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21. 发明授权

US4375542A Kijanimicin antibiotics and derivatives thereof 失效
标题翻译：吉他霉素抗生素及其衍生物
公开(公告)号：US4375542A
公开(公告)日：1983-03-01
申请号：US195048
申请日：1980-10-08
申请人： Jay A. Waitz , Mahesh G. Patel , Ann C. Horan
发明人： Jay A. Waitz , Mahesh G. Patel , Ann C. Horan
IPC分类号： C12P19/60 , A61K20060101 , A61K31/335 , A61K31/535 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P17/00 , A61P29/00 , A61P31/04 , A61P33/02 , A61P35/00 , C07D313/00 , C07G3/00 , C07G11/00 , C07H17/04 , C07H17/08 , C12N20060101 , C12N1/20 , C12P20060101 , C12P1/06 , C12P17/02 , C12P17/08 , C12P19/44 , C12P19/56 , C12P19/62 , C12R20060101 , C12R1/03
CPC分类号： C12R1/03 , C07H17/08 , C12P19/60
摘要： Actinomadura Kijaniata nov. sp produces a novel antibiotic which we have designated kijanimicin. The antibiotic or cationic salts thereof exhibit anti-acne, antitumor, antimalarial, antibacterial and anti-inflammatory activity.
摘要翻译： Actinomadura Kijaniata nov。 sp产生一种我们已经指定了kijanimicin的新型抗生素。其抗生素或阳离子盐表现出抗痤疮，抗肿瘤，抗疟疾，抗菌和抗炎活性。

22. 发明授权

US06476062B2 Chemokine receptor antagonists 失效
公开(公告)号：US06476062B2
公开(公告)日：2002-11-05
申请号：US09815853
申请日：2001-03-23
申请人： Min Chu , Ronald A. Mierzwa , Joseph Terracciano , Mahesh G. Patel
发明人： Min Chu , Ronald A. Mierzwa , Joseph Terracciano , Mahesh G. Patel
IPC分类号： C07D20704
CPC分类号： C07D207/44 , C12P17/10 , C12R1/645
摘要： Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium globosum Kunze SCH 1705, ATCC 74489., pharmaceutical compositions containing the compounds and the use of the CCR-5 antagonist compounds and compositions to treat HIV-1 infections in humans are disclosed.

23. 发明授权

US5837691A Actinomadura vulgaris subsp vulgaris and antimicrobial complex and antimicrobial 失效
标题翻译：寻常型Actinomadura寻常型和抗菌复合抗菌
公开(公告)号：US5837691A
公开(公告)日：1998-11-17
申请号：US747456
申请日：1991-08-12
申请人： Vinod R. Hegde , Ann C. Horan , Mahesh G. Patel , Ingrid-Agneta Gunnarsson
发明人： Vinod R. Hegde , Ann C. Horan , Mahesh G. Patel , Ingrid-Agneta Gunnarsson
IPC分类号： C07H17/02 , C12P19/60 , A61K31/71 , C07H17/08
CPC分类号： C12R1/03 , C07H17/02 , C12P19/60 , Y10S435/825
摘要： A novel macrolactam monosaccharide isolated from an antimicrobial complex 517 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura vulgaris subsp. vulgaris ATCC 53748.
摘要翻译：从在受控条件下发酵生产的抗微生物复合物517分离的新型大环内酰胺单糖，其使用微生物Actinomadura vulgaris subsp。寻常型ATCC 53748。

24. 发明授权

US5618809A Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 失效
标题翻译：来自糖酵母（Aerobolithrix aerocolonigenes copiosa subsp。）的Indolocarbazoles nov SCC 1951 ATCC 53856
公开(公告)号：US5618809A
公开(公告)日：1997-04-08
申请号：US394937
申请日：1995-02-27
申请人： Ellen B. Barrabee , Ann C. Horan , Frank A. Gentile , Mahesh G. Patel
发明人： Ellen B. Barrabee , Ann C. Horan , Frank A. Gentile , Mahesh G. Patel
IPC分类号： C12P17/18 , C07D498/22 , A61K31/55
CPC分类号： C12P17/18
摘要： N-alkanoyl derivatives of staurospodne represented by the formula I ##STR1## wherein R.sub.a and R.sub.b are each H or ##STR2## wherein R.sub.1 and R.sub.2 are independently H or --OH or --OCH.sub.3 and R.sub.3 is OH, NHCH.sub.3, NCH COCH.sub.3 or NHCOCH.sub.3 and R.sub.4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when R.sub.a and R.sub.b .dbd.A, and R.sub.1.dbd.H.sub.2 or OH R.sub.3 is not NHCH.sub.3 ; (2) when R.sub.a and R.sub.b.dbd. B, then R.sub.1 .dbd.R.sub.4 .dbd.OH or R.sub.1 .dbd.R.sub.4 .dbd.H; (3) when R.sub.a .dbd.R.sub.b .dbd.H R.sub.1 .dbd.--OCH.sub.3, and (4) when R.sub.a and R.sub.b .dbd.A, and R.sub.1 .dbd.H and R.sub.2 .dbd.OCH.sub.3, then R3 is not and ##STR3## pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed.
摘要翻译：其中R a和R b各自为H或A，其中R 1和R 2独立地为H或-OH或-OCH 3且R 3为OH，NHCH 3， NCH COCH 3或NHCOCH 3和R 4是OH或H及其立体化学异构体，条件是（1）当R a和R b = A时，R 1 = H 2或OH R 3不是NHCH 3; （2）当Ra和Rb = B时，R1 = R4 = OH或R1 = R4 = H; （3）当Ra = Rb = H R1 = -OCH3时，和（4）当Ra和Rb = A，R1 = H和R2 = OCH3时，R3不是和其中用于抑制肌球蛋白光的药物组合物链激酶，蛋白激酶C或肿瘤细胞增殖，以及在温血动物如人中产生抗高血压作用和抗炎作用。

25. 发明授权

US5449685A Method and composition for treating HIV-type 1 infections 失效
标题翻译：用于治疗HIV-1型感染的方法和组合物
公开(公告)号：US5449685A
公开(公告)日：1995-09-12
申请号：US966125
申请日：1992-10-23
申请人： Mahesh G. Patel , Vincent P. Gullo , Jerome Schwartz
发明人： Mahesh G. Patel , Vincent P. Gullo , Jerome Schwartz
IPC分类号： A61K38/00 , A61K31/335 , A61P31/12 , A61P31/18 , C07K5/06 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/29
CPC分类号： C07K5/06026 , A61K31/335
摘要： A method of treating mammals infected with HIV-1, or AIDS by administering a therapeutically effective amount of a compound represented by formula I ##STR1## or a pharmaceutically acceptable salt or ester thereof or stereoisomer thereof and pharmaceutical compositions containing it are disclosed.
摘要翻译：公开了通过施用治疗有效量的式I化合物或其酯或其立体异构体和含有它的药物组合物来治疗感染HIV-1或AIDS的哺乳动物的方法。

26. 发明授权

US5352707A Method for treating airway congestion 失效
标题翻译：治疗气道堵塞的方法
公开(公告)号：US5352707A
公开(公告)日：1994-10-04
申请号：US857889
申请日：1992-03-26
申请人： Shirley A. Pompni , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
发明人： Shirley A. Pompni , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
IPC分类号： A61K31/135
CPC分类号： A61K31/135 , Y10S514/826
摘要： A method for treating airway congestion which comprises administering an effective amount of the compound of formula II which follows ##STR1## or a pharmaceutically acceptable salt thereof.
摘要翻译：一种治疗气道充血的方法，其包括施用有效量的II型II化合物或其药学上可接受的盐。

27. 发明授权

US5217986A Anti-allergy agent 失效
标题翻译：抗过敏剂
公开(公告)号：US5217986A
公开(公告)日：1993-06-08
申请号：US858275
申请日：1992-03-26
申请人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
发明人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
IPC分类号： C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.
摘要翻译：描述了式（IMAGE）I的化合物。该化合物在H3受体测定中是有活性的，并且是H3拮抗剂。因此，式I化合物可用于治疗诸如哮喘，鼻炎，呼吸道充血，炎症，心律失常，高血压，超低运动性和胃肠道酸分泌等疾病和病症，中枢神经系统（CNS），偏头痛和青光眼。

28. 发明授权

US5780442A Orthosomycins from micromonospora carbonacae 失效
标题翻译：来自微单孢菌的正粘菌素
公开(公告)号：US5780442A
公开(公告)日：1998-07-14
申请号：US604692
申请日：1996-02-21
申请人： Ronald A. Mierzwa , Min Chu , John K. Jenkins , Mahesh G. Patel
发明人： Ronald A. Mierzwa , Min Chu , John K. Jenkins , Mahesh G. Patel
IPC分类号： C07H19/01 , A61K31/71 , C07H15/00
CPC分类号： C07H19/01
摘要： Orthosomycins have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africana designated SCC 2146. These compounds are antibacterial agents. Compositions and methods for treating bacterial infections are also described.
摘要翻译：已经从微生物Micromonospora Carbonacea var Africana指定为SCC 2146的发酵液中分离出了直链霉菌素。这些化合物是抗菌剂。还描述了治疗细菌感染的组合物和方法。

29. 发明授权

US4743594A Antibiotic, antitumor compounds and their use 失效
标题翻译：抗生素，抗肿瘤化合物及其用途
公开(公告)号：US4743594A
公开(公告)日：1988-05-10
申请号：US651498
申请日：1984-09-17
申请人： Ann C. Horan , Jerzy Golik , James A. Matson , Mahesh G. Patel
发明人： Ann C. Horan , Jerzy Golik , James A. Matson , Mahesh G. Patel
IPC分类号： C07H19/23 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P31/00 , A61P31/04 , A61P35/00 , C07H19/044 , C12N1/20 , C12P19/28 , C12P19/38 , C12P19/58 , C12R1/03 , A61K31/71 , C07H17/00
CPC分类号： C12P19/38 , C07H19/044 , C12P19/58
摘要： Actinomadura melliaura nov. sp. (ATCC 39691) produces four novel compounds which we have designated AT 2433 A.sub.1, AT 2433 A.sub.2, AT 2433 B.sub.1 and AT 2433 B.sub.2. The novel compounds or pharmaceutically acceptable salts thereof exhibit antibacterial and antitumor activity.
摘要翻译：放线菌（Actinomadura melliaura nov。） sp。（ATCC 39691）生产四种新化合物，我们指定了AT 2433 A1，AT 2433 A2，AT 2433 B1和AT 2433 B2。新化合物或其药学上可接受的盐具有抗细菌和抗肿瘤活性。

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