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21. 发明授权

US08586073B2 Methods and formulations for administration of resolvin anti-inflammatory compounds 有权
标题翻译：用于给予安氏抗炎化合物的方法和制剂
公开(公告)号：US08586073B2
公开(公告)日：2013-11-19
申请号：US13359560
申请日：2012-01-27
申请人： Susan J. Drapeau , Kelly B. Emerton , Daniel A. Shimko
发明人： Susan J. Drapeau , Kelly B. Emerton , Daniel A. Shimko
IPC分类号： A61F2/02
CPC分类号： A61K45/06 , A61K9/0014 , A61K9/0063 , A61K9/06 , A61K9/145 , A61K9/146 , A61K9/50 , A61K31/202 , A61K2300/00
摘要： The invention relates to resolvins and their use as anti-inflammatory compounds. The resolvins may be administered in a variety of forms, including drug depots comprising polymers or lipids. The pharmaceutical formulations of the present invention may be used to treat a variety of conditions including acute pain and chronic pain.
摘要翻译：本发明涉及溶胶凝胶及其作为抗炎化合物的用途。可以以各种形式施用溶解素，包括包含聚合物或脂质的药物贮库。本发明的药物制剂可用于治疗各种病症，包括急性疼痛和慢性疼痛。

22. 发明申请

US20130274763A1 METHODS AND DEVICES FOR FACET JOINT PREPARATION AND IMPLANT DELIVERY 审中-公开
标题翻译：用于FACET接头制备和植入物传递的方法和装置
公开(公告)号：US20130274763A1
公开(公告)日：2013-10-17
申请号：US13446156
申请日：2012-04-13
申请人： Susan J. Drapeau , Daniel A. Shimko
发明人： Susan J. Drapeau , Daniel A. Shimko
IPC分类号： A61B17/50
CPC分类号： A61B17/7064 , A61B17/025 , A61B17/1671 , A61B17/88 , A61B2017/0256
摘要： A system for treating a tissue site is provided, the system including a graft preparation device for treating a tissue site, the preparation device including an elongate inner member having a proximal end connected to a handle and a distal end including an abrasive end configured for abrading the tissue site, and an elongate outer member movably attached to the elongate inner member, the elongate outer member including a tapered end. The elongate outer member is movable between a first position for covering the abrasive end and a second position for exposing the abrasive end. Following treatment of the tissue site using the graft preparation device to remove soft tissue and cause bleeding, the tissue site is distracted and an implant body is inserted into the tissue site.
摘要翻译：提供了一种用于治疗组织部位的系统，所述系统包括用于治疗组织部位的移植物制备装置，所述制备装置包括细长内部构件，所述细长内部构件具有连接到手柄的近端和包括研磨端的研磨端组织部位和可移动地附接到细长内部构件的细长外部构件，细长外部构件包括锥形端部。细长外部构件可在用于覆盖研磨端的第一位置和用于暴露研磨端的第二位置之间移动。在使用移植物制备装置处理组织部位以除去软组织并引起渗血之后，分散组织部位并将植入体插入组织部位。

23. 发明授权

US08556908B2 Osteochondral implant procedure and device 有权
标题翻译：骨软骨植入手术和装置
公开(公告)号：US08556908B2
公开(公告)日：2013-10-15
申请号：US11680318
申请日：2007-02-28
申请人： Jeffrey H. Nycz , Keith M. Kinnane , Susan J. Drapeau , Daniel Shimko , Jeetendra Bharadwaj
发明人： Jeffrey H. Nycz , Keith M. Kinnane , Susan J. Drapeau , Daniel Shimko , Jeetendra Bharadwaj
IPC分类号： A61B5/00 , A61B17/58
CPC分类号： A61B17/1764 , A61B2017/00946
摘要： A surgical procedure according to which a slotted film is positioned over an area of a bone to be milled; and a portion of a milling assembly is inserted in the defect, with another portion of the assembly extending through one of the slots so that the slot can be used as a guide to mill the bone.
摘要翻译：一种外科手术，根据该手术，开槽的薄膜位于要碾磨的骨的区域上; 并且铣削组件的一部分插入缺陷中，组件的另一部分延伸穿过其中一个槽，使得该槽可以用作铣削骨的引导件。

24. 发明申请

US20120172885A1 SURGICAL TACK DELIVERY SYSTEM, METHOD AND KIT 有权
标题翻译：外科输送系统，方法和工具包
公开(公告)号：US20120172885A1
公开(公告)日：2012-07-05
申请号：US12983544
申请日：2011-01-03
申请人： Susan J. Drapeau , Kelly Brook Emerton , Daniel Andrew Shimko
发明人： Susan J. Drapeau , Kelly Brook Emerton , Daniel Andrew Shimko
IPC分类号： A61B17/56
CPC分类号： A61B17/92 , A61B17/86 , A61B17/865
摘要： A system for delivering a surgical tack in tissue includes a driver, comprising: a shaft having a slot and a channel; and a handle slidably connected to said shaft and having a driving mechanism, said driving mechanism having a driving pin for providing a downward force through said shaft; and a tack cartridge having a plurality of tacks and adapted to be received in said slot and further adapted to feed said tacks between said driving mechanism and said channel.
摘要翻译：用于在组织中递送手术钉的系统包括驱动器，包括：具有狭槽和通道的轴; 以及可滑动地连接到所述轴并具有驱动机构的手柄，所述驱动机构具有用于通过所述轴提供向下的力的驱动销; 以及具有多个钉并且适于被容纳在所述槽中的进一步适于在所述驱动机构和所述通道之间进给所述钉的钉仓。

25. 发明申请

US20120101404A1 Methods for Detecting Osteolytic Conditions in the Body 审中-公开
标题翻译：检测体内溶骨质素的方法
公开(公告)号：US20120101404A1
公开(公告)日：2012-04-26
申请号：US13315332
申请日：2011-12-09
申请人： Jeffrey H. Nycz , Susan J. Drapeau , William T. Donofrio
发明人： Jeffrey H. Nycz , Susan J. Drapeau , William T. Donofrio
IPC分类号： A61B5/01 , A61B5/00
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/01 , A61B5/076 , A61B5/4528 , A61B5/6882 , A61B17/68 , A61B17/86 , A61F2/2803 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/3804 , A61F2/40 , A61F2/4202 , A61F2/4261 , A61F2/44 , A61F2/4609 , A61F2002/30405 , A61F2002/30448 , A61F2002/30449 , A61F2002/3067 , A61F2002/30794 , A61F2002/3403 , A61F2002/3404 , A61F2002/3412 , A61F2002/3414 , A61F2002/3429 , A61F2002/3611 , A61F2002/3625 , A61F2002/48 , A61F2002/488 , A61F2220/0025 , A61F2220/005 , A61F2250/0002
摘要： Methods and systems for detecting a biological response indicative of osteolysis or preconditions in bone.
摘要翻译：用于检测指示骨质溶解或前提条件的生物反应的方法和系统。

26. 发明申请

US20120046663A1 BONE SCORING DEVICE 有权
标题翻译：骨刻度装置
公开(公告)号：US20120046663A1
公开(公告)日：2012-02-23
申请号：US12857741
申请日：2010-08-17
申请人： Daniel Andrew Shimko , Susan J. Drapeau , Kelly Brook Emerton
发明人： Daniel Andrew Shimko , Susan J. Drapeau , Kelly Brook Emerton
IPC分类号： A61B17/16
CPC分类号： A61B17/1659
摘要： A bone scoring device having a body, a scoring member configured to engage a bone surface and a first biasing member connected to and configured to rotate the scoring member is provided. The scoring member being axially movable between a first, non-rotatable position, such that the scoring member is engaged with the body and a second rotatable position such that the scoring member is released from engagement with the body and freely rotates. The scoring member having an abrasive surface to score the surface of the bone in which it is put in contact. A method for using the scoring device as well as a kit including the scoring device are also provided.
摘要翻译：本发明提供了一种具有身体的骨骼刻痕装置，被配置为接合骨表面的划痕部件和连接到并构造成旋转刻划部件的第一偏压部件。所述刻痕构件可在第一不可旋转位置之间轴向移动，使得所述刻划构件与所述主体接合，并且所述第二可旋转位置使得所述刻划构件与所述主体脱离接合并自由旋转。所述评分构件具有研磨表面以对与其接触的骨的表面进行计分。还提供了使用评分装置的方法以及包括评分装置的工具箱。

27. 发明授权

US07960098B2 Methods and compositions for the preservation of cells and tissues 有权
标题翻译：用于保存细胞和组织的方法和组合物
公开(公告)号：US07960098B2
公开(公告)日：2011-06-14
申请号：US11777093
申请日：2007-07-12
申请人： Josee Roy , Susan J. Drapeau , Daniel A. Shimko
发明人： Josee Roy , Susan J. Drapeau , Daniel A. Shimko
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/021
摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.
摘要翻译：公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存，然后运输和植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。

28. 发明授权

US07892724B2 Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs 有权
标题翻译：使用包含两种低分子量PEG的溶液增强哺乳动物细胞，组织和器官的存活力的方法
公开(公告)号：US07892724B2
公开(公告)日：2011-02-22
申请号：US11777167
申请日：2007-07-12
申请人： Daniel A. Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
发明人： Daniel A. Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
IPC分类号： A01N1/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/021 , C12N5/0018 , C12N2500/30 , C12N2500/46 , C12N2500/60
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
摘要翻译：公开了用于保存，储存和运输生物体组织，器官和分离细胞群体的组合物和方法。特别地，所公开的组合物和方法允许哺乳动物细胞，组织和器官从合适的供体动物中收获，长时间储存并转运到受体植入部位，所有细胞，组织和器官都不会显着损失细胞活力，生物活性和 /或组织完整性。

29. 发明授权

US07850656B2 Devices and methods for delivering medical agents 有权
标题翻译：用于递送医疗药剂的装置和方法
公开(公告)号：US07850656B2
公开(公告)日：2010-12-14
申请号：US11118125
申请日：2005-04-29
申请人： William F. McKay , Susan J. Drapeau
发明人： William F. McKay , Susan J. Drapeau
IPC分类号： A61M5/00
CPC分类号： A61M5/3148 , A61B17/3478 , A61B2017/00247 , A61B2017/00261 , A61B2018/00392 , A61M5/32 , A61M5/3291 , A61M5/3298 , A61M2005/341
摘要： Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.
摘要翻译：描述了用于将医疗剂递送到患者组织体积（例如脊椎盘的内部空间）内的多个位置的新方法，并且还用于在医疗剂递送期间从其中移除材料以增强输送。还描述了医疗输送装置，例如构造成便于将医疗药剂区域递送到患者组织的针组件。

30. 发明授权

US07838022B2 Malleable implants containing demineralized bone matrix 有权
标题翻译：含有脱钙骨基质的韧性植入物
公开(公告)号：US07838022B2
公开(公告)日：2010-11-23
申请号：US11415037
申请日：2006-05-01
申请人： Susan J. Drapeau , Kathy L. Chamness , William F. McKay
发明人： Susan J. Drapeau , Kathy L. Chamness , William F. McKay
IPC分类号： A61F2/28 , A61K35/32
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.
摘要翻译：描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。固体包括颗粒状胶原和颗粒脱矿质骨基质。液体载体包括含有多糖的水性介质。还描述了制备和使用这种医药组合物的方法。

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