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21. 发明申请

US20110008765A1 USE OF THREE-DIMENSIONAL MICROFABRICATED TISSUE ENGINEERED SYSTEMS FOR PHARMACOLOGIC APPLICATIONS 有权
标题翻译：三维微晶组织工程系统在药理学应用中的应用
公开(公告)号：US20110008765A1
公开(公告)日：2011-01-13
申请号：US12707469
申请日：2010-02-17
申请人： Joseph P. Vacanti , Robert Rubin , Wing Cheung
发明人： Joseph P. Vacanti , Robert Rubin , Wing Cheung
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： C12Q1/48 , B33Y80/00 , C12Q1/00 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/42 , C12Q1/44 , G01N33/5038 , G01N33/5088
摘要： The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and/or efficacy can be determined.
摘要翻译：本发明一般涉及组织工程，药物发现和药物开发领域的组合。它更具体地提供了用于测试实验药物的功效和安全性，定义实验药物的代谢途径和表征现有药物的性质（例如副作用，新用途）的新方法和材料。优选地，在三维组织工程系统中进行评价，其中可以确定药物毒性，代谢，相互作用和/或功效。

22. 发明授权

US07670797B2 Method of determining toxicity with three dimensional structures 有权
标题翻译：用三维结构测定毒性的方法
公开(公告)号：US07670797B2
公开(公告)日：2010-03-02
申请号：US11183115
申请日：2005-07-15
申请人： Joseph P. Vacanti , Robert Rubin , Wing Cheung , Jeffrey T. Borenstein
发明人： Joseph P. Vacanti , Robert Rubin , Wing Cheung , Jeffrey T. Borenstein
IPC分类号： C12Q1/24
CPC分类号： C12Q1/48 , B33Y80/00 , C12Q1/00 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/42 , C12Q1/44 , G01N33/5038 , G01N33/5088
摘要： A method of determining toxicity of a test agent in a tissue including A) incubating a test agent within a three-dimensional tissue engineered structure comprising a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, and wherein the first mold or polymer scaffold has microchannels comprising vessels that bifurcate, and B) obtaining information from step A) to assess toxicity.
摘要翻译：一种测定试剂在组织中的毒性的方法，包括A）在包含第一模具或聚合物支架，半透膜和第二模具或聚合物支架的三维组织工程结构内温育试验剂，其中半透膜设置在第一和第二模具或聚合物支架之间，并且其中第一模具或聚合物支架具有包含分叉的容器的微通道，以及B）从步骤A）获得信息以评估毒性。

23. 发明授权

US07326788B2 Quinolinone derivatives as inhibitors of c-fms kinase 有权
标题翻译：喹啉酮衍生物作为c-fms激酶的抑制剂
公开(公告)号：US07326788B2
公开(公告)日：2008-02-05
申请号：US10894940
申请日：2004-07-20
申请人： Mark J. Wall , Mark R. Player , Raymond Joseph Patch , Sanath Meegalla , Jian Liu , Carl R. Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
发明人： Mark J. Wall , Mark R. Player , Raymond Joseph Patch , Sanath Meegalla , Jian Liu , Carl R. Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
IPC分类号： C07D215/38 , C07D215/44
CPC分类号： C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译：本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5，其中，R 6，R 6，Y 1，Y 2，Y 3，Y 4， SUP＆amp; X和X在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

24. 发明申请

US20050044321A1 Method and system for multiprocess cache management 审中-公开
标题翻译：用于多进程缓存管理的方法和系统
公开(公告)号：US20050044321A1
公开(公告)日：2005-02-24
申请号：US10921002
申请日：2004-08-17
申请人： Jan Bialkowski , Wing Cheung
发明人： Jan Bialkowski , Wing Cheung
IPC分类号： G06F12/00 , G06F12/08
CPC分类号： G06F12/084
摘要： A cache management system in a multiprocessing computing system avoids blocking subsequent memory requests to access data in the cache after a previous memory request to access the data in the cache generates a cache miss and while the cache is being updated with the data. The previous memory request and subsequent memory requests are stored in a piggyback FIFO while the data is retrieved from a memory device. The cache is then updated with the data and the previous memory request and subsequent memory requests are processed on the cache.
摘要翻译：多处理计算系统中的高速缓存管理系统避免在先前的存储器请求之后访问高速缓存中的数据时产生高速缓存未命中以及在使用该数据更新高速缓存时阻塞在高速缓存中访问数据的后续存储器请求。先前的存储器请求和随后的存储器请求被存储在搭载FIFO中，同时从存储器件检索数据。然后使用数据更新缓存，并且先前的存储器请求和随后的存储器请求在高速缓存上被处理。

25. 发明授权

US5995995A Apparatus and method for scheduling virtual circuit data for DMA from a host memory to a transmit buffer memory 失效
标题翻译：用于将DMA的虚拟电路数据从主机存储器调度到发送缓冲存储器的装置和方法
公开(公告)号：US5995995A
公开(公告)日：1999-11-30
申请号：US712698
申请日：1996-09-12
申请人： Robert E. Thomas , Robert J. Simcoe , Peter J. Roman , Anna Charny , Wing Cheung
发明人： Robert E. Thomas , Robert J. Simcoe , Peter J. Roman , Anna Charny , Wing Cheung
IPC分类号： H04L12/56 , H04Q11/04 , G06F9/00
CPC分类号： H04L12/5602 , H04Q11/0478 , H04L2012/5651 , H04L2012/5679
摘要： A method of scheduling the transmission of cells from a network node involves storing entries in a schedule table at predetermined locations, wherein each location represents a point in time at which a cell is to be transmitted. Each entry in the table contains a pointer to a list of virtual circuits having cells scheduled for transmission at the time corresponding to the location of the entry in the table. When a VC has a cell to be transmitted at a particular time, the VC is queued to the head, rather than the tail, of the list of VCs pointed to by the pointer located at the entry in the table corresponding to the time at which the cell is to be transmitted. The VC is therefore the first VC transmitted from the list of VCs.
摘要翻译：调度来自网络节点的小区的传输的方法包括在预定位置处存储调度表中的条目，其中每个位置表示要发送小区的时间点。表中的每个条目包含指向在与表中的条目的位置相对应的时间被调度用于传输的小区的虚拟电路的列表的指针。当VC具有要在特定时间发送的小区时，VC排队到位于表中对应于表的时间的指针指向的VC列表的头部而不是尾部，传输单元。因此，VC是从VC列表中发送的第一个VC。

26. 发明授权

US5822612A Apparatus and method for managing schedule table pointers 失效
标题翻译：用于管理计划表指针的装置和方法
公开(公告)号：US5822612A
公开(公告)日：1998-10-13
申请号：US713047
申请日：1996-09-12
申请人： Robert E. Thomas , Peter J. Roman , Koichi Tanaka , Wing Cheung
发明人： Robert E. Thomas , Peter J. Roman , Koichi Tanaka , Wing Cheung
IPC分类号： H04L12/56 , H04Q11/04 , G06F13/00 , G06F13/28
CPC分类号： H04Q11/0478 , H04L2012/5658 , H04L2012/5679 , H04L2012/5681
摘要： An apparatus and method for scheduling data transfers between a host and adapter. A schedule table data structure resides in a memory on the adapter. Each location in the schedule table represents a point in time at which data is to be transmitted from the adapter. A current time counter advances at the rate at which data is to be transmitted from the node. A pointer points to successive locations in the schedule table, and advances through the schedule table at a rate faster than the current time counter advances so that the value stored in the pointer represents a point in time which is ahead of the point in time currently represented by the value output from the current time counter. A request for a data transfer between the host and adapter is generated when a valid entry exists at the location pointed to by the pointer. The value of the pointer at the time the request is generated is stored as the last valid time. When a new entry is to be stored in the schedule table, it is stored at a location in the schedule table immediately after the location corresponding to the last valid time, and the pointer is reset to point to the location immediately after the location corresponding to the last valid time.
摘要翻译：一种用于调度主机和适配器之间的数据传输的装置和方法。调度表数据结构驻留在适配器上的存储器中。调度表中的每个位置表示要从适配器发送数据的时间点。当前时间计数器以从节点发送数据的速率前进。指针指向调度表中的连续位置，并且以比当前时间计数器更快的速率前进到调度表，使得存储在指针中的值表示在当前表示的时间点之前的时间点由当前时间计数器输出的值。当指针所指向的位置存在有效条目时，会生成主机和适配器之间的数据传输请求。生成请求时指针的值存储为最后一个有效时间。当新的条目要存储在调度表中时，它被紧紧地存储在与最后有效时间相对应的位置之后的调度表中的一个位置处，并且指针被重新设置为指向紧邻在对应于最后一个有效时间。

27. 发明申请

US20110299536A1 METHOD AND SYSTEM FOR LINK AGGREGATION ACROSS MULTIPLE SWITCHES 有权
标题翻译：用于多个开关连接聚合的方法和系统
公开(公告)号：US20110299536A1
公开(公告)日：2011-12-08
申请号：US13092864
申请日：2011-04-22
申请人： Joseph Juh-En Cheng , Wing Cheung , John Michael Terry , Suresh Vobbilisetty , Surya P. Varanasi , Parviz Ghalambor
发明人： Joseph Juh-En Cheng , Wing Cheung , John Michael Terry , Suresh Vobbilisetty , Surya P. Varanasi , Parviz Ghalambor
IPC分类号： H04L12/56
CPC分类号： H04L45/66 , H04L12/4625 , H04L12/4633 , H04L45/00 , H04L45/245 , H04L49/70 , Y02D50/30
摘要： One embodiment of the present invention provides a switch. The switch includes a forwarding mechanism and a control mechanism. During operation, the forwarding mechanism forwards frames based on their Ethernet headers. The control mechanism operates the switch in conjunction with a separate physical switch as a single logical switch and assigns a virtual switch identifier to the logical switch, wherein the virtual switch identifier is associated with a link aggregation group.
摘要翻译：本发明的一个实施例提供一种开关。交换机包括转发机制和控制机制。在运行期间，转发机制基于它们的以太网报头转发帧。所述控制机构将所述交换机与单独的物理交换机一起操作为单个逻辑交换机，并向所述逻辑交换机分配虚拟交换机标识符，其中所述虚拟交换机标识符与链路聚合组相关联。

28. 发明申请

US20110299533A1 INTERNAL VIRTUAL NETWORK IDENTIFIER AND INTERNAL POLICY IDENTIFIER 审中-公开
标题翻译：内部虚拟网络标识符和内部策略标识符
公开(公告)号：US20110299533A1
公开(公告)日：2011-12-08
申请号：US13050102
申请日：2011-03-17
申请人： Shunjia Yu , Anoop Ghanwani , Phanidhar Koganti , Mythilikanth Raman , Rajiv Krishnamurthy , John Michael Terry , Wing Cheung , Joseph Juh-En Cheng , Surya P. Varanasi
发明人： Shunjia Yu , Anoop Ghanwani , Phanidhar Koganti , Mythilikanth Raman , Rajiv Krishnamurthy , John Michael Terry , Wing Cheung , Joseph Juh-En Cheng , Surya P. Varanasi
IPC分类号： H04L12/56
CPC分类号： H04L12/4604 , H04L12/4625
摘要： Systems and techniques for processing and forwarding packets are described. Some embodiments provide a system (e.g., a switch) which determines an internal virtual network identifier and/or an internal policy identifier for a packet based on a port on which the packet was received and/or one or more fields in the packet. The system can then process and forward the packet based on the internal virtual network identifier and/or internal policy identifier. In some embodiments, the system encapsulates the packet in a TRILL (Transparent Interconnection of Lots of Links) packet by adding a TRILL header to the packet. In some embodiments, the scope of an internal virtual network identifier and/or an internal policy identifier may not extend beyond a switch or a module within a switch.
摘要翻译：描述了处理和转发数据包的系统和技术。一些实施例提供了一种系统（例如交换机），其基于接收到分组的端口和/或分组中的一个或多个字段来确定分组的内部虚拟网络标识符和/或内部策略标识符。然后系统可以基于内部虚拟网络标识符和/或内部策略标识符处理和转发数据包。在一些实施例中，通过向分组添加TRILL报头，系统将分组封装在TRILL（多个链路的透明互连）分组中。在一些实施例中，内部虚拟网络标识符和/或内部策略标识符的范围可能不会超出交换机内的交换机或模块。

29. 发明授权

US07688815B2 Method and system for a multi-stage interconnect switch 有权
标题翻译：多级互连开关的方法和系统
公开(公告)号：US07688815B2
公开(公告)日：2010-03-30
申请号：US10920789
申请日：2004-08-17
申请人： Jan Bialkowski , Wing Cheung
发明人： Jan Bialkowski , Wing Cheung
IPC分类号： H04L12/50
CPC分类号： H04L49/1515 , H04L45/00 , H04L45/30 , H04L49/3018
摘要： An interconnect switch stores data messages received from one or more source devices and prioritizes the data messages received from each source device based on the order that the data messages were received from the source device. For each available destination device associated with the interconnect switch, the interconnect switch identifies the data messages with the highest priority that are to be routed to the available destination device and selects one of the identified data messages for the available destination device. The interconnect switch then routes the selected data messages to the available destination devices.
摘要翻译：互连交换机存储从一个或多个源设备接收的数据消息，并且基于从源设备接收数据消息的顺序来优先从每个源设备接收的数据消息。对于与互连交换机相关联的每个可用目的地设备，互连交换机识别要被路由到可用目的地设备的具有最高优先级的数据消息，并且为可用目的地设备选择所识别的数据消息中的一个。然后，互连交换机将所选择的数据消息路由到可用的目的地设备。

30. 发明申请

US20060128624A1 Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration 审中-公开
公开(公告)号：US20060128624A1
公开(公告)日：2006-06-15
申请号：US11338500
申请日：2006-01-24
申请人： Wing Cheung , David Gibson , Christine Cote , Els Vercammen
发明人： Wing Cheung , David Gibson , Christine Cote , Els Vercammen
IPC分类号： A61K38/18 , G06F19/00
CPC分类号： G16C20/30 , A61K38/00 , A61K38/1816 , G16H50/50 , A61K38/14 , A61K33/24 , A61K31/70 , A61K31/505 , A61K31/475 , A61K31/28 , A61K2300/00
摘要： The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

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