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21. 发明授权

US08045176B2 Methods for mapping tissue with optical coherence tomography data 有权
标题翻译：用光学相干断层扫描数据绘制组织的方法
公开(公告)号：US08045176B2
公开(公告)日：2011-10-25
申请号：US12822054
申请日：2010-06-23
申请人： Matthew J. Everett , Paul F. Stetson , Scott A. Meyer , Shahram Shawn Dastmalchi
发明人： Matthew J. Everett , Paul F. Stetson , Scott A. Meyer , Shahram Shawn Dastmalchi
IPC分类号： G01B11/02 , G06K9/00
CPC分类号： A61B3/10 , A61B3/00 , A61B3/102 , A61B5/0059 , A61B5/0066 , G01B9/02048 , G01B9/02089 , G01B9/02091 , G01N21/4795 , G06F19/00
摘要： Various methods are disclosed for mapping optical coherence tomography (OCT) data to facilitate review and diagnosis. In one aspect, high resolution 2D line scans are obtained along with lower density 3D cube scans and displayed in a manner to provide context to the clinician. In another aspect, OCT data is analyzed to provide information about non-uniformities of the tissue. Binary image maps of maps useful for determining tautness of membranes are also disclosed.
摘要翻译：公开了各种用于映射光学相干断层扫描（OCT）数据的方法以便于检查和诊断。在一个方面，获得高分辨率2D线扫描以及较低密度的3D立方体扫描，并以向临床医生提供上下文的方式显示。在另一方面，分析OCT数据以提供关于组织的非均匀性的信息。还公开了可用于确定膜紧张度的地图的二进制图像映射。

22. 发明授权

US07433046B2 Patterned spinning disk based optical phase shifter for spectral domain optical coherence tomography 失效
标题翻译：用于光谱相干层析成像的基于旋转圆盘的光学移相器
公开(公告)号：US07433046B2
公开(公告)日：2008-10-07
申请号：US10933795
申请日：2004-09-03
申请人： Matthew J. Everett , Scott A. Meyer , Yan Zhou
发明人： Matthew J. Everett , Scott A. Meyer , Yan Zhou
IPC分类号： G01B9/02
CPC分类号： A61B3/102 , A61B3/1005 , G01B9/02012 , G01B9/02044 , G01B9/02049 , G01B9/02069 , G01B9/02091 , G01B2290/35
摘要： A low cost patterned spinning disk is disclosed for achieving relatively rapid discrete optical phase shifts for an optical beam. The invention is particularly useful in a spectral domain optical coherence tomography system. The disk contains stepped patterns of different heights and/or refractive index distribution such that as it spins, an optical beam passing through or being reflected by the disk will experience different discrete optical phase delays. The disk can be operated as a phase shifter or it can be operated in synchronization with an intensity modulating chopper disk or a direct intensity modulation of the light source. The disk can also contain intensity modulating patterns such that both phase shifting and intensity modulation can be achieved at the same time. Various possible methods are also disclosed for the fabrication of the disk.
摘要翻译：公开了一种低成本图案旋转盘，用于实现光束的相对快速的离散光学相移。本发明在频域光学相干断层摄影系统中特别有用。盘包含不同高度和/或折射率分布的阶梯图案，使得当其旋转时，通过或被盘反射的光束将经历不同的离散光学相位延迟。磁盘可以作为移相器来操作，或者可以与强度调制斩波盘同步操作，也可以与光源进行直接强度调制。磁盘还可以包含强度调制模式，使得可以同时实现相移和强度调制。还公开了用于制造盘的各种可能的方法。

23. 发明授权

US07508525B2 High efficiency balanced detection interferometer 失效
标题翻译：高效平衡检测干涉仪
公开(公告)号：US07508525B2
公开(公告)日：2009-03-24
申请号：US12150375
申请日：2008-04-28
申请人： Yan Zhou , Matthew J. Everett , Martin Hacker
发明人： Yan Zhou , Matthew J. Everett , Martin Hacker
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02091 , G01B2290/40
摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In one set of embodiments, a pair of cascaded 2×2 couplers is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.
摘要翻译：公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。在一组实施例中，使用一对级联的2x2耦合器来沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

24. 发明授权

US08085408B2 Spectral domain optical coherence tomography system 有权
标题翻译：光谱光学相干断层扫描系统
公开(公告)号：US08085408B2
公开(公告)日：2011-12-27
申请号：US12842935
申请日：2010-07-23
申请人： Matthew J. Everett , Martin Hacker
发明人： Matthew J. Everett , Martin Hacker
IPC分类号： G01B11/02
CPC分类号： G01B9/02077 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02091 , G01B2290/65 , G01B2290/70 , G01N21/4795
摘要： An optical coherence tomography device is disclosed for improved imaging. Reduced levels of speckle in the images generated by the device are obtained by forming a B-scan from a plurality of A-scans, wherein each resolution cell of the B-scan is generated through compounding of a subset of the A-scans and wherein at least some of the subset of A-scans are separated by at least half the diameter of a speckle cell both tangent to and orthogonal to the B-scan at that cell.
摘要翻译：公开了一种用于改进成像的光学相干断层摄影装置。通过从多个A扫描形成B扫描获得由装置产生的图像中的散斑水平的降低，其中B扫描的每个分辨率单元通过A扫描的子集的复合而产生，其中 A扫描的子集中的至少一部分与在该细胞上与B扫描相切且与其正交的斑点细胞的直径的至少一半分开。

25. 发明授权

US07388672B2 High efficiency balanced detection interferometer 有权
标题翻译：高效平衡检测干涉仪
公开(公告)号：US07388672B2
公开(公告)日：2008-06-17
申请号：US11264871
申请日：2005-11-02
申请人： Yan Zhou , Matthew J. Everett , Martin Hacker
发明人： Yan Zhou , Matthew J. Everett , Martin Hacker
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B2290/40
摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In a first set of embodiments, a 3×3 coupler is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. In an alternate set of embodiments, a pair of cascaded 2×2 couplers provides a similar function. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.
摘要翻译：公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。在第一组实施例中，使用3x3耦合器沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。在另一组实施例中，一对级联的2x2耦合器提供类似的功能。干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

26. 发明申请

US20080239294A1 High efficiency balanced detection interferometer 失效
标题翻译：高效平衡检测干涉仪
公开(公告)号：US20080239294A1
公开(公告)日：2008-10-02
申请号：US12150375
申请日：2008-04-28
申请人： Yan Zhou , Matthew J. Everett , Martin Hacker
发明人： Yan Zhou , Matthew J. Everett , Martin Hacker
IPC分类号： G01N21/00 , G01B9/02
CPC分类号： G01B9/02091 , G01B2290/40
摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In one set of embodiments, a pair of cascaded 2×2 couplers is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.
摘要翻译：公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。在一组实施例中，使用一对级联的2x2耦合器来沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

27. 发明授权

US09033510B2 Systems and methods for efficiently obtaining measurements of the human eye using tracking 有权
标题翻译：使用跟踪有效获得人眼测量的系统和方法
公开(公告)号：US09033510B2
公开(公告)日：2015-05-19
申请号：US13433127
申请日：2012-03-28
申请人： Harihar Narasimha-Iyer , Matthew J. Everett
发明人： Harihar Narasimha-Iyer , Matthew J. Everett
IPC分类号： A61B3/00 , A61B3/10 , A61B3/14 , A61B5/00 , G06T7/20
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0033 , A61B3/113 , A61B3/12 , A61B3/145 , A61B5/0066 , G06T7/246 , G06T2207/10101 , G06T2207/20081 , G06T2207/30041 , G06T2210/41
摘要： Systems and methods for efficiently obtaining optical coherence tomography (OCT) measurement data with reduced effects of motion are presented. One embodiment involves determining the amount of motion present during the collection of an OCT data set based on images of the eye collected at the same time as the OCT data, and recollecting select portions of the OCT data set when the amount of eye motion is determined to exceed a predetermined threshold. Another embodiment includes enabling or disabling a tracking feature based on the quality of the images available for tracking. Another embodiment includes reducing the effect of motion in the axial direction based on a comparison to a model of the eye constructed from OCT data. The method can also be used to reduce the presence of mirror image artifacts in an OCT image.
摘要翻译：提出了有效获得具有减少的运动影响的光学相干断层扫描（OCT）测量数据的系统和方法。一个实施例涉及基于与OCT数据同时收集的眼睛的图像来确定OCT收集OCT数据集期间的运动量，以及当确定眼睛运动量时，重新收集OCT数据集的选择部分超过预定阈值。另一个实施例包括基于可用于跟踪的图像的质量启用或禁用跟踪特征。另一实施例包括基于与由OCT数据构造的眼睛模型的比较来减小轴向运动的影响。该方法还可用于减少OCT图像中镜像伪影的存在。

28. 发明申请

US20130120757A1 METHODS, SYSTEMS AND APPLICATIONS OF VARIABLE IMAGING DEPTH IN FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：方法，系统和可变成像深度在FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY中的应用
公开(公告)号：US20130120757A1
公开(公告)日：2013-05-16
申请号：US13354066
申请日：2012-01-19
申请人： Lingfeng YU , Matthew J. Everett , Mary K. Durbin , Utkarsh Sharma
发明人： Lingfeng YU , Matthew J. Everett , Mary K. Durbin , Utkarsh Sharma
IPC分类号： A61B3/10 , G01B9/02
CPC分类号： A61B3/102 , G01B9/02004 , G01B9/02069 , G01B9/02091 , G01N21/4795
摘要： Systems, methods and applications for adjusting the imaging depth of a Fourier Domain optical coherence tomography system without impacting the axial resolution of the system are presented. One embodiment of the invention involves changing the sweep rate of a swept-source OCT system while maintaining the same data acquisition rate and spectral bandwidth of the source. Another embodiment involves changing the data acquisition rate of a SS-OCT system while maintaining the same sweep rate over the same spectral bandwidth. Several applications of variable imaging depth in the field of ophthalmic imaging are described.
摘要翻译：提出了一种用于调整傅立叶域光学相干断层扫描系统的成像深度而不影响系统轴向分辨率的系统，方法和应用。本发明的一个实施例涉及改变扫频源OCT系统的扫描速率，同时维持源的相同的数据采集速率和光谱带宽。另一实施例涉及改变SS-OCT系统的数据采集速率，同时在相同的光谱带宽上保持相同的扫描速率。描述了眼科成像领域可变成像深度的几种应用。

29. 发明授权

US07400410B2 Optical coherence tomography for eye-length measurement 有权
标题翻译：光学相干断层扫描用于眼睛测量
公开(公告)号：US07400410B2
公开(公告)日：2008-07-15
申请号：US11243665
申请日：2005-10-05
申请人： Chris Baker , Matthew J. Everett
发明人： Chris Baker , Matthew J. Everett
IPC分类号： G01B11/02 , G01B9/02 , A61B3/14
CPC分类号： A61B3/102 , A61B3/1005 , A61B5/0066
摘要： An accurate measure of eye length can be obtained using concurrent OCT measurements. A position OCT device can be used to continually monitor the position of the front surface of the cornea, while a distance OCT device can determine the apparent distance between the front surface of the cornea and the front surface of the retina. Since the eye is likely to move during the period of time between measurements of the cornea and retina, the monitored position of the cornea can be used to correct the apparent length measurement by the amount of eye movement over that period of time, in order to obtain an accurate measure of eye length. In some embodiments a single OCT device can serve the dual role of monitoring eye position while making eye length measurements.
摘要翻译：使用并行OCT测量可以获得眼睛长度的精确测量。位置OCT装置可以用于连续监视角膜前表面的位置，而距离OCT装置可以确定角膜前表面和视网膜的前表面之间的表观距离。由于眼睛可能在角膜和视网膜的测量之间的时间段期间移动，所以可以使用角膜的监视位置来校正视力长度测量量在该时间段内的眼睛移动量，以便获得眼睛长度的准确度量。在一些实施例中，单个OCT设备可以起到监视眼睛位置的双重作用，同时进行眼睛长度测量。

30. 发明授权

US08801187B1 Methods to reduce variance in OCT analysis of the macula 有权
标题翻译：减少黄斑OCT分析方法的方法
公开(公告)号：US08801187B1
公开(公告)日：2014-08-12
申请号：US13250699
申请日：2011-09-30
申请人： Robert W. Knighton , Matthew J. Everett , Mary K. Durbin , Jonathan D. Oakley
发明人： Robert W. Knighton , Matthew J. Everett , Mary K. Durbin , Jonathan D. Oakley
IPC分类号： A61B3/12 , G06F17/00 , A61B3/10
CPC分类号： A61B3/102 , A61B3/0025 , G06T7/0012 , G06T7/12 , G06T7/162 , G06T7/60 , G06T2207/10101 , G06T2207/30041
摘要： Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations in foveal size are corrected by radial transformation. Variations in layer thickness are corrected by axial shifting. Diagnosis is performed by comparing OCT images from a patient to the improved normative database.
摘要翻译：提出了分析黄斑的光学相干断层扫描（OCT）图像以减少变异并改善疾病诊断的方法。本发明的一个实施例涉及选择分析位置和数据分割技术以利用结构均匀性。另一个实施例旨在通过将数据库的各个成员变换为对应于标准黄疸来减少规范数据集合中的差异。通过径向变换校正中心凹大小的变化。通过轴向移动来校正层厚度的变化。通过比较患者的OCT图像和改进的规范数据库来进行诊断。

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