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21. 发明授权

US06485471B1 Bellowed fluid delivery apparatus 有权
标题翻译：波纹流体输送装置
公开(公告)号：US06485471B1
公开(公告)日：2002-11-26
申请号：US09518817
申请日：2000-03-03
申请人： Maury Zivitz , Raghbir Singh Bhullar , Brian S. Hill
发明人： Maury Zivitz , Raghbir Singh Bhullar , Brian S. Hill
IPC分类号： A61M5178
CPC分类号： A61M5/1452 , A61M5/148 , A61M5/282 , A61M2005/14506 , A61M2005/14533
摘要： A fluid-delivery apparatus for delivering a medicament to a patient is provided in accordance with the present invention. The apparatus includes a housing defining a passageway, a bellowed ampoule positioned to lie in the passageway of the housing, and a piston. The bellowed ampoule includes a body with first and second ends and is formed to define a cavity configured to contain the medicament. The piston presses the second end of the ampoule toward the first end to dispense the medicament from the cavity. In addition, the fluid-delivery apparatus includes a visible non-linear scale that represents the relationship between a volume of medicament delivered from the first end of the ampoule and a distance that the piston has traveled in the housing toward the first end.
摘要翻译：根据本发明提供了一种用于将药物递送到患者的流体输送装置。该装置包括限定通道的壳体，定位成位于壳体的通道中的波纹安瓿和活塞。波纹安瓿包括具有第一和第二端的主体并且形成为限定被配置为容纳药物的腔。活塞将安瓿的第二端朝向第一端压入以从药腔分配药剂。此外，流体输送装置包括可见的非线性标度，其表示从安瓿的第一端输送的药物的体积与活塞在壳体中朝向第一端行进的距离之间的关系。

22. 发明授权

US5762770A Electrochemical biosensor test strip 失效
标题翻译：电化学生物传感器试片
公开(公告)号：US5762770A
公开(公告)日：1998-06-09
申请号：US496939
申请日：1995-06-30
申请人： G. John Pritchard , Joseph E. Bateson , Brian S. Hill , Brian A. Heald , Scott E. Hubbard
发明人： G. John Pritchard , Joseph E. Bateson , Brian S. Hill , Brian A. Heald , Scott E. Hubbard
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/54
CPC分类号： C12Q1/00 , C12Q1/006
摘要： An electrochemical biosensor test strip that has a minimum volume blood sample requirement of about 9 microliters. The test strip has working and counter electrodes that are substantially the same size and made of the same electrically conducting material placed on a first insulating substrate. Overlaying the electrodes is a second insulating substrate, which includes a cutout portion that forms a reagent well. The cutout portion exposes a smaller area of the counter electrode than the working electrode. A reagent for analysis of an analyte substantially covers the exposed areas of working and counter electrodes in the reagent well. Overlaying the reagent well and affixed to the second insulating substrate is a spreading mesh that is impregnated with a surfactant. The small cutout portion of 4 millimeters by 4.2 millimeters, small mesh of 6 millimeters by 5.8 millimeters, and small amount of reagent, 4 microliters before drying, allow the test strip to analyze a whole blood sample of about 9 microliters.
摘要翻译：电化学生物传感器测试条具有约9微升的最小体积血液样本要求。测试条具有基本上相同尺寸并由放置在第一绝缘基板上的相同导电材料制成的工作对电极。覆盖电极是第二绝缘基板，其包括形成试剂的切口部分。切除部分暴露对电极的面积比工作电极的面积小。用于分析分析物的试剂基本上覆盖试剂阱中的工作和对电极的暴露区域。将试剂叠加并固定到第二绝缘基底上的是用表面活性剂浸渍的铺展网。 4毫米×4.2毫米的小切口部分，6毫米×5.8毫米的小网孔和少量试剂，干燥前4微升，允许测试条分析约9微升的全血样品。

23. 发明授权

US5165407A Implantable glucose sensor 失效
标题翻译：植入式葡萄糖传感器
公开(公告)号：US5165407A
公开(公告)日：1992-11-24
申请号：US682560
申请日：1991-04-09
申请人： George S. Wilson , Dilbir S. Bindra , Brian S. Hill , Daniel R. Thevenot , Robert Sternberg , Gerard Reach , Yanan Zhang
发明人： George S. Wilson , Dilbir S. Bindra , Brian S. Hill , Daniel R. Thevenot , Robert Sternberg , Gerard Reach , Yanan Zhang
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/1486 , C12Q1/00 , G01N27/30 , G01N27/416 , G01N33/487
CPC分类号： C12Q1/006 , A61B5/14865 , A61B5/6848
摘要： Implantable enzymatic sensors (25, 43, 44) for biochemicals such as glucose are provided having an ideal size and geometry for optional long term implantation and linear responses over the concentration ranges of interest. The sensors (25, 43, 44) include an elongated body (10, 26, 46) supporting an indicating electrode section having an appropriate enzyme immobilized thereon to present an enzymatic indicating surface (21, 33, 54). A permeable synthetic polymer membrane (24, 42, 56) is applied over the sensor body (10, 26, 46) to protect the enzyme and regulate diffusion of analyte therethrough, to ensure linearity of sensor response. The sensors (25, 43) are of flexible design and can be implanted using a catheter. Alternately, the sensor (44) includes an internal indicating electrode body (46) housed within an apertured, hollow needle (48). A holder (66) affixed to the needle (48) allows for easy manipulation and implantation of the sensor (44).
摘要翻译：提供了用于生物化学品如葡萄糖的可植入酶传感器（25,43,44），其具有理想的尺寸和几何尺寸，用于在所关注的浓度范围内进行可选的长期植入和线性响应。传感器（25,43,44）包括支撑指示电极部分的细长体（10,26,46），所述指示电极部分具有固定在其上的合适的酶以呈现酶指示表面（21,33,54）。将可渗透的合成聚合物膜（24,42,56）施加在传感器主体（10,26,46）上以保护酶并调节分析物通过其的扩散，以确保传感器响应的线性。传感器（25,43）具有柔性设计，并且可以使用导管植入。或者，传感器（44）包括容纳在有孔的空心针（48）内的内部指示电极体（46）。固定在针（48）上的支架（66）可以方便地操作和植入传感器（44）。

24. 发明授权

US07063774B2 Recloseable biosensor 失效
公开(公告)号：US07063774B2
公开(公告)日：2006-06-20
申请号：US10281717
申请日：2002-10-28
申请人： Raghbir Singh Bhullar , Douglas Paul Walling , Brian S. Hill
发明人： Raghbir Singh Bhullar , Douglas Paul Walling , Brian S. Hill
IPC分类号： G01N27/327
CPC分类号： B01L3/5023 , B01L2200/082 , B01L2300/043 , B01L2300/046 , B01L2300/047 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406 , G01N33/52
摘要： A biosensor is provided that comprises a substrate, a sample site positioned on the substrate, a cover coupled to the substrate, and biocide positioned between the substrate and the cover. The biosensor may also include desiccant. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.

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