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21. 发明申请

US20070253939A1 Cell delivery system 审中-公开
标题翻译：细胞递送系统
公开(公告)号：US20070253939A1
公开(公告)日：2007-11-01
申请号：US11787273
申请日：2007-04-16
申请人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
发明人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
IPC分类号： A61K35/36 , A61Q7/00
CPC分类号： C12N5/0627 , A61K35/12 , A61K35/36
摘要： Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.
摘要翻译：使用药物和/或头发移植手术治疗秃发或脱发。本发明涉及一种治疗秃发的改进方法。在一个方面，提供了一种用于在位于外皮表面下面的真皮层中诱导毛囊形成的方法，其包括使用受控输送装置将诱导性皮肤鞘细胞和/或诱导性真皮乳头细胞直接递送到真皮层中。感应细胞的传送不需要进入预先存在的毛孔。用于治疗秃发的受控递送装置的使用是本发明的另一方面。

22. 发明申请

US20060057542A1 Bone regeneration 失效
公开(公告)号：US20060057542A1
公开(公告)日：2006-03-16
申请号：US11171965
申请日：2005-06-30
申请人： Paul Sharpe , Michael Leek , Paul Kemp , Ewan Campbell
发明人： Paul Sharpe , Michael Leek , Paul Kemp , Ewan Campbell
IPC分类号： A61C5/00
CPC分类号： A61L27/3804 , A61K35/12 , A61L27/3604 , A61L27/3865 , A61L27/3895 , A61L2430/02 , C12N5/0606 , C12N5/0623 , C12N5/0663
摘要： The present invention is based on the discovery that when a tooth primordium is inserted into a mammalian jaw and tooth formation follows, new alveolar bone around the new tooth forms. The present invention is based on the idea of stimulating new tooth formation via the implantation of tooth primordia at selected places in the jaw (e.g. at four points in the molar regions) to result in the formation of bony protuberances which could facilitate denture retention. The teeth may then be removed from the jaw of the patient to leave the new alveolar bone.

23. 发明授权

US5536656A Preparation of tissue equivalents by contraction of a collagen gel layered on a collagen gel 失效
标题翻译：通过层叠在胶原凝胶上的胶原凝胶的收缩来制备组织当量
公开(公告)号：US5536656A
公开(公告)日：1996-07-16
申请号：US193809
申请日：1994-02-09
申请人： Paul Kemp , Eugene Bell , David T. Kagan , Valerie Mason , John Cavallaro
发明人： Paul Kemp , Eugene Bell , David T. Kagan , Valerie Mason , John Cavallaro
IPC分类号： A61L27/00 , A61L27/60 , C12M3/06 , C12N5/071 , G01N33/50 , C12N5/00 , A61F2/00 , A61F13/00 , C12M3/04
CPC分类号： C12N5/0698 , A61L27/60 , C12M25/04 , C12N2502/094 , C12N2502/1323 , C12N2533/54
摘要： Tissue equivalents are produced by applying a solution of collagen without cells to a permeable membrane, gelling to produce a collagen gel on the membrane, applying a mixture of collagen and a contractile agent to the collagen gel, gelling the mixture and allowing the resultant gel to undergo radial contraction which is controlled by the collagen gel on the membrane. A suitable contractile agent is fibroblast cells. A skin tissue equivalent is produced by disposing human epidermal cells on the contracted collagen gel and allowing epidermalization to occur. A nutrient medium can be supplied to the cells. An absorbent member may be disposed adjacent the permeable membrane opposite the collagen gel on the membrane. The permeable membrane can be the bottom of an inner well disposed in an outer well for containing a nutrient medium in contact with the membrane. The nutrient medium may be contained in the outer well in an agarose gel in contact with the membrane.
摘要翻译：组织当量是通过将无细胞的胶原溶液施用于可渗透的膜，凝胶化以在膜上产生胶原凝胶，将胶原蛋白和收缩剂的混合物施用于胶原凝胶，胶凝该混合物并使所得凝胶经受由膜上的胶原凝胶控制的径向收缩。合适的收缩剂是成纤维细胞。通过将人表皮细胞置于收缩的胶原凝胶上并允许发生表皮化而产生皮肤组织当量。可以向细胞提供营养培养基。吸收构件可以设置在与膜上的胶原凝胶相对的可渗透膜附近。渗透膜可以是设置在外壁中的用于容纳与膜接触的营养培养基的内部井的底部。营养培养基可以包含在与膜接触的琼脂糖凝胶的外孔中。

24. 发明授权

US5343426A Data formater/converter for use with solid-state disk memory using storage devices with defects 失效
公开(公告)号：US5343426A
公开(公告)日：1994-08-30
申请号：US897164
申请日：1992-06-11
申请人： Charles Cassidy , Paul Kemp
发明人： Charles Cassidy , Paul Kemp
IPC分类号： G06F11/10 , G11C29/00 , H03M13/00
CPC分类号： G06F11/1044 , G11C29/88
摘要： A computer system includes a main memory that is able to make use of DRAM memory devices having a relatively high level of bad cells (hard faults). An EDC circuit is provided which uses combinatorial logic to perform a BCH code type of error detection and correction. A primary feature is the recognition that due to use of high density integrated circuits--gate arrays--it is no longer necessary to use sequential logic to decode the multiple-bit error correcting codes. An EDC with 128-bits of data and a check bit field 41-bits wide, using a BCH code, constructed in ASIC sea-of-gates technology using about 87,000 logic gates, can correct 5-bits in error and can detect 6-bits in error. By using multiple-bit EDC in the controller for main memory, it is no longer necessary that all DRAM devices be ostensibly "perfect." A certain density of non-functional memory cells can be tolerated, yet the memory system will still return perfect data. The added cost of multiple-bit EDC, including the added cost of extra storage for the check bits and the EDC circuit itself, is more than compensated by reduced cost of the DRAMs. In a addition the computer system includes a solid-state disk type memory for a computer system is able to make use of DRAM memory devices having a relatively high level of bad cells (hard faults). An EDC circuit is employed to perform a Reed-Solomon code type of error detection and correction. A primary feature is the recognition that it is no longer necessary that all DRAM devices be ostensibly "perfect." A certain density of non-functional memory cells can be tolerated, yet the memory system will still return perfect data. The added cost of multiple-bit EDC, including the added cost of extra storage for the check bits and the EDC circuit itself, is more than compensated by reduced cost of the DRAMs. A preferred data formatter circuit to convert between symbol and word data is also described.

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