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21. 发明授权

US07951383B2 Attenuated parainfluenza virus (PIV) vaccines 有权
标题翻译：减毒副流感病毒（PIV）疫苗
公开(公告)号：US07951383B2
公开(公告)日：2011-05-31
申请号：US11785364
申请日：2007-04-17
申请人： Brian R. Murphy , Peter L. Collins , Mario H. Skiadopoulos
发明人： Brian R. Murphy , Peter L. Collins , Mario H. Skiadopoulos
IPC分类号： A61K39/155 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , A61K2039/70 , C07K2319/00 , C12N2760/18434 , C12N2760/18451 , C12N2760/18461 , C12N2760/18634 , C12N2760/18651 , C12N2760/18661 , C12N2760/18671 , C12N2760/18734 , C12N2760/18751 , C12N2760/18761 , C12N2810/60
摘要： The invention provides isolated nucleic acids encoding recombinant genomes or antigenomes of Human Parainfluenza Viruses that are useful as vaccines. The recombinant genomes or antigenomes can be incorporated into expression vectors for production of recombinant viruses in vitro. The invention also provides recombinant Human Parainfluenza viruses having one or more mutations that attenuate replication of the virus in a host.
摘要翻译：本发明提供编码人类副流感病毒的重组基因组或抗原单体的分离的核酸，其可用作疫苗。重组基因组或抗原单体可以并入用于体外重组病毒生产的表达载体中。本发明还提供具有一种或多种突变的重组人副流感病毒，所述突变减弱病毒在宿主中的复制。

22. 发明申请

US20100330120A1 HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES 审中-公开
标题翻译：具有分离的P和C基因的人类流感病毒病毒
公开(公告)号：US20100330120A1
公开(公告)日：2010-12-30
申请号：US12599095
申请日：2008-05-08
申请人： Peter L. Collins , Brian R. Murphy , Mario H. Skiadopoulos , Emmalene J. Bartlett , Alexander C. Schmidt , Ann-Marie M. Cruz
发明人： Peter L. Collins , Brian R. Murphy , Mario H. Skiadopoulos , Emmalene J. Bartlett , Alexander C. Schmidt , Ann-Marie M. Cruz
IPC分类号： A61K39/155 , C12N7/01 , C07H21/04 , C12N7/04 , A61P37/04 , A61P31/14
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C12N15/86 , C12N2760/18634 , C12N2760/18643 , C12N2760/18661
摘要： The invention provides self replicating infectious recombinant paramyxoviruses where the P and C genes are separated rated. The recombinant paramyxoviruses preferably have one or more attenuating mutations and/or at least one temperature sensitive mutation and one non-temperature sensitive mutation. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a C protein and a separate monocistronic polynucleotide encoding a P protein. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
摘要翻译：本发明提供了自我复制的感染性重组副粘病毒，其中P和C基因被分级。重组副粘病毒优选具有一个或多个减毒突变和/或至少一个温度敏感突变和一个非温度敏感突变。在一些实施方案中，重组副粘病毒具有编码C蛋白的单独变体多核苷酸和编码P蛋白的分离的单顺反子多核苷酸。还提供了使用如本文所述的重组副粘病毒的组合物和方法。

23. 发明授权

US07250171B1 Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein 有权
标题翻译：构建和使用表达嵌合糖蛋白的重组副流感病毒
公开(公告)号：US07250171B1
公开(公告)日：2007-07-31
申请号：US09459062
申请日：1999-12-10
申请人： Tao Tao , Mario H. Skiadopoulos , Peter L. Collins , Brian R. Murphy
发明人： Tao Tao , Mario H. Skiadopoulos , Peter L. Collins , Brian R. Murphy
IPC分类号： A61K31/155 , C12N15/00
CPC分类号： C12N15/86 , A61K2039/5256 , C07K2319/00 , C12N2760/18643
摘要： Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome modified to encode a chimeric glycoprotein incorporating one or more heterologous antigenic domains, fragments, or epitopes of a second, antigenically distinct HPIV. These chimeric viruses are infectious and attenuated in humans and other mammals and are useful in vaccine formulations for eliciting an immune responses against one or more PIVs, and, optionally against respiratory syncytial virus (RSV). Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a HPIV vector genome or antigenome combined or integrated with one or more heterologous genome segment(s) encoding one or more antigenic determinant(s) of a heterologous PIV to encode a chimeric glycoprotein. In preferred aspects of the invention, the chimeric virus is attenuated for use as a vaccine agent by additional mutations or nucleotide modifications introduced into the chimeric genome or antigenome.
摘要翻译：提供了嵌合副流感病毒（PIV），其包含PIV载体基因组或经修饰的反义基因组，以编码掺入一个或多个异源抗原结构域，片段或第二抗原性不同HPIV表位的嵌合糖蛋白。这些嵌合病毒在人和其他哺乳动物中是感染性和减毒性的，并且可用于引发针对一种或多种PIV的免疫应答的疫苗制剂，以及任选地抗呼吸道合胞病毒（RSV）。还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或反基因组的载体，其包括与编码异源PIV的一个或多个抗原决定簇的一个或多个异源基因组片段组合或整合的HPIV载体基因组或抗原子集，编码嵌合糖蛋白。在本发明的优选方面，嵌合病毒通过引入到嵌合基因组或反基因组中的附加突变或核苷酸修饰来减毒用作疫苗剂。

24. 发明授权

US07208161B1 Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences 失效
标题翻译：从克隆的核苷酸序列产生减毒副流感病毒疫苗
公开(公告)号：US07208161B1
公开(公告)日：2007-04-24
申请号：US09083793
申请日：1998-05-22
申请人： Brian R. Murphy , Peter L. Collins , Anna P. Durbin , Mario H. Skiadopoulos , Tao Tao
发明人： Brian R. Murphy , Peter L. Collins , Anna P. Durbin , Mario H. Skiadopoulos , Tao Tao
IPC分类号： A61K39/155 , C12N7/00
CPC分类号： C07K16/1027 , A61K39/00 , A61K2039/5254 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18622 , C12N2760/18643 , C12N2760/18661
摘要： Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a nucleoprotein (N), phosphoprotein (P), and a large (L) polymerase protein to produce isolated infectious PIV particles. The recombinant PIV genome and antigenome can be modified to produce desired changes, for example to incorporate attenuating mutations from biologically derived PIV mutants or to create chimeric PIV clones, to generate attenuated, immunogenic viruses for vaccine use.
摘要翻译：分离的多核苷酸分子提供用于重组PIV疫苗生产的重组PIV基因组和抗原单体。可以用核蛋白（N），磷酸化蛋白（P）和大的（L）聚合酶蛋白来表达重组基因组或反基因组以产生分离的感染性PIV颗粒。可以修饰重组PIV基因组和反义基因组以产生所需的变化，例如从生物衍生的PIV突变体引入减毒突变或产生嵌合PIV克隆，以产生用于疫苗使用的减毒的免疫原性病毒。

25. 发明授权

US07201907B1 Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines 有权
标题翻译：减毒的人 - 牛嵌合副流感病毒（PIV）疫苗
公开(公告)号：US07201907B1
公开(公告)日：2007-04-10
申请号：US09586479
申请日：2000-06-01
申请人： Alexander C. Schmidt , Mario H. Skiadopoulos , Peter L. Collins , Brian R. Murphy , Jane E. Bailly , Anna P. Durbin
发明人： Alexander C. Schmidt , Mario H. Skiadopoulos , Peter L. Collins , Brian R. Murphy , Jane E. Bailly , Anna P. Durbin
IPC分类号： A61K39/12 , A61K39/155
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C12N2760/18634 , C12N2760/18643 , C12N2760/18645 , C12N2760/18661 , C12N2810/6072
摘要： Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune response or as vectors for introducing heterologous genes into a host. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete “background” PIV genome or antigenome derived from or patterned after a human or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different PIV virus to form the human-bovine chimeric PIV genome or antigenome.
摘要翻译：嵌合人 - 牛副流感病毒（PIV）在人类和其他哺乳动物中具有感染性和减毒性，并且在疫苗制剂中单独使用或组合用于引发抗PIV免疫应答或作为将异源基因导入宿主的载体。还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或抗原组的载体，其包括部分或完整的人或牛PIV“背景”基因组或反基因组，其与一个或多个异源基因或基因组片段组合或整合，不同的PIV。本发明的嵌合人牛PIV包括部分或完整的“背景”PIV基因组或反义基因组，其衍生自或构图在人或牛PIV病毒与一个或多个异源基因或不同基因组的基因组片段组合 PIV病毒形成人 - 牛嵌合PIV基因组或抗原组。

26. 发明授权

US06713066B1 Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 有权
标题翻译：涉及M2 ORF2修饰的减毒呼吸道合胞病毒疫苗的生产
公开(公告)号：US06713066B1
公开(公告)日：2004-03-30
申请号：US09611829
申请日：2000-07-07
申请人： Peter L. Collins , Brian R. Murphy , Alison Bermingham
发明人： Peter L. Collins , Brian R. Murphy , Alison Bermingham
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C12N7/00 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561
摘要： Recombinant respiratory syncytial virus (RSV) are provided in which expression of the second translational open reading frame encoded by the M2 gene (M2ORF2) is reduced or ablated to yield novel RSV vaccine candidates. Expression of M2 ORF2 is reduced or ablated by modifying a recombinant RSV genome or antigenome to incorporate a frame shift mutation, or one or more stop codons in M2 ORF2. Alternatively, M2 ORF2 is deleted in whole or in part to render the M2-2 protein partially or entirely non-functional or to disrupt its expression altogether. M2 ORF2 deletion and knock out mutants possess highly desirable phenotypic characteristics for vaccine development. These changes specify one or more desired phenotypic changes in the resulting virus or subviral particle. Vaccine candidates are generated that show a change in mRNA transcription, genomic or antigenomic RNA replication, viral growth characteristics, viral antigen expression, viral plaque size, and/or a change in cytopathogenicity. In addition, M2-2 knock out or deletion virus exhibits increased levels of synthesis of viral proteins in cell culture, providing an enriched source of viral antigen or protein for purification and use as a noninfectious subunit vaccine.
摘要翻译：提供了重组呼吸道合胞病毒（RSV），其中由M2基因（M2ORF2）编码的第二翻译开放阅读框的表达被减少或消融以产生新的RSV疫苗候选物。 M2 ORF2的表达通过修饰重组RSV基因组或抗原组合来结合帧移位突变或M2 ORF2中的一个或多个终止密码子来减少或消除。或者，M2 ORF2全部或部分缺失，以使M2-2蛋白部分或完全不起作用或完全破坏其表达。 M2 ORF2缺失和敲除突变体对于疫苗开发具有非常需要的表型特征。这些变化指定所得病毒或亚病毒颗粒中的一种或多种期望的表型变化。产生疫苗候选物，其显示mRNA转录，基因组或反基因组RNA复制，病毒生长特征，病毒抗原表达，病毒斑块大小和/或细胞致病性变化的变化。此外，M2-2敲除或缺失病毒在细胞培养物中表现出增加的病毒蛋白质合成水平，提供用于纯化和用作非感染性亚单位疫苗的病毒抗原或蛋白质的丰富来源。

27. 发明授权

US09034343B2 Attenuated human parainfluenza virus, methods and uses thereof 有权
标题翻译：减毒人副流感病毒，其方法和用途
公开(公告)号：US09034343B2
公开(公告)日：2015-05-19
申请号：US13501447
申请日：2006-01-10
申请人： Mario H. Skiadopoulos , Brian R. Murphy , Peter L. Collins , Sheila Nolan
发明人： Mario H. Skiadopoulos , Brian R. Murphy , Peter L. Collins , Sheila Nolan
IPC分类号： A61K39/155 , C12N15/86 , C12N7/04 , C12N7/01 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/18722 , C12N2760/18743 , C12N2760/18761
摘要： The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
摘要翻译：本发明提供了自我复制的感染性重组副粘病毒。重组副粘病毒优选具有一个或多个减毒突变。在一些实施方案中，重组副粘病毒具有编码P蛋白的单独变体多核苷酸和编码V蛋白的分离的单顺反子多核苷酸。在一些实施方案中，重组副粘病毒具有至少一个温度敏感突变和一个非温度敏感突变。还提供了使用如本文所述的重组副粘病毒的组合物和方法。

28. 发明申请

US20110143422A1 RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HYPIV2) FROM CDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS 有权
标题翻译：从CDNA恢复重组人腺病毒病毒2型（HYPIV2），并将重组HPIV2用于免疫组化和作为载体免疫PIV和其他人类病原体的免疫应答
公开(公告)号：US20110143422A1
公开(公告)日：2011-06-16
申请号：US11863196
申请日：2007-09-27
申请人： Mario H. SKIADOPOULOS , Brian R. Murphy , Peter L. Collins
发明人： Mario H. SKIADOPOULOS , Brian R. Murphy , Peter L. Collins
IPC分类号： C12N7/00 , C07H21/04 , C12N7/01 , C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/18334 , C12N2760/18634 , C12N2760/18643 , C12N2760/18722 , C12N2760/18734 , C12N2760/18743 , C12N2760/18762
摘要： Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV2 genome or antigenome.
摘要翻译：提供重组人副流感病毒2型（HPIV2）病毒和相关的免疫原性组合物和方法。根据本发明提供的包含HPIV2嵌合和嵌合载体病毒的重组HPIV2病毒在许可哺乳动物受试者，包括人中是感染性和减毒的，并且可用于免疫原性组合物中，用于引发针对一种或多种PIV的免疫应答更多的非PIV病原体，或针对PIV和非PIV病原体。还提供了分离的多核苷酸分子和掺入重组HPIV2基因组或抗原组的载体。

29. 发明授权

US07704491B2 Recombinant human metapneumovirus and its use 失效
标题翻译：重组人间质肺病毒及其用途
公开(公告)号：US07704491B2
公开(公告)日：2010-04-27
申请号：US10789400
申请日：2004-02-27
申请人： Peter L. Collins , Stephane Biacchesi , Ursula Buchholz , Mario H. Skiadopoulos , Brian R. Murphy
发明人： Peter L. Collins , Stephane Biacchesi , Ursula Buchholz , Mario H. Skiadopoulos , Brian R. Murphy
IPC分类号： A01N63/00 , A61K39/12 , A61K39/155
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18362 , C12N2760/18634 , C12N2760/18643
摘要： Recombinant HMPV (rHMPV) and related immunogenic compositions and methods are provided. The rHMPVs, including chimeric and chimeric HMPV vectors viruses, provided according to the current disclosure are infectious and attenuated in permissive mammalian subjects, including humans. The rHMPVs are useful in immunogenic compositions for eliciting an immune response against HPIV, against one or more non-HMPV pathogens, or against a HMPV and a non-HMPV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HMPV genome or antigenome.
摘要翻译：提供重组HMPV（rHMPV）和相关的免疫原性组合物和方法。根据本公开提供的rHMPV（包括嵌合和嵌合HMPV载体病毒）在许可哺乳动物受试者，包括人中是传染性和减毒的。 rHMPV可用于免疫原性组合物，用于引发针对一种或多种非HMPV病原体或针对HMPV和非HMPV病原体的针对HPIV的免疫应答。还提供了分离的多核苷酸分子和掺入重组HMPV基因组或反基因组的载体。

30. 发明授权

US07622123B2 Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines 有权
标题翻译：减毒的人 - 牛嵌合副流感病毒（PIV）疫苗
公开(公告)号：US07622123B2
公开(公告)日：2009-11-24
申请号：US10982223
申请日：2004-11-04
申请人： Mario H. Skiadopoulos , Peter L. Collins , Brian R. Murphy , Alexander C. Schmidt
发明人： Mario H. Skiadopoulos , Peter L. Collins , Brian R. Murphy , Alexander C. Schmidt
IPC分类号： A61K39/155
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , C07K14/005 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2760/18661
摘要： Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete “background” PIV genome or antigenome derived from or patterned after a human or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different PIV virus to form the human-bovine chimeric PIV genome or antigenome.
摘要翻译：嵌合人 - 牛副流感病毒（PIV）在人类和其他哺乳动物中具有感染性和减毒性，并且在疫苗制剂中单独使用或组合用于引发抗PIV免疫应答。还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或抗原组的载体，其包括部分或完整的人或牛PIV“背景”基因组或反基因组，其与一个或多个异源基因或基因组片段组合或整合，不同的PIV。本发明的嵌合人牛PIV包括部分或完整的“背景”PIV基因组或反义基因组，其衍生自或构图在人或牛PIV病毒与一个或多个异源基因或不同基因组的基因组片段组合 PIV病毒形成人 - 牛嵌合PIV基因组或抗原组。

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