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21. 发明申请

US20110152759A1 USE OF BIOMARKERS AND THERAPEUTIC AGENTS WITH SURGICAL DEVICES 有权
标题翻译：使用生物标志物和治疗药物与外科手术
公开(公告)号：US20110152759A1
公开(公告)日：2011-06-23
申请号：US12971249
申请日：2010-12-17
申请人： Jeffrey W. Clymer , Prasanna Malaviya , Donna L. Korvick , Kevin L. Houser , Cory G. Kimball , Foster B. Stulen , Frederick E. Shelton, IV , Chester O. Baxter, III , Taylor W. Aronhalt
发明人： Jeffrey W. Clymer , Prasanna Malaviya , Donna L. Korvick , Kevin L. Houser , Cory G. Kimball , Foster B. Stulen , Frederick E. Shelton, IV , Chester O. Baxter, III , Taylor W. Aronhalt
IPC分类号： A61M37/00 , A61B10/00
CPC分类号： A61B5/4839 , A61B5/14546 , A61B5/486 , A61B5/7282 , A61B5/742 , A61B10/0283 , A61B10/06 , A61B18/1445 , A61B2046/236 , A61B2218/008 , A61M2037/0007
摘要： Biomarkers are collected and used to determine biological propensities of a patient, to determine the efficacy of medical devices, to select and administer therapeutic agents, to select medical devices, to make adjustments to medical devices, and/or to adjust surgical techniques. An apparatus includes a port to draw a biological fluid (e.g., a mist) from a surgical site. The apparatus includes a sensor having a cantilevered beam. The beam includes substances selected to attract certain biomarkers as the fluid is communicated across the beam. The same apparatus or another apparatus is used to administer a therapeutic agent based at least in part on collected biomarker data. The therapeutic agent delivery apparatus may include a device that is also used to create a wound at a surgical site. For instance, a harmonic surgical instrument may be used to both collect biomarkers and administer a therapeutic agent (e.g., gene therapy using sonoporation).
摘要翻译：生物标志物被收集并用于确定患者的生物倾向性，以确定医疗装置的功效，选择和施用治疗剂，选择医疗装置，调整医疗装置和/或调整手术技术。一种装置包括从外科手术部位抽取生物流体（例如，雾）的端口。该装置包括具有悬臂梁的传感器。梁包括当流体在横梁上连通时选择用于吸引某些生物标志物的物质。使用相同的装置或另一装置至少部分地基于收集的生物标志物数据来施用治疗剂。治疗剂递送装置可以包括也用于在手术部位创建伤口的装置。例如，可以使用谐波手术器械来收集生物标志物并施用治疗剂（例如，使用声波光刻的基因治疗）。

22. 发明授权

US07854735B2 Energy-based medical treatment system and method 有权
标题翻译：基于能量的医疗系统和方法
公开(公告)号：US07854735B2
公开(公告)日：2010-12-21
申请号：US11355463
申请日：2006-02-16
申请人： Kevin L. Houser , Sarah A. Noschang , Jorge N. Gutierrez
发明人： Kevin L. Houser , Sarah A. Noschang , Jorge N. Gutierrez
IPC分类号： A61B18/18
CPC分类号： A61B17/320092 , A61B18/1442 , A61B2017/00026 , A61B2017/00084 , A61B2018/00875 , A61B2090/064
摘要： A method for medical treatment includes beginning coagulating patient tissue using an energy-based clamp coagulator, determining the clamping force, and measuring the acoustic impedance of the patient tissue. The method also includes compensating the measured acoustic impedance for clamp pressure and monitoring the coagulation using at least the compensated measured acoustic impedance. A first medical treatment system includes an energy-based clamp coagulator, an acoustic-impedance measurer, and a force measurer. A second system includes an energy-based clamp coagulator having a clamping member which includes, or is adapted to function as, an electrical-impedance-measuring electrode for measuring an electrical impedance of the clamped patient tissue. A third system includes an energy-based clamp coagulator having a clamping member which includes, or is adapted to function as, a temperature sensor for measuring a temperature of the clamped patient tissue.
摘要翻译：一种用于医疗的方法包括使用能量夹具凝结器开始凝固患者组织，确定夹紧力并测量患者组织的声阻抗。该方法还包括补偿测得的压阻声压，并使用至少补偿的测量声阻抗来监测凝结。第一种医疗系统包括能量钳式凝结器，声阻抗测量器和力测量器。第二系统包括能量夹具凝结器，其具有夹紧构件，该夹紧构件包括用于测量夹持的患者组织的电阻抗的电阻抗测量电极，或适于用作电阻抗测量电极。第三系统包括具有夹紧构件的能量夹紧凝结器，所述夹紧构件包括用于测量被夹紧的患者组织的温度的温度传感器，或适合于其作用。

23. 发明申请

US20100042126A1 ULTRASOUND MEDICAL INSTRUMENT HAVING A MEDICAL ULTRASONIC BLADE 审中-公开
标题翻译：超声波医用仪器有超声波刀片
公开(公告)号：US20100042126A1
公开(公告)日：2010-02-18
申请号：US12603599
申请日：2009-10-22
申请人： Kevin L. Houser , Shinichi Miyala , Atsunori Kozuki
发明人： Kevin L. Houser , Shinichi Miyala , Atsunori Kozuki
IPC分类号： A61B17/32
CPC分类号： A61B17/320092 , A61B2017/003 , A61B2017/00336 , A61B2017/22015 , A61B2017/320089 , A61B2017/320094
摘要： A first ultrasound medical instrument includes a medical ultrasonic blade having first, second and third blade portions. The second blade portion is more bendable than either of the first and third blade portions. A second ultrasound medical instrument includes a medical ultrasonic blade having a proximal blade portion and a distal blade portion. The distal blade portion bends more easily than does the proximal blade portion. The distal blade portion includes a distal end portion adapted to contact and ultrasonically treat patient tissue. A third ultrasonic medical instrument includes a medical ultrasonic blade. The medical ultrasonic blade includes a proximal blade portion having a centerline and includes a distal blade portion in contact with the proximal blade portion at a substantially planar interface. The interface is oriented at a non-zero angle with respect to a perpendicular to the centerline at the interface.
摘要翻译：第一超声波医疗器械包括具有第一，第二和第三叶片部分的医用超声波刀片。第二叶片部分比第一和第三叶片部分中的任何一个更可弯曲。第二超声波医疗器械包括具有近端叶片部分和远侧叶片部分的医用超声波刀片。远端叶片部分比近侧叶片部分更容易弯曲。远端叶片部分包括适于接触并超声波处理患者组织的远端部分。第三超声波医疗器械包括医用超声波刀片。医用超声波刀片包括具有中心线的近端刀片部分，并且包括在基本平坦的界面处与近侧刀片部分接触的远侧刀片部分。界面相对于在界面处的中心线的垂直线成非零角度定向。

24. 发明授权

US07621930B2 Ultrasound medical instrument having a medical ultrasonic blade 有权
标题翻译：超声医疗仪器具有医用超声波刀片
公开(公告)号：US07621930B2
公开(公告)日：2009-11-24
申请号：US11336274
申请日：2006-01-20
申请人： Kevin L. Houser
发明人： Kevin L. Houser
IPC分类号： A61B17/32
CPC分类号： A61B17/320092 , A61B17/320068 , A61B2017/003 , A61B2017/00336 , A61B2017/22015
摘要： A first ultrasound medical instrument includes a medical ultrasonic blade having first, second and third blade portions. The second blade portion is more bendable than either of the first and third blade portions. A second ultrasound medical instrument includes a medical ultrasonic blade having a proximal blade portion and a distal blade portion. The distal blade portion bends more easily than does the proximal blade portion. The distal blade portion includes a distal end portion adapted to contact and ultrasonically treat patient tissue. A third ultrasonic medical instrument includes a medical ultrasonic blade. The medical ultrasonic blade includes a proximal blade portion having a centerline and includes a distal blade portion in contact with the proximal blade portion at a substantially planar interface. The interface is oriented at a non-zero angle with respect to a perpendicular to the centerline at the interface.
摘要翻译：第一超声波医疗器械包括具有第一，第二和第三叶片部分的医用超声波刀片。第二叶片部分比第一和第三叶片部分中的任何一个更可弯曲。第二超声波医疗器械包括具有近端叶片部分和远侧叶片部分的医用超声波刀片。远端叶片部分比近侧叶片部分更容易弯曲。远端叶片部分包括适于接触并超声波处理患者组织的远端部分。第三超声波医疗器械包括医用超声波刀片。医用超声波刀片包括具有中心线的近端刀片部分，并且包括在基本平坦的界面处与近侧刀片部分接触的远侧刀片部分。界面相对于在界面处的中心线的垂直线成非零角度定向。

25. 发明申请

US20090036913A1 Surgical instruments 有权
标题翻译：手术器械
公开(公告)号：US20090036913A1
公开(公告)日：2009-02-05
申请号：US11888222
申请日：2007-07-31
申请人： Eitan Wiener , Kenneth S. Kramer , Foster B. Stulan , Ashvanl K. Madan , Kevin L. Houser
发明人： Eitan Wiener , Kenneth S. Kramer , Foster B. Stulan , Ashvanl K. Madan , Kevin L. Houser
IPC分类号： A61B17/32
CPC分类号： A61B17/320068 , A61B17/320092 , A61B2017/00084 , A61B2017/00106 , A61B2017/00128 , A61B2017/00353 , A61B2018/00607 , A61B2018/00642 , A61B2018/00791 , A61N7/02
摘要： A surgical device. The surgical device may comprise a transducer, an end effector, a generator and a control circuit. The transducer may be configured to provide vibrations. The end effector may be coupled to the transducer and may extend from the transducer along the longitudinal axis. The generator may provide an electrical signal to the transducer. Also, the control circuit may modify a current amplitude of the electrical signal in response to a change in a vibration frequency of the end effector. Accordingly to various embodiments, the control circuit may detect a first contribution to a vibration frequency of the end effector, the first contribution originating from tissue in contact with the end effector. Also, according to various embodiments, the control circuit may indicate a change in a vibration frequency of the end effector.
摘要翻译：手术器械。手术装置可以包括换能器，末端执行器，发电机和控制电路。换能器可以被配置成提供振动。端部执行器可以耦合到换能器并且可以沿着纵向轴线从换能器延伸。发生器可以向换能器提供电信号。此外，控制电路可以响应于端部执行器的振动频率的变化来修改电信号的电流幅度。根据各种实施例，控制电路可以检测对端部执行器的振动频率的第一贡献，来自与端部执行器接触的组织的第一贡献。此外，根据各种实施例，控制电路可以指示端部执行器的振动频率的变化。

26. 发明授权

US4761665A High speed print/cartridge printer/feeder 失效
标题翻译：高速打印/墨盒打印机/进纸器
公开(公告)号：US4761665A
公开(公告)日：1988-08-02
申请号：US20302
申请日：1987-03-02
申请人： Michael J. Piatt , Kevin L. Houser
发明人： Michael J. Piatt , Kevin L. Houser
IPC分类号： B41J13/00 , B41J2/185 , B41J25/00 , G01D15/16 , G01D15/28
CPC分类号： B41J25/006 , B41J2/185 , B41J2002/1853
摘要： A high-speed ink jet printing apparatus adapted for use with a plurality of insertable print/cartridges and having a platen for transporting successive line portions of a print medium through a linear print zone, includes a carriage with a plurality of nests for supporting, positioning and electrically coupling respective print/cartridges in the printer, the nests being spaced along the transverse dimension of the linear print zone in a manner dividing it into a plurality of discrete transverse subportions of equal length. A traversing device reciprocates the carriage in forward and return directions parallel to the linear print zone. The movement of the traverse is approximately equal to the length of the print zone divided by the number of nest means of the carriage. The printer can include a sheet supply station, and a platen constructed to feed successive sheets from the supply station into a print path leading to the print zone and the carriage can include guides for directing fed sheets along the print path. The printer also includes a plurality of drop catchers located proximate the print zone at transversely spaced locations, and movable with respect to supported print/cartridges.
摘要翻译：一种适用于多个可插入打印/墨盒并具有用于通过线性打印区传送打印介质的连续行部分的台板的高速喷墨打印设备，包括具有多个嵌套的托架，用于支撑，定位并且电连接打印机中的各个打印/墨盒，所述巢沿着线性印刷区的横向尺寸以将其分成多个相等长度的离散横向子部分的方式间隔开。横动装置使托架向前和平行于线性打印区的返回方向往复运动。横移的运动大致等于打印区域的长度除以托架的嵌套装置的数量。打印机可以包括供纸台和压板，其被构造成将连续的纸张从供应站进给到通向打印区域的打印路径，并且托架可以包括用于沿着打印路径引导进给的纸张的引导件。打印机还包括在横向间隔开的位置处位于打印区附近的多个落下捕获器，并且可相对于支撑的打印/盒移动。

27. 发明授权

US4709247A High resolution, print/cartridge ink, jet printer 失效
标题翻译：高分辨率，打印/墨盒墨水，喷墨打印机
公开(公告)号：US4709247A
公开(公告)日：1987-11-24
申请号：US945133
申请日：1986-12-22
申请人： Michael J. Piatt , Kevin L. Houser
发明人： Michael J. Piatt , Kevin L. Houser
IPC分类号： B41J2/175 , B41J25/34 , G01D15/16
CPC分类号： B41J2/17546 , B41J25/34
摘要： A high resolution ink jet printing system includes a plurality of substantially identical print/cartridges each having an orifice plate comprising: (i) an array of orifices located in a precisely interspaced relation and (ii) a detent means precisely located with respect to the orifice array. The system provides a carriage for insertably supporting such print/cartridges and for traversing them along a linear print zone in a direction substantially perpendicular to the direction of print medium feed. The carriage has reference surfaces for respectively positioning the detent means of inserted print/cartridges at predetermined locations that are precisely vertically offset relative to the direction of carriage traverse. In such system the printing droplets from the vertically offset orifice arrays of inserted and indexed print/cartridges will be vertically interlaced in each printing traverse of the carriage.
摘要翻译：高分辨率喷墨打印系统包括多个基本上相同的打印/墨盒，每个印刷/墨盒具有孔板，其包括：（i）位于精确间隔关系中的孔阵列，和（ii）相对于孔口精确定位的定位装置数组。该系统提供用于可插入地支撑这种打印/盒的托架，并且沿着基本上垂直于打印介质进给的方向的线性打印区域横向移动。托架具有参考表面，用于分别将插入的打印/墨盒的定位装置定位在相对于滑架横向方向精确垂直偏移的预定位置处。在这种系统中，来自插入和分度的打印/墨盒的垂直偏移孔阵列的印刷液滴将在托架的每次打印遍历中垂直交错。

28. 发明授权

US09820768B2 Ultrasonic surgical instruments with control mechanisms 有权
公开(公告)号：US09820768B2
公开(公告)日：2017-11-21
申请号：US13538733
申请日：2012-06-29
申请人： Jacob S. Gee , Foster B. Stulen , Kevin L. Houser , Craig N. Faller , Sora Rhee , William D. Dannaher , Gregory W. Johnson
发明人： Jacob S. Gee , Foster B. Stulen , Kevin L. Houser , Craig N. Faller , Sora Rhee , William D. Dannaher , Gregory W. Johnson
IPC分类号： A61B17/32 , A61F9/007 , A61B34/00 , A61B34/30 , A61B17/00 , A61B17/22 , A61B90/50
CPC分类号： A61B17/320092 , A61B34/30 , A61B34/71 , A61B2017/003 , A61B2017/00305 , A61B2017/00323 , A61B2017/00327 , A61B2017/00526 , A61B2017/00734 , A61B2017/22015 , A61B2017/22018 , A61B2090/508 , A61F9/00745
摘要： Various embodiments are directed to surgical instruments for use in handheld applications or with robotic surgical systems. The surgical instruments may comprise an end effector to treat tissue and a shaft extending proximally from the end effector along a longitudinal axis. Some embodiments may be usable with an instrument mounting portion of a robotic surgical instrument. For example, the shaft may extend proximally to the instrument mounting portion.

29. 发明授权

US09782214B2 Surgical instrument with sensor and powered control 有权
公开(公告)号：US09782214B2
公开(公告)日：2017-10-10
申请号：US13277328
申请日：2011-10-20
申请人： Kevin L. Houser , Foster B. Stulen , William D. Dannaher , Frederick E. Shelton, IV , Geoffrey S. Strobl , Aaron C. Voegele , Timothy P. Lessek , Gavin M. Monson , Barry C. Worrell , Hitesh Jain
发明人： Kevin L. Houser , Foster B. Stulen , William D. Dannaher , Frederick E. Shelton, IV , Geoffrey S. Strobl , Aaron C. Voegele , Timothy P. Lessek , Gavin M. Monson , Barry C. Worrell , Hitesh Jain
IPC分类号： A61B18/14 , A61B17/32 , A61B34/00 , A61B18/00 , A61B17/00 , A61B90/00 , A61B34/30
CPC分类号： A61B18/1442 , A61B17/320092 , A61B34/30 , A61B34/76 , A61B2017/00039 , A61B2017/00084 , A61B2017/00119 , A61B2017/00212 , A61B2017/00398 , A61B2018/00642 , A61B2018/00773 , A61B2018/00791 , A61B2018/00988 , A61B2018/1455 , A61B2090/064
摘要： A surgical instrument includes a temperature sensor and a control unit that is operable to deactivate an end effector of the surgical instrument. In some versions the temperature sensor detects the temperature of a transducer, while in others the temperature sensor detects the temperature of the end effector. The surgical instrument may also include a trigger and a trigger position sensor. A force sensor or a position sensor may be included to determine the force and/or position of the transmission assembly. The end effector may also include a force sensor or a micro coil. A surgical instrument having a sensor may be included in a surgical system that includes a control unit and a remote controller. In some instances the remote controller may have one or more force-feedback components. In addition, a device interface and a surgeon interface may be included to remotely adjust the settings of the control unit.

30. 发明授权

US09675375B2 Ultrasonic surgical system and method 有权
公开(公告)号：US09675375B2
公开(公告)日：2017-06-13
申请号：US11392040
申请日：2006-03-29
申请人： Kevin L. Houser , William T. Donofrio , Foster B. Stulen
发明人： Kevin L. Houser , William T. Donofrio , Foster B. Stulen
IPC分类号： A61B17/32 , A61B34/32 , A61B34/00 , A61B34/30 , A61B34/37 , A61B17/00
CPC分类号： A61B17/320092 , A61B34/30 , A61B34/32 , A61B34/37 , A61B34/70 , A61B34/71 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/00199
摘要： An ultrasonic surgical system has an ultrasonic unit including an instrument operatively connected to an ultrasonic generator, wherein the instrument has an ultrasonic end effector on the distal end of a shaft. The system further includes a positioning unit including a movable arm adapted for releasably holding the instrument, whereby an operator may direct the positioning unit to position the end effector at a surgical site inside a body cavity of a patient for performing a plurality of surgical tasks. The system further includes a control unit operatively connected to the ultrasonic and positioning units, wherein the control unit is programmable with a surgical subroutine for performing the surgical tasks. The system further includes a user interface operatively connected to the control unit for initiating an operative cycle of the surgical subroutine such that the surgical tasks are automatically performed during the operative cycle.

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