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21. 发明授权

US5883343A Downpeak group optimization 失效
标题翻译： Downpeak组优化
公开(公告)号：US5883343A
公开(公告)日：1999-03-16
申请号：US758827
申请日：1996-12-04
申请人： Robert C. MacDonald , Christian Semoroz
发明人： Robert C. MacDonald , Christian Semoroz
IPC分类号： B66B3/00 , B66B1/18 , B66B1/20 , G05B13/02
CPC分类号： B66B1/20
摘要： A system and method for optimally allocating elevator cars of an elevator group to serve downpeak traffic. The system monitors a "snap shot" of pending down hall calls and forms groups based upon an initialized floor separation value or response range. If the number of groups formed is greater than the number of available elevator cars in the elevator group, the system increments the floor separation value by "+1" and regroups the "snap-shot" of pending down hall calls. This procedure may be repeated until the number of formed groups is equal to or less than the number of allocable elevator cars. The system may then allocate each formed group to a respective available elevator car to serve the downpeak traffic.
摘要翻译：一种用于最佳地分配电梯组的电梯轿厢以提供低速交通的系统和方法。该系统基于初始化的楼层间隔值或响应范围来监视未完成的门厅呼叫和窗体组的“快照”。如果形成的组数大于电梯组中可用的电梯轿厢的数量，则系统将楼层间隔值增加“+1”，并重新组合未决的门厅呼叫的“快照”。可以重复该过程，直到所形成的组的数量等于或小于可分配的电梯轿厢的数量。然后，系统可以将每个形成的组分配给相应的可用的电梯轿厢，以服务于低速行驶。

22. 发明授权

US5855910A Cationic phospholipids for transfection 失效
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US5855910A
公开(公告)日：1999-01-05
申请号：US470928
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.
摘要翻译：公开了一类新型的阳离子磷脂及其合成方法。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质体转染中是有效的。这些新型磷脂是特别有吸引力的，因为它们不仅在脂质体转染中有效，而且非常便宜且易于制备。

23. 发明授权

US5695780A Cationic phospholipids for transfection 失效
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US5695780A
公开(公告)日：1997-12-09
申请号：US468379
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald
发明人： Gary W. Ashley , Robert C. MacDonald
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88 , A61K31/66 , A61K31/675
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and a novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic lacids. These novel phospholipids are particularly attractive because they are extremely cheap and easy to make.
摘要翻译：公开了一类新型的阳离子磷脂及其合成方法。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质转染中是有效的。这些新型磷脂是特别有吸引力的，因为它们是非常便宜和容易制造的。

24. 发明授权

US4532089A Method of preparing giant size liposomes 失效
标题翻译：制备巨型脂质体的方法
公开(公告)号：US4532089A
公开(公告)日：1985-07-30
申请号：US570950
申请日：1984-01-14
申请人： Robert C. MacDonald
发明人： Robert C. MacDonald
IPC分类号： A61K9/127 , B01J13/02 , A61K9/52
CPC分类号： A61K9/1277 , Y10S436/829 , Y10T428/2984
摘要： Large size liposomes are produced from small unilamellar vesicles by incorporating a polar compound in an aqueous dispersion of the vesicles, subjecting the dispersion to repeated freeze-thaw cycles, and thereafter dialyzing the vesicles against a hypoosmotic medium. The freeze-thaw cycles aggregate the vesicles and increase their internal concentration of polar compound. During dialysis the vesicles imbibe water, rupture, and form enlarged liposomes.
摘要翻译：通过在小泡的水性分散体中加入极性化合物，使分散体经受反复冻融循环，然后将透泡液与渗透不良的培养基进行透析，从小单层囊泡中制备大尺寸脂质体。冻融循环聚集囊泡并增加其极性化合物的内部浓度。在透析期间，囊泡吸收水分，破裂并形成脂质体扩大。

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