专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US4604389A Benzazepine derivatives 失效
标题翻译：苯扎西平衍生物
公开(公告)号：US4604389A
公开(公告)日：1986-08-05
申请号：US732204
申请日：1985-05-08
申请人： Manfred Reiffen , Klaus Noll , Joachim Heider , Volkhard Austel , Norbert Hauel , Walter Kobinger , Christian Lillie
发明人： Manfred Reiffen , Klaus Noll , Joachim Heider , Volkhard Austel , Norbert Hauel , Walter Kobinger , Christian Lillie
IPC分类号： A61K31/55 , A61P9/06 , C07C59/64 , C07D223/16 , C07D233/16 , C07D243/04 , C07D405/12 , C07D491/04 , C07D491/056 , C07D521/00
CPC分类号： C07D223/16 , C07C59/64 , C07D243/04 , C07D405/12 , C07D491/04
摘要： This invention relates to benzazepine derivatives of formula I ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;R.sub.1 is hydrogen, chlorine, bromine, C.sub.1 -C.sub.3 alkyl, amino, C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3 dialkylamino, acylamino, hydroxy, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy;R.sub.2 is hydrogen, chlorine, bromine, hydroxy, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy or, together with R.sub.1, can be C.sub.1 -C.sub.3 alkylenedioxy;R.sub.3 is hydrogen, chlorine, bromine or C.sub.1 -C.sub.3 alkoxy;R.sub.4 is hydrogen, benzyl, C.sub.1 -C.sub.3 alkyl or C.sub.3 -C.sub.5 alkenyl;R.sub.5 is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy;R.sub.6 is hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy or, together with R.sub.5, can be a C.sub.1 -C.sub.2 alkylenedioxy;X is an imino, optionally substituted by a benzyl or C.sub.1 -C.sub.3 alkyl, or is oxygen, sulphur, sulphinyl or sulphonyl;Y is an imino, optionally substituted by a benzyl or C.sub.1 -C.sub.3 alkyl, or is methylene or carbonyl;m and n are each independently 2, 3 or 4; and nontoxic, pharmaceutically acceptable addition salts thereof. These compounds have valuable pharmacological properties, particularly the effect of lowering heart rate and reducing the O.sub.2 requirement of the heart.
摘要翻译：本发明涉及式I的苯并氮杂衍生物，其中A是-CH 2 CH 2 - 或-CH = CH-; R1是氢，氯，溴，C1-C3烷基，氨基，C1-C3烷基氨基，C1-C3二烷基氨基，酰氨基，羟基，C1-C3烷氧基或苯基C1-C3烷氧基; R2是氢，氯，溴，羟基，C1-C3烷基，C1-C3烷氧基或苯基C1-C3烷氧基，或与R1一起可以是C1-C3亚烷基二氧基; R3是氢，氯，溴或C1-C3烷氧基; R4是氢，苄基，C1-C3烷基或C3-C5烯基; R5是氢，卤素，C1-C3烷基或C1-C3烷氧基; R 6是氢，C 1 -C 3烷基或C 1 -C 3烷氧基，或与R 5一起可以是C 1 -C 2亚烷基二氧基; X是任选被苄基或C 1 -C 3烷基取代的亚氨基，或是氧，硫，亚磺酰基或磺酰基; Y是任选被苄基或C 1 -C 3烷基取代的亚氨基，或亚甲基或羰基; m和n各自独立地为2,3或4; 和无毒的药学上可接受的加成盐。这些化合物具有有价值的药理学特性，特别是降低心率并降低心脏O2需求的作用。

22. 发明授权

US4584293A Aminotetralin derivatives 失效
标题翻译：氨基四氢萘衍生物
公开(公告)号：US4584293A
公开(公告)日：1986-04-22
申请号：US732199
申请日：1985-05-08
申请人： Manfred Reiffen , Joachim Heider , Volkhard Austel , Norbert Hauel , Walter Kobinger , Christian Lillie
发明人： Manfred Reiffen , Joachim Heider , Volkhard Austel , Norbert Hauel , Walter Kobinger , Christian Lillie
IPC分类号： A61K31/55 , A61P9/06 , A61P9/08 , A61P9/10 , C07C45/00 , C07C45/51 , C07C49/755 , C07C57/58 , C07C59/64 , C07C205/56 , C07D223/16 , C07D243/04 , C07D491/056 , C07D521/00
CPC分类号： C07D223/16 , C07C205/56 , C07C45/00 , C07C45/513 , C07C49/755 , C07C57/58 , C07C59/64 , C07D231/12 , C07D233/56 , C07D243/04 , C07D249/08
摘要： This invention related to new aminotetralin derivatives of formula I ##STR1## wherein ##STR2## B is methylene or, when A is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --NH--CO-- or --CH.sub.2 --CO--, B can also be carbonyl or thiocarbonyl;E is a C.sub.2 -C.sub.4 straight-chain alkylene, optionally substituted by a C.sub.1 -C.sub.3 alkyl, or is 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene;R.sub.1 is hydrogen, fluorine, chlorine, bromine, trifluoromethyl, nitro, amino, C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3 dialkylamino, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkylthio, hydroxy, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy;R.sub.2 is hydrogen, chlorine, bromine, hydroxy, C.sub.1 -C.sub.3 alkoxy phenyl C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkyl or, together with R.sub.1, can be a C.sub.1 -C.sub.2 alkylenedioxy;R.sub.3 and R.sub.4 are each independently selected from hydrogen, fluorine, chlorine, bromine, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, nitro, amino, C.sub.1 -C.sub.3 alkylamino, or C.sub.1 -C.sub.3 dialkylamino, or together can be methylenedioxy; andR.sub.5 is hydrogen, C.sub.3 -C.sub.5 alkenyl, C.sub.1 -C.sub.3 alkyl, or phenyl C.sub.1 -C.sub.3 alkyl, and nontoxic, pharmaceutically acceptable addition salts thereof which have valuable pharmacological properties, particularly a long-lasting heart rate lowering effect and the effect of reducing the O.sub.2 requirement of the heart.
摘要翻译：本发明涉及新的式I的氨基蝶呤衍生物，其中B是亚甲基，或当A是-CH 2 -CH 2 - 时，-CH = CH-，-NH-CO-或-CH 2 -CO-，B也可以是羰基或硫代羰基; E是任选被C 1 -C 3烷基取代的C 2 -C 4直链亚烷基，或是2-羟基 - 正丙烯，2-羟基 - 正丁烯或3-羟基 - 正丁烯; R1是氢，氟，氯，溴，三氟甲基，硝基，氨基，C1-C3烷基氨基，C1-C3二烷基氨基，C1-C3烷基，C1-C3烷硫基，羟基，C1-C3烷氧基或苯基C1-C3烷氧基; R2是氢，氯，溴，羟基，C1-C3烷氧基苯基C1-C3烷氧基或C1-C3烷基，或与R1一起可以是C1-C2亚烷基二氧基; R 3和R 4各自独立地选自氢，氟，氯，溴，C 1 -C 3烷基，羟基，C 1 -C 3烷氧基，硝基，氨基，C 1 -C 3烷基氨基或C 1 -C 3二烷基氨基，或一起可以是亚甲二氧基; 并且R 5是氢，C 3 -C 5烯基，C 1 -C 3烷基或苯基C 1 -C 3烷基，以及其无毒的药学上可接受的加成盐，其具有有价值的药理学性质，特别是持久的心率降低效果和降低心脏的O2要求。

23. 发明授权

US4176184A Imidazoisoquinoline-diones and salts thereof 失效
标题翻译：咪唑并异喹啉二酮及其盐
公开(公告)号：US4176184A
公开(公告)日：1979-11-27
申请号：US925461
申请日：1978-07-17
申请人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Walter Kobinger , Christian Lillie , Willi Diederen , Walter Haarmann
发明人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Walter Kobinger , Christian Lillie , Willi Diederen , Walter Haarmann
IPC分类号： A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/535 , A61P7/02 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/20 , C07D217/24 , C07D471/04
CPC分类号： C07D471/04 , C07D217/24 , Y10S514/821
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl; phenyl-lower alkyl; cycloalkyl of 3 to 6 carbon atoms; phenyl; mono- or di-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, hydroxyl, methoxy, methylmercapto, methylsulfinyl, methylsulfonyl or benzyloxy; andA is hydrogen or ##STR2## where R.sub.2 is hydrogen or lower alkyl;R.sub.3 is lower alkyl or dimethoxyphenyl-lower alkyl; orR.sub.2 and R.sub.3, together with each other and the nitrogen atom to which they are attached, are piperidino, morpholino or N'-lower alkyl-piperazino; andn is 2 or 3;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives, antithrombotics and antiarrhythmics.
摘要翻译：其中R 1是低级烷基的式IMAMA的化合物; 苯基 - 低级烷基; 3至6个碳原子的环烷基; 苯基; 羟基，甲氧基，甲基巯基，甲基亚磺酰基，甲基磺酰基或苄氧基的取代基可以相同或不同。和A是氢或者其中R 2是氢或低级烷基; R3是低级烷基或二甲氧基苯基 - 低级烷基; 或R 2和R 3彼此连接并且与它们相连的氮原子是哌啶子基，吗啉代或N'-低级烷基 - 哌嗪子基; n为2或3; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂，低血糖剂，抗血栓药物和抗心律失常药物。

24. 发明授权

US4026891A 5- Or 6-pyridazinyl-benzimidazoles and salts thereof 失效
标题翻译： 5-或6-哒嗪基 - 苯并咪唑及其盐
公开(公告)号：US4026891A
公开(公告)日：1977-05-31
申请号：US583641
申请日：1975-06-04
申请人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Rudolf Kadatz , Willi Diederen
发明人： Volkhard Austel , Eberhard Kutter , Joachim Heider , Wolfgang Eberlein , Rudolf Kadatz , Willi Diederen
IPC分类号： C07D403/04 , A61K20060101 , A61K31/415 , A61K31/495 , A61K31/50 , A61K31/535 , A61P7/02 , A61P9/04 , A61P9/12 , C07D20060101 , C07D235/04 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/14 , C07D235/18 , C07D235/24 , C07D235/28 , C07D237/00 , C07D237/02 , C07D237/04 , C07D237/08 , C07D237/12 , C07D237/14 , C07D237/20 , C07D247/00 , C07D295/12 , C07D403/02 , C07D403/10 , C07D403/14 , C07D413/14
CPC分类号： Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, trifluoromethyl, alkyl of 1 to 5 carbon atoms, mercapto, lower alkyl-mercapto, phenyl, fluoro-phenyl, tolyl, hydroxy-phenyl, methylmercapto-phenyl, methylsulfinyl-phenyl, methylsulfonyl-phenyl, dimethylamino-phenyl, or mono-, di- or tri-methoxy-substituted phenyl;A is hydrogen or, together with B, a double bond,B is hydrogen, alkyl of 1 to 3 carbon atoms or, together with A, a double bond;C is, together with R.sub.2, a double bond, or, together with R.sub.3, oxygen;R.sub.2 is hydrogen, alkyl of 1 to 3 carbon atoms or, together with C, a double bond; andR.sub.3 is chlorine, methylamino, morpholino, 4-methylpiperazino or, when R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, together with C, oxygen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, antithrombotics and cardiotonics.
摘要翻译：其中R 1为氢，三氟甲基，1至5个碳原子的烷基，巯基，低级烷基 - 巯基，苯基，氟 - 苯基，甲苯基，羟基 - 苯基，甲基巯基 - 苯基，甲基亚磺酰基 - 苯基，甲基磺酰基苯基，二甲基氨基 - 苯基或单 - ，二 - 或三 - 甲氧基取代的苯基; A为氢或与B一起为双键，B为氢，1〜3个碳原子的烷基，或与A一起为双键; C与R2一起为双键，或与R3一起为氧; R 2是氢，1至3个碳原子的烷基，或与C一起形成双键; 并且R 3是氯，甲基氨基，吗啉代，4-甲基哌嗪基，或者当R 2是氢或有1至3个碳原子的烷基与C，氧时; 和非毒性，药理学上可接受的酸添加量; 该化合物作为有效的低分子量有机抗体，抗生素和心脏病。

25. 发明授权

US5650424A Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：环状脲衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5650424A
公开(公告)日：1997-07-22
申请号：US521338
申请日：1995-08-29
申请人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Guenter Linz , Thomas Mueller , Johannes Weisenberger , Wolfgang Eisert
发明人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Guenter Linz , Thomas Mueller , Johannes Weisenberger , Wolfgang Eisert
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5355 , A61K31/54 , A61K31/541 , A61K31/675 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , C07D211/58 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/70 , C07D233/72 , C07D233/74 , C07D233/76 , C07D235/26 , C07D239/10 , C07D239/36 , C07D249/12 , C07D285/10 , C07D309/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D471/04 , C07F9/6506
CPC分类号： C07D285/10 , C07D211/58 , C07D233/32 , C07D233/70 , C07D233/72 , C07D235/26 , C07D239/10 , C07D239/36 , C07D249/12 , C07D309/12 , C07D401/04 , C07D403/04 , C07D471/04 , C07F9/65061
摘要： The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的环脲衍生物，其中Ra，Rb，X和Y如本文所定义，含有衍生物的药物组合物及其制备方法。

26. 发明授权

US5612335A Cyclic compounds and pharmaceutical compositions containing them 失效
标题翻译：含有它们的环状化合物和药物组合物
公开(公告)号：US5612335A
公开(公告)日：1997-03-18
申请号：US434136
申请日：1995-05-02
申请人： F. Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Brian Guth , Thomas Muller , Johannes Weisenberger
发明人： F. Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Brian Guth , Thomas Muller , Johannes Weisenberger
IPC分类号： C07D403/02 , A61K31/395 , A61K31/41 , A61K31/47 , A61K31/4725 , A61K31/55 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/04 , C07D403/04 , C07D403/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07F9/6558 , C07D223/16
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的环状衍生物，其中Ra，Rb，X和Y如权利要求1所定义，互变异构体，立体异构体包括其混合物及其盐，特别是其生理上可接受的盐其具有有价值的药理学性质，优选聚集抑制作用的有机或无机酸或碱，含有该化合物的药物组合物及其制备方法。

27. 发明授权

US5519036A Cyclic derivatives pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：含有这些化合物的环状衍生物药物组合物及其制备方法
公开(公告)号：US5519036A
公开(公告)日：1996-05-21
申请号：US200125
申请日：1994-02-22
申请人： F. Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Brian Guth , Thomas Muller , Johannes Weisenberger
发明人： F. Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Brian Guth , Thomas Muller , Johannes Weisenberger
IPC分类号： C07D403/02 , A61K31/395 , A61K31/41 , A61K31/47 , A61K31/4725 , A61K31/55 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/04 , C07D403/04 , C07D403/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07F9/6558
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的环状衍生物，其中Ra，Rb，X和Y如权利要求1所定义，互变异构体，立体异构体包括其混合物及其盐，特别是其生理上可接受的盐其具有有价值的药理学性质，优选聚集抑制作用的有机或无机酸或碱，含有该化合物的药物组合物及其制备方法。

28. 发明授权

US4716169A Imidazo[1,2a]pyridines and their use as cardiotonic agents 失效
标题翻译：咪唑并[1,2a]吡啶并用作强心剂
公开(公告)号：US4716169A
公开(公告)日：1987-12-29
申请号：US810008
申请日：1985-12-17
申请人： Joachim Heider , Norbert Hauel , Volkhard Austel , Klaus Noll , Andreas Bomhard , Jacques van Meel , Willi Diederen
发明人： Joachim Heider , Norbert Hauel , Volkhard Austel , Klaus Noll , Andreas Bomhard , Jacques van Meel , Willi Diederen
IPC分类号： A61K31/435 , A61K31/495 , A61P7/02 , A61P9/04 , C07D471/04 , C07D487/04 , A61K31/41
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to new imidazo derivatives of the formula ##STR1## wherein "A-D and R.sup.1 -R.sup.3 are as defined in the specification". The new compounds have valuable pharmacological properties, particularly antithrombotic and cardiovascular properties such as a cardiotonic activity and/or an effect on blood pressure, and can be prepared using methods known per se.
摘要翻译：本发明涉及式（I）的新的咪唑衍生物，其中“A-D和R 1 -R 3如说明书中所定义”。新化合物具有有价值的药理学性质，特别是抗血栓形成和心血管性质，例如强心剂活性和/或对血压的作用，并且可以使用本身已知的方法制备。

29. 发明授权

US4656171A 2-phenyl-imidazo-pyrazines, useful as cardiotonics 失效
标题翻译： 2-苯基 - 咪唑并吡嗪，可用作强心剂
公开(公告)号：US4656171A
公开(公告)日：1987-04-07
申请号：US675299
申请日：1984-11-27
申请人： Volkhard Austel , Norbert Hauel , Joachim Heider , Manfred Reiffen , Jacobus C. A. Van Meel , Willi Diederen
发明人： Volkhard Austel , Norbert Hauel , Joachim Heider , Manfred Reiffen , Jacobus C. A. Van Meel , Willi Diederen
IPC分类号： A61K31/50 , A61K31/53 , A61P9/02 , A61P9/04 , C07D487/04 , A61K31/495 , C07D471/02
CPC分类号： C07D487/04
摘要： Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N.dbd. or --CH.dbd., provided, however, that at least two of them must be --N.dbd., and when A and C are both --N.dbd., at least one or both of B and D must be --N.dbd.; andR.sub.1, R.sub.2 and R.sub.3 are substituents of diverse types;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.
摘要翻译：其中A，B，C和D各自独立地为-N =或-CH =，但条件是其中至少两个必须为-N =，并且当A和C均为 - N =，B和D中的至少一个或两个必须为-N =; 并且R1，R2和R3是不同类型的取代基; 互变异构体和无毒的，药学上可接受的酸加成盐。这些化合物可用作强心剂。

30. 发明授权

US4616018A Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones 失效
标题翻译：苯并三唑基-4,5-二氢-3（2H） - 哒嗪酮
公开(公告)号：US4616018A
公开(公告)日：1986-10-07
申请号：US749580
申请日：1985-06-27
申请人： Norbert Hauel , Volkhard Austel , Joachim Heider , Manfred Reiffen , Willi Diederen , Walter Haarman
发明人： Norbert Hauel , Volkhard Austel , Joachim Heider , Manfred Reiffen , Willi Diederen , Walter Haarman
IPC分类号： A61K31/50 , A61K31/501 , A61P7/02 , A61P9/12 , C07D237/04 , C07D249/18 , C07D401/14 , C07D403/04 , C07D403/02
CPC分类号： C07D401/14 , C07D237/04 , C07D249/18 , C07D403/04 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives and antithrombotics.
摘要翻译：其中R 1是氢的式IMAMA的化合物; 1至7个碳原子的烷基; 3至7个碳原子的环烷基; 其中取代基是吡啶基，甲基吡啶基，苯基，单 - ，二 - 或三取代的苯基，其中可以相同或不同的苯环上的取代基选自由一个氨基，一个二甲基氨基，一至两个羟基，一至三个甲氧基和一至三个卤素组成的组; 2至4个碳原子的ω-单取代的烷基，其中取代基是羟基或二（1至3个碳原子的烷基）氨基; 苯基; 单卤代苯基; 未取代的或单取代的1至6个碳原子的直链或支链烷酰基，其中取代基是苯基，甲氧基苯基或3-7个碳原子的环烷基; 或未取代或单取代的苯基磺酰基，其中取代基是甲基或甲氧基; R2为氢或1〜3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂，低血糖剂和抗血栓药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式