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21. 发明授权

US5256760A Condensation copolymers with sequenced mer structure 失效
标题翻译：具有测序mer结构的缩合共聚物
公开(公告)号：US5256760A
公开(公告)日：1993-10-26
申请号：US884965
申请日：1992-05-15
申请人： Michael J. Jaffe , Marie Borzo , Edward C. Chenevey , Eui W. Choe , M. Ishaq Haider , Subhash Makhija
发明人： Michael J. Jaffe , Marie Borzo , Edward C. Chenevey , Eui W. Choe , M. Ishaq Haider , Subhash Makhija
IPC分类号： C08G63/06 , C08G63/19 , C08G63/60 , C08G69/44 , C08G63/00 , C08G63/02
CPC分类号： C08G63/19 , C08G63/065 , C08G63/605 , C08G69/44
摘要： A method of making controlled sequence condensation copolymers from mer systems capable of forming at least two unique recurring units is disclosed and claimed. Sequenced polyesters containing the residue of hydroxyacids are specifically exemplified.
摘要翻译：公开并要求保护能够形成至少两个独特重复单元的聚合体系的受控序列缩合共聚物的方法。具体列举了含有羟基酸残基的测序聚酯。

22. 发明申请

US20130116617A1 NEEDLE ASSEMBLY FOR MIXING OF SUBSTANCES 有权
标题翻译：用于混合物质的针头组件
公开(公告)号：US20130116617A1
公开(公告)日：2013-05-09
申请号：US13810675
申请日：2010-07-22
申请人： Frank Martin , Richard J. Klug , M. Ishaq Haider
发明人： Frank Martin , Richard J. Klug , M. Ishaq Haider
IPC分类号： A61M5/32
CPC分类号： A61M5/3294 , A61M5/2448 , A61M5/346 , A61M5/347 , A61M2005/2474
摘要： In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.
摘要翻译：在本发明的一个方面，提供一种针组件，其包括：主体，其具有近端，远端和位于其间的通道，所述主体被配置为安装到注射器; 所述针固定到所述主体，所述针具有近端和远端，所述远端从所述主体的远端向远侧延伸并且被形成为用于插入到患者体内，所述针的近端与所述通道连通; 以及设置在针的近端的近侧的通道中的过滤器。有利地，提供针组件，其允许混合至少两种物质以准备注射，而不改变相关联的注射器。

23. 发明申请

US20120184914A1 DISPOSABLE INJECTION DEVICE 有权
标题翻译：不可注入的注射装置
公开(公告)号：US20120184914A1
公开(公告)日：2012-07-19
申请号：US13429555
申请日：2012-03-26
申请人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
发明人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
IPC分类号： A61M5/315 , A61M5/32
CPC分类号： A61M5/3234 , A61M5/2033 , A61M5/2429 , A61M5/46 , A61M5/502 , A61M2005/2013 , A61M2005/3247 , A61M2037/0023
摘要： An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the .locking mechanism prevents the needle from being placed in the injection position.
摘要翻译：提供注射装置。该装置包括具有限定第一开口的第一端的壳体。柱塞被容纳在壳体的第一开口内以在第一和第二位置之间移动。盒体设置在壳体中，并且具有用作药物的储存器的内部。输送针设置在壳体内并且经由可中断流体通道与储存器流体连通。锁定机构设置在壳体中。在柱塞的第一位置，输送针由柱塞封闭，并且在柱塞的第二位置中，输送针位于注射位置，并且柱塞启动锁定机构，由此当柱塞返回到第一位置时。锁定机构防止针头被置于注射位置。

24. 发明申请

US20120041394A1 OPTIMIZED INTRACRANIAL CATHETERS FOR CONVECTION-ENHANCED DELIVERY OF THERAPEUTICS 有权
标题翻译：优化的治疗加速输血管内导管
公开(公告)号：US20120041394A1
公开(公告)日：2012-02-16
申请号：US13143536
申请日：2010-01-11
申请人： M. Ishaq Haider , Frank Martin , Bruce Clyde Roberts , Jason B. Alarcon
发明人： M. Ishaq Haider , Frank Martin , Bruce Clyde Roberts , Jason B. Alarcon
IPC分类号： A61B17/34
CPC分类号： A61M25/0068 , A61M25/007 , A61M25/0606
摘要： A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.
摘要翻译：一种可引导导管，其包括由套管针线内部支撑的热反应性粘弹性材料。可引导导管还包括多个倒角的尖端和插入在导管的内表面和套管针的外表面之间的间隙，使得启动流体被允许流过导管并且清除被捕获在套管针和套管针之间的空气导管的内表面。在插入导管之后，套管针被去除并且通过导管输注治疗剂。

25. 发明申请

US20110306934A1 SYSTEMS AND METHODS FOR PROVIDING A CONVECTION-ENHANCED DELIVERY DEVICE 有权
标题翻译：用于提供对流增强传送装置的系统和方法
公开(公告)号：US20110306934A1
公开(公告)日：2011-12-15
申请号：US13143535
申请日：2010-01-11
申请人： M. Ishaq Haider , Frank Martin , Richard Klug
发明人： M. Ishaq Haider , Frank Martin , Richard Klug
IPC分类号： A61M25/02
CPC分类号： A61M25/02 , A61M2025/024
摘要： A delivery device system is provided for assisting a patient and physician in maintaining a depth and position of an inserted catheter within a target tissue. The delivery device includes a base member that is secured to an external surface of the patient. The base member includes an aperture through which a catheter is inserted to access the target tissue. The base member further includes a hinged clip that selectively locks into a closed position to secure the catheter within the delivery device and maintain a desired insertion depth of the catheter within the target tissue. The base member further includes a receiving channel for compatibly and adjustably securing an adapter portion of the catheter in a horizontal orientation.
摘要翻译：提供递送装置系统，用于帮助患者和医生保持插入的导管在目标组织内的深度和位置。输送装置包括固定到患者的外表面的基部构件。基部构件包括孔，插入导管以进入目标组织。基部构件还包括铰接夹，其选择性地锁定到关闭位置以将导管固定在输送装置内并且保持导管在目标组织内的期望的插入深度。基部构件还包括用于将导管的适配器部分以水平取向相容且可调节地固定的接收通道。

26. 发明授权

US07905866B2 Disposable injection device 有权
标题翻译：一次性注射装置
公开(公告)号：US07905866B2
公开(公告)日：2011-03-15
申请号：US11769214
申请日：2007-06-27
申请人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
发明人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
IPC分类号： A61M5/20 , A61M5/32 , A61M5/00
CPC分类号： A61M5/3234 , A61M5/2033 , A61M5/2429 , A61M5/46 , A61M5/502 , A61M2005/2013 , A61M2005/3247 , A61M2037/0023
摘要： An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.
摘要翻译：提供注射装置。该装置包括具有限定第一开口的第一端的壳体。柱塞被容纳在壳体的第一开口内以在第一和第二位置之间移动。盒体设置在壳体中，并且具有用作药物的储存器的内部。输送针设置在壳体内并且经由可中断流体通道与储存器流体连通。锁定机构设置在壳体中。在柱塞的第一位置，输送针由柱塞封闭，并且在柱塞的第二位置中，输送针被放置在注射位置，并且柱塞启动锁定机构，由此当柱塞返回到第一位置时，锁定机构防止针头置于注射位置。

27. 发明授权

US06187437B1 Process for making high denier multilobal filaments of thermotropic liquid crystalline polymers and compositions thereof 有权
标题翻译：用于制备热致液晶聚合物的高旦数多叶长丝的方法及其组合物
公开(公告)号：US06187437B1
公开(公告)日：2001-02-13
申请号：US09150921
申请日：1998-09-10
申请人： M. Ishaq Haider , John Anthony Flint , Michael Jaffe , Joseph J. DiBiase , John Edward Cornetta
发明人： M. Ishaq Haider , John Anthony Flint , Michael Jaffe , Joseph J. DiBiase , John Edward Cornetta
IPC分类号： B32B2734
CPC分类号： D01F6/82 , D01D5/253 , D01F6/62 , D01F6/84 , Y10T428/2969 , Y10T428/2973 , Y10T428/2975
摘要： The present invention discloses and claims a novel process for the formation of high denier as-spun and heat-treated multilobal filaments of a thermotropic liquid crystalline polymer. Preferred embodiments include process for the formation of as-spun and heat treated octalobal monofilaments of a few wholly aromatic polyesters and polyesteramides. The process involves (a) heating of a thermotropic liquid crystalline polymer to above its melting transition temperature; (b) passing said molten polymer through an extrusion chamber equipped with an extrusion capillary having a multilobal cross-section to form a multilobal filament; and (c) winding the filament at a suitable draw-down. The filaments so formed are of at least 50 denier per filament (dpf) and feature essentially uniform molecular orientation across their cross-section. In a final optional step, the filaments are heat treated in stages to form filaments exhibiting excellent tensile properties. Both as-spun and heat-treated filaments feature remarkably good tensile properties comparable to those of round filaments. Most importantly, the multilobal filaments of this invention feature much superior adhesion properties than the conventional round filaments.
摘要翻译：本发明公开并要求一种用于形成热致伸缩液晶聚合物的高旦旦纺丝和热处理多叶长丝的新方法。优选的实施方案包括形成几种完全芳族聚酯和聚酯酰胺的初纺和热处理的八面体单丝的方法。该方法包括（a）将热致液晶聚合物加热至其熔融转变温度以上; （b）使所述熔融聚合物通过装备有具有多叶横截面的挤出毛细管的挤出室以形成多叶长丝; 和（c）将丝缠绕在合适的拉伸下。如此形成的细丝具有至少50旦尼尔/丝（dpf），并且在其横截面上具有基本均匀的分子取向。在最后的任选步骤中，细丝被分阶段热处理以形成显示出优异拉伸性能的长丝。初纺和热处理的长丝具有与圆丝相当的非常好的拉伸性能。最重要的是，本发明的多叶长丝具有比常规圆丝更好的粘合性能。

28. 发明授权

US08603040B2 Disposable injection device 有权
标题翻译：一次性注射装置
公开(公告)号：US08603040B2
公开(公告)日：2013-12-10
申请号：US13429555
申请日：2012-03-26
申请人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
发明人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M5/3234 , A61M5/2033 , A61M5/2429 , A61M5/46 , A61M5/502 , A61M2005/2013 , A61M2005/3247 , A61M2037/0023
摘要： An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.
摘要翻译：提供注射装置。该装置包括具有限定第一开口的第一端的壳体。柱塞被容纳在壳体的第一开口内以在第一和第二位置之间移动。盒体设置在壳体中，并且具有用作药物的储存器的内部。输送针设置在壳体内并且经由可中断流体通道与储存器流体连通。锁定机构设置在壳体中。在柱塞的第一位置，输送针由柱塞封闭，并且在柱塞的第二位置中，输送针被放置在注射位置，并且柱塞启动锁定机构，由此当柱塞返回到第一位置时，锁定机构防止针头置于注射位置。

29. 发明授权

US08157768B2 Disposable injection device 有权
标题翻译：一次性注射装置
公开(公告)号：US08157768B2
公开(公告)日：2012-04-17
申请号：US12980574
申请日：2010-12-29
申请人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
发明人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
IPC分类号： A61M5/00 , A61M5/32
CPC分类号： A61M5/3234 , A61M5/2033 , A61M5/2429 , A61M5/46 , A61M5/502 , A61M2005/2013 , A61M2005/3247 , A61M2037/0023
摘要： An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the .locking mechanism prevents the needle from being placed in the injection position.
摘要翻译：提供注射装置。该装置包括具有限定第一开口的第一端的壳体。柱塞被容纳在壳体的第一开口内以在第一和第二位置之间移动。盒体设置在壳体中，并且具有用作药物的储存器的内部。输送针设置在壳体内并且经由可中断流体通道与储存器流体连通。锁定机构设置在壳体中。在柱塞的第一位置，输送针由柱塞封闭，并且在柱塞的第二位置中，输送针位于注射位置，并且柱塞启动锁定机构，由此当柱塞返回到第一位置时。锁定机构防止针头被置于注射位置。

30. 发明申请

US20110098641A1 DISPOSABLE INJECTION DEVICE 有权
标题翻译：不可注入的注射装置
公开(公告)号：US20110098641A1
公开(公告)日：2011-04-28
申请号：US12980574
申请日：2010-12-29
申请人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
发明人： M. Ishaq Haider , Timothy Erskine , Ronald J. Pettis
IPC分类号： A61M5/50
CPC分类号： A61M5/3234 , A61M5/2033 , A61M5/2429 , A61M5/46 , A61M5/502 , A61M2005/2013 , A61M2005/3247 , A61M2037/0023
摘要： An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.
摘要翻译：提供注射装置。该装置包括具有限定第一开口的第一端的壳体。柱塞被容纳在壳体的第一开口内以在第一和第二位置之间移动。盒体设置在壳体中，并且具有用作药物的储存器的内部。输送针设置在壳体内并且经由可中断流体通道与储存器流体连通。锁定机构设置在壳体中。在柱塞的第一位置，输送针由柱塞封闭，并且在柱塞的第二位置中，输送针被放置在注射位置，并且柱塞启动锁定机构，由此当柱塞返回到第一位置时，锁定机构防止针头置于注射位置。

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