专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US08206957B2 Process for the enzymatic preparation of citronellal 有权
标题翻译：香茅醛酶的制备方法
公开(公告)号：US08206957B2
公开(公告)日：2012-06-26
申请号：US12159531
申请日：2006-12-19
申请人： Andreas Schädler , Thomas Friedrich , Rainer Stürmer , Sabine Rinck
发明人： Andreas Schädler , Thomas Friedrich , Rainer Stürmer , Sabine Rinck
IPC分类号： C12P7/24
CPC分类号： C12P7/24 , C12N9/001
摘要： A process for preparing optically active saturated aldehydes or alcohols of the formula (2) from α,β-unsaturated aldehydes of the formula (1) by reduction in the presence of an enoate reductase (i) having the polypeptide sequence SEQ ID No. 1 or 2, or (ii) having a polypeptide sequence which is at least 80% identical to the sequence of SEQ ID No. 1 or 2.
摘要翻译：通过在具有多肽序列SEQ ID No.的烯酸还原酶（i）的存在下还原从式（1）的α，β-不饱和醛制备式（2）的旋光性饱和醛或醇的方法。 1或2，或（ii）具有与SEQ ID No.1或2的序列至少80％相同的多肽序列。

22. 发明授权

US07785847B2 Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus 有权
标题翻译：使用azoarcus脱氢酶从链烷醇生产光学活性醇的方法
公开(公告)号：US07785847B2
公开(公告)日：2010-08-31
申请号：US11579292
申请日：2005-05-04
申请人： Rainer Stürmer , Maria Keβeler , Bernhard Haur , Thomas Friedrich , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Maria Keβeler , Bernhard Haur , Thomas Friedrich , Michael Breuer , Hartwig Schröder
IPC分类号： C12P7/22 , C12P7/04 , C12P17/00 , C12N9/04 , C12N9/14 , C12N1/20 , C07H21/04
CPC分类号： C07D333/22 , C07D333/16 , C12P17/00
摘要： The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, wherein R2, R3 and R4 independently represent H or a lower alkyl or lower alkoxy group and X− represents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and R1 are defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.
摘要翻译：本发明涉及一种制备式（I）的光学活性链烷醇的方法，其中n为0-5的整数; Cyc表示任选取代的单核或多核，饱和或不饱和的碳环或杂环，并且R 1表示卤素，SH，OH，NO 2，NR 2 R 3或NR 2 R 3 R 4 + X - ，其中R 2，R 3和R 4独立地表示H或低级烷基或低级烷氧基，X-表示抗衡离子。根据本发明，在含有式（II）的烷酮的培养基中温育选自脱氢酶，醛还原酶和羰基还原酶的酶的酶（E），其中n，R 1和R 1如上定义，在存在下的还原当量。将式（II）化合物酶还原成式（I）化合物，并且通过使用酶（E）使牺牲醇与相应的牺牲酮反应，并且至少部分除去牺牲酮来再生反应期间消耗的还原当量从反应介质中分离出如此制备的产物（I）。

23. 发明授权

US06596520B1 Immobilizing lipase by adsorption from a crude solution onto nonpolar polyolefin particles 失效
标题翻译：通过从粗溶液中吸附到非极性聚烯烃颗粒上来固定脂肪酶
公开(公告)号：US06596520B1
公开(公告)日：2003-07-22
申请号：US09610943
申请日：2000-07-06
申请人： Thomas Friedrich , Rainer Stürmer
发明人： Thomas Friedrich , Rainer Stürmer
IPC分类号： C12P762
CPC分类号： C12N9/20 , C12N11/08 , Y10S435/874 , Y10S435/875
摘要： Immobilized lipase is prepared by adsorbing lipase from a crude lipase solution onto polyolefin particles such as polypropylene particles which are nonpolar. The crude solution may be a cell-free culture broth. Lipase sources include Pseudomonas burkholderia and Pseudomonas aeruginosa. Uses of the immobilized lipase include enantioselective conversion of substrates such as enantioselective acylating or hydrolyzing.
摘要翻译：通过将脂肪酶从粗脂肪酶溶液吸附到聚烯烃颗粒如非极性的聚丙烯颗粒上来制备固定的脂肪酶。粗溶液可以是无细胞培养液。脂肪酶来源包括铜绿假单胞菌（Pseudomonas burkholderia）和铜绿假单胞菌（Pseudomonas aeruginosa）。固定化脂肪酶的用途包括底物的对映选择性转化，如对映选择性酰化或水解。

24. 发明授权

US07229803B2 Reaction of (di)amines in the presence of a lysine oxidase and of a reducing agent 失效
标题翻译：（二）胺在赖氨酸氧化酶和还原剂存在下的反应
公开(公告)号：US07229803B2
公开(公告)日：2007-06-12
申请号：US10474601
申请日：2002-04-08
申请人： Thomas Friedrich , Norbert Zimmermann , Rainer Stürmer
发明人： Thomas Friedrich , Norbert Zimmermann , Rainer Stürmer
IPC分类号： C12P17/00 , C12P17/10 , C12P13/00 , C12P11/00 , C12P7/02
CPC分类号： C12P17/10 , C12P7/04 , C12P7/18 , C12P17/14
摘要： The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing cyclic secondary amines suitable for ultimately synthesizing piperidine-2-carboxylic acid and proline derivatives, useful, for example as thrombin inhibitors.
摘要翻译：本发明涉及在赖氨酸氧化酶和还原剂存在下使（二）胺作为底物反应的方法，得到醇，二醇或环状仲胺。在一个具体实施方案中，本发明涉及制备适于最终合成哌啶-2-羧酸和脯氨酸衍生物的环状仲胺的方法，其可用作例如凝血酶抑制剂。

25. 发明授权

US07816107B2 Method for producing an optically active 2-methyl-alkane-1-ol from the corresponding 2-methylalk-2-en-1-al, comprising carbonyl-selective reduction, enantioselective hydration and lipase-catalyzed, stereoselective acylation in order to enrich the desired 有权
标题翻译：从相应的2-甲基-2-烯-1-烯制备光学活性2-甲基 - 烷-1-醇的方法，包括羰基选择性还原，对映选择性水合和脂肪酶催化的立体选择性酰化，以富集想要的
公开(公告)号：US07816107B2
公开(公告)日：2010-10-19
申请号：US11576317
申请日：2005-09-22
申请人： Christoph Jäkel , Gunnar Heydrich , Rainer Stürmer , Rocco Paciello
发明人： Christoph Jäkel , Gunnar Heydrich , Rainer Stürmer , Rocco Paciello
IPC分类号： C12P7/04
CPC分类号： C12P7/04 , C07B2200/07 , C07C29/14 , C07C29/141 , C07C29/172 , C12C11/02 , C07C33/025 , C07C31/125
摘要： A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps: (i) carbonyl-selective reduction of 2-methylalk-2-en-1-al of the general formula (I) to 2-methylalk-2-en-1-ol of the general formula (II), (ii) enantioselective hydrogenation of 2-methylalk-2-en-1-ol to the general formula (iii), (iii) increasing the optical yield of the optically active 2-methylalkan-1-ol (III) obtained in step (ii) by a lipase-catalyzed acylation reaction, where the radical R means C1-C10-alkyl.
摘要翻译：一种制备通式（III）的光学活性2-甲基烷-1-醇的方法，包括以下步骤：（i）通式（I）的2-甲基-α-烯-1-醇的羰基选择性还原）到通式（II）的2-甲基-2-烯-1-醇，（ii）2-甲基烯-2-烯-1-醇与通式（iii）的对映选择性氢化，（iii）增加通过脂肪酶催化的酰化反应在步骤（ii）中获得的光学活性2-甲基
链烷-1-醇（III）的光学收率，其中基团R是指C 1 -C 10 - 烷基。

26. 发明授权

US07435563B2 Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol 有权
标题翻译：（S）-3-甲基氨基-1-（噻吩-2-基）丙-1-醇的制备方法
公开(公告)号：US07435563B2
公开(公告)日：2008-10-14
申请号：US10522888
申请日：2003-07-31
申请人： Rainer Stürmer
发明人： Rainer Stürmer
IPC分类号： C07D333/16 , C07D333/22
CPC分类号： C07D333/20 , C07B2200/07
摘要： The present invention relates to a process for the preparation of enantiomerically pure (S)-3-methyl-amino-1-(thien-2-yl)propan-1-ol of the formula II-S by obtainment of (S)-3-hydroxy-3-thien-2-ylpropionitrile from its enantiomer mixture with the R isomer and the subsequent reaction of (S)-3-hydroxy-3-thien-2-ylpropionitrile with hydrogen and methylamine in the presence of a catalyst to give II-S.
摘要翻译：本发明涉及制备式II-S的对映体纯（S）-3-甲基 - 氨基-1-（噻吩-2-基）丙-1-醇的方法，通过获得（S） - （S）-3-羟基-3-噻吩-2-基丙腈与其对映异构体混合物与R异构体反应，随后在催化剂存在下将（S）-3-羟基-3-噻吩-2-基丙腈与氢和甲胺反应，得到给予II-S。

27. 发明授权

US07259264B2 3-methylamino-1-(2-thienyl)-1-propanone, production and use thereof 有权
标题翻译： 3-甲基氨基-1-（2-噻吩基）-1-丙酮的制备及其应用
公开(公告)号：US07259264B2
公开(公告)日：2007-08-21
申请号：US10542003
申请日：2004-01-15
申请人： Rainer Stürmer
发明人： Rainer Stürmer
IPC分类号： C07D333/16 , C07D333/20
CPC分类号： C07D333/16
摘要： The present invention relates to the preparation of 3-methylamino-1-(2-thienyl)-1-propanone and its use for preparing the pharmaceutical (+)-(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate—(trade name Duloxetine®).
摘要翻译：本发明涉及3-甲基氨基-1-（2-噻吩基）-1-丙酮的制备及其制备药物（+） - （S）-N-甲基-3-（1-萘氧基）-1-丙酮的用途。 3-（2-噻吩基）丙胺草酸盐 - （商品名称）。

28. 发明授权

US06548704B2 Racemization of optically active amines 失效
公开(公告)号：US06548704B2
公开(公告)日：2003-04-15
申请号：US10012344
申请日：2001-12-12
申请人： Frank Funke , Shelue Liang , Andreas Kramer , Rainer Stürmer , Arthur Höhn
发明人： Frank Funke , Shelue Liang , Andreas Kramer , Rainer Stürmer , Arthur Höhn
IPC分类号： C07C2968
CPC分类号： C07C213/02 , B01J23/80 , B01J35/023 , B01J37/0009 , B01J37/0201 , B01J37/031 , B01J37/035 , C07B2200/07 , C07C209/68 , C07C209/88 , C07C217/08 , C07C211/07
摘要： Optically active amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 may also be hydrogen (H), with the radicals being able to bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, are racemized by reacting the optically active amine I in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at elevated temperature, wherein the catalyst comprises the active components copper and zinc oxide and a support material.

29. 发明申请

US20100291641A1 PROCESS FOR CONTINUOUSLY PREPARING URETHANE-CONTAINING (METH)ACRYLIC ESTERS 有权
标题翻译：连续制备含有（甲基）丙烯酸酯的方法
公开(公告)号：US20100291641A1
公开(公告)日：2010-11-18
申请号：US12778426
申请日：2010-05-12
申请人： Jürgen Däuwel , Steffen Maurer , Rainer Stürmer
发明人： Jürgen Däuwel , Steffen Maurer , Rainer Stürmer
IPC分类号： C12P13/02
CPC分类号： C12P13/02 , C12P7/62
摘要： A process for preparing urethane-containing (meth)acrylic esters (U) by reacting a urethane-containing alcohol (A) with a (meth)acrylic ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) with an enzyme (E) as a catalyst in a reactor, wherein the (meth)acrylic ester of a saturated alcohol (G) and the urethane-containing alcohol (A) are passed continuously through at least one fixed bed reactor filled with an immobilized enzyme (E) as a catalyst.
摘要翻译：在至少一种聚合抑制剂（P）的存在下，使含氨基甲酸酯的醇（A）与饱和醇（G）的（甲基）丙烯酸酯反应制备含氨基甲酸酯的（甲基）丙烯酸酯（U））与反应器中的催化剂（E）反应，其中饱和醇（G）的含（甲基）丙烯酸酯和含氨基甲酸酯的醇（A）连续通过至少一个装有固定化酶（E）作为催化剂。

30. 发明授权

US06977270B2 Tocotrienolquinone cyclization product with an anti-hypercholesterol effect 有权
标题翻译：生育三烯酚环化产物具有抗高胆固醇的作用
公开(公告)号：US06977270B2
公开(公告)日：2005-12-20
申请号：US10332863
申请日：2001-07-13
申请人： Kai-Uwe Baldenius , Hartwig Schröder , Klaus Krämer , Karin Schein , Rainer Stürmer
发明人： Kai-Uwe Baldenius , Hartwig Schröder , Klaus Krämer , Karin Schein , Rainer Stürmer
IPC分类号： A23L33/105 , A61K31/343 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , C07C46/06 , C07C50/28 , C07D307/94 , C07D317/72 , H61K31/343
CPC分类号： C07D307/94 , A23L33/105
摘要： A description is given of the use of at least one compound of the formula I where R1, R2, R3 and R4 independently of one another are H or C1-C6-alkyl; and the use of a compound of the formula I for medical use.
摘要翻译：给出了使用至少一种式I的化合物的用途，其中R 1，R 2，R 3，R 3和R 2 > 4个彼此独立地是H或C 1 -C 6 - 烷基; 以及使用式I化合物用于医疗用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式