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21. 发明申请

US20090123923A1 Method for obtaining information regarding quantity of DNA after non-methylated cytosine converting treatment in analysis of DNA methylation 审中-公开
标题翻译：在DNA甲基化分析中获得非甲基化胞嘧啶转化处理后的DNA量的方法
公开(公告)号：US20090123923A1
公开(公告)日：2009-05-14
申请号：US11987461
申请日：2007-11-30
申请人： Noriaki Yamamoto , Masahiro Kajita , Takayuki Takahata , Ayako Sakai , Hideki Ishihara
发明人： Noriaki Yamamoto , Masahiro Kajita , Takayuki Takahata , Ayako Sakai , Hideki Ishihara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2523/125 , C12Q2531/113
摘要： The present invention provides an easy and accurate method for obtaining information regarding a quantity of DNA included in a sample used for analyzing a methylation of a target DNA, comprising steps of: treating a biological sample containing DNA including the target DNA with a non-methylated cytosine converting agent for converting non-methylated cytosine of the DNA into another base; and obtaining information regarding a quantity of DNA included in the sample treated in the treating step by using an oligonucleotide complementary to a cytosine-free region of the target DNA.
摘要翻译：本发明提供了一种用于获得关于用于分析靶DNA的甲基化的样品中包含的DNA量的信息的简单且准确的方法，包括以下步骤：用含有非甲基化的DNA包含靶DNA的生物样品用于将DNA的非甲基化胞嘧啶转化成另一种碱基的胞嘧啶转化剂; 并且通过使用与靶DNA的无胞嘧啶区域互补的寡核苷酸获得关于处理步骤中处理的样品中包含的DNA的量的信息。

22. 发明授权

US07358063B2 Method of detecting PS2V 有权
标题翻译：检测PS2V的方法
公开(公告)号：US07358063B2
公开(公告)日：2008-04-15
申请号：US10484152
申请日：2002-07-17
申请人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
发明人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
IPC分类号： G01N33/53 , G01N33/537 , G01N33/542 , G01N1/30 , G01N33/566 , G01N33/567 , G01N33/48
CPC分类号： G01N33/6896
摘要： A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a secondary antibody recognizing PS2 or PS2V by any of the following procedures: (a) reacting with a secondary antibody having been enzyme-labeled and recognizing PS2 or PS2V; (b) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with an avidinylated or streptoavidinylated enzyme; (c) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with a biotinylated enzyme and avidin or streptoavidin; and (d) reacting with a secondary antibody recognizing PS2 or PS2V and then reacting with an antibody having been enzyme-labeled and recognizing the secondary antibody; then adding the substrate of the above enzyme and detecting the product formed by the enzyme reaction.
摘要翻译：一种检测PS2V的方法，其特征在于包括使样品中的PS2V与与固相结合的一抗并特异性识别PA2V，然后通过以下任一方法与识别PS2或PS2V的二抗反应：（a）使二抗被酶标记并识别PS2或PS2V; （b）与已经生物素化并识别PS2或PS2V的第二抗体反应，然后与二脱水或链脲霉素化酶反应; （c）与已经生物素化并识别PS2或PS2V的二级抗体反应，然后与生物素化的酶和抗生物素蛋白或链霉亲和素反应; 和（d）与识别PS2或PS2V的二抗反应，然后与经酶标记的抗体和识别第二抗体反应; 然后加入上述酶的底物并检测通过酶反应形成的产物。

23. 发明授权

US07348477B2 Electronic keyboard musical instrument 失效
标题翻译：电子键盘乐器
公开(公告)号：US07348477B2
公开(公告)日：2008-03-25
申请号：US11241129
申请日：2005-09-29
申请人： Hideki Ishihara , Naohisa Mori
发明人： Hideki Ishihara , Naohisa Mori
IPC分类号： G10C3/02
CPC分类号： G10H1/34 , G10H1/32
摘要： Casing of an electronic keyboard musical instrument includes two discrete parts: a main casing section; and a rear casing section. The main casing section includes a bottom plate having a keyboard section placed thereon, a keyslip portion extending upward from the bottom plate in front of the keyboard section, and left and right side plates extending upward from the bottom plate at left and right sides of the keyboard section. The rear casing section includes a roof plate forming a rear upper surface of the casing, and a back plate extending downward from a rear edge of the roof plate. The rear casing section is detachably attached to the main casing section by means of a slidingly-attaching structure for slidingly attaching the rear casing section to the left and right side plates of the main casing section.
摘要翻译：电子键盘乐器的套管包括两个分立的部件：主壳体部分; 和后壳体部分。主壳体部分包括一个底板，其上有一个键盘部分，从键盘部分前面的底板向上延伸的键盘部分，以及从底板向左和向右延伸的左右侧板键盘部分。后壳体部分包括形成壳体的后上表面的顶板和从顶板的后边缘向下延伸的后板。后壳体部分通过用于将后壳体部分滑动地附接到主壳体部分的左侧和右侧板的滑动结构可拆卸地附接到主壳体部分。

24. 发明申请

US20060292645A1 Method and reagent for measuring kinase activity 审中-公开
标题翻译：测定激酶活性的方法和试剂
公开(公告)号：US20060292645A1
公开(公告)日：2006-12-28
申请号：US11473550
申请日：2006-06-23
申请人： Tomoko Matsushima , Hideki Ishihara
发明人： Tomoko Matsushima , Hideki Ishihara
IPC分类号： G01N33/574
CPC分类号： C12Q1/485 , G01N33/573 , G01N33/57446
摘要： A method of measuring the activity of a kinase to which imatinib mesylate can bind is described. In the method, a kinase contained in a sample, to which imatinib mesylate can bind, a substrate for the kinase, and ATP are mixed. A phosphate group of ATP is thereby transferred to a tyrosine residue of the substrate by the action of the kinase. After a labeled substance capable of binding is bound to the substrate having the phosphate group transferred thereto, a signal emitted by the labeled substance is detected. On the basis of this detection result, the activity of the kinase is calculated.
摘要翻译：描述了测量甲磺酸伊马替尼可以结合的激酶活性的方法。在该方法中，包含在甲磺酸伊马替尼可以结合的样品中的激酶用于激酶的底物和ATP混合。因此ATP的磷酸基团通过激酶的作用转移到底物的酪氨酸残基。在能够结合的标记物质与转移了磷酸基团的底物结合后，检测出被标记物质发出的信号。在该检测结果的基础上，计算激酶的活性。

25. 发明授权

US06972358B2 Electronic keyboard musical instrument 有权
公开(公告)号：US06972358B2
公开(公告)日：2005-12-06
申请号：US11016307
申请日：2004-12-17
申请人： Hideki Ishihara , Naohisa Mori
发明人： Hideki Ishihara , Naohisa Mori
IPC分类号： G10H1/32 , G10C3/02
CPC分类号： G10H1/34 , G10H1/32
摘要： Casing of an electronic keyboard musical instrument includes two discrete parts: a main casing section; and a rear casing section. The main casing section includes a bottom plate having a keyboard section placed thereon, a keyslip portion extending upward from the bottom plate in front of the keyboard section, and left and right side plates extending upward from the bottom plate at left and right sides of the keyboard section. The rear casing section includes a roof plate forming a rear upper surface of the casing, and a back plate extending downward from a rear edge of the roof plate. The rear casing section is detachably attached to the main casing section by means of a slidingly-attaching structure for slidingly attaching the rear casing section to the left and right side plates of the main casing section.

26. 发明申请

US20050245407A1 Fragrance composition 审中-公开
标题翻译：香料组成
公开(公告)号：US20050245407A1
公开(公告)日：2005-11-03
申请号：US10523814
申请日：2003-08-08
申请人： Hideki Ishihara , Hirohisa Fujihara , Yoshihiro Takada , Hiroyuki Terazaki
发明人： Hideki Ishihara , Hirohisa Fujihara , Yoshihiro Takada , Hiroyuki Terazaki
IPC分类号： A61K8/37 , A61Q5/00 , A61Q13/00 , C11D3/50
CPC分类号： A61Q5/02 , A61K8/37 , A61Q13/00
摘要： A combination of a musk with one or more ingredients of specific chemical structures in particular proportions makes it possible to obtain a fragrance composition which can mask an odor peculiar to an acidic hair cosmetic composition and is also excellent in long-term stability. By combining fragrant materials selected as desired from (E) ingredients each characterized primarily by the abundant release of a scent from foam, (F) ingredients each characterized primarily by the abundant release of a scent from a bottle mouth and (G) ingredients each characterized by good persistence of scent, an excellent fragrance composition can be obtained with a good balance among the abundant release of a scent from foam, the abundant release of a scent from a bottle mouth, and good persistence of scent.
摘要翻译：麝香与特定化学结构的一种或多种成分的组合特别的比例使得可以获得能够掩蔽酸性毛发化妆品组合物特有的气味的香味组合物，并且也具有优异的长期稳定性。通过组合（E）成分选择的香料，每种成分的主要特征在于主要是从泡沫中大量释放气味，（F）成分各自主要表现为从瓶口中大量释放气味，（G）每种成分的成分通过良好的香味持久性，可以在泡沫充分释放气味，从瓶口中充分释放气味和良好的气味持久性之间获得良好的平衡。

27. 发明授权

US06888053B2 Electronic keyboard musical instrument 失效
标题翻译：电子键盘乐器
公开(公告)号：US06888053B2
公开(公告)日：2005-05-03
申请号：US10722328
申请日：2003-11-24
申请人： Hideki Ishihara , Naohisa Mori
发明人： Hideki Ishihara , Naohisa Mori
IPC分类号： G10H1/32 , G10C3/02
CPC分类号： G10H1/34 , G10H1/32
摘要： Casing of an electronic keyboard musical instrument includes two discrete parts: a main casing section; and a rear casing section. The main casing section includes a bottom plate having a keyboard section placed thereon, a keyslip portion extending upward from the bottom plate in front of the keyboard section, and left and right side plates extending upward from the bottom plate at left and right sides of the keyboard section. The rear casing section includes a roof plate forming a rear upper surface of the casing, and a back plate extending downward from a rear edge of the roof plate. The rear casing section is detachably attached to the main casing section by means of a slidingly-attaching structure for slidingly attaching the rear casing section to the left and right side plates of the main casing section.
摘要翻译：电子键盘乐器的套管包括两个分立的部件：主壳体部分; 和后壳体部分。主壳体部分包括一个底板，其上有一个键盘部分，从键盘部分前面的底板向上延伸的键盘部分，以及从底板向左和向右延伸的左右侧板键盘部分。后壳体部分包括形成壳体的后上表面的顶板和从顶板的后边缘向下延伸的后板。后壳体部分通过用于将后壳体部分滑动地附接到主壳体部分的左侧和右侧板的滑动结构可拆卸地附接到主壳体部分。

28. 发明申请

US20050003339A1 Method of detecting ps2v 有权
标题翻译：检测ps2v的方法
公开(公告)号：US20050003339A1
公开(公告)日：2005-01-06
申请号：US10484152
申请日：2002-07-17
申请人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
发明人： Masaya Tohyama , Yuichi Yasuda , Yasushi Hasui , Hideki Ishihara , Koichi Yamagata
IPC分类号： G01N33/68 , C12Q1/70
CPC分类号： G01N33/6896
摘要： A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a secondary antibody recognizing PS2 or PS2V by any of the following procedures: (a) reacting with a secondary antibody having been enzyme-labeled and recognizing PS2 or PS2V; (b) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with an avidinylated or streptoavidinylated enzyme; (c) reacting with a secondary antibody having been biotinylated and recognizing PS2 or PS2V and then reacting with a biotinylated enzyme and avidin or streptoavidin; and (d) reacting with a secondary antibody recognizing PS2 or PS2V and then reacting with an antibody having been enzyme-labeled and recognizing the secondary antibody; then adding the substrate of the above enzyme and detecting the product formed by the enzyme reaction.
摘要翻译：一种检测PS2V的方法，其特征在于包括使样品中的PS2V与与固相结合的一抗并特异性识别PA2V，然后通过以下任一方法与识别PS2或PS2V的二抗反应：（a）使二抗被酶标记并识别PS2或PS2V; （b）与已经生物素化并识别PS2或PS2V的第二抗体反应，然后与二脱水或链脲霉素化酶反应; （c）与已经生物素化并识别PS2或PS2V的二级抗体反应，然后与生物素化的酶和抗生物素蛋白或链霉亲和素反应; 和（d）与识别PS2或PS2V的二抗反应，然后与经酶标记的抗体和识别第二抗体反应; 然后加入上述酶的底物并检测通过酶反应形成的产物。

29. 发明授权

US08131520B2 Cancer diagnostic device 有权
标题翻译：癌症诊断装置
公开(公告)号：US08131520B2
公开(公告)日：2012-03-06
申请号：US12286699
申请日：2008-10-01
申请人： Hideki Ishihara , Tomoko Matsushima
发明人： Hideki Ishihara , Tomoko Matsushima
IPC分类号： G06F7/60 , G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , C12Q1/485 , G01N2333/9121 , G01N2800/52 , G06F19/20 , G06F19/24
摘要： A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.
摘要翻译：公开了一种用于支持癌症诊断的装置，其提供用于决定是否向被检查的癌症患者施用蒽环类抗癌药物的信息。具体地说，该装置构成为能够从要检查的癌症患者的恶性肿瘤获得两种细胞周期蛋白依赖性激酶（CDK）的活性和表达，并从两种CDK中获得CDK参数。此外，设备确定包括预定CDK参数的样本数据，以及确定的样本数据的显示信息。根据上述成分，使用者能够容易地知道尽管施用了蒽环类抗癌药物，癌肿瘤患者的肿瘤是否与待检查的癌症患者的肿瘤相似。。

30. 发明申请

US20100147132A1 ELECTRONIC KEYBOARD INSTRUMENT 有权
标题翻译：电子键盘仪表
公开(公告)号：US20100147132A1
公开(公告)日：2010-06-17
申请号：US12640632
申请日：2009-12-17
申请人： Akiko Shinjo , Hideki Ishihara , Takashi Kato , Takashi Fujita
发明人： Akiko Shinjo , Hideki Ishihara , Takashi Kato , Takashi Fujita
IPC分类号： G10C3/06
CPC分类号： G10H1/32
摘要： An electronic keyboard instrument in which the efficiency of sound emission is enhanced by preventing a soundboard portion having a large vibration amplitude from being hidden by a musical score plate to make sound emission of the soundboard to be hardly hindered by the musical score plate. A musical stand device is disposed rearward of a key-depression part of a keyboard and right above the soundboard, and has a musical score plate disposed close to and parallel to an upper surface of the soundboard when the musical score plate is in a fallen state. The soundboard is excited for sound production by transducers disposed on a lower surface of the soundboard. The transducers are disposed at positions where the transducers do not overlap, as viewed in plan, the musical score plate which is in the fallen state.
摘要翻译：一种电子键盘乐器，其中通过防止具有较大振动振幅的音板部分被音乐记号板隐藏而增强了声音发射的效率，使得音板的声音发射几乎不受音乐记录板的阻碍。音乐台装置设置在键盘的按键部分的正后方的正上方，并且当乐谱板处于跌落状态时具有靠近并平行于音板上表面的乐谱板。通过放置在音板下表面的传感器，音板可以很好地发声。换能器设置在换能器不重叠的位置，如在计划中所看到的处于坠落状态的乐谱。

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