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21. 发明授权

US08222044B2 Test strip with flared sample receiving chamber 有权
标题翻译：带有扩口样品接收室的测试条
公开(公告)号：US08222044B2
公开(公告)日：2012-07-17
申请号：US13297501
申请日：2011-11-16
申请人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
发明人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
IPC分类号： G01N21/75
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

22. 发明授权

US08071030B2 Test strip with flared sample receiving chamber 有权
标题翻译：带有扩口样品接收室的测试条
公开(公告)号：US08071030B2
公开(公告)日：2011-12-06
申请号：US10872027
申请日：2004-06-18
申请人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
发明人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
IPC分类号： G01N33/48
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

23. 发明授权

US07287318B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07287318B2
公开(公告)日：2007-10-30
申请号：US10703408
申请日：2003-11-07
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
IPC分类号： H01R43/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译：提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。生物传感器还包括位于反应区上的试剂。在优选的实施方案中，凹部限定反应区的至少一部分。

24. 发明授权

US08551308B2 Biosensor and method of making 有权
标题翻译：生物传感器和制作方法
公开(公告)号：US08551308B2
公开(公告)日：2013-10-08
申请号：US12238101
申请日：2008-09-25
申请人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
发明人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
IPC分类号： G01N27/327 , C12Q1/25 , H05K3/00
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译：具有电极元件的电化学生物传感器具有光滑，高质量的边缘。这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量形成它们

25. 发明申请

US20120055626A1 TEST STRIP WITH FLARED SAMPLE RECEIVING CHAMBER 有权
标题翻译：带有采样样品的测试条
公开(公告)号：US20120055626A1
公开(公告)日：2012-03-08
申请号：US13297501
申请日：2011-11-16
申请人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
发明人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
IPC分类号： B32B37/02 , B32B38/04 , B32B37/14
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

26. 发明授权

US07867369B2 Biosensor with multiple electrical functionalities 有权
标题翻译：具有多种电气功能的生物传感器
公开(公告)号：US07867369B2
公开(公告)日：2011-01-11
申请号：US10871843
申请日：2004-06-18
申请人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
发明人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
IPC分类号： G01N27/327
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
摘要翻译：具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。

27. 发明申请

US20090056120A1 BIOSENSOR AND METHOD OF MAKING 有权
公开(公告)号：US20090056120A1
公开(公告)日：2009-03-05
申请号：US12238101
申请日：2008-09-25
申请人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
发明人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.

28. 发明授权

US06447657B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06447657B1
公开(公告)日：2002-09-10
申请号：US09729296
申请日：2000-12-04
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
IPC分类号： G01N2726
CPC分类号： G01N27/3272
摘要： A biosensor is provided that includes first and second plate elements, wherein each plate elements has first and second ends and first and second lateral borders. In addition, the biosensor includes a spacer positioned to lie between the first and second plate elements so that at least a portion of the first and second plate elements cooperate with one another to form opposite walls of a capillary space. Further, the first ends and at least a portion of the lateral borders define a fluid sample-receiving portion in communication with the capillary space. Electrodes are positioned in the capillary space of the biosensor.
摘要翻译：提供了包括第一和第二板元件的生物传感器，其中每个板元件具有第一和第二端以及第一和第二横向边界。此外，生物传感器包括定位成位于第一和第二板元件之间的间隔件，使得第一和第二板元件的至少一部分彼此配合以形成毛细管空间的相对壁。此外，第一端部和横向边界的至少一部分限定了与毛细管空间连通的流体样品接收部分。电极位于生物传感器的毛细管空间中。

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