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21. 发明申请

US20070166376A1 Solid pharmaceutical preparation 有权
标题翻译：固体药物制剂
公开(公告)号：US20070166376A1
公开(公告)日：2007-07-19
申请号：US11578450
申请日：2005-04-13
申请人： Masahiko Koike
发明人： Masahiko Koike
IPC分类号： A61K31/4439 , A61K31/155 , A61K9/20
CPC分类号： A61K9/209 , A61K9/2027 , A61K9/2054 , A61K9/2853 , A61K9/2866 , A61K31/155 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The present invention provides a solid preparation containing an insulin sensitizer and an active ingredient (except insulin sensitizers), which shows in vivo dissolution behavior of an insulin sensitizer, which is similar to the dissolution behavior of an insulin sensitizer from “a solid preparation containing an insulin sensitizer alone as an active ingredient”. The present invention provides a solid preparation containing (1) a layer containing an insulin sensitizer, and (2) a layer containing (a) an active ingredient (except insulin sensitizers), (b) microcrystalline cellulose having a mean particle size of 5-25 μm, (c) microcrystalline cellulose having a mean particle size of 30-100 μm and (d) polyvinylpyrrolidone K-90.
摘要翻译：本发明提供了含有胰岛素敏化剂和活性成分（胰岛素敏化剂除外）的固体制剂，其显示胰岛素敏化剂的体内溶出行为，其类似于胰岛素敏化剂从“含有单独的胰岛素敏化剂作为活性成分“。本发明提供一种固体制剂，其含有（1）含有胰岛素敏化剂的层，和（2）含有（a）活性成分（胰岛素敏化剂除外）的层，（b）平均粒径为5〜 25微米，（c）平均粒径为30-100微米的微晶纤维素和（d）聚乙烯吡咯烷酮K-90。

22. 发明申请

US20050287207A1 Solid preparation 有权
标题翻译：固体制剂
公开(公告)号：US20050287207A1
公开(公告)日：2005-12-29
申请号：US10530262
申请日：2003-10-06
申请人： Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
发明人： Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
IPC分类号： A61K9/28 , A61K9/20 , A61K9/30 , A61K31/155 , A61K31/427 , A61K31/4439 , A61K45/06 , A61P3/10 , A61K31/426
CPC分类号： A61K45/06 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/155 , A61K31/427 , A61K2300/00
摘要： The present invention provides a solid preparation containing an insulin sensitizer and an active ingredient (except insulin sensitizers), which is useful as a therapeutic drug for diabetes and the like, and which is superior in preparation characteristics such as content uniformity and dissolution property of the insulin sensitizer and the active ingredient (except insulin sensitizers), preparation hardness and the like.
摘要翻译：本发明提供了含有胰岛素敏化剂和活性成分（胰岛素敏化剂除外）的固体制剂，其可用作糖尿病等的治疗药物，其制备特性如内容物均匀性和溶出性优异，胰岛素敏化剂和活性成分（胰岛素敏化剂除外），制剂硬度等。

23. 发明授权

US6034314A Automatic performance data conversion system 失效
标题翻译：自动演奏数据转换系统
公开(公告)号：US6034314A
公开(公告)日：2000-03-07
申请号：US918312
申请日：1997-08-26
申请人： Masahiko Koike
发明人： Masahiko Koike
IPC分类号： G10H1/00 , G10H7/00
CPC分类号： G10H1/0075
摘要： An automatic performance data conversion system having: a storage unit for storing a rule for converting automatic performance data from a first type into a second type, the rule indicating a correspondence between data strings of the automatic performance data of the first and second types; an input unit for inputting the automatic performance data of the fist type; a data converting unit for converting the automatic performance data from the first type into the second type by rearranging a data string contained in the automatic performance data of the first type input by the input unit in accordance with the rule; and an output unit for outputting the automatic performance data of the second type converted by the data converting unit.
摘要翻译：一种自动演奏数据转换系统，具有：存储单元，用于存储用于将自动演奏数据从第一类型转换成第二类型的规则，该规则指示第一类型和第二类型的自动演奏数据的数据串之间的对应关系; 用于输入第一类型的自动演奏数据的输入单元; 数据转换单元，用于通过根据规则重新排列由输入单元输入的第一类型的自动演奏数据中包含的数据串，将自动演奏数据从第一类型转换成第二类型; 以及输出单元，用于输出由数据转换单元转换的第二类型的自动演奏数据。

24. 发明授权

US4179971A Pitch bend apparatus for electronic musical instrument 失效
标题翻译：电子乐器曲折装置
公开(公告)号：US4179971A
公开(公告)日：1979-12-25
申请号：US944293
申请日：1978-09-21
申请人： Toshiyuki Takahashi , Masahiko Koike , Haruyuki Suzuki
发明人： Toshiyuki Takahashi , Masahiko Koike , Haruyuki Suzuki
IPC分类号： G10H1/02 , G10H5/00
CPC分类号： G10H1/02 , G10H5/002 , G10H2210/225 , Y10S84/18
摘要： A pitch bend apparatus for electronic musical instrument having a voltage-controlled oscillator that works as a tone generator is provided with a first variable resistor for operating the pitch bend as well as a second variable resistor for setting a varying width of pitch bend or a maximum amount of pitch deviation. The varying width of the pitch bend is controlled by connecting the first and second variable resistors into an amplifier circuit to control the gain thereof, or by controlling the voltage applied to the first variable resistor by means of the second variable resistor.
摘要翻译：具有作为音调发生器工作的压控振荡器的电子乐器的俯仰装置设置有用于操作音调弯曲的第一可变电阻器以及用于设定俯仰弯曲宽度或最大值的第二可变电阻器音高偏差量。通过将第一和第二可变电阻器连接到放大器电路中以控制其增益，或者通过借助于第二可变电阻器控制施加到第一可变电阻器的电压来控制音调弯曲的变化的宽度。

25. 发明授权

US4173164A Electronic musical instrument with frequency modulation of a tone signal with an audible frequency signal 失效
标题翻译：具有音频信号的频率调制的电子乐器，具有可听频率信号
公开(公告)号：US4173164A
公开(公告)日：1979-11-06
申请号：US909370
申请日：1978-05-25
申请人： Takeshi Adachi , Masahiko Koike , Toshiyuki Takahashi
发明人： Takeshi Adachi , Masahiko Koike , Toshiyuki Takahashi
IPC分类号： G10H1/06 , G10H5/00 , G10H1/04
CPC分类号： G10H5/002 , G10H1/06 , Y10S84/08
摘要： An electronic musical instrument comprises first and second voltage-controlled frequency-variable oscillators responsive to application of a pitch determining voltage signal from a keyboard circuit to produce first and second audible frequency signals, respectively. The second audible frequency signal is coupled to the first voltage-controlled oscillator to produce a frequency-modulated tone signal to be sounded in which the first audible frequency signal is frequency-modulated with the second audible frequency signal. The content of harmonic components in a musical tone can be increased by sideband components resulting from frequency modulation. The second audible frequency signal may be amplitude-controlled to be proportional, in amplitude, to the magnitude of pitch determining voltage signal, amplitude-modulated with a time-varying control waveform, and/or waveform-modified to provide desirable modulation effects. The mixture of the pitch determining voltage signal and the second audible frequency signal may be coupled to the first voltage-controlled oscillator through an absolute value circuit. The second audible frequency signal may be also coupled to a sound system together with the frequency-modulated tone signal.
摘要翻译：电子乐器包括响应于来自键盘电路的音调确定电压信号的应用而分别产生第一和第二可听频率信号的第一和第二压控频率可变振荡器。第二可听频率信号耦合到第一压控振荡器以产生要被发声的调频音调信号，其中第一可听频率信号用第二可听频率信号进行频率调制。音调中的谐波分量的内容可以通过由频率调制产生的边带分量来增加。第二可听频率信号可以被幅度控制成在振幅上成比例的音调确定电压信号的幅度，用时变控制波形进行幅度调制，和/或波形修改以提供期望的调制效果。音调确定电压信号和第二可听频率信号的混合可以通过绝对值电路耦合到第一压控振荡器。第二可听频率信号也可以与调频音调信号一起耦合到声音系统。

26. 发明授权

US4121489A Electronic musical instrument having plural oscillators starting in phase 失效
标题翻译：具有从同相开始的多个振荡器的电子乐器
公开(公告)号：US4121489A
公开(公告)日：1978-10-24
申请号：US708300
申请日：1976-07-26
申请人： Takeshi Adachi , Masahiko Koike
发明人： Takeshi Adachi , Masahiko Koike
IPC分类号： G10H5/00 , G10H1/04
CPC分类号： G10H5/002
摘要： An electronic musical instrument comprises a plurality of tone generators for independently producing tone signals having slightly different frequencies, though fundamentally corresponding to the note of a key depressed on a keyboard; and a mixing circuit coupled to the outputs of the tone generators. The respective tone generators are provided with a control input and are brought to start in the same phase in response to application of an initial synchronizing pulse to the control inputs, thereby attaining clear rise of musical sounds immediately upon key depression. The synchronizing pulse may be produced necessarily at the instant of key depression only when an output of the mixing circuit has a amplitude level lower than a predetermined level.
摘要翻译：电子乐器包括多个音调发生器，用于独立地产生具有略微不同频率的音调信号，尽管它们基本上对应于在键盘上按下的键的音符; 以及耦合到音调发生器的输出的混合电路。相应的音调发生器设置有控制输入，并且响应于向控制输入施加初始同步脉冲而在同一相位中启动，从而在键按压时立即获得音乐声音的清晰上升。只有当混合电路的输出具有低于预定电平的幅度电平时，可能必须在键按压时产生同步脉冲。

27. 发明授权

US3974729A Automatic rhythm playing apparatus 失效
标题翻译：自动节奏播放装置
公开(公告)号：US3974729A
公开(公告)日：1976-08-17
申请号：US552732
申请日：1975-02-25
申请人： Masahiko Koike
发明人： Masahiko Koike
IPC分类号： G10H1/40 , G10F1/00
CPC分类号： G10H1/40 , G10H2210/361
摘要： The automatic rhythm producing apparatus according to the invention is capable of providing a clock pulse used for obtaining a basic tempo of a rhythm sound with an irregular pulse period as desired. The apparatus comprises an oscillator for producing a saw-tooth wave signal, a plurality of comparators for comparing this saw-tooth wave signal and a set reference voltage, pulse generation circuits for producing pulses in response to the outputs of the comparators, voltage dividers for supplying the set reference voltages to the comparators, a variable voltage power supply for supplying a variable voltage to the voltage dividers and a pulse generation circuit for producing a pulse when the level of the saw-tooth wave signal drops to zero. The pulse period of a clock pulse obtained by combining the outputs of these pulse generation circuits can be made irregular by suitably varying the variable constant voltage.
摘要翻译：根据本发明的自动节奏产生装置能够提供用于根据需要获得具有不规则脉冲周期的节奏声音的基本节奏的时钟脉冲。该装置包括用于产生锯齿波信号的振荡器，用于比较该锯齿波信号和设定参考电压的多个比较器，用于响应于比较器的输出产生脉冲的脉冲发生电路，用于向比较器提供设定的参考电压，用于向分压器提供可变电压的可变电压电源和当锯齿波信号的电平降到零时产生脉冲的脉冲产生电路。通过组合这些脉冲发生电路的输出而获得的时钟脉冲的脉冲周期可以通过适当地改变可变恒定电压而变得不规则。

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