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21. 发明授权

US6117101A Circumferential ablation device assembly 有权
公开(公告)号：US6117101A
公开(公告)日：2000-09-12
申请号：US199736
申请日：1998-11-25
申请人： Chris J. Diederich , Michael D. Lesh , James C. Peacock, III , Michael R. Ross
发明人： Chris J. Diederich , Michael D. Lesh , James C. Peacock, III , Michael R. Ross
IPC分类号： A61B17/00 , A61B18/00 , A61B18/14 , A61F2/958 , A61N7/02 , A61B17/20
CPC分类号： A61B18/1492 , A61B18/00 , A61M25/1002 , A61N7/02 , A61B2017/00243 , A61B2018/00083 , A61B2018/00148 , A61B2018/00214 , A61M2210/125 , A61N7/022
摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive "maze"-type procedure in the region of the pulmonary vein ostia in the left ventricle. A cylindrical ultrasound transducer is provided on an inner member within the balloon and forms the circumferential ablation member by emitting a radial ultrasound signal which is circumferential to the transducer and highly collimated to the transducer's length. The circumferential ultrasound signal sonically couples to the balloon's outer skin to form the circumferential ablation element that is adapted to ablate a circumferential path of tissue engaged to the balloon.

22. 发明申请

US20120197388A1 COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD 有权
标题翻译：加工植入，系统和方法
公开(公告)号：US20120197388A1
公开(公告)日：2012-08-02
申请号：US13099532
申请日：2011-05-03
申请人： Alex Khairkhahan , Michael D. Lesh
发明人： Alex Khairkhahan , Michael D. Lesh
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12172 , A61B2017/00867 , A61B2017/0412 , A61B2017/0448 , A61B2017/0464 , A61B2017/048 , A61B2017/0649 , A61F2/2454 , A61F2/2457 , A61F2/2466 , A61F2250/0003
摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.
摘要翻译：植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

23. 发明授权

US08080032B2 Method and device for left atrial appendage occlusion 有权
标题翻译：左心耳闭塞的方法和装置
公开(公告)号：US08080032B2
公开(公告)日：2011-12-20
申请号：US10674553
申请日：2003-09-30
申请人： Erik J. van der Burg , Dino De Cicco , Andrew G. C. Frazier , Alexander K. Khairkhahan , Marc S. Kreidler , Michael D. Lesh , Chad C. Roue
发明人： Erik J. van der Burg , Dino De Cicco , Andrew G. C. Frazier , Alexander K. Khairkhahan , Marc S. Kreidler , Michael D. Lesh , Chad C. Roue
IPC分类号： A61M29/00
CPC分类号： A61B17/12122 , A61B17/0057 , A61B17/12022 , A61B17/12031 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B17/12195 , A61B17/122 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615 , A61B2017/00619 , A61B2017/00632 , A61B2017/00867 , A61B2017/081 , A61B2017/1205 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0071 , A61F2230/008 , A61M25/10 , A61M2025/1054 , A61M2210/125
摘要： A device and method for obliterating or occluding a body cavity or passageway, in particular, the left atrial appendage of a patient's heart. The procedure can be carried out intraoperatively, but is preferably carried out percutaneously by use of a delivery catheter to position an occluding device adjacent a patient's left atrial appendage. The occluding device may prevent the passage of embolic or other material to or from the left atrial appendage by volumetrically filling the appendage, closing the opening of the appendage with an occluding member, or pulling the tissue around the opening of the appendage together and fixing it in a closed state.
摘要翻译：用于消除或闭塞体腔或通道的装置和方法，特别是患者心脏的左心耳。该程序可以在手术中进行，但是优选通过使用输送导管经皮进行以将闭塞装置定位在患者的左心耳附近。闭塞装置可以阻止栓塞或其他材料通过体积方式填充附件，使闭塞构件闭合附件的开口，或将附件的开口附近的组织拉在一起并将其固定处于关闭状态。

24. 发明授权

US07799011B2 Catheter system and method for delivery of therapeutic compounds to cardiac tissue 失效
标题翻译：导管系统和将治疗化合物递送至心脏组织的方法
公开(公告)号：US07799011B2
公开(公告)日：2010-09-21
申请号：US11809022
申请日：2007-05-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61M31/00
CPC分类号： A61M25/0136 , A61B17/22 , A61B2017/00243 , A61B2017/22082 , A61B2017/3488 , A61B2018/00273 , A61B2018/00815 , A61B2018/1425 , A61B2018/1435 , A61B2090/3784 , A61M25/0084 , A61M25/0133 , A61M25/0147 , A61N7/02
摘要： This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.
摘要翻译：这是用于将对比流体治疗或引入组织，特别是心脏组织的方法和装置。所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除。这允许所选择的治疗或造影剂被限制在特定部位。导管还可以包括可视化组件，其包括在身体的远端处的换能器。

25. 发明授权

US07731681B2 Catheter positioning system 有权
标题翻译：导管定位系统
公开(公告)号：US07731681B2
公开(公告)日：2010-06-08
申请号：US10805738
申请日：2004-03-22
申请人： Alan K. Schaer , Michael D. Lesh
发明人： Alan K. Schaer , Michael D. Lesh
IPC分类号： A61M35/00
CPC分类号： A61M25/0668 , A61B17/22012 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2017/22038 , A61B2018/00214 , A61B2018/00285 , A61B2018/00577 , A61B2018/00839 , A61M2210/125 , A61N7/02 , C08L2201/12
摘要： The present invention relates to a system adapted to position a medical device, such as an ablation catheter, at a location where a pulmonary vein extends from an atrium. The system optimally includes a deflectable catheter and a sheath. An ablation member is disclosed for use with the positioning system, wherein the deflectable catheter and the sheath cooperate so as to facilitate positioning of the ablation member at the location.
摘要翻译：本发明涉及一种适于将医疗装置（例如消融导管）定位在肺静脉从心房延伸的位置处的系统。该系统最佳地包括可偏转导管和护套。公开了一种与定位系统一起使用的消融构件，其中可偏转导管和护套配合，以便于消融构件在该位置的定位。

26. 发明申请

US20080275569A1 Tissue Augmentation Device 审中-公开
标题翻译：组织增强装置
公开(公告)号：US20080275569A1
公开(公告)日：2008-11-06
申请号：US11575493
申请日：2005-09-15
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61F2/10 , A61B17/3209 , A61M29/02
CPC分类号： A61B17/3468 , A61B90/02 , A61B2017/00539 , A61B2017/00747 , A61B2017/00792 , A61F2/0036 , A61F2/0059 , A61F2/12 , A61F2250/0003
摘要： A medical device and methods for filling tissue are disclosed. The device has a first configuration for delivery into tissue to be filled and a second configuration in which the device either expands, or is forced to expand within the tissue to be filled. The exterior profile of the expanded device may be customized along its length, to achieve a desired result. The device is adapted to be placed in the skin, and may be used to reduce facial wrinkles or augment facial features such as the lips.
摘要翻译：公开了用于填充组织的医疗装置和方法。该装置具有用于输送到待填充的组织中的第一构造和第二构造，其中该装置在待填充的组织内膨胀或被迫膨胀。扩展装置的外部轮廓可以沿其长度被定制，以实现期望的结果。该装置适于放置在皮肤中，并且可用于减少面部皱纹或增加诸如嘴唇的面部特征。

27. 发明授权

US07340307B2 Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall 有权
标题翻译：组织消融装置组装和将肺静脉口与电壁隔离的方法
公开(公告)号：US07340307B2
公开(公告)日：2008-03-04
申请号：US10996523
申请日：2004-11-24
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B18/18
CPC分类号： A61N7/02 , A61B18/00 , A61B18/08 , A61B18/1492 , A61B2017/00243 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.
摘要翻译：本发明涉及组织消融系统和方法，其通过在肺静脉从心房延伸的位置烧蚀组织的周边区域来治疗心律失常。该系统包括具有消融元件的圆周消融构件，并且还包括用于将消融构件输送到该位置的输送组件。圆周消融部件通常在不同构型之间是可调节的，以允许通过输送护套输送到心房中，以及消融元件与组织的圆周区域之间的消融耦合。

28. 发明授权

US07089063B2 Deflectable tip catheter with guidewire tracking mechanism 有权
公开(公告)号：US07089063B2
公开(公告)日：2006-08-08
申请号：US09858523
申请日：2001-05-16
申请人： Michael D. Lesh , Michael R. Ross , James C Peakcock, III , Kevin J. Taylor
发明人： Michael D. Lesh , Michael R. Ross , James C Peakcock, III , Kevin J. Taylor
IPC分类号： A61F2/00
CPC分类号： A61B17/2202 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2018/00083 , A61B2018/00095 , A61B2018/00214 , A61B2018/00238 , A61B2018/00285 , A61B2018/00375 , A61B2018/00898 , A61M25/0108 , A61N7/02
摘要： A deflectable tip catheter that is used in combination with a guidewire for delivery of an ablation element to target areas of a patient's vasculature. The deflectable tip catheter has a handle portion, an elongated shaft and a deflectable tip portion. A guidewire lumen extends through the elongated shaft and deflectable tip portion. A guidewire passes through the guidewire lumen and exits from a port in the distal end of the deflectable tip portion. The deflectable tip of the catheter is deflected by manipulation of the handle portion to direct the advancement of the guidewire as the guidewire is advanced out of the distal port. By using the deflectable tip portion to direct the advancement of the guidewire, the physician's ability to navigate sharp angles is greatly improved. The deflectable tip catheter is particularly suitable for delivering an ablation element to a pulmonary vein or pulmonary vein branch for performing circumferential ultrasound vein ablation to treat atrial fibrillation.

29. 发明授权

US07044135B2 Device and method for forming a circumferential conduction block in a pulmonary vein 有权
公开(公告)号：US07044135B2
公开(公告)日：2006-05-16
申请号：US10233157
申请日：2002-08-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B19/00
CPC分类号： A61B18/10 , A61B18/08 , A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00369 , A61B2018/00375 , A61B2018/00577 , A61B2018/00642 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/1407 , A61B2218/002 , A61M25/1002 , A61M2025/1075 , A61M2210/125 , A61N7/022
摘要： This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.

30. 发明授权

US06964660B2 Tissue ablation device assembly and method of electrically isolating a pulmonary vein ostium from an atrial wall 有权
标题翻译：组织消融装置组装及将肺静脉口与电壁隔离的方法
公开(公告)号：US06964660B2
公开(公告)日：2005-11-15
申请号：US10274742
申请日：2002-10-21
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B17/00 , A61B18/00 , A61B18/08 , A61B18/14 , A61F2/958 , A61N7/02 , A61B18/18
CPC分类号： A61N7/02 , A61B18/00 , A61B18/08 , A61B18/1492 , A61B2017/00243 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.
摘要翻译：本发明涉及组织消融系统和方法，其通过在肺静脉从心房延伸的位置烧蚀组织的周边区域来治疗心律失常。该系统包括具有消融元件的圆周消融构件，并且还包括用于将消融构件输送到该位置的输送组件。圆周消融部件通常在不同构型之间是可调节的，以允许通过输送护套输送到心房中，以及消融元件与组织的圆周区域之间的消融耦合。

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