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21. 发明授权

US06890908B1 Modified ribozymes 失效
标题翻译：改良的核酶
公开(公告)号：US06890908B1
公开(公告)日：2005-05-10
申请号：US08936657
申请日：1997-09-24
申请人： Fritz Eckstein , Wolfgang Pieken , Fritz Benseler , David B. Olsen , David M. Williams , Olaf Heidenreich
发明人： Fritz Eckstein , Wolfgang Pieken , Fritz Benseler , David B. Olsen , David M. Williams , Olaf Heidenreich
IPC分类号： A61K31/70 , A61K31/00 , A61K31/712 , A61K38/00 , A61K48/00 , A61P31/18 , C07H21/02 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/113
CPC分类号： C12N15/1132 , A61K38/00 , C12N15/113 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/322
摘要： The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino and disubstituted amino groups, a process for the preparation of modified RNA molecules and the use of modified RNA molecules as therapeutic agents and biocatalysts.
摘要翻译：本发明涉及具有至少一种修饰核苷的催化活性的RNA分子，其中核糖2'-位的羟基被选自卤素，巯基，叠氮基，氨基，单取代的修饰基团氨基和二取代的氨基，制备修饰的RNA分子的方法和使用修饰的RNA分子作为治疗剂和生物催化剂。

22. 发明授权

US5698687A Modified ribozymls 失效
标题翻译：改良的核酶
公开(公告)号：US5698687A
公开(公告)日：1997-12-16
申请号：US434501
申请日：1995-05-04
申请人： Fritz Eckstein , Wolfgang Pieken , Fritz Benseler , David B. Olsen , David M. Williams , Olaf Heindenreich
发明人： Fritz Eckstein , Wolfgang Pieken , Fritz Benseler , David B. Olsen , David M. Williams , Olaf Heindenreich
IPC分类号： A61K31/70 , A61K31/00 , A61K31/712 , A61K38/00 , A61K48/00 , A61P31/18 , C07H21/02 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/113 , C07H21/04 , C07H21/00 , C12P19/34
CPC分类号： C12N15/1132 , C12N15/113 , A61K38/00 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/322
摘要： The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the fibose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino, and disubstituted andno groups, a process for the preparation of modified KNA molecules and the use of modified KNA molecules as therapeutic agents and biocatalysts.
摘要翻译：本发明涉及具有至少一种修饰核苷的催化活性的RNA分子，其中纤维糖2位的羟基被选自卤素，巯基，叠氮基，氨基，单取代的修饰基团氨基和二取代和无基团，制备改性KNA分子的方法和使用修饰的KNA分子作为治疗剂和生物催化剂。

23. 发明授权

US5431071A Knife blades 失效
标题翻译：刀片
公开(公告)号：US5431071A
公开(公告)日：1995-07-11
申请号：US117105
申请日：1993-12-08
申请人： David M. Williams
发明人： David M. Williams
IPC分类号： B26B9/00 , C21D9/18
CPC分类号： C21D9/18 , B26B9/00
摘要： The invention relates to knife blades and in particular to a method of their production, and has for its object the provision of a knife blade with a cutting edge formed by a surface harder than the material of the body of the blade. This objective is met by a method comprising grinding a first face (2) of a V-shaped cutting edge to one side of the blank (1) to locate the lower edge of the first side face (2) at the approximate mid-point across the thickness of the blank (1), providing on the partly-ground blank (1) a hard surface (3) around the periphery of the blank (1) at least over the height of the first ground face (2) and grinding a second face (4) of the V-shaped cutting edge to the opposite side of the blank (1), to locate the V-shaped cutting edge at the approximate mid-point across the thickness of the blank (1).
摘要翻译： PCT No.PCT / GB92 / 00756 Sec。 371日期：1993年12月8日 102（e）日期1993年12月8日PCT提交1992年4月24日PCT公布。出版物WO92 / 19424 本发明涉及刀片，特别涉及一种刀片的制造方法，其目的在于提供一种具有切削刃的刀片，刀刃由比本体的材料硬的表面形成刀片。该目的通过一种方法来实现，该方法包括将V形切割刃的第一面（2）研磨到坯料（1）的一侧，以将第一侧面（2）的下边缘定位在近似中点在坯件（1）的厚度上，至少在第一接地面（2）的高度上至少在第一接地面（2）的高度上提供围绕坯料（1）的周边的部分地面的坯料（1）上的硬表面（3） V形切割边缘的第二面（4）到坯料（1）的相对侧，以将V形切割边缘定位在穿过坯料（1）的厚度的近似中点处。

24. 外观设计

USD282189S Toy bear figure with backpack 失效
公开(公告)号：USD282189S
公开(公告)日：1986-01-14
申请号：US517602
申请日：1983-07-27
申请人： David M. Williams , Richard A. Chase , John J. Fisher, III , Lois E. Kelly
设计人： David M. Williams , Richard A. Chase , John J. Fisher, III , Lois E. Kelly

25. 发明授权

US4441790A Lift truck safety mirror 失效
标题翻译：起重车安全镜
公开(公告)号：US4441790A
公开(公告)日：1984-04-10
申请号：US290853
申请日：1981-08-07
申请人： David M. Williams , Charles L. Curtis
发明人： David M. Williams , Charles L. Curtis
IPC分类号： B60R1/10 , B66F9/075
CPC分类号： B60R1/10 , B66F9/07504
摘要： An over the load viewing system for lift trucks and the like, includes a first mirror fixed in position in the line of sight of the vehicle operator with a second mirror pivotally mounted on arms extending above the vehicle and moveable on the arms between a viewing position and retractable to a non-viewing position with latch means for latching the second mirror assembly in the viewing position and uni-directional drive means for rotating the mirror to the viewing position.
摘要翻译：在用于起重车等的负载观察系统上方包括第一反射镜，其被固定在车辆操作者的视线中的适当位置，其中第二反射镜可枢转地安装在在车辆上方延伸的臂上，并且可以在观察位置并且通过用于将第二反射镜组件锁定在观察位置的闩锁装置可伸缩到非观察位置，以及将反射镜旋转到观察位置的单向驱动装置。

26. 外观设计

USD266101S Combined puzzle and construction toy 失效
公开(公告)号：USD266101S
公开(公告)日：1982-09-07
申请号：US96259
申请日：1979-11-20
申请人： Lawrence B. Grubb , Danny E. Simpson , Louis S. Hoffman , David M. Williams
设计人： Lawrence B. Grubb , Danny E. Simpson , Louis S. Hoffman , David M. Williams

27. 发明申请

US20140329079A1 FIRE RESISTANT COMPOSITE STRUCTURE 审中-公开
标题翻译：耐火复合结构
公开(公告)号：US20140329079A1
公开(公告)日：2014-11-06
申请号：US14366023
申请日：2011-12-27
申请人： Junqiang Liu , Scott T. Matteucci , Robert C. Clieslinski , Giuseppe Vairo , Luigi Bertucelli , David M. Williams
发明人： Junqiang Liu , Scott T. Matteucci , Robert C. Clieslinski , Giuseppe Vairo , Luigi Bertucelli , David M. Williams
IPC分类号： B32B5/18 , B32B27/40
CPC分类号： B32B5/18 , B32B3/10 , B32B27/40 , B32B2255/205 , B32B2266/0278 , B32B2307/3065 , Y10T428/249982
摘要： The present invention relates to fire resistant composite structures. As an example, a fire resistant composite structure can have a foam material located between a first facing and a second facing, and a barrier layer on the foam material. The barrier layer can include an adhesive material and a heat absorption material, where the heat absorption material has a melting point of 40° C. to 140° C. and is 15 weight percent to 99 weight percent of the barrier layer.
摘要翻译：本发明涉及耐火复合结构。作为示例，耐火复合结构可以具有位于第一面向和第二面之间的泡沫材料以及泡沫材料上的阻挡层。阻挡层可以包括粘合剂材料和吸热材料，其中吸热材料的熔点为40℃至140℃，为阻挡层的15重量％至99重量％。

28. 发明申请

US20120204338A1 MACERATING APPARATUS AND METHOD 有权
公开(公告)号：US20120204338A1
公开(公告)日：2012-08-16
申请号：US13169789
申请日：2011-06-27
申请人： Matthew S. Heinsler , Donald M. Pohler , David M. Williams
发明人： Matthew S. Heinsler , Donald M. Pohler , David M. Williams
IPC分类号： E03D9/10 , B23P17/04
CPC分类号： E03D9/10 , B02C18/0092 , E03D11/11 , Y10T29/49721
摘要： A macerating apparatus for a toilet in which the problem of jamming the macerator at startup is solved by rapidly detecting the flushing of the toilet and accelerating the macerator before motion-jamming solid objects in the effluent from the toilet can reach the macerator. The macerating apparatus may be comprised of a macerating cutter operatively connected to a motor, and a sensor in communication with the motor. The sensor may detect the flow of effluent from the toilet toward the macerator, the flow of makeup water from the supply tank into the toilet, or the mechanical action of the mechanism used to flush the toilet. The apparatus may include an intake basket having an asymmetric inlet tube and containing the macerating cutter, wherein the asymmetry of the inlet tube provides additional operating clearance between a cutting blade of the macerating cutter and the intake basket.

29. 发明申请

US20110118769A1 AORTIC DISSECTION SEPTAL CUTTING TOOL 有权
标题翻译：动态隔离切割工具
公开(公告)号：US20110118769A1
公开(公告)日：2011-05-19
申请号：US12620360
申请日：2009-11-17
申请人： Cody L. Bliss , Edward H. Cully , Joel M. Greene , Joshua J. Lovekamp , Michael C. Nilson , Himanshu Jagdish Patel , David M. Williams , William P. Witort
发明人： Cody L. Bliss , Edward H. Cully , Joel M. Greene , Joshua J. Lovekamp , Michael C. Nilson , Himanshu Jagdish Patel , David M. Williams , William P. Witort
IPC分类号： A61B17/22
CPC分类号： A61B17/320016 , A61B17/3201 , A61B17/32075 , A61B18/1492 , A61B2017/00778 , A61B2017/22039 , A61B2017/22052 , A61B2017/22069 , A61M25/003 , A61M2025/0037
摘要： The present invention relates to medical cutting tools for treating aortic septal dissections. The cutting tool is provided with a delivery catheter and has a remotely actuated cutting blade or cutting wire component. The cutting tool is provided with at least one displacement element. The displacement element assists in placement of the cutting tool at a desired location. The displacement element also assists in maintaining contact between the cutting blade and tissue being cut.
摘要翻译：本发明涉及用于治疗主动脉间隔解剖的医疗切割工具。切割工具设置有输送导管，并且具有远程致动的切割刀片或切割线部件。切割工具设置有至少一个位移元件。位移元件有助于将切割工具放置在期望的位置。位移元件还有助于保持切割刀片和被切割的组织之间的接触。

30. 发明申请

US20110085919A1 Alarm System for a Sump Pump Assembly 有权
标题翻译：水泵组件报警系统
公开(公告)号：US20110085919A1
公开(公告)日：2011-04-14
申请号：US12576214
申请日：2009-10-08
申请人： David M. Williams , Jeffrey D. Goodenbery , Ronald D. Waldron
发明人： David M. Williams , Jeffrey D. Goodenbery , Ronald D. Waldron
IPC分类号： F04B53/00 , G08B21/00
CPC分类号： F04B49/02 , F04B49/025 , F04D13/08 , F04D15/0077 , F04D15/0218
摘要： An alarm system is provided for generating an alert when a water-powered sump pump is activated and water is being used by the water-powered sump pump. The alarm system includes a water sensor for detecting if water within a sump reaches the sensor and a housing for containing sensor electronics, wherein the water sensor is supported by the housing. In addition, a clamp is attached to the housing for releasably attaching the housing to a pipe such that the alarm system may be positioned to alert a user when water-powered sump pump is activated.
摘要翻译：提供了一种报警系统，用于当水力发电泵被启动并且水被水泵的泵使用时产生警报。报警系统包括水传感器，用于检测贮槽内的水是否到达传感器，以及用于容纳传感器电子器件的壳体，其中水传感器由壳体支撑。此外，夹具附接到壳体以将壳体可释放地附接到管道，使得可以定位警报系统以在水力泵浦泵被激活时警告用户。

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