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21. 发明申请

US20050026863A1 Delivery of therapeutic gene products by intestinal cell expression 审中-公开
标题翻译：通过肠细胞表达递送治疗性基因产物
公开(公告)号：US20050026863A1
公开(公告)日：2005-02-03
申请号：US10911082
申请日：2004-08-03
申请人： Michael German , Ira Goldfine , Stephen Rothman
发明人： Michael German , Ira Goldfine , Stephen Rothman
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/28 , A61K48/00 , A61P3/10 , A61P9/10 , A61P31/04 , C07K14/61 , C12N15/85
CPC分类号： A61K38/28 , A61K38/27 , A61K48/00 , C07K14/61
摘要： Intestinal epithelial cells of a mammalian subject are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect. Intestinal cell transformation is accomplished by administration of a formulation containing DNA and is preferably administered orally. Oral or other intragastrointestinal routes of administration provide a simple method of administration. The expressed protein is secreted directly into the gastrointestinal tract and/or bloodstream to obtain therapeutic blood levels of the protein, thereby treating the patient in need of the protein. The delivery system of the invention provides short or long term delivery of therapeutic gene products.
摘要翻译：遗传改变哺乳动物受试者的肠上皮细胞以可操作地掺入表达具有所需治疗效果的蛋白质的基因。通过施用含有DNA的制剂来实现肠细胞转化，并且优选口服施用。口服或其他胃肠道给药途径提供简单的给药方法。表达的蛋白质直接分泌到胃肠道和/或血液中以获得蛋白质的治疗血液水平，从而治疗需要蛋白质的患者。本发明的递送系统提供治疗性基因产物的短期或长期递送。

22. 发明授权

US06566342B2 Gene therapy by secretory gland expression 失效
公开(公告)号：US06566342B2
公开(公告)日：2003-05-20
申请号：US09755492
申请日：2001-01-04
申请人： Michael German , Ira D. Goldfine , Stephen S. Rothman
发明人： Michael German , Ira D. Goldfine , Stephen S. Rothman
IPC分类号： A61K4800
CPC分类号： A61K38/37 , A61K38/1709 , A61K38/1816 , A61K38/27 , A61K38/28 , A61K48/00
摘要： Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein. The transformed secretory gland cells provide long term therapeutic cures for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.

23. 发明授权

US06225290B1 Systemic gene therapy by intestinal cell transformation 失效
标题翻译：通过肠细胞转化进行全身基因治疗
公开(公告)号：US06225290B1
公开(公告)日：2001-05-01
申请号：US08717084
申请日：1996-09-19
申请人： Michael German , Ira D. Goldfine , Stephen S. Rothman
发明人： Michael German , Ira D. Goldfine , Stephen S. Rothman
IPC分类号： A61K4800
CPC分类号： A61K38/28 , A61K38/27 , A61K48/00 , C07K14/61
摘要： Intestinal epithelial cells of a mammalian subject are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect. Intestinal cell transformation is accomplished by administration of a formulation composed primarily of naked DNA, and is preferably administered orally. Oral or other intragastrointestinal routes of administration provide a simple method of administration, while the use of naked nucleic acid avoids the complications associated with use of viral vectors to accomplish gene therapy. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein. The transformed intestinal epithelial cells provide short or long term therapeutic cures for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.
摘要翻译：遗传改变哺乳动物受试者的肠上皮细胞以可操作地掺入表达具有所需治疗效果的蛋白质的基因。通过施用主要由裸DNA组成的制剂来实现肠细胞转化，优选口服施用。口服或其他胃肠道途径提供了简单的给药方法，而使用裸核酸避免了与使用病毒载体相关的完成基因治疗的并发症。表达的蛋白质直接分泌到胃肠道和/或血液中以获得蛋白质的治疗血液水平，从而治疗需要蛋白质的患者。转化的肠上皮细胞为与特定蛋白质缺乏相关的疾病提供短期或长期治疗性治疗，或适于通过蛋白质的过表达进行治疗。

24. 发明授权

US08467655B2 Patch panel cable information detection systems and methods 失效
标题翻译：配线架电缆信息检测系统及方法
公开(公告)号：US08467655B2
公开(公告)日：2013-06-18
申请号：US13228122
申请日：2011-09-08
申请人： Michael German , Daniel W. Macauley , G. Mabud Choudhury
发明人： Michael German , Daniel W. Macauley , G. Mabud Choudhury
IPC分类号： G02B6/00
CPC分类号： H04Q1/136 , G02B6/3895 , G02B6/4452 , H04Q1/138
摘要： A communications system includes a plurality of patch panels, wherein each patch panel has a plurality of connector ports on a front surface thereof that are each connected to a respective communication line, and one or more optical couplers/connector ports on a rear surface thereof for linking two or more patch panels together. A cable for linking patch panels includes opposite ends and a respective connector at each end that is configured to be removably secured within a respective coupler/connector port on the rear surface. Each connector has an RFID tag attached thereto. An RF antenna is secured to each patch panel adjacent each respective coupler, and each antenna is configured to activate and read information from a cable RFID tag when a cable connector is secured within a coupler adjacent thereto.
摘要翻译：通信系统包括多个接线板，其中每个接线板在其前表面上具有多个连接器端口，每个连接器端口连接到相应的通信线路，以及在其后表面上的一个或多个光耦合器/连接器端口，用于将两个或更多个接线板连接在一起。用于连接接线板的电缆包括相对端部，并且在每个端部处的相应连接器构造成可移除地固定在后表面上的相应联接器/连接器端口内。每个连接器都附有RFID标签。 RF天线固定到每个相应耦合器附近的每个接线板，并且每个天线被配置为当电缆连接器固定在与其相邻的耦合器内时从电缆RFID标签激活和读取信息。

25. 发明申请

US20120198246A1 AUTOMATED INFRASTRUCTURE MANAGEMENT SYSTEMS AND METHODS FOR ENABLING REAL TIME ENERGY MANAGEMENT 有权
标题翻译：自动化基础设施管理系统和实现能源管理的方法
公开(公告)号：US20120198246A1
公开(公告)日：2012-08-02
申请号：US13353808
申请日：2012-01-19
申请人： Michael German , Niall McAndrew
发明人： Michael German , Niall McAndrew
IPC分类号： G06F1/26
CPC分类号： H04Q1/03 , G06F1/3231 , H04Q1/136 , H04Q1/142 , H04Q1/149
摘要： Automated infrastructure management systems and methods document infrastructure elements within a facility, provide a comprehensive record of all network-connected equipment within a facility, and facilitate trouble shooting of network-connected equipment. An automated infrastructure management system includes a plurality of intelligent patch panels, each comprising a plurality of connector ports connected to individual communication channels of a network, a controller in communication with at least some of the intelligent patch panels that obtains connectivity information for the intelligent patch panel's ports, and management software in communication with the controller. The management software performs various functions including correlating the interconnection information for the intelligent patch panels with the physical location information for telecommunications in its database, applying energy management policies to a respective communication channel, providing real time physical location information for devices connected to communication channels to a network switch, and displaying real time physical location information of the devices.
摘要翻译：自动化基础设施管理系统和方法记录设施内的基础设施元素，提供设施内所有网络连接设备的全面记录，并有助于网络连接设备的故障排除。自动化基础设施管理系统包括多个智能接线板，每个智能接线板包括连接到网络的各个通信信道的多个连接器端口，与至少一些智能接线板通信的控制器，该智能接线板获得智能接线片的连接信息面板的端口和与控制器通信的管理软件。管理软件执行各种功能，包括将智能接线板的互连信息与其数据库中的电信的物理位置信息相关联，将能量管理策略应用于相应的通信信道，为连接到通信信道的设备提供实时物理位置信息网络交换机，并显示设备的实时物理位置信息。

26. 发明申请

US20060160396A1 Methods, systems and computer program products for notifying telecommunications system technicians of pending work orders 审中-公开
标题翻译：方法，系统和计算机程序产品，用于通知电信系统技术人员的待命工单
公开(公告)号：US20060160396A1
公开(公告)日：2006-07-20
申请号：US11312943
申请日：2005-12-20
申请人： Daniel Macauley , Michael German , Matias Peluffo , Hester Tsui
发明人： Daniel Macauley , Michael German , Matias Peluffo , Hester Tsui
IPC分类号： H01R13/625
CPC分类号： H04M3/2254 , H04Q1/136
摘要： Methods, systems and computer program products that notify technicians of work to be performed on a telecommunications system are provided. Interconnections with patch panel connector ports are monitored and a work order is generated in response to detecting the relocation of a patch cord connector at a patch panel. A technician automatically is notified that a work order has been generated. The technician is requested to acknowledge receipt of a work order notification. If an acknowledgement is not received within a predetermined period of time, an alternate technician is notified of the work order. A list of work orders are displayed on a display in communication with the telecommunications system. Displayed work orders can be filtered such that the a technician only views work orders he/she is authorized to view. A technician can select a displayed work order and retrieve additional information from a server managing the work orders.
摘要翻译：提供通知技术人员在电信系统上执行工作的方法，系统和计算机程序产品。与接线板连接器端口的互连被监控，并且响应于在接线板检测到跳线连接器的重定位而产生工作指令。通知技术人员已经生成工单。技术人员被要求确认收到工单通知。如果在预定时间段内没有接收到确认，则向备用技术人员通知工单。工作单列表显示在与电信系统通信的显示器上。可以过滤显示的工作单，以便技术人员仅查看他/她有权查看的工作订单。技术人员可以选择显示的工单，并从管理工单的服务器检索附加信息。

27. 发明申请

US20060160395A1 Methods, systems and computer program products for connecting and monitoring network equipment in a telecommunications system 审中-公开
标题翻译：在电信系统中连接和监测网络设备的方法，系统和计算机程序产品
公开(公告)号：US20060160395A1
公开(公告)日：2006-07-20
申请号：US11312914
申请日：2005-12-20
申请人： Daniel Macauley , Michael German , Matias Peluffo , George Brooks
发明人： Daniel Macauley , Michael German , Matias Peluffo , George Brooks
IPC分类号： H01R13/625
CPC分类号： H04Q1/136 , H04M3/10 , H04M3/22 , H04M3/36 , H04M2201/14 , H04Q1/14
摘要： Methods, systems and computer program products for interconnecting network equipment with a telecommunications system includes identifying a patch panel connector port to be connected to a network equipment port, generating a work order for connecting the identified patch panel connector port to the network equipment port via a patch cord, monitoring the identified patch panel connector port to detect whether a patch cord connector has been inserted therein within a predetermined period of time, and monitoring the network equipment port for communications activity within a predetermined period of time. If a patch cord connector has not been inserted within the identified patch panel connector port within the predetermined period of time and/or if communications activity has not been detected at the network equipment port within the predetermined period of time, a technician is notified. Network equipment ports and patch panel ports are monitored for authorized and unauthorized connections.
摘要翻译：用于将网络设备与电信系统互连的方法，系统和计算机程序产品包括识别要连接到网络设备端口的接插板连接器端口，产生用于经由以下操作将所识别的接线板连接器端口连接到网络设备端口的工作命令监视所识别的接线板连接器端口，以检测在预定时间段内是否插入了跳线连接器，并且在预定时间段内监视网络设备端口以进行通信活动。如果在预定时间段内没有将接插线连接器插入识别的接线板连接器端口内，和/或如果在预定时间段内没有在网络设备端口处检测到通信活动，则通知技术人员。监控网络设备端口和接线板端口，以进行授权和未经授权的连接。

28. 发明申请

US20060148279A1 Telecommunications patching system that utilizes RFID tags to detect and identify patch cord interconnections 有权
公开(公告)号：US20060148279A1
公开(公告)日：2006-07-06
申请号：US11295349
申请日：2005-12-06
申请人： Michael German , Golam Choudhury , Daniel Macauley , Danny Satterthwaite , Peter Tucker
发明人： Michael German , Golam Choudhury , Daniel Macauley , Danny Satterthwaite , Peter Tucker
IPC分类号： H01R29/00
CPC分类号： H04Q1/138 , H01R13/465 , H01R13/518 , H01R29/00
摘要： A telecommunications patching system includes a patch panel having a plurality of connector ports, and having an RFID reader and RF antennas associated with the connector ports. A plurality of patch cords are configured to selectively interconnect pairs of the connector ports. Each patch cord has opposite ends and a respective connector secured to each end that is configured to be removably secured within a connector port. Each connector of a respective patch cord includes an RFID tag. The RFID tags for a respective patch cord have the same unique identifier stored therewithin. The RF antenna associated with a connector port emits RF signals that cause a patch cord connector RFID tag to transmit its identifier. Each RF antenna detects the transmitted identifier of a patch cord connector RFID tag when the respective patch cord connector is inserted within, and removed from, a respective one of the connector ports.

29. 发明授权

US06831070B2 Delivery of therapeutic gene products by intestinal cell expression 失效
标题翻译：通过肠细胞表达递送治疗性基因产物
公开(公告)号：US06831070B2
公开(公告)日：2004-12-14
申请号：US09811323
申请日：2001-03-16
申请人： Michael German , Ira D. Goldfine , Stephen S. Rothman
发明人： Michael German , Ira D. Goldfine , Stephen S. Rothman
IPC分类号： A61K4800
CPC分类号： A61K38/28 , A61K38/27 , A61K48/00 , C07K14/61
摘要： The present invention provides methods of delivering a secreted protein into the bloodstream of a mammal. A nucleic acid molecule encoding the protein is introduced into the gastrointestinal tract of the mammal, and the nucleic acid molecule enters an intestinal epithelial cell, where the protein is produced and secreted into the bloodstream of the mammal.
摘要翻译：本发明提供了将分泌蛋白递送到哺乳动物的血液中的方法。编码蛋白质的核酸分子被引入到哺乳动物的胃肠道中，核酸分子进入肠上皮细胞，其中蛋白质被产生并分泌到哺乳动物的血液中。

30. 发明授权

US06255289B1 Gene delivery by secretory gland expression 失效
标题翻译：基因递送通过分泌腺表达
公开(公告)号：US06255289B1
公开(公告)日：2001-07-03
申请号：US09130886
申请日：1998-08-07
申请人： Michael German , Ira D. Goldfine , Stephen S. Rothman
发明人： Michael German , Ira D. Goldfine , Stephen S. Rothman
IPC分类号： A61K4800
CPC分类号： A61K38/37 , A61K38/1709 , A61K38/1816 , A61K38/27 , A61K38/28 , A61K48/00
摘要： Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein. The transformed secretory gland cells provide long term therapeutic cures for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.
摘要翻译：分泌腺细胞，特别是胰腺和唾液腺细胞被遗传改变以可操作地掺入表达对哺乳动物受试者具有期望的治疗作用的蛋白质的基因。表达的蛋白质直接分泌到胃肠道和/或血液中以获得蛋白质的治疗血液水平，从而治疗需要蛋白质的患者。转化的分泌腺细胞为与特定蛋白质缺乏相关的疾病提供长期治疗性治疗，或者适于通过蛋白质的过表达进行治疗。

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