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21. 发明授权

US5460950A Expression of PACE in host cells and methods of use thereof 失效
标题翻译： PACE在宿主细胞中的表达及其使用方法
公开(公告)号：US5460950A
公开(公告)日：1995-10-24
申请号：US885972
申请日：1992-05-20
申请人： Philip J. Barr , Anthony J. Brake , Randal J. Kaufman , Louise Wasley , Patricia Tekamp-Olson , Polly A. Wong
发明人： Philip J. Barr , Anthony J. Brake , Randal J. Kaufman , Louise Wasley , Patricia Tekamp-Olson , Polly A. Wong
IPC分类号： C12N5/10 , C07K14/755 , C12N9/50 , C12N9/64 , C12N15/09 , C12N15/57 , C12P21/02 , C12N15/00 , C12N15/81 , C12N15/85
CPC分类号： C12N9/6454 , C07K14/755
摘要： Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.
摘要翻译：提供用于内肽酶生产的组合物和方法，以及提高加工异源前体多肽对成熟多肽（包括需要γ-羧化生物活性的蛋白质）的效率。这些组合物和方法利用重组PACE，一种特异于二元氨基酸位点的哺乳动物内肽酶。

22. 发明授权

US4424211A 2'Deoxy-5-(2-halogenovinyl)-uridines, pharmaceutical compositions and method of use 失效
标题翻译： 2'Deoxy-5-（2-卤代乙烯基） - 尿苷，药物组合物和使用方法
公开(公告)号：US4424211A
公开(公告)日：1984-01-03
申请号：US332757
申请日：1981-12-21
申请人： Albert S. Jones , Richard T. Walker , Erik D. A. de Clercq , Philip J. Barr
发明人： Albert S. Jones , Richard T. Walker , Erik D. A. de Clercq , Philip J. Barr
IPC分类号： C07H19/073 , A61K31/505 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7072 , A61P31/12 , C07F7/18 , C07H19/06 , C07H19/08
CPC分类号： C07H19/06 , C07F7/1856 , Y10S514/934
摘要： The novel substance E-5-(2-bromovinyl)-2'-deoxyuridine and its corresponding iodovinyl derivative are gifted with specific antiviral activities towards herpes simplex virus. They may be synthesized by a condensation reaction followed by separation of anomers.
摘要翻译：新型物质E-5-（2-溴乙烯基）-2'-脱氧尿苷及其相应的碘乙烯衍生物具有针对单纯疱疹病毒的特异性抗病毒活性。它们可以通过缩合反应合成，然后分离出异构体。

23. 发明申请

US20120142099A1 NOVEL BAK BINDING PROTEIN, DNA ENCODING THE PROTEIN, AND METHODS OF USE THEREOF 审中-公开
标题翻译：新蛋白结合蛋白，编码蛋白的DNA及其使用方法
公开(公告)号：US20120142099A1
公开(公告)日：2012-06-07
申请号：US13009228
申请日：2011-01-19
申请人： Michael C. Kiefer , Paul A. Fitzpatrick , Helen L. Gibson , Philip J. Barr
发明人： Michael C. Kiefer , Paul A. Fitzpatrick , Helen L. Gibson , Philip J. Barr
IPC分类号： C12N5/02
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K2319/00 , G01N2333/47 , G01N2500/02 , G01N2510/00
摘要： The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.
摘要翻译：本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。本发明还提供了结合Bak的BBP。本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。本发明还提供了特异性结合BBP的抗体。本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。本发明还提供了用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。本发明另外包括称为“BBP结合域”的新肽，以及涉及Bak和BBP之间的相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。

24. 发明授权

US07914771B2 Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor 有权
标题翻译：通过低剂量吸入蛋白酶抑制剂治疗慢性阻塞性肺疾病
公开(公告)号：US07914771B2
公开(公告)日：2011-03-29
申请号：US11077276
申请日：2005-03-09
申请人： Philip J. Barr , Philip A. Pemberton , Helen L. Gibson
发明人： Philip J. Barr , Philip A. Pemberton , Helen L. Gibson
IPC分类号： A61K38/55 , A61K9/14
CPC分类号： A61K9/0073 , A24B15/30 , A24D1/002 , A24D3/14 , A61K38/57
摘要： The present invention encompasses methods and compositions for the treatment and prevention of chronic obstructive pulmonary disease (COPD) or emphysema, typically smoking-induced emphysema. More specifically, the present invention relates to the treatment and prevention of COPD or emphysema by inhalation of alpha one-antitrypsin (AAT).
摘要翻译：本发明包括用于治疗和预防慢性阻塞性肺疾病（COPD）或肺气肿（通常是吸烟诱发的肺气肿）的方法和组合物。更具体地，本发明涉及通过吸入α一抗胰蛋白酶（AAT）治疗和预防COPD或肺气肿。

25. 发明授权

US07876276B1 Antenna near-field probe station scanner 有权
标题翻译：天线近场探头台扫描仪
公开(公告)号：US07876276B1
公开(公告)日：2011-01-25
申请号：US11499982
申请日：2006-08-02
申请人： Afroz J. Zaman , Richard Q. Lee , William G. Darby , Philip J. Barr , Kevin M Lambert , Felix A. Miranda
发明人： Afroz J. Zaman , Richard Q. Lee , William G. Darby , Philip J. Barr , Kevin M Lambert , Felix A. Miranda
IPC分类号： G01R29/10
CPC分类号： G01R29/105 , H01Q3/08
摘要： A miniaturized antenna system is characterized non-destructively through the use of a scanner that measures its near-field radiated power performance. When taking measurements, the scanner can be moved linearly along the x, y and z axis, as well as rotationally relative to the antenna. The data obtained from the characterization are processed to determine the far-field properties of the system and to optimize the system. Each antenna is excited using a probe station system while a scanning probe scans the space above the antenna to measure the near field signals. Upon completion of the scan, the near-field patterns are transformed into far-field patterns. Along with taking data, this system also allows for extensive graphing and analysis of both the near-field and far-field data. The details of the probe station as well as the procedures for setting up a test, conducting a test, and analyzing the resulting data are also described.
摘要翻译：小型化天线系统通过使用测量其近场辐射功率性能的扫描仪非破坏性地表征。当进行测量时，扫描仪可以沿x，y和z轴线性移动，以及相对于天线旋转。处理从表征获得的数据以确定系统的远场属性并优化系统。每个天线使用探测台系统激励，而扫描探针扫描天线上方的空间来测量近场信号。扫描完成后，近场图案被转换为远场图案。随着采集数据，该系统还可以对近场和远场数据进行广泛的绘图和分析。还描述了探测台的细节以及建立测试，进行测试和分析所得数据的过程。

26. 发明授权

US07419801B2 Methods of protein production in yeast 失效
标题翻译：酵母中蛋白质生产的方法
公开(公告)号：US07419801B2
公开(公告)日：2008-09-02
申请号：US10914863
申请日：2004-08-09
申请人： Philip J. Barr , Helen L. Gibson
发明人： Philip J. Barr , Helen L. Gibson
IPC分类号： C12N15/00 , C12P21/00 , C12Q1/68 , C12N15/63
CPC分类号： C12N15/81 , C07K14/811 , C07K14/8121 , C07K14/8125
摘要： Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, and where the polynucleotide contains one or more yeast-preferred codons. Host cells are cultured under conditions where, after an initial batch phase, oxygen concentration is kept high and glucose feed is regulated so that the yeast cells stay in respiratory metabolism.
摘要翻译：提供载体，宿主细胞和方法用于在酵母中生产蛋白质。载体通常含有选择基因，酵母2微米序列和编码多肽的多核苷酸，其中多核苷酸可操作地连接至启动子，并且其中多核苷酸含有一个或多个酵母优选的密码子。在初始分批阶段之后，保持高浓度的氧浓度并调节葡萄糖进料以使酵母细胞保持呼吸代谢的条件下培养宿主细胞。

27. 发明申请

US20080095806A1 Composition And Method For Treating Inflammatory Diseases Using Protease Inhibitors 审中-公开
标题翻译：使用蛋白酶抑制剂治疗炎症疾病的组合物和方法
公开(公告)号：US20080095806A1
公开(公告)日：2008-04-24
申请号：US10535609
申请日：2003-11-20
申请人： Ian C. Bathurst , Philip A. Pemberton , David J. Sundin , James W. Mayhew , Arturo J. Angel , Philip J. Barr
发明人： Ian C. Bathurst , Philip A. Pemberton , David J. Sundin , James W. Mayhew , Arturo J. Angel , Philip J. Barr
IPC分类号： A61K38/55 , A61K9/00
CPC分类号： A61K38/57 , A61K2800/782
摘要： Compositions containing a protease inhibitor and methods of use and production are described. The compositions contain an effective amount of a protease inhibitor in a carrier or diluent and are used for the treatment of inflammatory or hyperproliferic mucocutaneous disorders. The carrier or diluent is preferably a gelling agent, and the composition is a topical gel formulation containing alpha 1-antitrypsin in an aqueous liquid or viscous gel formulation.
摘要翻译：描述了含有蛋白酶抑制剂的组合物和使用和生产方法。组合物在载体或稀释剂中含有有效量的蛋白酶抑制剂，并用于治疗炎症性或过度增生性粘膜皮肤病。载体或稀释剂优选是胶凝剂，并且该组合物是在水性液体或粘稠凝胶制剂中含有α1-抗胰蛋白酶的局部凝胶制剂。

28. 发明授权

US06258566B1 Production of polyketides in bacteria and yeast 有权
标题翻译：在细菌和酵母中生产聚酮化合物
公开(公告)号：US06258566B1
公开(公告)日：2001-07-10
申请号：US09422073
申请日：1999-10-21
申请人： Philip J. Barr , Daniel V. Santi , Gary W. Ashley , Rainer Ziermann
发明人： Philip J. Barr , Daniel V. Santi , Gary W. Ashley , Rainer Ziermann
IPC分类号： C12P1962
CPC分类号： C12N9/1288 , A01K2217/05 , C07K2319/00 , C12N9/00 , C12N9/1025 , C12N15/52 , C12N15/70 , C12N15/76 , C12N15/81 , C12P7/26 , C12P7/42 , C12P17/162 , C12P19/62
摘要： Hybrid and novel polyketide synthases (PKSs) and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo acyl carrier protein (ACP) synthase.
摘要翻译：通过使用多重载体系统产生杂合和新型聚酮化合物合酶（PKS）和聚酮化合物。通过将PKS系统的各种催化活性放置在单独的载体上提供的组合可能性允许构建改进的PKS和聚酮化合物库。此外，聚酮化合物可以在通常不通过供应所需的PKS的表达系统，全酰酰基载体蛋白（ACP）合酶的表达系统）的情况下产生聚酮化合物的宿主中生产。

29. 发明授权

US6068994A Ubiquitin expression system 失效
标题翻译：泛素表达系统
公开(公告)号：US6068994A
公开(公告)日：2000-05-30
申请号：US428278
申请日：1995-04-25
申请人： Philip J. Barr
发明人： Philip J. Barr
IPC分类号： C07K14/16 , C07K14/57 , C07K14/81 , C12N15/81 , C07K19/00 , C12M15/62
CPC分类号： C07K14/005 , C07K14/57 , C07K14/8125 , C12N15/81 , C12N2740/16122 , C12N2740/16222
摘要： The present invention provides an improved ubiquitin fusion system for gene expression in yeast systems which allows for the regulatable high level production of heterologous proteins having destabilizing amino terminal residues. The ubiquitin fusion proteins expressed in yeast are cleaved precisely in vivo by an endogenous ubiquitin-specific hydrolase to yield heterologous proteins such as human alpha-1-antitrypsin, human gamma-interferon and human immunodeficiency virus integrase protein, all of which initiate with destabilizing residues. An expression vector containing a synthetic gene for monomeric yeast ubiquitin was constructed and expressed under the control of a glucose regulatable yeast promoter. Inclusion of unique restriction sites at the 3'-end of the synthetic ubiquitin gene allows for precise in-frame insertion of heterologous genes. The system can be used to increase expression of poorly expressed proteins and to produce proteins having selective amino-terminal destabilizing residues.
摘要翻译：本发明提供了改进的用于酵母系统中基因表达的泛素融合系统，其允许可调节的高水平产生具有不稳定氨基末端残基的异源蛋白质。在酵母中表达的泛素融合蛋白通过内源泛素特异性水解酶在体内精确地切割，得到异源蛋白质，例如人α-1-抗胰蛋白酶，人γ-干扰素和人免疫缺陷病毒整合酶蛋白，所有这些都起始于不稳定残基。构建含有单体酵母泛素合成基因的表达载体，并在葡萄糖可调节酵母启动子的控制下进行表达。在合成泛素基因的3'末端包含独特的限制性位点允许异源基因的精确的帧内插入。该系统可用于增加表达差的蛋白质的表达并产生具有选择性氨基末端去稳定化残基的蛋白质。

30. 发明授权

US6004579A Compositions which inhibit apoptosis, methods of making the compositions and uses thereof 失效
标题翻译：抑制凋亡的组合物，制备组合物的方法及其用途
公开(公告)号：US6004579A
公开(公告)日：1999-12-21
申请号：US704732
申请日：1997-09-04
申请人： Ian C. Bathurst , Matthew W. Foehr , John G. Goddard , L. David Tomei , Philip J. Barr
发明人： Ian C. Bathurst , Matthew W. Foehr , John G. Goddard , L. David Tomei , Philip J. Barr
IPC分类号： A61K47/24 , A61K9/127 , A61K31/00 , A61K31/66 , A61K31/683 , A61K31/685 , A61K41/00 , A61P43/00
CPC分类号： A61K31/685 , A61K31/66 , A61K9/127 , Y10S514/844 , Y10S514/863 , Y10S514/88
摘要： The present invention provides compositions that inhibit apoptosis, methods for making the compositions, and methods of use thereof.
摘要翻译： PCT No.PCT / US96 / 14752 Sec。 371日期：1997年9月4日 102（e）1997年9月4日PCT PCT 1996年9月13日PCT公布。出版物WO97 / 09989 日本1997年3月20日本发明提供了抑制凋亡的组合物，制备该组合物的方法及其使用方法。

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