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21. 发明授权

US5851983A Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology 失效
标题翻译：弹性蛋白酶抑制多肽及其重组基因技术生产方法
公开(公告)号：US5851983A
公开(公告)日：1998-12-22
申请号：US963538
申请日：1992-10-20
申请人： Takashi Sugiyama , Takashi Kamimura , Kenichi Masuda , Masahiro Okada , Eiko Ohtsuka , Atsushi Imaizumi , Kunihito Watanabe , Tetsuya Suga , Yohichi Matsumoto , Akiko Takeuchi
发明人： Takashi Sugiyama , Takashi Kamimura , Kenichi Masuda , Masahiro Okada , Eiko Ohtsuka , Atsushi Imaizumi , Kunihito Watanabe , Tetsuya Suga , Yohichi Matsumoto , Akiko Takeuchi
IPC分类号： A61K38/00 , C07K14/81 , A61K38/16 , C12N15/41
CPC分类号： C07K14/811 , A61K38/00 , C07K2319/50
摘要： The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity wherein inhibitory activity of a trypsin-like serine protease does not exceed 1/10 of elastase inhibitory activity, and polypeptides having the above-mentioned biological activity wherein one or more than one amino acid is added, one or more than one amino acid is deleted and/or one or more than one amino acid is replaced. The present invention also provides a process for the production of the above-mentioned protein or other protein via a corresponding fused protein.
摘要翻译：本发明提供了包含人分泌型白细胞蛋白酶抑制剂（SLPI）的C末端一半并且具有弹性蛋白酶抑制活性的弹性蛋白酶抑制性多肽，其中胰蛋白酶样丝氨酸蛋白酶的抑制活性不超过+ E， + EE的弹性蛋白酶抑制活性，以及具有上述生物活性的多肽，其中加入一个或多于一个氨基酸，一个或多于一个氨基酸被缺失和/或一个或多于一个氨基酸被替换。本发明还提供了通过相应的融合蛋白生产上述蛋白质或其它蛋白质的方法。

22. 发明授权

US5693499A Process for preparing human coagulation factor VIII protein complex 失效
标题翻译：制备人凝血因子VIII蛋白复合物的方法
公开(公告)号：US5693499A
公开(公告)日：1997-12-02
申请号：US276594
申请日：1994-07-18
申请人： Hiroshi Yonemura , Yoshitaka Tajima , Keishin Sugawara , Kenichi Masuda
发明人： Hiroshi Yonemura , Yoshitaka Tajima , Keishin Sugawara , Kenichi Masuda
IPC分类号： A61K38/43 , A61P7/04 , C07K14/435 , C07K14/745 , C07K14/755 , C12N5/10 , C12N9/06 , C12N15/09 , C12N15/12 , C12N15/53 , C12N15/57 , C12N15/85 , C12P21/02 , C12R1/91 , C12N15/63 , C12N15/79
CPC分类号： C12N9/0028 , C07K14/755 , C12N15/85 , C12N2800/108 , C12N2830/42 , C12N2840/20
摘要： A plasmid for expression of human coagulation factor VIII H-chain, a plasmid for expression of human coagulation factor VIII L-chain, an animal cell transformed with either said H-chain expression plasmid or said L-chain expression plasmid or with both thereof, and a process for preparing a human coagulation factor VIII protein complex which comprises forming a transformed animal cell by introducing both said H-chain expression plasmid and said L-chain expression plasmid into said animal cell, culturing said cell to produce the human coagulation factor VIII protein complex in the culture medium and collecting the same. The process of the present invention allows for the production of a safe factor VIII at a high expression level applicable for the production of Factor VIII on an industrial scale.
摘要翻译：用于表达人凝血因子VIIIH链的质粒，用于表达人凝血因子VIIIL链的质粒，用所述H链表达质粒或所述L链表达质粒或其两者转化的动物细胞，以及制备人凝血因子VIII蛋白质复合物的方法，其包括通过将所述H链表达质粒和所述L链表达质粒都引入所述动物细胞中形成转化的动物细胞，培养所述细胞以产生人凝血因子VIII 蛋白复合物在培养基中收集。本发明的方法允许以适用于工业规模生产因子VIII的高表达水平生产安全因子VIII。

23. 发明授权

US5654042A Powder coating system for difficult to handle powders 失效
标题翻译：粉末涂料系统难以处理粉末
公开(公告)号：US5654042A
公开(公告)日：1997-08-05
申请号：US481292
申请日：1995-06-07
申请人： Takashi Watanabe , Kenichi Masuda , Shigeki Kasahara , Masashi Sakurazawa
发明人： Takashi Watanabe , Kenichi Masuda , Shigeki Kasahara , Masashi Sakurazawa
IPC分类号： B05B5/16 , B05B7/14 , B05B15/00 , B05D1/06 , B05C11/10 , B05C13/02
CPC分类号： B05B15/003 , B05B5/1683 , B05B7/1404 , Y10S118/05
摘要： A powder coating system for difficult to handle powders includes a powder hopper containing fluidized powder particles, a pump body connected to the hopper and having an inlet in communication with the hopper, an ejector nozzle mounted to the pump body and aimed at an outlet thereof, a second nozzle mounted to the pump body and aimed at the inlet thereof and a powder application device for receiving powder particles from the outlet of the pump body and spraying them onto an article to be coated. The ejector nozzle sprays pressurized air toward the outlet to transport powder particles along a flow path which extends from the powder hopper into the pump body via the inlet and then out of the pump body via the outlet. The second nozzle sprays air pulses at the inlet in a direction opposite the particle flow along the flow path caused by the ejector nozzle. This spray from the second nozzle creates microvibrations in the inlet of the pump body to eliminate powder particle adherence and cohesion thereat. The pump body may have separate, spaced intake and ejector portions, with the ejector nozzle mounted in the ejection portion and the second nozzle mounted on the intake portion.
摘要翻译： PCT No.PCT / US93 / 12391 Sec。 371日期：1995年6月7日 102（e）日期1995年6月7日PCT提交1993年12月16日PCT公布。出版物WO94 / 13405 日期1994年6月23日粉末涂料系统，其难以处理的粉末包括含有流化粉末颗粒的粉末料斗，与料斗连接并具有与料斗连通的入口的泵体，安装在泵体上的喷射器喷嘴，在其出口处，安装到泵体并针对其入口的第二喷嘴和用于从泵体的出口接收粉末颗粒并将其喷涂到待涂覆的制品上的粉末施加装置。喷射器喷嘴将压缩空气朝向出口喷射，以沿着从粉末料斗经由入口延伸到泵体中的流动路径输送粉末颗粒，然后经由出口离开泵体。第二喷嘴在入口处沿着由喷射器喷嘴引起的流动路径的颗粒流相反的方向喷射空气脉冲。来自第二喷嘴的喷雾在泵体的入口处产生微振动，以消除粉末颗粒的附着力和内聚力。泵体可以具有分离的，间隔开的进气和喷射器部分，喷射器喷嘴安装在喷射部分中，第二喷嘴安装在进气部分上。

24. 发明授权

US5378612A Culture medium for production of recombinant protein 失效
标题翻译：用于生产重组蛋白的培养基
公开(公告)号：US5378612A
公开(公告)日：1995-01-03
申请号：US997670
申请日：1992-12-28
申请人： Kazuyuki Nakashima , Izumi Mimaki , Takayoshi Hamamoto , Kenichi Masuda
发明人： Kazuyuki Nakashima , Izumi Mimaki , Takayoshi Hamamoto , Kenichi Masuda
IPC分类号： C07K14/755 , C12N5/00 , C12N5/02 , C12P21/02
CPC分类号： C07K14/755 , C12N5/0018 , C12P21/02 , C12N2500/12 , C12N2500/36 , C12N2500/50
摘要： A culture medium without or with a low level of protein for culturing a transformed animal cell capable of continuously producing a protein prepared by using a genetic engineering technique, which contains a nonionic surfactant and cyclodextrin, and a method for producing a protein which comprises culturing a transformed animal cell capable of producing the desired protein prepared by using a genetic engineering technique in the culture medium.
摘要翻译：没有或具有低水平蛋白质的培养基，用于培养能够连续生产使用含有非离子表面活性剂和环糊精的基因工程技术制备的蛋白质的转化动物细胞，以及用于生产蛋白质的方法，包括培养能够通过在培养基中使用遗传工程技术制备所需蛋白质的转化动物细胞。

25. 发明授权

US4965350A Pyridopyrimidine nucleotide compounds 失效
标题翻译：吡啶并嘧啶核苷酸化合物
公开(公告)号：US4965350A
公开(公告)日：1990-10-23
申请号：US351317
申请日：1989-05-11
申请人： Hideo Inoue , Eiko Ohtsuka , Akihiro Imura , Kenichi Masuda , Takashi Kamimura
发明人： Hideo Inoue , Eiko Ohtsuka , Akihiro Imura , Kenichi Masuda , Takashi Kamimura
IPC分类号： C07H19/04 , C07H19/10 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H19/10 , C07H21/00
摘要： Pyridopyrimidine nucleotide derivatives expressed by formula (I), which are fluorescent and capable of forming base pairing with guanine or adenine, and oligo- or polynucleotide which have at least one of these derivatives in their molecules or at their molecular terminals: ##STR1## wherein X.sub.1 and X.sub.1 respectively represent ##STR2## (in which n indicates an integer of 0, 1, 2, or 3; however, in no case X.sub.1 and Y.sub.1 both indicate n=O); Z.sub.1 indicates a hydrogen atom or ##STR3## (in which n indicates an integer of 1, 2, or 3); W.sub.1 indicates a hydrogen atom or a hydroxyl group. As for R.sub.1 and R.sub.2, in case where R.sub.1 is an amino group or halogen, R.sub.2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position, and in case where R.sub.2 is a hydrogen atom or an lower alkyl group, R.sub.1 indicates a carbonyl bond ##STR4## formed with the carbon atom at the 7-position.
摘要翻译：荧光并能够与鸟嘌呤或腺嘌呤形成碱基配对的式（I）表示的吡哆嘧啶核苷酸衍生物以及在其分子或其分子末端具有至少一种这些衍生物的寡核苷酸或多核苷酸：（ I）其中X1和X1分别表示（其中n表示0,1,2或3的整数;然而，在任何情况下，X1和Y1均不表示n = O）; Z1表示氢原子或（其中n表示1,2或3的整数）; W1表示氢原子或羟基。对于R 1和R 2，在R 1为氨基或卤素的情况下，R 2表示7位的碳原子和8位的氮原子之间的单键，在R 2为氢原子的情况下或低级烷基，R 1表示与7-位上的碳原子形成的羰基键“IMAGE”。

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