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21. 发明授权

US06403960B1 Correction for spatial variations of deadtime of a monolithic scintillator based detector in a medical imaging system 失效
标题翻译：校正基于单片闪烁体的检测器在医学成像系统中的死区时间的空间变化
公开(公告)号：US06403960B1
公开(公告)日：2002-06-11
申请号：US09302161
申请日：1999-04-29
申请人： Donald R. Wellnitz , Michael J. Petrillo , Lingxiong Shao
发明人： Donald R. Wellnitz , Michael J. Petrillo , Lingxiong Shao
IPC分类号： G01T1164
CPC分类号： G01T1/171
摘要： A nuclear medicine imaging system includes the capability to correct for the deadtime, including the capability to correct for spatial variations in deadtime across the imaging surface of a detector. The imaging system includes one or more radiation detectors, each using a large, monolithic scintillation crystal. Each detector has deadtime associated with it. A given detector is used to acquire an energy profile of a patient based on emission radiation. The detector includes a number of timing channels. The energy profile is used to select a zone influence map indicating the extent of spatial overlap in response between the various timing channels. Emission data of the patient is then acquired during an emission scan. During acquisition of the emission data, a rate meter assigned to each timing channel samples the number of counts associated with each timing channel to acquire deadtime data. A unique deadtime function is provided for each unique zone represented in the zone influence map, including each region of overlap. The deadtime data acquired from the rate meters are then applied to the deadtime functions to correct the emission data for deadtime on a pixel-by-pixel basis. An image is generated based on the deadtime-corrected data.
摘要翻译：核医学成像系统包括校正死时间的能力，包括校正跨越检测器的成像表面的死时间的空间变化的能力。成像系统包括一个或多个辐射检测器，每个使用大的单片闪烁晶体。每个检测器都有与之相关的死区。给定的检测器用于基于发射辐射来获取患者的能量分布。检测器包括多个定时通道。能量分布用于选择区域影响图，指示各种定时通道之间响应的空间重叠程度。然后在发射扫描期间获取患者的排放数据。在获取排放数据期间，分配给每个定时通道的速率计对与每个定时通道相关联的计数进行采样以获取死区数据。为区域影响图中表示的每个独特区域提供独特的死区功能，包括每个重叠区域。然后将从速率计获得的死区时间数据应用于死区时间功能，以逐个像素为基础校正死时间的发射数据。基于死时间校正数据生成图像。

22. 发明授权

US5998793A Method and apparatus for correcting for random coincidences in a nuclear medicine imaging system 失效
标题翻译：用于校正核医学成像系统中的随机巧合的方法和装置
公开(公告)号：US5998793A
公开(公告)日：1999-12-07
申请号：US62226
申请日：1998-04-17
申请人： Lingxiong Shao , David Coles
发明人： Lingxiong Shao , David Coles
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1647
摘要： A method and apparatus for correcting for random coincidences in a gamma camera imaging system are provided, based on the distribution of the object to be imaged as well as the measured singles and coincidence rates. Gamma radiation emitted from the object is detected for multiple projection angles, including detection of a plurality of coincidence events, to generate an object profile. The singles rate and the coincidence rate are also measured for each of the projection angles. A randoms distribution representing random coincidences in the detected coincidence events is then determined, including computing a randoms profile as the convolution of the object profile and a Gaussian function. The determination of the randoms distribution further includes computing a randoms fraction for each of the projection angles based on the measured singles rate and the measured coincidence rate, and then computing the randoms distribution based on the randoms profile and the randoms fraction for each of the projection angles. The coincidence projection data are corrected based on the randoms distribution prior to generating emission images.
摘要翻译：基于待成像对象的分布以及测量的单个和一致率，提供了用于校正伽马相机成像系统中的随机重合的方法和装置。检测从对象发射的伽马辐射用于多个投影角度，包括检测多个重合事件，以产生对象轮廓。对于每个投影角度也测量单打速率和一致率。然后确定在检测到的重合事件中表示随机符合的随机分布，包括计算随机分布作为对象分布的卷积和高斯函数。随机分布的确定还包括基于所测量的单数率和测量的一致率来计算每个投影角度的随机分数，然后基于随机分布和每个投影的随机分数来计算随机分布角度。基于在产生发射图像之前的随机分布来校正重合投影数据。

23. 发明授权

US09123260B2 Receiver operating characteristic-based training 有权
标题翻译：接收机操作特性为基础的训练
公开(公告)号：US09123260B2
公开(公告)日：2015-09-01
申请号：US12675414
申请日：2008-08-26
申请人： Horace Hines , Lingxiong Shao , Zuo Zhao , Xiyun Song
发明人： Horace Hines , Lingxiong Shao , Zuo Zhao , Xiyun Song
IPC分类号： G09B23/28
CPC分类号： G09B23/286 , G06F19/00
摘要： A presentation component (118) presents information from one or more data source(s) (102) to an assessor for assessment. A receiver operating characteristic (ROC) analyzer 120 uses an ROC analysis technique to evaluate the performance of the assessor. A feedback component (126) provides feedback as to the assessor's performance. A data manipulator (114) facilitates manipulation of the presented data.
摘要翻译：呈现组件（118）将来自一个或多个数据源（102）的信息提供给评估者进行评估。接收机工作特性（ROC）分析器120使用ROC分析技术来评估评估者的性能。反馈组件（126）提供关于评估者绩效的反馈。数据操纵器（114）有助于对所呈现的数据的操纵。

24. 发明授权

US08411915B2 Motion compensation in functional imaging 有权
标题翻译：功能成像中的运动补偿
公开(公告)号：US08411915B2
公开(公告)日：2013-04-02
申请号：US11997410
申请日：2006-07-27
申请人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer C. Carlsen , Carsten Meyer
发明人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer C. Carlsen , Carsten Meyer
IPC分类号： G06K9/00
CPC分类号： A61B6/503 , A61B5/113 , A61B5/7289 , A61B6/037 , A61B6/5235 , A61B6/541 , A61B8/0883 , G06F19/00 , G06T7/20 , G06T11/005 , G06T2207/30004 , G06T2211/412
摘要： Medical images are collected in a plurality of cardiac and respiratory phases. The images are transformed into a series of respiratory compensated images with the plurality of cardiac phases, but all at a common respiration phase. The series of respiratory compensated images are transformed into one image at a selected cardiac phase and the common respiration phase. In some embodiments, a database of gated transform matrices is generated. The database may be based on specific patient information or on information generated from a pool of patients. The database may account for respiratory motion, cardiac contractile motion, other physiological motion, or combinations thereof. For a current image to be motion corrected, the transformation matrices collected in the database are used to estimate a current set of transformation matrices accounting for the motion in the current image, and a motion-compensated image is generated based on the current set of transform matrices.
摘要翻译：在多个心脏和呼吸相中收集医学图像。图像被转换成具有多个心脏相的一系列呼吸补偿图像，但都在共同的呼吸阶段。一系列呼吸补偿图像在选定的心脏相和共同的呼吸期转化为一个图像。在一些实施例中，生成门控变换矩阵的数据库。数据库可以基于具体的患者信息或从患者池产生的信息。数据库可以解释呼吸运动，心脏收缩运动，其他生理运动或其组合。对于要进行运动校正的当前图像，使用在数据库中收集的变换矩阵来估计当前图像中运动的当前转换矩阵，并且基于当前变换集合生成运动补偿图像矩阵。

25. 发明授权

US6008493A Method and apparatus for performing correction of emission contamination and deadtime loss in a medical imaging system 失效
标题翻译：用于执行医疗成像系统中的排放污染和死时间损失校正的方法和装置
公开(公告)号：US6008493A
公开(公告)日：1999-12-28
申请号：US865930
申请日：1997-05-30
申请人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
发明人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
IPC分类号： G01T1/161 , G01T1/17 , G01T1/29 , G01T1/166
CPC分类号： G01T1/1611 , G01T1/171 , G01T1/2985
摘要： A method of correcting for deadtime and for emission contamination of a transmission scan in a nuclear camera system is provided. The transmission scan is used to correct positron emission tomography (PET) images for attenuation. The camera system includes two detectors and two corresponding single-photon point sources that are collimated to produce fanbeam illumination profiles. A transmission detection window and an emission contamination detection window is defined on each detector. Radiation from each source is scanned axially across the field of view of the corresponding detector in synchronization with the corresponding transmission detection window to acquire transmission projection data. The emission contamination detection windows are also scanned axially concurrently with, but offset from, the transmission detection windows to acquire emission data. Events detected in the transmission detection windows are used to add counts from appropriate locations of the transmission projection on an event-by-event basis as those events are detected. Events detected in the emission contamination detection windows are used to subtract counts from appropriate locations of the transmission projection on an event-by-event basis as those events are detected. The number of counts by which a given location is incremented or decremented for each detected event is determined event-by-event from a look-up table based on the current singles rate.
摘要翻译：提供了一种校正核相机系统中的发射扫描的死区时间和发射污染的方法。透射扫描用于校正正电子发射断层摄影（PET）图像以进行衰减。相机系统包括两个检测器和两个对准的单光子点源，其被准直以产生扇形照明轮廓。在每个检测器上定义传输检测窗口和排放污染检测窗口。与对应的传输检测窗口同步地从相应检测器的视野轴向扫描来自每个源的辐射以获取传输投影数据。排放污染检测窗口也与传输检测窗口轴向同时扫描但偏移以获取发射数据。在发送检测窗口中检测到的事件用于在检测到事件时逐个事件的基础上从传输投影的适当位置添加计数。在发射污染检测窗口中检测到的事件用于在检测到事件时逐个事件基础上从传输投影的适当位置减去计数。基于当前单打率，从查找表中逐个事件确定给定位置对于每个检测到的事件递增或递减的计数次数。

26. 发明申请

US20130142411A1 DUAL MODALITY IMAGING INCLUDING QUALITY METRICS 有权
标题翻译：双重模态成像，包括质量度量
公开(公告)号：US20130142411A1
公开(公告)日：2013-06-06
申请号：US13817150
申请日：2011-08-17
申请人： Angela Da Silva , Horace Hines , Lingxiong Shao , Hongjie Liang , Anna Exner , Andreas Goedicke
发明人： Angela Da Silva , Horace Hines , Lingxiong Shao , Hongjie Liang , Anna Exner , Andreas Goedicke
IPC分类号： G06T11/00
CPC分类号： G06T11/003 , G06T7/33 , G06T11/008 , G06T2207/10084 , G06T2207/30048
摘要： An anatomical image data set and an emission image data set are acquired for a subject. An attenuation map is generated from the anatomical image data set. The emission image data set is reconstructed to generate an emission image. The reconstructing includes correcting for attenuation of emission radiation in the subject using the attenuation map. A value is calculated for a quality assurance (QA) metric quantifying alignment of the attenuation map with the emission image. The emission image is displayed or printed together with the calculated quality assurance metric. In some embodiments, prior to the reconstructing the attenuation map is registered with the emission image data set by performing a global rigid registration followed by a local non-rigid registration of a region of interest.
摘要翻译：获取对象的解剖图像数据集和发射图像数据集。从解剖图像数据集生成衰减图。重建发射图像数据集以产生发射图像。重建包括使用衰减图校正受试者中发射辐射的衰减。针对质量保证（QA）量度计算衰减图与发射图像的对准的值。排放图像与计算的质量保证度量一起显示或打印。在一些实施例中，在重建之前，通过执行全局刚性配准，随后是感兴趣区域的局部非刚性配准，将衰减图与发射图像数据集进行配准。

27. 发明申请

US20090087065A1 ACCOUNTING FOR FOREIGN OBJECTS WHEN CREATING CT-BASED ATTENUATION MAPS 审中-公开
标题翻译：在创建基于CT的衰减准则时对外部对象的会计
公开(公告)号：US20090087065A1
公开(公告)日：2009-04-02
申请号：US12278001
申请日：2007-01-29
申请人： Angela J. DaSilva , Lingxiong Shao
发明人： Angela J. DaSilva , Lingxiong Shao
IPC分类号： G06K9/00
CPC分类号： G01T1/1615 , A61B6/037 , A61B6/4452 , A61B6/4458
摘要： In a method for generating an attenuation map (30), image elements of a reconstructed tomographic image (24) are segmented into at least first, second, and third classes (50, 52, 54). Each image element of the first class (50) is transformed using a first image element value-dependent attenuation transform (60). Each image element of the second class (52) is transformed using a second image element value-dependent attenuation transform (62) different from the first image element value-dependent attenuation transform. Each image element of the third class (54) is transformed using a third image element value-dependent attenuation transform (64) different from both the first and second image element value-dependent attenuation transforms.
摘要翻译：在用于产生衰减图（30）的方法中，重构断层图像（24）的图像元素被分割为至少第一，第二和第三类（50,52,54）。使用第一图像元素值依赖衰减变换（60）来变换第一类（50）的每个图像元素。使用与第一图像元素值相关的衰减变换不同的第二图像元素值依赖衰减变换（62）来变换第二类（52）的每个图像元素。使用与第一和第二图像元素值相关的衰减变换两者不同的第三图像元素值依赖衰减变换（64）来变换第三类（54）的每个图像元素。

28. 发明授权

US06410920B1 Method and apparatus for performing correction of emission contamination and deadtime loss in a medical imaging system 失效
标题翻译：用于执行医疗成像系统中的排放污染和死时间损失校正的方法和装置
公开(公告)号：US06410920B1
公开(公告)日：2002-06-25
申请号：US09400745
申请日：1999-09-21
申请人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
发明人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
IPC分类号： G01T1164
CPC分类号： G01T1/2985 , A61B6/00 , A61B6/037 , G01T1/1611 , G01T1/171
摘要： A method of correcting for deadtime and for emission contamination of a transmission scan in a nuclear camera system is provided. The transmission scan is used to correct positron emission tomography (PET) images for attenuation. The camera system includes two detectors and two corresponding single-photon point sources that are collimated to produce fanbeam illumination profiles. A transmission detection window and an emission contamination detection window is defined on each detector. Radiation from each source is scanned axially across the field of view of the corresponding detector in synchronization with the corresponding transmission detection window to acquire transmission projection data. The emission contamination detection windows are also scanned axially concurrently with, but offset from, the transmission detection windows to acquire emission data. Events detected in the transmission detection windows are used to add counts from appropriate locations of the transmission projection on an event-by-event basis in real-time. Events detected in the emission contamination detection windows are used to subtract counts from appropriate locations of the transmission projection on an event-by-event basis as those events are detected. The number of counts by which a given location is incremented or decremented for each detected event is determined event-by-event from a look-up table based on the current singles rate.
摘要翻译：提供了一种校正核相机系统中的发射扫描的死区时间和发射污染的方法。透射扫描用于校正正电子发射断层摄影（PET）图像以进行衰减。相机系统包括两个检测器和两个对准的单光子点源，其被准直以产生扇形照明轮廓。在每个检测器上定义传输检测窗口和排放污染检测窗口。与对应的传输检测窗口同步地从相应检测器的视野轴向扫描来自每个源的辐射以获取传输投影数据。排放污染检测窗口也与传输检测窗口轴向同时扫描但偏移以获取发射数据。在传输检测窗口中检测到的事件用于实时地逐个事件地从传输投影的适当位置添加计数。在发射污染检测窗口中检测到的事件用于在检测到事件时逐个事件基础上从传输投影的适当位置减去计数。基于当前单打率，从查找表中逐个事件确定给定位置对于每个检测到的事件递增或递减的计数次数。

29. 发明授权

US5999588A Deadtime correction in a nuclear medicine imaging system 失效
标题翻译：核医学成像系统中的死时校正
公开(公告)号：US5999588A
公开(公告)日：1999-12-07
申请号：US62222
申请日：1998-04-17
申请人： Lingxiong Shao , Peter Nellemann , David Coles , Hugo Bertelsen , Jacobus Koster
发明人： Lingxiong Shao , Peter Nellemann , David Coles , Hugo Bertelsen , Jacobus Koster
IPC分类号： G01T1/164 , G01T20060101 , G01T1/161 , G01T1/20 , G06T5/00
CPC分类号： G01T1/1647 , G01T1/171
摘要： A method of correcting for deadtime in an attenuation map generated by a nuclear medicine imaging system is provided. The imaging system includes a gamma ray detector that is rotatable about an object to be imaged. A region is defined on the imaging surface of the detector, such as the edge of the field of view of the detector, such that during a transmission scan of the object, the radiation shadow of the object is substantially less likely to fall upon the defined region than upon other regions of the imaging surface. A blank transmission scan is then performed, including recording the radiation intensity level detected in the region as a reference intensity level. A transmission scan of the object is then performed to acquire an attenuation map of the object, including recording a radiation intensity level detected in the first region during the transmission scan. A correction value is then determined as the ratio of the reference intensity level to the intensity level detected in the region during the transmission scan. The attenuation map is then corrected for deadtime based on the correction value.
摘要翻译：提供了一种校正由核医学成像系统生成的衰减图中的死时间的方法。成像系统包括可围绕待成像对象旋转的伽马射线检测器。区域被定义在检测器的成像表面上，例如检测器视场的边缘，使得在物体的透射扫描期间，物体的辐射阴影实际上不太可能落在所定义的区域比成像表面的其他区域。然后执行空白传输扫描，包括将在该区域中检测到的辐射强度水平记录为参考强度水平。然后执行对象的传输扫描以获取对象的衰减图，包括记录在传输扫描期间在第一区域中检测到的辐射强度级别。然后将校正值确定为在透射扫描期间在该区域中检测到的基准亮度水平与强度水平的比率。然后根据校正值对衰减图进行死区校正。

30. 发明授权

US08977027B2 Dual modality imaging including quality metrics 有权
标题翻译：双重模态成像包括质量指标
公开(公告)号：US08977027B2
公开(公告)日：2015-03-10
申请号：US13817150
申请日：2011-08-17
申请人： Angela Da Silva , Horace Hines , Lingxiong Shao , Hongjie Liang , Anna Exner , Andreas Goedicke
发明人： Angela Da Silva , Horace Hines , Lingxiong Shao , Hongjie Liang , Anna Exner , Andreas Goedicke
IPC分类号： G06K9/00 , G06T11/00 , G06T7/00
CPC分类号： G06T11/003 , G06T7/33 , G06T11/008 , G06T2207/10084 , G06T2207/30048
摘要： An anatomical image data set and an emission image data set are acquired for a subject. An attenuation map is generated from the anatomical image data set. The emission image data set is reconstructed to generate an emission image. The reconstructing includes correcting for attenuation of emission radiation in the subject using the attenuation map. A value is calculated for a quality assurance (QA) metric quantifying alignment of the attenuation map with the emission image. The emission image is displayed or printed together with the calculated quality assurance metric. In some embodiments, prior to the reconstructing the attenuation map is registered with the emission image data set by performing a global rigid registration followed by a local non-rigid registration of a region of interest.
摘要翻译：获取对象的解剖图像数据集和发射图像数据集。从解剖图像数据集生成衰减图。重建发射图像数据集以产生发射图像。重建包括使用衰减图校正受试者中发射辐射的衰减。针对质量保证（QA）量度计算衰减图与发射图像的对准的值。排放图像与计算的质量保证度量一起显示或打印。在一些实施例中，在重建之前，通过执行全局刚性配准，随后是感兴趣区域的局部非刚性配准，将衰减图与发射图像数据集进行配准。

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