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21. 发明申请

US20060057697A1 Chondroitin systhetase and nucleic acid coding for the enzyme 有权
标题翻译：软骨素合成酶和核酸编码酶
公开(公告)号：US20060057697A1
公开(公告)日：2006-03-16
申请号：US10516100
申请日：2003-05-30
申请人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
发明人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
IPC分类号： C07H21/04 , C12P21/06 , C12P19/28 , C12N9/10
CPC分类号： C12N9/1048
摘要： A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine transferring activity.
摘要翻译：一种人源化的新型软骨素合成酶，其是用于合成软骨素的基础骨架的酶，具有葡萄糖醛酸转移活性和N-乙酰半乳糖胺转移活性。

22. 发明申请

US20060052335A1 Chondroitin synthetase and dna encoding the enzyme 有权
标题翻译：软骨素合成酶和dna编码酶
公开(公告)号：US20060052335A1
公开(公告)日：2006-03-09
申请号：US10516099
申请日：2003-05-30
申请人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
发明人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
IPC分类号： A61K31/737 , C12P21/06 , C12P19/28 , C12N9/10
CPC分类号： C12N9/1048 , C12P19/26
摘要： A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferase activity and N-acetylgalactosamine transferase activity.
摘要翻译：人源性新型软骨素合成酶，其是合成软骨素基础骨架的酶，具有葡糖醛酸转移酶活性和N-乙酰半乳糖胺转移酶活性。

23. 发明授权

US5624839A Process for culturing hepatocytes for formation of spheroids 失效
标题翻译：培养肝细胞以形成球状体的方法
公开(公告)号：US5624839A
公开(公告)日：1997-04-29
申请号：US453932
申请日：1995-05-30
申请人： Toshikazu Yada , Norio Koide , Koji Kimata
发明人： Toshikazu Yada , Norio Koide , Koji Kimata
IPC分类号： A61K35/407 , C08B37/00 , C08B37/08 , C12N5/00 , C12N5/071 , A61K31/715 , C07H1/00
CPC分类号： C12N5/0068 , C08B37/0063 , C12N5/0671 , C12N2501/90 , C12N2501/905 , C12N2501/91 , C12N2533/70
摘要： Hepatocytes spheroids can be formed by culturing hepatocytes in a culture vessel using a lipid-bound glycosaminoglycan as a culture substrate. Floating spheroids of hepatocytes can be obtained efficiently, which are capable of maintaining liver-specific functions and of keeping the spheroid form stably for a prolonged period of time.
摘要翻译：可以通过使用脂质结合的糖胺聚糖作为培养基质在培养容器中培养肝细胞来形成肝细胞球形体。可以有效地获得肝细胞的浮球，其能够保持肝脏特异性的功能并且保持球状体长时间稳定地形成。

24. 发明授权

US07476730B2 Sulfotransferase and DNA encoding the enzyme 失效
标题翻译：磺酰转移酶和编码酶的DNA
公开(公告)号：US07476730B2
公开(公告)日：2009-01-13
申请号：US11595410
申请日：2006-12-11
申请人： Hiroko Habuchi , Koji Kimata
发明人： Hiroko Habuchi , Koji Kimata
IPC分类号： C12P21/06 , C12Q1/68 , C12N9/10 , C12N15/70 , C08B37/10 , C07H21/04
CPC分类号： C12N9/13 , C12N9/10
摘要： A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDSNAc) heparin/completely desulfated N-resulfated (CDSNS) heparin ≧0.05 and a molecular weight as calculated from constituent amino acids of from 53,000 to 58,000 daltons.
摘要翻译：具有将硫酸盐转移到葡糖胺聚糖的糖胺残基的第6位的羟基上的糖胺聚糖6-O-磺基转移酶，其具有与满足完全脱硫的N-乙酰化（CDSNAc）肝素/完全脱硫的N的底物的相对活性的比例 - 硫酸化（CDSNS）肝素≥0.05，由构成氨基酸计算的分子量为53,000至58,000道尔顿。

25. 发明申请

US20070072268A1 Sulfotransferase and DNA encoding the enzyme 失效
标题翻译：磺酰转移酶和编码酶的DNA
公开(公告)号：US20070072268A1
公开(公告)日：2007-03-29
申请号：US11595410
申请日：2006-12-11
申请人： Hiroko Habuchi , Koji Kimata
发明人： Hiroko Habuchi , Koji Kimata
IPC分类号： C12P21/06 , C12P19/28 , C08B37/00 , C08B37/10 , C07H21/04 , C12N9/10 , C12N1/21
CPC分类号： C12N9/13 , C12N9/10
摘要： A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDSNAc) heparin/completely desulfated N-resulfated (CDSNS) heparin ≧0.05 and a molecular weight as calculated from constituent amino acids of from 53,000 to 58,000 daltons.
摘要翻译：具有将硫酸盐转移到葡糖胺聚糖的糖胺残基的第6位的羟基上的糖胺聚糖6-O-磺基转移酶，其具有与满足完全脱硫的N-乙酰化（CDSNAc）肝素/完全脱硫的N的底物的相对活性的比例 - 硫酸化（CDSNS）肝素≥0.05，由构成氨基酸计算的分子量为53,000至58,000道尔顿。

26. 发明授权

US5817487A Heparan sulfate 2-0-sulfotransferase 失效
标题翻译：硫酸肝素2-0-磺基转移酶
公开(公告)号：US5817487A
公开(公告)日：1998-10-06
申请号：US685659
申请日：1996-07-24
申请人： Masashi Kobayashi , Hiroko Habuchi , Osami Habuchi , Koji Kimata
发明人： Masashi Kobayashi , Hiroko Habuchi , Osami Habuchi , Koji Kimata
IPC分类号： C12N9/10 , C12R1/91 , C12P19/00 , C12P11/00 , C12P19/26
CPC分类号： C12N9/13
摘要： Heparan sulfate 2-O-sulfotransferase having the following properties is obtained from, for example, CHO cells: (i) action: sulfate group is transferred from a sulfate group donor selectively to the hydroxyl group at C-2 position of iduronic acid residue of a sulfate group acceptor; (ii) substrate specificity: sulfate group is transferred to heparan sulfate or CDSNS-heparin, but sulfate group is not transferred to chondroitin, chondroitin sulfate, dermatan sulfate, and keratan sulfate; (iii) optimum reaction pH: about pH 5 to 6.5; (iv) optimum ionic strength: about 50 to 200 mM when sodium chloride is used; and (v) inhibition and activation: the activity of the enzyme is increased by protamine, the activity of the enzyme is inhibited by adenosine-3',5'-diphosphate, and the activity of the enzyme is scarcely affected by dithiothreitol at 10 mM or less.
摘要翻译：具有以下性质的硫酸肝素2-O-磺基转移酶由例如CHO细胞获得：（i）作用：硫酸根基团从硫酸基供体选择性地转移到丙二酸残基C-2位的羟基硫酸酯基受体; （ii）底物特异性：硫酸盐转移到硫酸乙酰肝素或CDSNS-肝素，但硫酸根不转移到软骨素，硫酸软骨素，硫酸皮肤素和硫酸角质素; （iii）最佳反应pH：约pH5至6.5; （iv）最佳离子强度：当使用氯化钠时为约50至200mM; 和（v）抑制和活化：酶的活性由鱼精蛋白增加，酶的活性受到腺苷-3'，5'-二磷酸的抑制，酶的活性几乎不受二硫苏糖醇在10mM 或更少。

27. 发明申请

US20080070996A1 CHONDROITIN SYNTHASE AND NUCLEIC ACID ENCODING THE ENZYME 有权
标题翻译： CHONDROITIN SYNTHASE和核酸编码ENZYME
公开(公告)号：US20080070996A1
公开(公告)日：2008-03-20
申请号：US11748409
申请日：2007-05-14
申请人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
发明人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
IPC分类号： A61K35/00 , A61P43/00 , C07H21/00 , C12N1/00 , C12N15/63 , C12P19/04
CPC分类号： C12N9/1048
摘要： A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine transferring activity.
摘要翻译：一种人源化的新型软骨素合成酶，其是用于合成软骨素的基础骨架的酶，具有葡萄糖醛酸转移活性和N-乙酰半乳糖胺转移活性。

28. 发明授权

US07273729B2 Chondroitin synthase and DNA encoding the enzyme 有权
标题翻译：软骨素合成酶和编码酶的DNA
公开(公告)号：US07273729B2
公开(公告)日：2007-09-25
申请号：US10516099
申请日：2003-05-30
申请人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
发明人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
IPC分类号： C12N9/10 , C12N15/00 , C12N5/02 , C12P21/06 , C12P19/42 , C12P19/04 , C07H21/04
CPC分类号： C12N9/1048 , C12P19/26
摘要： A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferase activity and N-acetylgalactosamine transferase activity.
摘要翻译：人源性新型软骨素合成酶，其是合成软骨素基础骨架的酶，具有葡糖醛酸转移酶活性和N-乙酰半乳糖胺转移酶活性。

29. 发明申请

US20070160593A1 Sugar chain-cleaving agent 审中-公开
标题翻译：糖链切割剂
公开(公告)号：US20070160593A1
公开(公告)日：2007-07-12
申请号：US10569676
申请日：2004-08-25
申请人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada
发明人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada
IPC分类号： A61K38/47 , C07H21/04 , C08B37/00 , C12P19/28 , C12N9/24
CPC分类号： A61K38/47 , C12N9/2402 , C12Y302/01097
摘要： A sugar chain-cleaving agent, which comprises a protein having activity of degrading chondroitin and/or chondroitin sulfate; a medicament which comprises the sugar chain-cleaving agent as an active ingredient; a method for specifically cleaving a sugar chain, which comprises reacting the protein with chondroitin and/or chondroitin sulfate; and a method for specifically producing a sugar chain of which molecular weight is decreased, which reacting the protein with chondroitin and/or chondroitin sulfate.
摘要翻译：一种糖链切割剂，其包含具有降解软骨素和/或硫酸软骨素的活性的蛋白质; 包含糖链切割剂作为活性成分的药物; 一种用于特异性切割糖链的方法，其包括使所述蛋白质与软骨素和/或硫酸软骨素反应; 特异性地制造分子量降低的糖链，使蛋白与软骨素和/或硫酸软骨素反应的方法。

30. 发明授权

US6162908A Polypeptide of human-origin hyaluronate synthetase and DNA encoding the same 有权
标题翻译：人源性透明质酸合成多肽和编码相同的DNA
公开(公告)号：US6162908A
公开(公告)日：2000-12-19
申请号：US155768
申请日：1998-10-05
申请人： Naoki Itano , Koji Kimata
发明人： Naoki Itano , Koji Kimata
IPC分类号： C12N9/10 , C12N15/56 , C12N9/26 , C12N9/00
CPC分类号： C12N9/1051
摘要： A DNA encoding at least part of a hyaluronan synthase of human origin, particularly encoding the whole or a part of an amino acid sequence shown by SEQ ID NO: 4. A polypeptide of the hyaluronan synthase of human origin, which is encoded by the DNA, may have a substitution, deletion or insertion of one or more amino acid residues that does not substantially lower an activity of synthesizing hyaluronan. A polypeptide of the hyaluronan synthase of human origin or a part thereof encoded by the DNA is also provided.
摘要翻译： PCT No.PCT / JP97 / 01111 Sec。 371日期：1998年10月5日 102（e）日期1998年10月5日PCT 1997年3月31日PCT公布。公开号WO97 / 38113 日期1997年10月16日编码人源的透明质酸合成酶的至少一部分的DNA，特别是编码SEQ ID NO：4所示的全部或部分氨基酸序列。人源性透明质酸合酶的多肽由DNA编码，可能具有不显着降低合成透明质酸的活性的一个或多个氨基酸残基的取代，缺失或插入。还提供了人源的透明质酸合酶或其由DNA编码的部分的多肽。

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