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21. 发明申请

US20090264965A1 OPTIMIZING SIZE OF IMPLANTABLE MEDICAL DEVICES BY ISOLATING THE POWER SOURCE 有权
标题翻译：通过分离电源优化可植入医疗器械的尺寸
公开(公告)号：US20090264965A1
公开(公告)日：2009-10-22
申请号：US12340395
申请日：2008-12-19
申请人： Robert Fowler , Mark W. Cowan , N. Parker Willis , Axel F. Brisken , Debra S. Echt
发明人： Robert Fowler , Mark W. Cowan , N. Parker Willis , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/378
CPC分类号： A61N1/378 , A61N1/37217 , A61N1/37288
摘要： A wireless cardiac stimulation device comprising an implantable transmitter module housing a transmitter and a separately implantable battery module housing a battery for powering the transmitter and other device electronics via a subcutaneously routable electrical cable connecting the module is disclosed. The transmitter module contains a transmitter enclosure which comprises one or more ultrasound transducers. Having separate transmitter and battery modules allows implantation of the transmitter module closer to the target receiver implanted in tissue. A discrete battery module also enables easy replacement of the battery without disturbing the transmitter, which is highly desirable.
摘要翻译：公开了一种无线心脏刺激装置，其包括容纳发射器的可植入发射器模块和容纳用于通过连接所述模块的皮下可路由电缆为所述发射器和其它装置电子设备供电的单独可植入电池模块。发射机模块包含一个包含一个或多个超声换能器的发射机外壳。具有单独的发射器和电池模块允许植入发射器模块更靠近植入组织中的目标接收器。分立的电池模块还能够容易地更换电池而不干扰发射器，这是非常需要的。

22. 发明申请

US20090227999A1 VISUAL ELECTRODE ABLATION SYSTEMS 有权
标题翻译： VISUAL ELECTRODE ABLATION系统
公开(公告)号：US20090227999A1
公开(公告)日：2009-09-10
申请号：US12465903
申请日：2009-05-14
申请人： N. Parker Willis , Zachary J. Malchano , Chris A. Rothe , Vahid Saadat , Ruey-Feng Peh , David Miller , Edmund Tam
发明人： N. Parker Willis , Zachary J. Malchano , Chris A. Rothe , Vahid Saadat , Ruey-Feng Peh , David Miller , Edmund Tam
IPC分类号： A61B18/14 , A61B18/20 , A61N7/00
CPC分类号： A61B18/1492 , A61B1/00089 , A61B1/012 , A61B2017/00106 , A61B2018/00214 , A61B2018/00577 , A61B2018/00642 , A61B2018/00809 , A61B2018/00839 , A61B2018/1472 , A61B2218/002
摘要： Visual electrode ablation systems are described herein which include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An electric current may be passed through the fluid such that it passes directly to the tissue region being imaged and the electrical energy is conducted through the fluid without the need for a separate ablation probe or instrument to ablate the tissue being viewed.
摘要翻译：本文描述了视觉电极消融系统，其包括部署导管和可展开成扩展构型的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。电流可以通过流体，使得其直接通过被成像的组织区域，并且电能通过流体传导，而不需要单独的消融探针或器械来烧蚀被观察的组织。

23. 发明授权

US07517315B2 System and method for determining the proximity between a medical probe and a tissue surface 有权
标题翻译：用于确定医用探针和组织表面之间的接近度的系统和方法
公开(公告)号：US07517315B2
公开(公告)日：2009-04-14
申请号：US11213020
申请日：2005-08-26
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61B8/08
CPC分类号： A61B8/0833 , A61B1/00147 , A61B5/1076 , A61B5/6886
摘要： Methods and systems for determining a proximity between a medical probe (such as, e.g., the tip of the medical probe) having an ultrasound transducer and a tissue surface, is provided. The ultrasound transducer is operated in a first resonant mode to transmit a first ultrasound signal that intersects the tissue surface to create a first reflected ultrasound signal, and operating in a second different resonant mode to transmit a second ultrasound signal that intersects the tissue surface to create a second reflected ultrasound signal. The first and second reflected ultrasound signals are received, e.g., by the ultrasound transducer, and a proximity between a portion of the medical probe and the tissue surface is determined based on the received first and second reflected ultrasound signals.
摘要翻译：提供了用于确定具有超声换能器的医疗探针（例如，医疗探针的尖端）与组织表面之间的接近度的方法和系统。所述超声换能器以第一谐振模式操作以传送与所述组织表面相交的第一超声信号，以产生第一反射超声信号，并以第二不同谐振模式操作以传输与所述组织表面相交的第二超声信号，以产生第二反射超声信号。第一和第二反射的超声信号例如通过超声换能器接收，并且基于所接收的第一和第二反射超声信号来确定医疗探针的一部分与组织表面之间的接近度。

24. 发明授权

US07374537B2 Performing ultrasound ranging in the presence of ultrasound interference 有权
标题翻译：在存在超声波干扰的情况下进行超声波测距
公开(公告)号：US07374537B2
公开(公告)日：2008-05-20
申请号：US10951853
申请日：2004-09-27
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61B8/00 , G01S15/00
CPC分类号： G01S11/14 , A61B5/064 , A61B5/065 , A61B8/0833 , G01S5/30
摘要： A distance measuring system comprises first and second transducers, and an ultrasound ranging subsystem coupled to the first and second transducers for performing a plurality of distance measurements between the first and second transducers. The distance measurement system can have various applications, including medical applications, in which case, the first and second transducers can be mounted on a catheter. The distance measuring system further comprises a filter coupled to the ultrasound ranging subsystem for filtering ultrasound interference from the plurality of distance measurements (such as, e.g., eight), and outputting a distance based on the filtered distance measurements. The filter filters the ultrasound interference by selecting one of the plurality distance measurements, in which case, the outputted distance is the selected distance measurement. Because the ultrasound interference will typically represent itself as the shortest distance measurement, the selected distance measurement is preferably greater than the minimum distance measurement (such as, e.g., the maximum distance measurement), thereby filtering the ultrasound interference out.
摘要翻译：距离测量系统包括第一和第二换能器，以及耦合到第一和第二换能器的超声测距子系统，用于在第一和第二换能器之间执行多个距离测量。距离测量系统可以具有各种应用，包括医疗应用，在这种情况下，第一和第二换能器可以安装在导管上。距离测量系统还包括耦合到超声波测距子系统的滤波器，用于从多个距离测量（例如，8个）滤波超声波干扰，并且基于滤波的距离测量输出距离。滤波器通过选择多个距离测量中的一个来过滤超声波干扰，在这种情况下，输出的距离是所选择的距离测量。因为超声波干扰通常将自身表示为最短的距离测量，因此所选择的距离测量优选地大于最小距离测量（例如最大距离测量），从而过滤超声波干扰。

25. 发明授权

US09155587B2 Visual electrode ablation systems 有权
标题翻译：视觉电极消融系统
公开(公告)号：US09155587B2
公开(公告)日：2015-10-13
申请号：US12465903
申请日：2009-05-14
申请人： N. Parker Willis , Zachary J. Malchano , Chris A. Rothe , Vahid Saadat , Ruey-Feng Peh , David Miller , Edmund Tam
发明人： N. Parker Willis , Zachary J. Malchano , Chris A. Rothe , Vahid Saadat , Ruey-Feng Peh , David Miller , Edmund Tam
IPC分类号： A61B18/12 , A61B18/14 , A61B1/00 , A61B1/012 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B1/00089 , A61B1/012 , A61B2017/00106 , A61B2018/00214 , A61B2018/00577 , A61B2018/00642 , A61B2018/00809 , A61B2018/00839 , A61B2018/1472 , A61B2218/002
摘要： Visual electrode ablation systems are described herein which include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An electric current may be passed through the fluid such that it passes directly to the tissue region being imaged and the electrical energy is conducted through the fluid without the need for a separate ablation probe or instrument to ablate the tissue being viewed.
摘要翻译：本文描述了视觉电极消融系统，其包括部署导管和可展开成扩展构型的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。电流可以通过流体，使得其直接通过被成像的组织区域，并且电能通过流体传导，而不需要单独的消融探针或器械来烧蚀被观察的组织。

26. 发明授权

US08709008B2 Visual electrode ablation systems 有权
标题翻译：视觉电极消融系统
公开(公告)号：US08709008B2
公开(公告)日：2014-04-29
申请号：US12118439
申请日：2008-05-09
申请人： N. Parker Willis , Zachary J. Malchano , Chris A. Rothe , Vahid Saadat , Ruey-Feng Peh , David Miller , Edmund Tam
发明人： N. Parker Willis , Zachary J. Malchano , Chris A. Rothe , Vahid Saadat , Ruey-Feng Peh , David Miller , Edmund Tam
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B1/00089 , A61B1/012 , A61B2017/00106 , A61B2018/00214 , A61B2018/00577 , A61B2018/00642 , A61B2018/00809 , A61B2018/00839 , A61B2018/1472 , A61B2218/002
摘要： Visual electrode ablation systems are described herein which include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An electric current may be passed through the fluid such that it passes directly to the tissue region being imaged and the electrical energy is conducted through the fluid without the need for a separate ablation probe or instrument to ablate the tissue being viewed.
摘要翻译：本文描述了视觉电极消融系统，其包括部署导管和可展开成扩展构型的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。电流可以通过流体，使得其直接通过被成像的组织区域，并且电能通过流体传导，而不需要单独的消融探针或器械来烧蚀被观察的组织。

27. 发明授权

US08388540B2 Method and apparatus for orienting a medical image 有权
标题翻译：用于定向医学图像的方法和装置
公开(公告)号：US08388540B2
公开(公告)日：2013-03-05
申请号：US10319285
申请日：2002-12-13
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61B8/14
CPC分类号： A61B8/445 , A61B8/12 , A61B8/4245 , A61B8/4461 , A61B8/4483 , A61B8/52 , A61B8/54
摘要： The present invention provides systems, methods, and devices for orienting image data derived from body tissue. An imaging assembly is introduced into the body of a patient and rotated about an axis. A tracking beam mechanically associated with the imaging assembly is generated, such that the tracking rotates about the axis in unison with the imaging assembly. An angle that the rotating tracking beam makes between a reference rotational orientation and a reference point is determined. The reference rotational orientation can be associated with a fiducial point within the ultrasound image data, such that the ultrasound image can be oriented based on the determined tracking beam rotation angle.
摘要翻译：本发明提供了用于定向从身体组织导出的图像数据的系统，方法和装置。将成像组件引入患者的身体并绕轴线旋转。产生与成像组件机械相关联的跟踪梁，使得跟踪与成像组件一致地围绕轴线旋转。确定旋转跟踪光束在参考旋转方向和参考点之间形成的角度。参考旋转方向可以与超声图像数据内的基准点相关联，使得可以基于确定的跟踪光束旋转角度来定向超声图像。

28. 发明申请

US20100234924A1 OPERATION AND ESTIMATION OF OUTPUT VOLTAGE OF WIRELESS STIMULATORS 有权
标题翻译：无线刺激器输出电压的运算和估计
公开(公告)号：US20100234924A1
公开(公告)日：2010-09-16
申请号：US12721483
申请日：2010-03-10
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/362 , A61N1/37205 , A61N1/3756
摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau. Based on this ratio, the controller-transmitter uses a measured query spike voltage to estimate the output voltage delivered by the receiver-stimulator to tissue.
摘要翻译：控制器 - 发射器通过身体将声能传递到植入的声学接收器 - 刺激器。接收器 - 刺激器将声能转换成电能，并使用电极组件将电能传递到组织。接收器 - 刺激器将输送到组织的输出电压限制在预定的最大输出电压。在存在干扰声能源的情况下，输出电压在被传送到组织之前被限制。此外，控制器 - 发射器估计由植入的接收器 - 刺激器传送到组织的输出电压。控制器 - 发射器测量由接收器 - 刺激器传送到组织的电能产生的查询尖峰电压，并且计算预定最大输出电压和最大查询尖峰电压的比率。通过检测查询尖峰电压平台来计算最大查询尖峰电压。基于该比例，控制器 - 发射机使用测量的查询尖峰电压来估计接收器 - 刺激器传递给组织的输出电压。

29. 发明授权

US06805132B2 Performing ultrasound ranging in the presence of ultrasound interference 有权
标题翻译：在存在超声波干扰的情况下进行超声波测距
公开(公告)号：US06805132B2
公开(公告)日：2004-10-19
申请号：US10214441
申请日：2002-08-06
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61B1900
CPC分类号： G01S11/14 , A61B5/064 , A61B5/065 , A61B8/0833 , G01S5/30
摘要： A distance measuring system comprises first and second transducers, and an ultrasound ranging subsystem coupled to the first and second transducers for performing a plurality of distance measurements between the first and second transducers. The distance measurement system can have various applications, including medical applications, in which case, the first and second transducers can be mounted on a catheter. The distance measuring system further comprises a filter coupled to the ultrasound ranging subsystem for filtering ultrasound interference from the plurality of distance measurements (such as, e.g., eight), and outputting a distance based on the filtered distance measurements. The filter filters the ultrasound interference by selecting one of the plurality distance measurements, in which case, the outputted distance is the selected distance measurement. Because the ultrasound interference will typically represent itself as the shortest distance measurement, the selected distance measurement is preferably greater than the minimum distance measurement (such as, e.g., the maximum distance measurement), thereby filtering the ultrasound interference out.
摘要翻译：距离测量系统包括第一和第二换能器，以及耦合到第一和第二换能器的超声测距子系统，用于在第一和第二换能器之间执行多个距离测量。距离测量系统可以具有各种应用，包括医疗应用，在这种情况下，第一和第二换能器可以安装在导管上。距离测量系统还包括耦合到超声波测距子系统的滤波器，用于从多个距离测量（例如，8个）滤波超声波干扰，并且基于滤波的距离测量输出距离。滤波器通过选择多个距离测量中的一个来过滤超声波干扰，在这种情况下，输出的距离是所选择的距离测量。因为超声波干扰通常将自身表示为最短的距离测量，因此所选择的距离测量优选地大于最小距离测量（例如最大距离测量），从而过滤超声波干扰。

30. 发明申请

US20130274828A1 OPERATION AND ESTIMATION OF OUTPUT VOLTAGE OF WIRELESS STIMULATORS 有权
标题翻译：无线刺激器输出电压的运算和估计
公开(公告)号：US20130274828A1
公开(公告)日：2013-10-17
申请号：US13648027
申请日：2012-10-09
申请人： N. Parker Willis
发明人： N. Parker Willis
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/362 , A61N1/37205 , A61N1/3756
摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue. Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau. Based on this ratio, the controller-transmitter uses a measured query spike voltage to estimate the output voltage delivered by the receiver-stimulator to tissue.
摘要翻译：控制器 - 发射器通过身体将声能传递到植入的声学接收器 - 刺激器。接收器 - 刺激器将声能转换成电能，并使用电极组件将电能传递到组织。接收器 - 刺激器将输送到组织的输出电压限制在预定的最大输出电压。在存在干扰声能源的情况下，输出电压在被传送到组织之前被限制。此外，控制器 - 发射器估计由植入的接收器 - 刺激器传送到组织的输出电压。控制器 - 发射器测量由接收器 - 刺激器传送到组织的电能产生的查询尖峰电压，并且计算预定最大输出电压和最大查询尖峰电压的比率。通过检测查询尖峰电压平台来计算最大查询尖峰电压。基于该比例，控制器 - 发射机使用测量的查询尖峰电压来估计接收器 - 刺激器传递给组织的输出电压。

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