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21. 发明申请

US20150024389A1 METHOD FOR DETECTING BLADDER CANCER CELLS, PRIMER USED IN METHOD FOR DETECTING BLADDER CANCER CELLS, AND BLADDER CANCER MARKER 审中-公开
标题翻译：用于检测刮板癌细胞的方法，用于检测刮板癌细胞的方法，以及刮板癌标记
公开(公告)号：US20150024389A1
公开(公告)日：2015-01-22
申请号：US14345226
申请日：2012-03-14
申请人： Takashi Shimizu , Hiromu Suzuki , Minoru Toyota , Taiji Tsukamoto
发明人： Takashi Shimizu , Hiromu Suzuki , Minoru Toyota , Taiji Tsukamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178
摘要： Provided are: a method for detecting bladder cancer with high detection sensitivity, which has a high specificity for bladder cancer and is capable of detecting bladder cancer tissues with low grade of malignancy; and a bladder cancer marker. A method for detecting bladder cancer cells, which comprises detection of the amount of expressed bladder cancer marker in a subject sample collected from a subject, said bladder cancer marker being composed of one or more miRNAs selected from among miR-124, miR-9 and miR-137; a primer which is used in the method for detecting bladder cancer cells; and a bladder cancer marker.
摘要翻译：提供了一种检测灵敏度高的膀胱癌的方法，对膀胱癌具有高度的特异性，能够检测恶性程度低的膀胱癌组织; 和膀胱癌标志物。一种检测膀胱癌细胞的方法，其包括检测从受试者收集的受试者样品中表达的膀胱癌标志物的量，所述膀胱癌标志物由选自以下的一种或多种miRNA组成：miR-124，miR-9和 miR-137; 用于膀胱癌细胞检测方法中的引物; 和膀胱癌标志物。

22. 发明授权

US08133986B2 Methylated CpG island amplification (MCA) 有权
标题翻译：甲基化CpG岛扩增（MCA）
公开(公告)号：US08133986B2
公开(公告)日：2012-03-13
申请号：US12763917
申请日：2010-04-20
申请人： Jean-Pierre Issa , Stephen Baylin , Minoru Toyota
发明人： Jean-Pierre Issa , Stephen Baylin , Minoru Toyota
IPC分类号： C07H21/02 , C07H21/04 , C12P19/34 , C12N1/20 , C12N15/00
CPC分类号： C12Q1/6809 , C12Q1/48 , C12Q1/6855 , C12Q2531/113 , C12Q2525/191 , C12Q2521/331
摘要： The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated PcG sites and contacting the sample with an isoschizomer of the methylation sensitive restriction endonuclease, which cleaves both methylated and unmethylated CpG sites. The method also includes amplification of the CpG-containing nucleic acid using CpG-specific oligonucleotide primers. A method is also provided for detecting an age associated disorder by identification of a methylated CpG containing nucleic acid. A method is further provided for evaluating the responses of a cell to an agent. A kit is useful for detection of a CpG containing nucleic acid is also provided. Nucleic acid sequences encoding novel methylated clones.
摘要翻译：本发明提供了通过使核酸与切割未甲基化的PcG位点的甲基化敏感性限制性内切核酸酶接触并使样品与甲基化敏感性限制性内切核酸酶的等位异构体接触的方法，所述甲基化敏感性限制性内切核酸酶切割甲基化和未甲基化 CpG位点。该方法还包括使用CpG特异性寡核苷酸引物扩增含CpG的核酸。还提供了通过鉴定含甲基化CpG的核酸来检测年龄相关疾病的方法。还提供了一种用于评估细胞对试剂的反应的方法。还提供了用于检测含有CpG的核酸的试剂盒。编码新甲基化克隆的核酸序列。

23. 发明授权

US07700324B1 Methylated CpG island amplification (MCA) 有权
标题翻译：甲基化CpG岛扩增（MCA）
公开(公告)号：US07700324B1
公开(公告)日：2010-04-20
申请号：US09309175
申请日：1999-05-10
申请人： Jean-Pierre Issa , Stephen Baylin , Minoru Toyota
发明人： Jean-Pierre Issa , Stephen Baylin , Minoru Toyota
IPC分类号： C12P1/34 , C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6809 , C12Q1/48 , C12Q1/6855 , C12Q2531/113 , C12Q2525/191 , C12Q2521/331
摘要： The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated CpG sites and contacting the sample with an isoschizomer of the methylation sensitive restriction endonuclease, which cleaves both methylated and unmethylated CpG sites. The method also includes amplification of the CpG-containing nucleic acid using CpG-specific oligonucleotide primers A method is also provided for detecting an age associated disorder by identification of a methylated CpG containing nucleic acid. A method is further provided for evaluation the response of a cell to an agent A kit useful for detection of a CpG containing nucleic acid is also provided. Nucleic acid sequences encoding novel methylated clones.
摘要翻译：本发明提供了通过使核酸与切割未甲基化CpG位点的甲基化敏感性限制性内切核酸酶接触并使样品与甲基化敏感性限制性内切核酸酶的异构体接触的方法来鉴定含甲基化CpG的核酸，其将甲基化和未甲基化 CpG位点。该方法还包括使用CpG特异性寡核苷酸引物扩增含CpG的核酸。还提供了通过鉴定含甲基化CpG的核酸来检测年龄相关疾病的方法。还提供了用于评估细胞对试剂的反应的方法。还提供了可用于检测含CpG的核酸的试剂盒。编码新甲基化克隆的核酸序列。

24. 发明申请

US20100068702A1 Method for Detecting Disease-Related Marker Using Gastric Mucosal Lavage Fluid 审中-公开
标题翻译：使用胃粘膜灌洗液检测疾病相关标记物的方法
公开(公告)号：US20100068702A1
公开(公告)日：2010-03-18
申请号：US12227300
申请日：2007-05-15
申请人： Yoshiyuki Watanabe , Yoshiyuki Watanabe , Minoru Toyota , Kohzoh Imai , Yasuhisa Shinomura , Fumio Itoh , Takashi Tokino
发明人： Yoshiyuki Watanabe , Yoshiyuki Watanabe , Minoru Toyota , Kohzoh Imai , Yasuhisa Shinomura , Fumio Itoh , Takashi Tokino
IPC分类号： C12Q1/68 , A61B5/00
CPC分类号： C12Q1/6806
摘要： The invention relates to a sample containing a gastric mucosa lavage fluid collected from a subject who has received a gastric mucus removal treatment and a method for detecting a disease-related marker using the same. By using the sample of the invention, the disease-related marker can be detected conveniently, less invasively, highly sensitively and highly accurately.
摘要翻译：本发明涉及含有从接受胃粘液清除处理的受试者收集的胃粘膜灌洗液和使用其的疾病相关标记物检测方法的样品。通过使用本发明的样品，可以方便地，较少侵入性地，高灵敏度和高度准确地检测疾病相关标志物。

25. 发明授权

US07516999B2 Seat device for vehicle 失效
标题翻译：车辆座椅装置
公开(公告)号：US07516999B2
公开(公告)日：2009-04-14
申请号：US11126142
申请日：2005-05-11
申请人： Minoru Toyota
发明人： Minoru Toyota
IPC分类号： B60N2/02
CPC分类号： B60N2/3011 , B60N2/3022 , B60N2/3047 , B60N2/3065 , B60N2/3075 , B60N2/309 , B60N2/36
摘要： The seat device, disposed on the floor panel in the cabin with the instrument panel, comprises the driver seat, the assistant seat and the rear seat, wherein the assistant seat is foldable and movable forward close to the instrument panel to be located in the stored position where the length of the folded seat is made short, the rear seat is foldable and movable forward to be located in the stored position, and the assistant seat in the stored position and the rear seat in the stored position provide the substantially continuous storage space which is formed by back faces of respective seat backs and of the assistant seat and the rear seat. Thus, both the large space and the roomy cabin for passengers can be improved.
摘要翻译：座椅装置，设置在具有仪表板的机舱内的地板面板上，包括驾驶员座椅，辅助座椅和后座椅，其中辅助座椅是可折叠的并且可靠地靠近仪表板向前移动以被存放在存储的折叠座椅的长度短的位置，后座椅是可折叠的并且可向前移动以位于存储位置，并且处于存储位置的辅助座椅和处于存储位置的后座椅提供基本上连续的存储空间其由相应的座椅靠背和辅助座椅和后座椅的背面形成。因此，可以改善乘客的大空间和宽敞的客舱。

26. 发明授权

US6065776A Seat belt assemblies for vehicle 失效
标题翻译：车辆安全带组件
公开(公告)号：US6065776A
公开(公告)日：2000-05-23
申请号：US260419
申请日：1999-03-01
申请人： Minoru Toyota , Toshinori Sakamoto , Koji Nakao , Satoshi Nishikaji
发明人： Minoru Toyota , Toshinori Sakamoto , Koji Nakao , Satoshi Nishikaji
IPC分类号： B60R22/24 , B60R22/02 , B60R21/10
CPC分类号： B60R22/023
摘要： In a vehicle having a second row of seats designed for providing seats for three passengers and a third row of seats which are detachable, a seat belt unit for the third row has a webbing whose length is enough to reach a center seat of the second row, and which is pulled out via an anchor, as a fulcrum, designed rotatable to a position where it faces to the center seat. With this configuration, an elevation of the seats in the third row is set higher than that in the second row as well as an elevation of a mounting position of the anchor is set higher than that of an anchor for a second row seat belt unit, so that a passenger in the center seat is properly protected by the seat belt unit.
摘要翻译：在具有设计用于提供三个乘客的座位的第二排座椅和可拆卸的第三排座椅的车辆中，用于第三排的座椅安全带单元具有织带，其长度足以到达第二排的中心座，并且通过锚点拉出，作为支点，设计成可旋转到其面向中心座的位置。利用这种构造，将第三排中的座椅的高度设置为高于第二排中的座椅的高度，并且锚固件的安装位置的高度被设定为高于用于第二排安全带单元的锚的高度，使得中心座椅中的乘客被安全带单元适当地保护。

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