地引入包括基因治疗中的中枢神经组织等神经细胞等。

30. 发明申请

US20070141705A1 Method for producing viral vectors 审中-公开
标题翻译：生产病毒载体的方法
公开(公告)号：US20070141705A1
公开(公告)日：2007-06-21
申请号：US10587123
申请日：2005-01-20
申请人： Makoto Inoue , Hiroshi Ban , Akihiro Iida , Mamoru Hasegawa
发明人： Makoto Inoue , Hiroshi Ban , Akihiro Iida , Mamoru Hasegawa
IPC分类号： C12N5/08 , C12N7/01 , C12N15/86
CPC分类号： C12N7/00 , C12N2760/18851
摘要： The present invention provides methods for producing viruses, whose propagation depends on the cleavage of viral protein by a protease, in a manner independent of the protease. The methods of the present invention for producing viruses comprise producing viruses in the presence of a modified viral protein in which the protease cleavage sequence is changed to a cleavage sequence for an alternative protease. Viral vectors can be more efficiently produced by replacing the protease cleavage sequence with a cleavage sequence for a protease expressed endogenously in virus-producing cells. The methods of the present invention enable the production of high titer viruses using a wide variety of cells.
摘要翻译：本发明提供了以与蛋白酶无关的方式生产病毒的方法，其传播依赖于蛋白酶对病毒蛋白的切割。用于产生病毒的本发明的方法包括在修饰的病毒蛋白质的存在下产生病毒，其中将蛋白酶切割序列改变为用于替代性蛋白酶的切割序列。通过用在病毒产生细胞内源性表达的蛋白酶的切割序列替换蛋白酶切割序列可以更有效地产生病毒载体。本发明的方法能够使用多种细胞产生高滴度病毒。

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