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21. 发明授权

US08401636B2 Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的计时生理节律
公开(公告)号：US08401636B2
公开(公告)日：2013-03-19
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/18
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

22. 发明授权

US08108034B2 Systems and methods for valvular regurgitation detection 有权
标题翻译：瓣膜反流检测系统及方法
公开(公告)号：US08108034B2
公开(公告)日：2012-01-31
申请号：US11287978
申请日：2005-11-28
申请人： Abhilash Patangay , Krzysztof Z. Siejko
发明人： Abhilash Patangay , Krzysztof Z. Siejko
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36578
摘要： A system comprising an implantable medical device (IMD). The IMD includes an implantable sensor operable to produce an electrical signal representative of mechanical activity of a heart of a subject and a controller circuit coupled to the sensor. The controller circuit includes a wavelet filter module and a valvular regurgitation (VR) calculation module. The wavelet filter module is configured to extract signal energy information from the electrical signal. The energy information includes variation of signal amplitude with frequency and time. The VR calculation module is configured to calculate a measurement of VR for one or more heartbeats using the energy information.
摘要翻译：一种包括可植入医疗装置（IMD）的系统。 IMD包括可植入传感器，其可操作以产生代表受试者心脏的机械活动的电信号和耦合到传感器的控制器电路。控制器电路包括小波滤波器模块和瓣膜反流（VR）计算模块。小波滤波器模块被配置为从电信号中提取信号能量信息。能量信息包括信号幅度随频率和时间的变化。 VR计算模块被配置为使用能量信息来计算针对一个或多个心跳的VR的测量。

23. 发明申请

US20110301530A1 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统
公开(公告)号：US20110301530A1
公开(公告)日：2011-12-08
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/08 , A61N1/365 , A61M5/142
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

24. 发明授权

US08048001B2 Method and apparatus for detecting atrial filling pressure 有权
标题翻译：用于检测心房充盈压的方法和装置
公开(公告)号：US08048001B2
公开(公告)日：2011-11-01
申请号：US11558967
申请日：2006-11-13
申请人： Abhilash Patangay , Krzysztof Z. Siejko
发明人： Abhilash Patangay , Krzysztof Z. Siejko
IPC分类号： A61B5/0225 , A61B5/021
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

25. 发明申请

US20100274147A1 DETECTING ISCHEMIA WITH NONLINEAR HEART RATE VARIABILITY MEASURES 审中-公开
标题翻译：用非线性心率变异性测量法检测ISCHEMIA
公开(公告)号：US20100274147A1
公开(公告)日：2010-10-28
申请号：US12761047
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/3418 , G16H50/30
摘要： Systems and methods include accessing a plurality of cardiac indications. A heart rate variability metric is produced by analyzing the plurality of cardiac indications using a measurement from a class of nonlinear measurements. Nonlinear measurements include, but are not limited to, approximate entropy, X-Y scatter from a Poincaré plot, fractal dimension, and detrended fluctuation analysis, in various examples. Based on the heart rate variability metric, a cardiac ischemic state is detected.
摘要翻译：系统和方法包括访问多个心脏指示。通过使用来自一类非线性测量的测量来分析多个心脏指征来产生心率变异性度量。在各种实施例中，非线性测量包括但不限于近似熵，Poincaré图中的X-Y散射，分形维数和去趋势波动分析。基于心率变异性度量，检测到心脏缺血状态。

26. 发明申请

US20100073170A1 SYSTEM AND METHOD FOR DETECTION OF HF DECOMPENSATION BASED ON SIGNS AND SYMPTOMS 有权
标题翻译：基于标志和症状检测HF分解的系统和方法
公开(公告)号：US20100073170A1
公开(公告)日：2010-03-25
申请号：US12563882
申请日：2009-09-21
申请人： Krzysztof Z. Siejko , Viktoria A. Averina , Abhilash Patangay
发明人： Krzysztof Z. Siejko , Viktoria A. Averina , Abhilash Patangay
IPC分类号： G08B23/00 , G06N7/02 , G06N5/04
CPC分类号： A61B5/0205 , A61B5/0002 , A61B5/7264 , G06F19/00
摘要： In an example, physiologic information about a patient can be obtained and mapped to a first set of fuzzy logic membership functions, and a symptom status can be derived from the mapping of the physiologic information using a first fuzzy logic inference. In an example, the symptom status can be mapped to a second set of fuzzy logic membership functions, and a disease status can be derived from the mapping of the symptom status to the second set of fuzzy logic membership functions using a second fuzzy logic inference.
摘要翻译：在一个示例中，可以获得关于患者的生理信息并将其映射到第一组模糊逻辑隶属函数，并且可以使用第一模糊逻辑推断从生理信息的映射导出症状状态。在一个示例中，症状状态可被映射到第二组模糊逻辑隶属函数，并且可以使用第二模糊逻辑推理从症状状态与第二组模糊逻辑隶属函数的映射导出疾病状态。

27. 发明申请

US20080177156A1 ISCHEMIA DETECTION USING PRESSURE SENSOR 审中-公开
标题翻译：使用压力传感器进行ISCHEMIA检测
公开(公告)号：US20080177156A1
公开(公告)日：2008-07-24
申请号：US11624974
申请日：2007-01-19
申请人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
发明人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
IPC分类号： A61B5/0205 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure (“PAP”) signal of a pulmonary artery (“PA”) and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译：本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算将血液供应减少到至少一部分心脏使用来自PAP信号的信息。使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

28. 发明申请

US20080125820A1 ADAPTIVE SAMPLING OF HEART SOUNDS 有权
标题翻译：自适应采样心音
公开(公告)号：US20080125820A1
公开(公告)日：2008-05-29
申请号：US11564637
申请日：2006-11-29
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more parameters. The system alters one or more of the parameters as a function of one or more triggering events. The system then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered parameters.
摘要翻译：根据一个或多个参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。系统根据一个或多个触发事件改变一个或多个参数。该系统然后根据至少一个或多个改变的参数用一个或多个可植入医疗装置感测心脏声音。

29. 发明授权

US08700149B2 Estimating acute response to cardiac resynchronization therapy 失效
标题翻译：估计对心脏再同步治疗的急性反应
公开(公告)号：US08700149B2
公开(公告)日：2014-04-15
申请号：US13479979
申请日：2012-05-24
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

30. 发明授权

US08319648B2 System and method for detection of HF decompensation based on signs and symptoms 有权
标题翻译：基于体征和症状检测HF失代偿的系统和方法
公开(公告)号：US08319648B2
公开(公告)日：2012-11-27
申请号：US12563882
申请日：2009-09-21
申请人： Krzysztof Z. Siejko , Viktoria A. Averina , Abhilash Patangay
发明人： Krzysztof Z. Siejko , Viktoria A. Averina , Abhilash Patangay
IPC分类号： G08B23/00
CPC分类号： A61B5/0205 , A61B5/0002 , A61B5/7264 , G06F19/00
摘要： In an example, physiologic information about a patient can be obtained and mapped to a first set of fuzzy logic membership functions, and a symptom status can be derived from the mapping of the physiologic information using a first fuzzy logic inference. In an example, the symptom status can be mapped to a second set of fuzzy logic membership functions, and a disease status can be derived from the mapping of the symptom status to the second set of fuzzy logic membership functions using a second fuzzy logic inference.
摘要翻译：在一个示例中，可以获得关于患者的生理信息并将其映射到第一组模糊逻辑隶属函数，并且可以使用第一模糊逻辑推断从生理信息的映射导出症状状态。在一个示例中，症状状态可被映射到第二组模糊逻辑隶属函数，并且可以使用第二模糊逻辑推理从症状状态与第二组模糊逻辑隶属函数的映射导出疾病状态。

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