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21. 发明申请

US20100249946A1 TRANSCUTANEOUSLY ADJUSTABLE FLUID-FILLED IMPLANTS 审中-公开
标题翻译：经过可调节的流体填充的植入物
公开(公告)号：US20100249946A1
公开(公告)日：2010-09-30
申请号：US12412830
申请日：2009-03-27
申请人： Michael D. Lesh , Stewart Kume , Randy J. Kesten , Geoffrey Willis , Leo Centeno , Jeff Christian
发明人： Michael D. Lesh , Stewart Kume , Randy J. Kesten , Geoffrey Willis , Leo Centeno , Jeff Christian
IPC分类号： A61F2/02
CPC分类号： A61F2/0059 , A61F2250/0003
摘要： Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having a self-sealing membrane operably attached to a wall of the implant. The self-sealing membrane provides access for filling the device, and includes a first layer comprising a fabric. The fabric has a first plurality of yarn strands positioned in a first direction, and a second plurality of yarn strands positioned in a second direction. The first and second plurality of yarn strands intersect to form a matrix pattern with cells defined by free spaces between yarn strands. The membrane also includes a first elastomeric material configured to fill the cells as well as form a coating over the first and second plurality of yarn strand, and a second layer comprising a second elastomeric material. The second elastomeric material has a lower durometer than the first elastomeric material. Kits and systems are also disclosed.
摘要翻译：公开了可植入组织增强装置，方法和相关联的工具。所述装置包括可充气体，其具有可操作地附接到所述植入物的壁的自密封膜。自密封膜提供用于填充装置的通路，并且包括包括织物的第一层。织物具有沿第一方向定位的第一多根纱线和位于第二方向上的第二多根纱线。第一和第二多根纱线相交以形成具有由纱线之间的自由空间限定的细胞的矩阵图案。膜还包括构造成填充细胞并且在第一和第二多根纱线上形成涂层的第一弹性体材料，以及包含第二弹性体材料的第二层。第二弹性体材料具有比第一弹性体材料低的硬度。还披露了套件和系统。

22. 发明授权

US07799011B2 Catheter system and method for delivery of therapeutic compounds to cardiac tissue 失效
标题翻译：导管系统和将治疗化合物递送至心脏组织的方法
公开(公告)号：US07799011B2
公开(公告)日：2010-09-21
申请号：US11809022
申请日：2007-05-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61M31/00
CPC分类号： A61M25/0136 , A61B17/22 , A61B2017/00243 , A61B2017/22082 , A61B2017/3488 , A61B2018/00273 , A61B2018/00815 , A61B2018/1425 , A61B2018/1435 , A61B2090/3784 , A61M25/0084 , A61M25/0133 , A61M25/0147 , A61N7/02
摘要： This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.
摘要翻译：这是用于将对比流体治疗或引入组织，特别是心脏组织的方法和装置。所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除。这允许所选择的治疗或造影剂被限制在特定部位。导管还可以包括可视化组件，其包括在身体的远端处的换能器。

23. 发明授权

US07731681B2 Catheter positioning system 有权
标题翻译：导管定位系统
公开(公告)号：US07731681B2
公开(公告)日：2010-06-08
申请号：US10805738
申请日：2004-03-22
申请人： Alan K. Schaer , Michael D. Lesh
发明人： Alan K. Schaer , Michael D. Lesh
IPC分类号： A61M35/00
CPC分类号： A61M25/0668 , A61B17/22012 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2017/22038 , A61B2018/00214 , A61B2018/00285 , A61B2018/00577 , A61B2018/00839 , A61M2210/125 , A61N7/02 , C08L2201/12
摘要： The present invention relates to a system adapted to position a medical device, such as an ablation catheter, at a location where a pulmonary vein extends from an atrium. The system optimally includes a deflectable catheter and a sheath. An ablation member is disclosed for use with the positioning system, wherein the deflectable catheter and the sheath cooperate so as to facilitate positioning of the ablation member at the location.
摘要翻译：本发明涉及一种适于将医疗装置（例如消融导管）定位在肺静脉从心房延伸的位置处的系统。该系统最佳地包括可偏转导管和护套。公开了一种与定位系统一起使用的消融构件，其中可偏转导管和护套配合，以便于消融构件在该位置的定位。

24. 发明申请

US20080275569A1 Tissue Augmentation Device 审中-公开
标题翻译：组织增强装置
公开(公告)号：US20080275569A1
公开(公告)日：2008-11-06
申请号：US11575493
申请日：2005-09-15
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61F2/10 , A61B17/3209 , A61M29/02
CPC分类号： A61B17/3468 , A61B90/02 , A61B2017/00539 , A61B2017/00747 , A61B2017/00792 , A61F2/0036 , A61F2/0059 , A61F2/12 , A61F2250/0003
摘要： A medical device and methods for filling tissue are disclosed. The device has a first configuration for delivery into tissue to be filled and a second configuration in which the device either expands, or is forced to expand within the tissue to be filled. The exterior profile of the expanded device may be customized along its length, to achieve a desired result. The device is adapted to be placed in the skin, and may be used to reduce facial wrinkles or augment facial features such as the lips.
摘要翻译：公开了用于填充组织的医疗装置和方法。该装置具有用于输送到待填充的组织中的第一构造和第二构造，其中该装置在待填充的组织内膨胀或被迫膨胀。扩展装置的外部轮廓可以沿其长度被定制，以实现期望的结果。该装置适于放置在皮肤中，并且可用于减少面部皱纹或增加诸如嘴唇的面部特征。

25. 发明授权

US07340307B2 Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall 有权
标题翻译：组织消融装置组装和将肺静脉口与电壁隔离的方法
公开(公告)号：US07340307B2
公开(公告)日：2008-03-04
申请号：US10996523
申请日：2004-11-24
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B18/18
CPC分类号： A61N7/02 , A61B18/00 , A61B18/08 , A61B18/1492 , A61B2017/00243 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.
摘要翻译：本发明涉及组织消融系统和方法，其通过在肺静脉从心房延伸的位置烧蚀组织的周边区域来治疗心律失常。该系统包括具有消融元件的圆周消融构件，并且还包括用于将消融构件输送到该位置的输送组件。圆周消融部件通常在不同构型之间是可调节的，以允许通过输送护套输送到心房中，以及消融元件与组织的圆周区域之间的消融耦合。

26. 发明授权

US07089063B2 Deflectable tip catheter with guidewire tracking mechanism 有权
公开(公告)号：US07089063B2
公开(公告)日：2006-08-08
申请号：US09858523
申请日：2001-05-16
申请人： Michael D. Lesh , Michael R. Ross , James C Peakcock, III , Kevin J. Taylor
发明人： Michael D. Lesh , Michael R. Ross , James C Peakcock, III , Kevin J. Taylor
IPC分类号： A61F2/00
CPC分类号： A61B17/2202 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2018/00083 , A61B2018/00095 , A61B2018/00214 , A61B2018/00238 , A61B2018/00285 , A61B2018/00375 , A61B2018/00898 , A61M25/0108 , A61N7/02
摘要： A deflectable tip catheter that is used in combination with a guidewire for delivery of an ablation element to target areas of a patient's vasculature. The deflectable tip catheter has a handle portion, an elongated shaft and a deflectable tip portion. A guidewire lumen extends through the elongated shaft and deflectable tip portion. A guidewire passes through the guidewire lumen and exits from a port in the distal end of the deflectable tip portion. The deflectable tip of the catheter is deflected by manipulation of the handle portion to direct the advancement of the guidewire as the guidewire is advanced out of the distal port. By using the deflectable tip portion to direct the advancement of the guidewire, the physician's ability to navigate sharp angles is greatly improved. The deflectable tip catheter is particularly suitable for delivering an ablation element to a pulmonary vein or pulmonary vein branch for performing circumferential ultrasound vein ablation to treat atrial fibrillation.

27. 发明授权

US07044135B2 Device and method for forming a circumferential conduction block in a pulmonary vein 有权
公开(公告)号：US07044135B2
公开(公告)日：2006-05-16
申请号：US10233157
申请日：2002-08-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B19/00
CPC分类号： A61B18/10 , A61B18/08 , A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00369 , A61B2018/00375 , A61B2018/00577 , A61B2018/00642 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/1407 , A61B2218/002 , A61M25/1002 , A61M2025/1075 , A61M2210/125 , A61N7/022
摘要： This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.

28. 发明授权

US06964660B2 Tissue ablation device assembly and method of electrically isolating a pulmonary vein ostium from an atrial wall 有权
标题翻译：组织消融装置组装及将肺静脉口与电壁隔离的方法
公开(公告)号：US06964660B2
公开(公告)日：2005-11-15
申请号：US10274742
申请日：2002-10-21
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B17/00 , A61B18/00 , A61B18/08 , A61B18/14 , A61F2/958 , A61N7/02 , A61B18/18
CPC分类号： A61N7/02 , A61B18/00 , A61B18/08 , A61B18/1492 , A61B2017/00243 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.
摘要翻译：本发明涉及组织消融系统和方法，其通过在肺静脉从心房延伸的位置烧蚀组织的周边区域来治疗心律失常。该系统包括具有消融元件的圆周消融构件，并且还包括用于将消融构件输送到该位置的输送组件。圆周消融部件通常在不同构型之间是可调节的，以允许通过输送护套输送到心房中，以及消融元件与组织的圆周区域之间的消融耦合。

29. 发明授权

US06955173B2 Device and method for forming a circumferential conduction block in a pulmonary vein 有权
标题翻译：在肺静脉中形成圆周传导阻滞的装置和方法
公开(公告)号：US06955173B2
公开(公告)日：2005-10-18
申请号：US10233158
申请日：2002-08-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B17/00 , A61B17/22 , A61B18/08 , A61B18/14 , A61F2/958 , A61N7/02 , A61B19/00 , A61B18/18 , A61F7/12
CPC分类号： A61B18/10 , A61B18/08 , A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00369 , A61B2018/00375 , A61B2018/00577 , A61B2018/00642 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/1407 , A61B2218/002 , A61M25/1002 , A61M2025/1075 , A61M2210/125 , A61N7/022
摘要： This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.
摘要翻译：本发明是一种通过沿着肺静脉壁的肺组织周向路径形成圆周传导阻滞来诊断患有心律失常的患者的方法，所述肺静脉壁围绕肺静脉管腔并横切肺静脉的导电性，从而导致阻塞沿着静脉壁的纵向轴线并进入左心房壁。执行该方法以通过消融焦点来源或通过用圆周传导阻滞来将心源起点与心房壁一起沿着肺静脉壁治疗具有局灶性原发性起源的患者。圆周传导阻滞也形成在肺静脉中以便桥接两个线性损伤的相邻端，其中每个线性病变形成为在较小侵入性“迷宫”型的肺静脉和另一相邻的肺静脉之间延伸程序。在经皮腔内导管技术中使用周缘消融装置组件中的圆周消融元件，以便在肺静脉壁中形成圆周传导阻滞。

30. 发明授权

US06652515B1 Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall 有权
公开(公告)号：US06652515B1
公开(公告)日：2003-11-25
申请号：US09435281
申请日：1999-11-05
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B1818
CPC分类号： A61N7/02 , A61B18/00 , A61B18/08 , A61B18/1492 , A61B2017/00243 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.

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