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21. 发明申请

US20060081874A1 Starved source diffusion for avalanche photodiode 审中-公开
标题翻译：用于雪崩光电二极管的饥饿源扩散
公开(公告)号：US20060081874A1
公开(公告)日：2006-04-20
申请号：US10966491
申请日：2004-10-15
申请人： Daniel Francis , Rashit Nabiev , Richard Ratowsky , David Young , Sunil Thomas , Roman Dimitrov
发明人： Daniel Francis , Rashit Nabiev , Richard Ratowsky , David Young , Sunil Thomas , Roman Dimitrov
IPC分类号： H01L31/109
CPC分类号： H01L31/107 , H01L31/03529 , H01L31/18 , Y02E10/50
摘要： Starved source diffusion methods for forming avalanche photodiodes (APDs) are provided for controlling the edge effect. The edge effect is controlled by reducing edge gain near the edges of an APD active region. This is accomplished by creating a sloped diffusion front near the edges of the active region. The sloped diffusion front is advantageously formed in a single doping step by using a patterned mask during doping. The patterned mask reduces the depth to which dopants diffuse in areas where it only partly covers the underlying layer. By covering more of the underlying layer nearer the edge and progressively less towards the center, the sloped diffusion front is formed. The shallower diffusion depth near the edge reduces the edge gain, and therefore the edge effect. As a result, an APD to fiber misalignment is less likely, and possibility of edge breakdown is greatly reduced.
摘要翻译：用于形成雪崩光电二极管（APD）的饥饿源扩散方法用于控制边缘效应。边缘效应通过减少APD有效区域边缘附近的边缘增益来控制。这是通过在活动区域的边缘附近创建倾斜的扩散前端来实现的。倾斜的扩散前端有利地通过在掺杂期间使用图案化掩模在单个掺杂步骤中形成。图案化掩模减少掺杂剂在其仅部分覆盖下层的区域中扩散的深度。通过覆盖更靠近边缘的下层，并逐渐向中心倾斜，形成倾斜的扩散前沿。靠近边缘的较浅的扩散深度降低了边缘增益，因此降低了边缘效应。结果，APD对光纤的未对准不太可能，并且边缘击穿的可能性大大降低。

22. 发明申请

US20060081374A1 Process for downhole heating 审中-公开
标题翻译：井下加热工艺
公开(公告)号：US20060081374A1
公开(公告)日：2006-04-20
申请号：US11237074
申请日：2005-09-28
申请人： Ronald Bland , David Young , Marvin Pless , John Trenery
发明人： Ronald Bland , David Young , Marvin Pless , John Trenery
IPC分类号： E21B43/24 , E21B36/00
CPC分类号： E21B36/008 , E21B43/24
摘要： Neutral electrolytes, relatively neutral electrolytes, metal oxides, metal hydroxides and/or organic exothermic hydration chemicals may be hydrated with water at a controlled location in a subterranean formation to generate sufficient exothermic heat to at least soften and possibly melt and flow bitumen at or near the location. This controlled and localized heating would be useful in drilling through relatively thick bitumen or “tar” beds. In one non-limiting embodiment the exothermic hydration reaction does not generate appreciable amounts of gas. Alternatively, the exothermic reaction may be used to liberate hydrocarbons from gas hydrates in an embodiment where the evolution of gas is acceptable.
摘要翻译：中性电解质，相对中性的电解质，金属氧化物，金属氢氧化物和/或有机放热水合化学物质可以在地下地层中的受控位置用水水合，以产生足够的放热热量，以至少软化，并可能熔化和流动沥青在或接近那个地点。这种受控和局部加热可用于穿过相对较厚的沥青或“焦油”床。在一个非限制性实施方案中，放热水合反应不产生明显量的气体。或者，在气体逸出可接受的实施方案中，放热反应可用于从气体水合物中释放碳氢化合物。

23. 发明授权

US07027970B2 Tool for in vitro-in vivo correlation 失效
公开(公告)号：US07027970B2
公开(公告)日：2006-04-11
申请号：US10274649
申请日：2002-10-18
申请人： David Young , Sian E. Bigora , Leonid V. Gibiansky , William R. Gillespie , Theresa A. Shepard , Colm B. Farrell
发明人： David Young , Sian E. Bigora , Leonid V. Gibiansky , William R. Gillespie , Theresa A. Shepard , Colm B. Farrell
IPC分类号： G06G7/58
CPC分类号： G06F19/24
摘要： A biological modeling system and method for enhanced computer-aided analysis of biological response data provides information synthesized from immediate and extended release in vivo data and in vitro data. An executable model of a biological system is developed from information and structures based on the data. In a preferred embodiment, a two stage approach to modeling is used in the development of an IVIVC. The first stage of the procedure is deconvolution, where the percentage of drug absorbed is determined. In the second stage, the in vivo percentage absorbed data is correlated to the in vitro fraction or percentage dissolved data. This correlation then represents a point-to-point relationship between the in vitro dissolution and the in vivo input rate of the drug from the dosage form. In such a correlation, the in vitro dissolution and in vivo absorption profiles are either directly superimposable or may be made to be superimposable by the use of a scaling factor. Prior to the deconvolution stage, a unit impulse response function can be determined from immediate-release concentration-time data. This impulse response function is used in the deconvolution process to determine the in vivo percent absorbed for the extended release formulations. A nonlinear IVIVC model is developed that can incorporate time-scaling and time-shifting into the model if needed. After the two-stage modeling is completed, the predictability of the developed IVIVC model is evaluated by both internal and external validation.

24. 发明申请

US20060073144A1 Individualized anti-cancer antibodies 审中-公开
公开(公告)号：US20060073144A1
公开(公告)日：2006-04-06
申请号：US11240787
申请日：2005-09-30
申请人： David Young , Miyoko Takahashi
发明人： David Young , Miyoko Takahashi
IPC分类号： A61K39/395
CPC分类号： G01N33/6854 , A61K2039/505 , C07K16/00 , C07K16/30 , C07K2317/73 , G01N33/57484 , G01N2500/00
摘要： The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of their cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat tumor metastases. The anti-cancer antibodies can be conjugated to red blood cells obtained from that patient and re-infused for treatment of metastases based upon the recognition that metastatic cancers are usually well vascularized and the delivery of anti-cancer antibodies by red blood cells can have the effect of concentrating the antibodies at the site of the tumor.

25. 发明申请

US20060008013A1 Method and system for performing deblocking filtering 有权
标题翻译：执行去块滤波的方法和系统
公开(公告)号：US20060008013A1
公开(公告)日：2006-01-12
申请号：US10887132
申请日：2004-07-08
申请人： Oskar Pelc , Michael Zarubinsky , David Young
发明人： Oskar Pelc , Michael Zarubinsky , David Young
IPC分类号： H04B1/66 , G06K9/40
CPC分类号： H04N19/86 , H04N19/197 , H04N19/42 , H04N19/80
摘要： A system and method for filtering a frame, the method includes: (i) processing, by a processing unit executing instructions, at least one portion of a frame to provide at least one processed frame portion; (ii) performing, by a hardware filter, deblocking filtering of the at least one processed frame portion to provide at least one filtered frame portion; and (ii) storing the at least one filtered frame portion in a memory unit that is accessible by the processing unit; whereas the stage of processing is responsive to previously filtered frame portions. The system includes: (i) a processing unit, adapted to execute instructions such as to process at least one portion of a frame to provide at least one processed frame portion; (ii) a hardware filter, connected to the processing unit, adapted to deblocking filter the at least one processed frame portion to provide at least one filtered frame portion; and (iii) a memory unit, connected to the processing unit, adapted to store the at least one filtered frame portion; whereas the processing unit is adapted to process the at least one portion in response to previously filtered frame portions.
摘要翻译：一种用于过滤帧的系统和方法，所述方法包括：（i）通过执行指令的处理单元处理帧的至少一部分以提供至少一个经处理的帧部分; （ii）通过硬件滤波器执行所述至少一个经处理的帧部分的去块滤波以提供至少一个滤波的帧部分; 以及（ii）将所述至少一个滤波的帧部分存储在可由所述处理单元访问的存储器单元中; 而处理阶段响应于先前滤波的帧部分。该系统包括：（i）处理单元，适于执行诸如处理帧的至少一部分以提供至少一个已处理帧部分的指令; （ii）连接到所述处理单元的硬件滤波器，适于对所述至少一个经处理的帧部分进行去块滤波，以提供至少一个滤波的帧部分; 和（iii）连接到所述处理单元的适于存储所述至少一个滤波的帧部分的存储器单元; 而处理单元适于响应于先前滤波的帧部分来处理该至少一个部分。

26. 发明申请

US20050261512A1 Recycling polyethylene naphthalate containing materials in a process to produce diesters 有权
标题翻译：在生产二酯的过程中回收含有聚萘二甲酸乙二醇酯的材料
公开(公告)号：US20050261512A1
公开(公告)日：2005-11-24
申请号：US10849750
申请日：2004-05-20
申请人： Rosemary McMahon , John Macek , Gregory Hussmann , Michael Panzer , Raymond Eifert , David Young , Allen Mossman , J. Cleckler
发明人： Rosemary McMahon , John Macek , Gregory Hussmann , Michael Panzer , Raymond Eifert , David Young , Allen Mossman , J. Cleckler
IPC分类号： C07C67/03 , C07C67/08 , C07C67/36 , C07C67/52 , C07C67/54 , C07C69/76
CPC分类号： C07C67/52 , C07C67/03 , C07C67/08 , C07C67/54 , C07C69/76
摘要： A process for preparing a dialkylester of a naphthalenedicarboxylic acid comprising directing a liquid phase reaction mixture comprising a low molecular weight alcohol, a naphthalenedicarboxylic acid, a dialkylester of a naphthalenedicarboxylic acid, and a polyethylene naphthalate containing material, at a given temperature and pressure through series arranged reaction zones and subsequently removing a product comprising a dialkylester formed by the reaction of the naphthalenedicarboxylic acid and the polyethylene naphthalate containing material with the low molecular weight alcohol from a reaction zone. This invention is also directed to a process for preparing a purified dialkylester of a naphthalenedicarboxylic acid comprising a series of crystallization and distillation steps, and combinations thereof.
摘要翻译：一种制备萘二甲酸二烷基酯的方法，包括在给定的温度和压力下通过串联引入包含低分子量醇，萘二甲酸，萘二羧酸的二烷基酯和含聚萘二甲酸乙二酯的材料的液相反应混合物并且随后从反应区除去包含由萘二甲酸与含聚萘二甲酸乙二醇酯的材料与低分子量醇反应形成的二烷基酯的产物。本发明还涉及一种制备萘二甲酸的纯化二烷基酯的方法，其包括一系列结晶和蒸馏步骤及其组合。

27. 发明申请

US20050211841A1 AIRCRAFT INTERIOR ARCHITECTURE 有权
标题翻译：飞机内部结构
公开(公告)号：US20050211841A1
公开(公告)日：2005-09-29
申请号：US10908140
申请日：2005-04-28
申请人： Peter Guard , David Young
发明人： Peter Guard , David Young
IPC分类号： B64C1/06 , B64C1/12 , B64D11/00 , B64D11/02 , B64D11/06
CPC分类号： B64D11/00155 , B64C1/066 , B64D11/00 , B64D11/0015 , B64D11/0023 , B64D11/003 , B64D2011/0046
摘要： Architectural archway structures for aircraft. The archway structure can be positioned individually, or in pairs or other sets along the length of the interior of an aircraft, such as a commercial passenger airplane. The archways extend across the ceiling of the interior of the cabin and extend downwardly to a point adjacent the luggage bins. End caps are provided to conform the end of the archways with the interior luggage bins. The invention provides a unique “look and feel” and architectural configuration, and does not result in seat loss.
摘要翻译：飞机建筑拱形结构。拱形结构可以沿着诸如商用乘客飞机的飞行器内部的长度单独地或成对地或其它组地定位。拱门延伸穿过机舱内部的天花板，并向下延伸到靠近行李箱的位置。提供端盖以使拱门的端部与内部行李箱一致。本发明提供了独特的“外观和感觉”和建筑结构，并且不会导致座椅损失。

28. 发明申请

US20050191305A1 Cancerous disease modifying antibodies 失效
公开(公告)号：US20050191305A1
公开(公告)日：2005-09-01
申请号：US11067366
申请日：2005-02-25
申请人： David Young , Susan Hahn , Lisa Cechetto
发明人： David Young , Susan Hahn , Lisa Cechetto
IPC分类号： A61K39/395 , A61K51/10 , A61P35/00 , C07K16/18 , C07K16/30 , C12N5/12 , C12N5/18 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/30 , C07K16/3046
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

29. 发明授权

US06770262B2 Nasal administration of agents for the treatment of gastroparesis 有权
标题翻译：鼻胃给药治疗胃轻瘫的药物
公开(公告)号：US06770262B2
公开(公告)日：2004-08-03
申请号：US09821139
申请日：2001-03-29
申请人： Laura S. Lehman , David Tierney , Anastassios D. Retzios , Michael Petrone , David Young , Carol B. Trapnell , Ruth Oliver
发明人： Laura S. Lehman , David Tierney , Anastassios D. Retzios , Michael Petrone , David Young , Carol B. Trapnell , Ruth Oliver
IPC分类号： A61K912
CPC分类号： A61K9/0043 , A61K31/16 , A61K31/165 , A61K31/166 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to a method for the treatment of gastroparesis by the use of metoclopramide nasal formulation.
摘要翻译：本发明涉及通过使用甲氧氯普胺鼻制剂治疗胃轻瘫的方法。

30. 发明授权

US06374969B1 Truck assembly for luggage 失效
标题翻译：卡车组装行李
公开(公告)号：US06374969B1
公开(公告)日：2002-04-23
申请号：US09481920
申请日：2000-01-13
申请人： David Young
发明人： David Young
IPC分类号： A45C514
CPC分类号： A45C5/14
摘要： A truck assembly and luggage associated therewith includes a base panel, a bottom panel and side panels. The bottom panel and the side panels intersect the base panel at a mutual edge. Two wheel cavities extend through the base panel and the bottom panel and across the mutual edge to receive wheels. Axles are positionable in mounting panels to each side of each wheel cavity. The mounting panels include semicircular mounting surfaces and access passages thereto. Mounting caps include plates and extended bosses with cap surfaces forming segments of a cylinder to cooperate with the semicircular mounting surfaces to form cylindrical mountings. Axles are positioned in the cylindrical mountings and in turn rotatably mount the wheels. Reusable fasteners in the form of screws hold the plates to the base panel of the truck assembly. A slidably mounted handle associated with the luggage case is positioned to be parallel to the bottom panel and at the far side of the case from the base panel.
摘要翻译：与其相关联的卡车组件和行李箱包括底板，底板和侧板。底板和侧板在相互边缘处与基板相交。两个轮腔通过底板和底板延伸穿过相互的边缘以接收轮子。轴可以在每个车轮腔的每一侧的安装面板上定位。安装面板包括半圆形安装表面和通向其的通道。安装盖包括板和延伸的凸台，其具有形成圆柱体段的盖表面以与半圆形安装表面配合以形成圆柱形安装件。轴位于圆柱形安装件中，并且可旋转地安装车轮。螺钉形式的可重复使用的紧固件将板固定到卡车组件的底板上。与行李箱相关联的可滑动安装的手柄被定位成平行于底板并且在壳体的远侧与基板平行。

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