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21. 发明授权

US08323622B2 Ionic complex nanoparticles for detecting heparanase activities and method for preparing the same 有权
标题翻译：用于检测肝素酶活性的离子复合纳米颗粒及其制备方法
公开(公告)号：US08323622B2
公开(公告)日：2012-12-04
申请号：US12472405
申请日：2009-05-27
申请人： Ick-Chan Kwon , Kwang-Meyung Kim , Kui-Won Choi , Kyeong-Soon Park , Seul-Ki Lee
发明人： Ick-Chan Kwon , Kwang-Meyung Kim , Kui-Won Choi , Kyeong-Soon Park , Seul-Ki Lee
IPC分类号： A61B5/00
CPC分类号： C12Q1/34 , A61K49/0054 , G01N2333/924
摘要： Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia.
摘要翻译：公开了用于检测乙酰肝素酶活性的离子复合纳米粒子及其制备方法。更具体地，公开了用于检测乙酰肝素酶活性的离子复合纳米颗粒，其中由肝素酶和阳离子生物相容性聚合物特异性降解的负离子底物聚合物彼此离子地结合，并且荧光团或猝灭剂与每种聚合物结合。用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以应用于筛选新型药物的方法，例如防止肝素酶过度表达的抑制剂。发生肝素酶过度表达的各种细胞和组织可能在癌细胞，癌组织和各种炎性疾病的组织中非侵入性成像。因此，用于检测乙酰肝素酶活性的离子络合物纳米颗粒可以有效地用于早期诊断各种疾病和不治之症，包括自身免疫疾病如癌症，骨关节炎，类风湿性关节炎和痴呆。

22. 发明授权

US06191193B1 Microspheric embolic materials having a dual structure of poly(vinyl acetate) core and poly(vinyl alcohol) shell and method for preparing the same 有权
标题翻译：具有聚（乙酸乙烯酯）芯和聚（乙烯醇）壳的双重结构的微球栓塞材料及其制备方法
公开(公告)号：US06191193B1
公开(公告)日：2001-02-20
申请号：US09627403
申请日：2000-07-27
申请人： Chul-Joo Lee , Won-Seok Lyoo , Ick-Chan Kwon , Se-Geun Lee , Jae-Pil Kim , Moon-Hee Han
发明人： Chul-Joo Lee , Won-Seok Lyoo , Ick-Chan Kwon , Se-Geun Lee , Jae-Pil Kim , Moon-Hee Han
IPC分类号： C08F11808
CPC分类号： C08J3/126 , C08F6/04 , C08F8/12 , C08J2331/04 , C08J2429/04 , Y10S525/902 , Y10S526/909 , C08F118/08
摘要： A method for separating poly(vinyl acetate) particles having various particle sizes, which have been prepared by suspension polymerization of vinyl acetate monomers, into respective microspheric poly(vinyl acetate) particles with uniform particle size distribution by the use of inorganic salt as a dispersing and antistatic agent, a method for preparing the microspheric embolic particles of a dual structure consisting of poly(vinyl acetate) core/poly(vinyl alcohol) shell by suspending the separated poly(vinyl acetate) particles into an aqueous alkali solution and subjecting the suspended particles to a heterogeneous surface saponification and the microspheric embolic particles prepared.
摘要翻译：通过使用无机盐作为分散体，将通过乙酸乙烯酯单体的悬浮聚合制备的具有各种粒径的聚（乙酸乙烯酯）颗粒分离成各自的具有均匀粒度分布的微球聚（乙酸乙烯酯）颗粒的方法和抗静电剂，通过将分离的聚（乙酸乙烯酯）颗粒悬浮在碱性水溶液中并使悬浮的聚（乙酸乙烯酯）壳悬浮的聚（乙酸乙烯酯）芯/聚（乙烯醇）壳组成的双重结构的微球状栓塞颗粒的制备方法颗粒到异质表面皂化和微球栓塞颗粒制备。

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