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21. 发明授权

US06830898B2 Microorganisms and assays for the identification of antibiotics 有权
标题翻译：用于鉴定抗生素的微生物和测定
公开(公告)号：US06830898B2
公开(公告)日：2004-12-14
申请号：US09813453
申请日：2001-03-20
申请人： R. Rogers Yocum , Thomas A. Patterson
发明人： R. Rogers Yocum , Thomas A. Patterson
IPC分类号： C12Q118
CPC分类号： C12N9/1205 , C12N15/52 , C12P13/02 , C12P17/04
摘要： The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
摘要翻译：本发明的特征在于用于鉴定可用作抗生素和抗菌剂的化合物和组合物的方法。特别地，本发明的特征在于用于鉴定称为CoaX的先前未鉴定的靶蛋白的调节剂的方法。具有高通量测定系统以及用于鉴定CoaX调节剂的测定试剂盒。还具有coaX核酸分子和纯化的CoaX蛋白，以及重组载体和微生物，包括该基因，coaX。

22. 发明授权

US07858335B2 Microorganisms and assays for the identification of antibiotics 有权
标题翻译：用于鉴定抗生素的微生物和测定
公开(公告)号：US07858335B2
公开(公告)日：2010-12-28
申请号：US11709370
申请日：2007-02-22
申请人： R. Rogers Yocum , Thomas A. Patterson
发明人： R. Rogers Yocum , Thomas A. Patterson
IPC分类号： C12Q1/02 , C12P21/00 , C12N9/00 , C12N1/20 , C12N15/09 , C07H21/00
CPC分类号： C12N9/1205 , C12N15/52 , C12P13/02 , C12P17/04
摘要： The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
摘要翻译：本发明的特征在于用于鉴定可用作抗生素和抗菌剂的化合物和组合物的方法。特别地，本发明的特征在于用于鉴定称为CoaX的先前未鉴定的靶蛋白的调节剂的方法。具有高通量测定系统以及用于鉴定CoaX调节剂的测定试剂盒。还具有coaX核酸分子和纯化的CoaX蛋白，以及重组载体和微生物，包括该基因，coaX。

23. 发明授权

US09845513B2 Method of producing succinic acid and other chemicals using sucrose-containing feedstock 有权
公开(公告)号：US09845513B2
公开(公告)日：2017-12-19
申请号：US13993150
申请日：2011-12-13
申请人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
发明人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
IPC分类号： C12P7/46 , C12R1/01 , C12N9/10 , C12N9/16 , C12P7/18 , C12P7/42
CPC分类号： C12R1/01 , C12N9/1051 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/46 , C12Y301/03024
摘要： This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains. The genes involved in the transport and metabolism of sucrose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the sucrose transport and metabolism by strains already known to have some ability for sucrose utilization in biological fermentation.

24. 发明授权

US08871489B2 Metabolic evolution of Escherichia coli strains that produce organic acids 有权
标题翻译：产生有机酸的大肠杆菌菌株的代谢进化
公开(公告)号：US08871489B2
公开(公告)日：2014-10-28
申请号：US13394176
申请日：2010-11-17
申请人： Tammy Grabar , Wei Gong , R. Rogers Yocum
发明人： Tammy Grabar , Wei Gong , R. Rogers Yocum
IPC分类号： C12N1/20 , C12N1/00 , C12N15/74 , C07H21/04 , C07K14/245 , C12P7/46 , C12P7/54 , C12P7/40
CPC分类号： C07K14/245 , C12P7/40 , C12P7/46 , C12P7/54
摘要： This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
摘要翻译：本发明涉及先前优化用于在发酵条件下以商业上显着的量生产有机酸的微生物生物的代谢进化，其中使用己糖作为最小矿物培养基中的唯一碳源。作为这种代谢进化的结果，微生物生物体获得使用来自纤维素材料的戊糖的生长能力，同时保持原始生长动力学，有机酸生产速率和使用己糖作为碳源的能力。本发明还公开了赋予在生产商业上大量有机酸中同时使用己糖和戊糖的能力的微生物中的遗传变化。

25. 发明申请

US20120225461A1 ORGANIC ACID PRODUCTION IN MICROORGANISMS BY COMBINED REDUCTIVE AND OXIDATIVE TRICABOXYLIC ACID CYLCE PATHWAYS 有权
标题翻译：通过组合还原和氧化三羧酸的循环途径在微生物中有机酸生产
公开(公告)号：US20120225461A1
公开(公告)日：2012-09-06
申请号：US13508095
申请日：2010-11-18
申请人： Sudhanshu Dole , R. Rogers Yocum
发明人： Sudhanshu Dole , R. Rogers Yocum
IPC分类号： C12P7/46 , C12N1/21
CPC分类号： C12N15/52 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12P7/46
摘要： This invention relates to succinic acid production from renewable feedstock using microbial biocatalysts genetically modified to produce succinic acid in commercially significant quantities. More specifically, this invention relates to the genetic manipulations in the pathway of carbon from renewable feedstock to succinic acid.
摘要翻译：本发明涉及使用经遗传修饰以生产商业上显着量的琥珀酸的微生物生物催化剂从可再生原料生产琥珀酸。更具体地，本发明涉及从可再生原料到琥珀酸的碳通路中的遗传操作。

26. 发明申请

US20140234923A1 FERMENTATION OF GLYCEROL TO ORGANIC ACIDS 审中-公开
标题翻译：甘油对有机酸的发酵
公开(公告)号：US20140234923A1
公开(公告)日：2014-08-21
申请号：US14233830
申请日：2011-07-22
申请人： R. Rogers Yocum , Theron Hermann , Xiaohui Hu
发明人： R. Rogers Yocum , Theron Hermann , Xiaohui Hu
IPC分类号： C12P7/46 , C12P7/56
CPC分类号： C12P7/46 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1205 , C12N15/52 , C12P7/56 , C12Y101/01008 , C12Y101/05003
摘要： The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity.
摘要翻译：本发明是通过使用甘油作为碳源的生物发酵来生产有机酸和其它有用的化学品的领域。描述了能够以高产率和高纯度将甘油转化成有机有机酸的新型微生物和发酵方法。

27. 发明申请

US20130337519A1 METHOD OF PRODUCING SUCCINIC ACID AND OTHER CHEMICALS USING SUCROSE-CONTAINING FEEDSTOCK 有权
标题翻译：使用含蔗糖的饲料生产农药和其他化学品的方法
公开(公告)号：US20130337519A1
公开(公告)日：2013-12-19
申请号：US13993150
申请日：2011-12-13
申请人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
发明人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
IPC分类号： C12P7/46 , C12R1/01
CPC分类号： C12R1/01 , C12N9/1051 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/46 , C12Y301/03024
摘要： This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains. The genes involved in the transport and metabolism of sucrose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the sucrose transport and metabolism by strains already known to have some ability for sucrose utilization in biological fermentation.
摘要翻译：本发明涉及通过用发酵培养基含有蔗糖的微生物进行发酵来生产化学品。作为具体实例，使用生物催化剂通过发酵从含蔗糖的可再生原料生产琥珀酸。这种生物催化剂的实例包括增强其利用蔗糖作为碳和能源的能力的微生物。本发明的生物催化剂来源于最初以以商业规模生产一种或多种化学物（例如琥珀酸和/或琥珀酸盐）的目的而构建的亲本菌株的遗传操作，其使用除了蔗糖。本发明的遗传操作涉及将参与蔗糖转运和代谢的外源基因导入亲本菌株。参与蔗糖运输和代谢的基因也可以在开发生物体之前被引入微生物以产生特定的化学物质。参与蔗糖运输和代谢的基因也可用于增加或改善已知在生物发酵中具有蔗糖利用能力的菌株的蔗糖转运和代谢。

28. 发明申请

US20120202259A1 METABOLIC EVOLUTION OF ESCHERICHIS COLI STRAINS THAT PRODUCE ORGANIC ACIDS 有权
标题翻译：生产有机酸的ESCHERICHIS COLI菌株的代谢演化
公开(公告)号：US20120202259A1
公开(公告)日：2012-08-09
申请号：US13394176
申请日：2010-11-17
申请人： Tammy Grabar , Wei Gong , R. Rogers Yocum
发明人： Tammy Grabar , Wei Gong , R. Rogers Yocum
IPC分类号： C12P7/40 , C12N1/21
CPC分类号： C07K14/245 , C12P7/40 , C12P7/46 , C12P7/54
摘要： This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
摘要翻译：本发明涉及先前优化用于在发酵条件下以商业上显着的量生产有机酸的微生物生物的代谢进化，其中使用己糖作为最小矿物培养基中的唯一碳源。作为这种代谢进化的结果，微生物生物体获得使用来自纤维素材料的戊糖的生长能力，同时保持原始生长动力学，有机酸生产速率和使用己糖作为碳源的能力。本发明还公开了赋予在生产商业上大量有机酸中同时使用己糖和戊糖的能力的微生物中的遗传变化。

29. 发明授权

US10041094B2 Fermentation of glycerol to organic acids 有权
公开(公告)号：US10041094B2
公开(公告)日：2018-08-07
申请号：US14233830
申请日：2011-07-22
申请人： R. Rogers Yocum , Theron Hermann , Xiaohui Hu
发明人： R. Rogers Yocum , Theron Hermann , Xiaohui Hu
IPC分类号： C12P7/46 , C12N1/20 , C12N15/52 , C07K14/245 , C12N9/04 , C12N9/12 , C12P7/56
CPC分类号： C12P7/46 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1205 , C12N15/52 , C12P7/56 , C12Y101/01008 , C12Y101/05003
摘要： The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity.

30. 发明授权

US08778656B2 Organic acid production in microorganisms by combined reductive and oxidative tricaboxylic acid cylce pathways 有权
标题翻译：微生物通过组合还原和氧化三羟甲基酸途径有机酸生产
公开(公告)号：US08778656B2
公开(公告)日：2014-07-15
申请号：US13508095
申请日：2010-11-18
申请人： Sudhanshu Dole , R. Rogers Yocum
发明人： Sudhanshu Dole , R. Rogers Yocum
IPC分类号： C12N1/20
CPC分类号： C12N15/52 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12P7/46
摘要： This invention relates to succinic acid production from renewable feedstock using microbial biocatalysts genetically modified to produce succinic acid in commercially significant quantities. More specifically, this invention relates to the genetic manipulations in the pathway of carbon from renewable feedstock to succinic acid.
摘要翻译：本发明涉及使用经遗传修饰以生产商业上显着量的琥珀酸的微生物生物催化剂从可再生原料生产琥珀酸。更具体地，本发明涉及从可再生原料到琥珀酸的碳通路中的遗传操作。

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