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21. 发明申请

US20070178501A1 System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology 审中-公开
标题翻译：根据标准化本体将基因型，表型和医学信息整合并验证成数据库的系统和方法
公开(公告)号：US20070178501A1
公开(公告)日：2007-08-02
申请号：US11634550
申请日：2006-12-06
申请人： Matthew Rabinowitz , Jonathan Sheena , Zachary Demko , Christopher Clark , Nigam Shah
发明人： Matthew Rabinowitz , Jonathan Sheena , Zachary Demko , Christopher Clark , Nigam Shah
IPC分类号： C12Q1/68 , G06F19/00 , G06Q50/00
CPC分类号： G06Q50/22 , G06Q50/24
摘要： The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.
摘要翻译：本文描述的系统使临床医师和研究人员能够使用来自临床试验和医疗记录的综合遗传和表型数据，为每位患者做出最安全，最有效的治疗决定。这涉及（i）为遗传，表型，临床，药代动力学，药效学和其他数据集创建标准化本体，（ii）创建翻译引擎以将异构数据集合集成到使用标准化本体的数据库中，以及（ iii）开发统计方法，使用综合数据进行数据验证和结果预测。该系统旨在与医院和实验室中的患者电子病历（EMR）进行接口，以提取特定患者的相关数据。该系统也可用于产生表型预测和增强的用于治疗临床医师的医学实验室报告。该系统也可以在利用在医疗和药物临床试验中创造的大量数据的背景下使用。本体和验证规则被设计为灵活的，以容纳不同的客户端集合。该系统还被设计为灵活的，以便它可以改变以适应科学进步并保持最佳配置。

22. 发明申请

US20110033862A1 METHODS FOR CELL GENOTYPING 审中-公开
标题翻译：细胞基因分析方法
公开(公告)号：US20110033862A1
公开(公告)日：2011-02-10
申请号：US12918445
申请日：2009-02-19
申请人： Matthew Rabinowitz , David S. Johnson , Johan Baner , Zachary Demko , Cengiz Cinnioglu
发明人： Matthew Rabinowitz , David S. Johnson , Johan Baner , Zachary Demko , Cengiz Cinnioglu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a cell, increasing the accuracy with which key alleles are measured in the context of a whole genome amplification. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, allowing the reconstruction of the cells haplotype. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, and the distribution of the various alleles in the different fractions may be used to determine the ploidy state of one or a plurality of chromosomes in the cell.
摘要翻译：本文公开了细胞基因分型的方法。用于确定有限数量的遗传数据可用的一个或少数细胞或来自片段DNA的基因组数据的方法可包括向细胞的全基因组扩增添加一种或多种靶向引物，增加细胞的准确度在全基因组扩增的情况下测量关键等位基因。来自单个细胞的遗传物质可以被分成各自的部分，每一个可以分开进行基因分型，允许重建细胞单元型。来自单个细胞的遗传物质可以分成各自的部分，每个可以分别进行基因分型，并且可以使用不同级分中各种等位基因的分布来确定细胞中一条或多条染色体的倍性状态。

23. 发明申请

US20110092763A1 Methods for Embryo Characterization and Comparison 审中-公开
标题翻译：胚胎表征与比较方法
公开(公告)号：US20110092763A1
公开(公告)日：2011-04-21
申请号：US12994260
申请日：2009-05-27
申请人： Matthew Rabinowitz , David S. Johnson , Nigam Shah , George Gemelos
发明人： Matthew Rabinowitz , David S. Johnson , Nigam Shah , George Gemelos
IPC分类号： A61B17/435 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed herein are methods for determining which embryos from a group of embryos are most likely to implant and develop as desired. In an embodiment of the present disclosure, one or more cells are biopsied from each of the embryos, and the genetic condition of those cells are determined. Within a group of embryos that each test positive for aneuploidy, the likelihood that each embryo contains euploid cells may be determined from the type of aneuploidy observed in the biopsied cells. This knowledge may be used to make a decision as to which embryos to transfer to a uterus. In an embodiment of the present disclosure, these determinations are made for the purpose of embryo selection in the context of in vitro fertilization.
摘要翻译：本文公开了用于根据需要确定来自一组胚胎最可能植入和发育的胚胎的方法。在本公开的一个实施方案中，从每个胚胎活检一个或多个细胞，并确定那些细胞的遗传条件。在一组胚胎中，每个胚胎均检测到非整倍体阳性，每个胚胎含有整倍体细胞的可能性可以从活检细胞中观察到的非整倍体类型确定。这些知识可能用于决定哪些胚胎转移到子宫。在本公开的一个实施方案中，这些确定是为了在体外受精的背景下进行胚胎选择的目的。

24. 发明授权

US06839024B2 Position determination using portable pseudo-television broadcast transmitters 有权
标题翻译：使用便携式伪电视广播发射机进行位置确定
公开(公告)号：US06839024B2
公开(公告)日：2005-01-04
申请号：US10356698
申请日：2003-01-31
申请人： James J. Spilker, Jr. , Matthew Rabinowitz
发明人： James J. Spilker, Jr. , Matthew Rabinowitz
IPC分类号： G01S1/00 , G01S5/00 , G01S5/02 , G01S5/14 , G01S19/46 , H04N7/24 , G01S1/08
CPC分类号： H04N21/25841 , A63F2300/205 , G01S5/0036 , G01S5/0054 , G01S5/0081 , G01S5/02 , G01S5/0205 , G01S5/021 , G01S5/0215 , G01S5/0221 , G01S5/0226 , G01S5/0236 , G01S5/145 , G01S19/46 , H04N21/235 , H04N21/2662 , H04N21/2668 , H04N21/41422 , H04N21/435 , H04N21/615 , H04N21/8126
摘要： An apparatus, method, and computer-readable media comprise a receiver adapted to receive a plurality of broadcast signals; a signal processor adapted to determine a position based on the received plurality of broadcast signals; a signal generator adapted to generate a ranging signal comprising a known component of a television signal; and a transmitter adapted to broadcast a signal comprising the ranging signal and a position signal comprising a description of the position.
摘要翻译：一种装置，方法和计算机可读介质包括适于接收多个广播信号的接收机; 信号处理器，其适于基于所接收的多个广播信号来确定位置; 信号发生器，适于生成包括电视信号的已知分量的测距信号; 以及发射机，其适于广播包括所述测距信号的信号和包括所述位置的描述的位置信号。

25. 发明授权

US06351740B1 Method and system for training dynamic nonlinear adaptive filters which have embedded memory 失效
标题翻译：用于训练具有嵌入式存储器的动态非线性自适应滤波器的方法和系统
公开(公告)号：US06351740B1
公开(公告)日：2002-02-26
申请号：US09201927
申请日：1998-12-01
申请人： Matthew Rabinowitz
发明人： Matthew Rabinowitz
IPC分类号： G06F1518
CPC分类号： G06N99/005 , H03H21/0016 , H03H2222/04
摘要： Described herein is a method and system for training nonlinear adaptive filters (or neural networks) which have embedded memory. Such memory can arise in a multi-layer finite impulse response (FIR) architecture, or an infinite impulse response (IIR) architecture. We focus on filter architectures with separate linear dynamic components and static nonlinear components. Such filters can be structured so as to restrict their degrees of computational freedom based on a priori knowledge about the dynamic operation to be emulated. The method is detailed for an FIR architecture which consists of linear FIR filters together with nonlinear generalized single layer subnets. For the IIR case, we extend the methodology to a general nonlinear architecture which uses feedback. For these dynamic architectures, we describe how one can apply optimization techniques which make updates closer to the Newton direction than those of a steepest descent method, such as backpropagation. We detail a novel adaptive modified Gauss-Newton optimization technique, which uses an adaptive learning rate to determine both the magnitude and direction of update steps. For a wide range of adaptive filtering applications, the new training algorithm converges faster and to a smaller value of cost than both steepest-descent methods such as backpropagation-through-time, and standard quasi-Newton methods. We apply the algorithm to modeling the inverse of a nonlinear dynamic tracking system 5, as well as a nonlinear amplifier 6.
摘要翻译：这里描述了一种用于训练具有嵌入式存储器的非线性自适应滤波器（或神经网络）的方法和系统。这种存储器可以出现在多层有限脉冲响应（FIR）架构或无限脉冲响应（IIR）架构中。我们专注于具有单独的线性动态组件和静态非线性组件的滤波器架构。这样的滤波器可以被构造成基于关于待仿真的动态操作的先验知识来限制它们的计算自由度。该方法对于由线性FIR滤波器和非线性广义单层子网组成的FIR架构是详细的。对于IIR案例，我们将方法扩展到使用反馈的一般非线性架构。对于这些动态架构，我们描述了如何应用优化技术，使更新更接近牛顿方向，而不是最速下降方法，如反向传播。我们详细介绍了一种新颖的自适应修正高斯牛顿优化技术，它利用自适应学习速率来确定更新步长的幅度和方向。对于广泛的自适应滤波应用，新的训练算法比最快下降方法（如反向传播通过时间和标准准牛顿法）收敛速度更快，成本更低。我们应用算法建模非线性动态跟踪系统5的逆，以及非线性放大器6。

26. 发明授权

US08102317B2 Location identification using broadcast wireless signal signatures 有权
标题翻译：使用广播无线信号签名的位置识别
公开(公告)号：US08102317B2
公开(公告)日：2012-01-24
申请号：US11284800
申请日：2005-11-22
申请人： Andy Lee , James J. Spilker, Jr. , Matthew Rabinowitz , Jimmy K. Omura
发明人： Andy Lee , James J. Spilker, Jr. , Matthew Rabinowitz , Jimmy K. Omura
IPC分类号： G01S3/02
CPC分类号： G01S5/0252 , H04H60/51 , H04W64/00
摘要： An apparatus comprises a receiver to receive a plurality of wireless television signals each representing a television channel, and a measurement circuit to identify the television channels based on the wireless television signals. One or more of a plurality of possible locations of the apparatus are selected based on identities of the television channels identified by the measurement circuit and a plurality of associations each associating one of the possible locations with identities of the television channels expected at one of the possible locations.
摘要翻译：一种装置包括接收多个代表电视频道的无线电视信号的接收机，以及基于无线电视信号识别电视频道的测量电路。基于由测量电路识别的电视频道的身份，选择多个可能的位置中的一个或多个，每个关联可以将可能位置中的一个与预期的电视频道中的一个相关联，位置。

27. 发明申请

US20110263269A1 Time, Frequency, And Location Determination For Femtocells 失效
标题翻译：毫微微小区的时间，频率和位置确定
公开(公告)号：US20110263269A1
公开(公告)日：2011-10-27
申请号：US12741346
申请日：2009-06-02
申请人： Ju-Yong Do , Guttorm Opshaug , James J. ER , Matthew Rabinowitz
发明人： Ju-Yong Do , Guttorm Opshaug , James J. ER , Matthew Rabinowitz
IPC分类号： H04W24/00
CPC分类号： H04W64/00 , H04W64/003 , H04W84/045
摘要： Apparatus having corresponding methods and tangible computer-readable media comprise: a measurement module adapted to generate measurements of a wireless television signal received by the apparatus and measurements of a wireless satellite positioning signal received by the apparatus; a location module adapted to determine a location of the apparatus based on the measurements of the wireless television signal and the measurements of the wireless satellite positioning signal; and a time module adapted to provide a clock control signal for the apparatus based on at least one of the measurements of the wireless television signal, and the measurements of the wireless satellite positioning signal.
摘要翻译：具有相应方法和有形计算机可读介质的装置包括：测量模块，其适于产生由所述装置接收的无线电视信号的测量值和由所述装置接收的无线卫星定位信号的测量值; 位置模块，其适于基于所述无线电视信号的测量结果和所述无线卫星定位信号的测量来确定所述设备的位置; 以及时间模块，其适于基于所述无线电视信号的所述测量中的至少一个以及所述无线卫星定位信号的测量来为所述装置提供时钟控制信号。

28. 发明授权

US07792156B1 ATSC transmitter identifier signaling 有权
标题翻译： ATSC发射机标识符信令
公开(公告)号：US07792156B1
公开(公告)日：2010-09-07
申请号：US12351841
申请日：2009-01-11
申请人： Andy Lee , James J. Spilker, Jr. , Matthew Rabinowitz
发明人： Andy Lee , James J. Spilker, Jr. , Matthew Rabinowitz
IPC分类号： H04J3/06
CPC分类号： H04J13/105 , H04H60/50 , H04H60/52 , H04J13/0029 , H04J13/0048
摘要： Apparatus having corresponding computer programs comprise: a code generator adapted to generate a transmitter identification block, wherein the transmitter identification block comprises 32 rows and 82 columns, wherein the first 66 symbols in each of the rows comprises a cyclically-extended 63-chip pseudonoise code that is selectively polarity-inverted according to a respective phase of a 32-chip Walsh code, and wherein each of the last 16 columns comprises a parity-extended 31-chip Gold code that is selectively polarity-inverted according to a respective phase of a 16-chip Walsh code; and a code inserter adapted to insert each of the rows into the reserved block of a respective one of 32 consecutive field synchronization segments in an Advanced Television Systems Committee (ATSC) television signal prior to transmission of the ATSC television signal.
摘要翻译：具有对应的计算机程序的装置包括：适于产生发射机识别块的码发生器，其中发射机标识块包括32行和82列，其中每行中的前66个符号包括循环扩展的63码片伪噪声码其根据32芯片沃尔什码的相应的相位被选择性地极性反转，并且其中最后16列中的每一列包括奇偶校验扩展的31芯片Gold码，其根据相应的相位被选择性地极性反转 16芯片沃尔什码; 以及代码插入器，其适于在传输ATSC电视信号之前将每个行插入高级电视系统委员会（ATSC）电视信号中的32个连续的场同步段中的相应一个的保留块。

29. 发明授权

US07692587B2 Rapid acquisition and correlation of synchronization codes for mobile devices with limited memory and computational power 失效
标题翻译：有限的存储器和计算能力的移动设备的同步码的快速采集和相关性
公开(公告)号：US07692587B2
公开(公告)日：2010-04-06
申请号：US10946070
申请日：2004-09-22
申请人： Matthew Rabinowitz , Michael J. Sabin , Jimmy K. Omura
发明人： Matthew Rabinowitz , Michael J. Sabin , Jimmy K. Omura
IPC分类号： G01S3/02
CPC分类号： H04H60/51 , G01S5/0221 , G01S5/14 , G01S5/145 , G01S19/09 , G01S19/31 , G01S19/46 , H04N5/211 , H04N5/4401 , H04N5/4446 , H04N5/455 , H04N21/25841 , H04N21/41407 , H04N21/435 , H04N21/4382 , H04N21/6112 , H04N21/6181 , H04N21/654 , H04N21/658
摘要： The present invention provides a method, system, and apparatus for rapidly acquiring and correlating synchronization codes for a mobile receiver used for position determination purposes. The receiver uses a processing unit to perform the correlation functions. The processing unit first computes, for each segment interval of the received signal, the phase offset of that interval. Each interval is appropriately adjusted to account for the computed phase offset. The processing unit then accumulates the phase-adjusted segment intervals, and may down-convert the accumulated signal to a baseband format from an intermediate frequency. The processing unit then correlates the accumulated signal with a reference signal to produce a correlation peak, from which the time delay of a synchronization code within the interval can be calculated. Ultimately, the receiver's position can be determined based on the calculated time delay.
摘要翻译：本发明提供一种用于快速获取和关联用于位置确定目的的移动接收机的同步码的方法，系统和装置。接收机使用处理单元执行相关功能。对于接收信号的每个段间隔，处理单元首先计算该间隔的相位偏移。适当调整每个间隔以计算相位偏移。处理单元然后累积相位调整的段间隔，并且可以将累积信号从中频降频转换为基带格式。然后，处理单元将累加的信号与参考信号相关联，以产生相关峰值，从而可以计算间隔内的同步码的时间延迟。最终，接收机的位置可以基于计算的时间延迟来确定。

30. 发明授权

US07372405B2 Position location using digital video broadcast television signals 有权
标题翻译：使用数字视频广播电视信号定位
公开(公告)号：US07372405B2
公开(公告)日：2008-05-13
申请号：US11532736
申请日：2006-09-18
申请人： Matthew Rabinowitz , James J. Spilker, Jr.
发明人： Matthew Rabinowitz , James J. Spilker, Jr.
IPC分类号： G01S3/02
CPC分类号： G01S5/0205 , A63F2300/205 , G01C21/206 , G01S5/0036 , G01S5/0054 , G01S5/0081 , G01S5/02 , G01S5/021 , G01S5/0215 , G01S5/145 , G01S19/46 , H04N21/25841 , H04N21/2662 , H04N21/2668 , H04N21/41422 , H04N21/615 , H04N21/8126
摘要： Apparatus to determine the position of a user terminal, the apparatus having corresponding methods and computer-readable media, comprises a receiver to receive, at the user terminal, a wireless orthogonal frequency-division multiplexing (OFDM) signal comprising a scattered pilot signal; and a processor to determine a pseudo-range based on the scattered pilot signal; wherein a position of the user terminal is determined based on the pseudo-range and a location of a transmitter of the OFDM signal.
摘要翻译：用于确定用户终端的位置的装置，具有相应方法的装置和计算机可读介质的装置包括：接收机，用于在用户终端处接收包括分散导频信号的无线正交频分复用（OFDM）信号; 以及处理器，用于基于所述分散导频信号来确定伪距离; 其中，基于OFDM信号的发射机的伪距和位置来确定用户终端的位置。

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