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21. 发明申请

US20050143789A1 Methods and systems for stimulating a peripheral nerve to treat chronic pain 审中-公开
标题翻译：刺激周围神经治疗慢性疼痛的方法和系统
公开(公告)号：US20050143789A1
公开(公告)日：2005-06-30
申请号：US11067111
申请日：2005-02-25
申请人： Todd Whitehurst , Kristen Jaax
发明人： Todd Whitehurst , Kristen Jaax
IPC分类号： A61N1/05 , A61N1/08 , A61N1/18 , A61N1/34
CPC分类号： A61N1/36071 , A61N1/08
摘要： Methods of treating chronic pain within a patient include applying at least one stimulus to a peripheral nerve within the patient with an implanted system control unit in accordance with one or more stimulation parameters. The stimulus is configured to treat the chronic pain. Systems for treating chronic pain within a patient include a system control unit configured to apply a stimulus to a peripheral nerve within the patient in accordance with one or more stimulation parameters. The system control unit is implanted within the patient and the stimulus is configured to treat the chronic pain.
摘要翻译：治疗患者的慢性疼痛的方法包括根据一个或多个刺激参数，用植入的系统控制单元对患者内的周围神经施加至少一种刺激。刺激被配置为治疗慢性疼痛。用于治疗患者中的慢性疼痛的系统包括系统控制单元，其被配置为根据一个或多个刺激参数对患者内的周围神经施加刺激。将系统控制单元植入患者体内，并且将刺激配置为治疗慢性疼痛。

22. 发明申请

US20050049651A1 Treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion 失效
标题翻译：通过电脑刺激和/或药物输注治疗情绪和/或焦虑症
公开(公告)号：US20050049651A1
公开(公告)日：2005-03-03
申请号：US10925519
申请日：2004-08-24
申请人： Todd Whitehurst , Kristen Jaax
发明人： Todd Whitehurst , Kristen Jaax
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36096 , A61M5/172 , A61M5/1723 , A61N1/37205 , A61N1/3787
摘要： A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以治疗情绪和/或焦虑症的系统和方法使用可植入系统控制单元（SCU），特别是可植入信号/脉冲发生器（IPG）或微刺激器在电刺激的情况下具有一个或多个电极，以及在药物输注的情况下具有一个或多个导管的可植入泵。在需要电刺激和药物刺激的情况下，使用一个或多个SCU。或者，优选地，当需要时，SCU提供电刺激和一种或多种刺激性药物。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。

23. 发明授权

US09700730B2 External charger with customizable magnetic charging field 有权
公开(公告)号：US09700730B2
公开(公告)日：2017-07-11
申请号：US13099906
申请日：2011-05-03
申请人： Rafael Carbunaru , Andrew DiGiore , Todd Whitehurst
发明人： Rafael Carbunaru , Andrew DiGiore , Todd Whitehurst
IPC分类号： A61N1/00 , A61N1/372 , A61N1/08 , A61N1/378
CPC分类号： A61N1/37229 , A61N1/08 , A61N1/37205 , A61N1/37211 , A61N1/378 , A61N1/3787
摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include a plurality of field customization coils for customizing the magnetic charging field generated by the external charger such that the magnetic charging field is not radially symmetric. For example, one embodiment includes a primary coil with a plurality of field customization coils distributed radially with respect to the coil. The generated magnetic charging field can be rendered radially asymmetric by selectively activating or disabling the field customization coils in response to data quantifying the coupling between the various implants and the field customization coils in the charger. If there is a relatively high coupling between a particular implant and a particular customization coil for example, that customization coil can be activated to counter the magnetic charging field at that location, while still maintaining a relatively high magnetic charging field at the location of other implants that may have lower couplings.

24. 发明申请

US20060212087A1 Implantable stimulator 失效
公开(公告)号：US20060212087A1
公开(公告)日：2006-09-21
申请号：US11081417
申请日：2005-03-15
申请人： Matthew Haller , Jay Daulton , Todd Whitehurst , Rafael Carbunaru
发明人： Matthew Haller , Jay Daulton , Todd Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/36007 , A61N1/37205
摘要： Exemplary implantable stimulators for stimulating a stimulation site within a patient include an electronic module configured to generate stimulation and a housing configured to house the electronic module. The housing has a shape allowing the a stimulator and a surgical device to be accommodated together within an insertion tool used to insert the stimulator into the patient. Exemplary methods of stimulating a stimulation site within a patient include generating stimulation with an electronic module and housing the electronic module in a housing. The housing has a shape allowing the housing and a surgical device to be accommodated together within an insertion tool used to insert the housing into the patient.

25. 发明申请

US20060036293A1 Methods for treating gastrointestinal disorders 有权
公开(公告)号：US20060036293A1
公开(公告)日：2006-02-16
申请号：US11192750
申请日：2005-07-29
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： A small implantable stimulator(s) having at least two electrodes is implanted adjacent to a gastrointestinal nerve and/or muscle for the stimulation treatment of gastrointestinal disorders, including gastrointestinal motility, sphincteric disorders, and/or eating disorders. The stimulator provides a means of stimulating tissue at a stimulation site when desired, and may be implanted via a minimal surgical procedure.

26. 发明申请

US20070129780A1 Cuff electrode arrangement for nerve stimulation and methods of treating disorders 有权
标题翻译：用于神经刺激的袖带电极装置和治疗疾病的方法
公开(公告)号：US20070129780A1
公开(公告)日：2007-06-07
申请号：US11294283
申请日：2005-12-05
申请人： Todd Whitehurst , Kirsten Jaax , Rafael Carbunaru
发明人： Todd Whitehurst , Kirsten Jaax , Rafael Carbunaru
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/37205
摘要： One embodiment is a stimulator arrangement for a nerve. The stimulator arrangement includes a cuff for placement around the nerve and a plurality of electrodes disposed on the cuff. The cuff comprises a first edge and defines a plurality of indentations along the first edge of the cuff. The stimulator arrangement may also include a stimulator unit coupled to the electrodes of the cuff. The stimulator unit may also be implantable.
摘要翻译：一个实施例是用于神经的刺激器装置。刺激器装置包括用于放置在神经周围的袖带和设置在袖带上的多个电极。袖带包括第一边缘并且限定沿着袖带的第一边缘的多个凹痕。刺激器装置还可以包括耦合到袖带的电极的刺激器单元。刺激器单元也可以是可植入的。

27. 发明申请

US20070112403A1 Electrode contact configurations for an implantable stimulator 有权
标题翻译：用于植入式刺激器的电极接触配置
公开(公告)号：US20070112403A1
公开(公告)日：2007-05-17
申请号：US11280582
申请日：2005-11-16
申请人： Michael Moffitt , Rafael Carbunaru , Todd Whitehurst , Alfred Mann
发明人： Michael Moffitt , Rafael Carbunaru , Todd Whitehurst , Alfred Mann
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： An exemplary implantable stimulator includes at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. One or more of the electrode contacts disposed on the stimulator are configured to deliver monopolar stimulation and/or multipolar stimulation. Exemplary methods of stimulating a stimulation site within a patient include providing at least one electrode contact array and at least one additional electrode contact. Both the electrode contact array and the additional electrode contact are disposed on an external surface of the stimulator. The electrode contact array includes multiple electrode contacts that are configured to have a first polarity. The additional electrode is configured to have a second polarity. The method further includes applying an electrical stimulation current to the stimulation site via one or more of the electrode contacts that are disposed on the stimulator.
摘要翻译：示例性可植入刺激器包括至少一个电极接触阵列和至少一个附加电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。设置在刺激器上的一个或多个电极接触器被配置成传递单极刺激和/或多极刺激。刺激患者内的刺激部位的示例性方法包括提供至少一个电极接触阵列和至少一个另外的电极接触。电极接触阵列和附加电极接触都设置在刺激器的外表面上。电极接触阵列包括被配置为具有第一极性的多个电极接触。附加电极被配置为具有第二极性。该方法还包括经由设置在刺激器上的一个或多个电极接触件向刺激部位施加电刺激电流。

28. 发明申请

US20060293723A1 Skull-mounted electrical stimulation system and method for treating patients 有权
标题翻译：头颅电刺激系统及治疗方法
公开(公告)号：US20060293723A1
公开(公告)日：2006-12-28
申请号：US10585233
申请日：2004-12-17
申请人： Todd Whitehurst , Rafael Carbunaru
发明人： Todd Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/52 , A61M2205/8243 , A61N1/0526 , A61N1/0529 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36114 , A61N1/37211 , A61N1/37229
摘要： A system and method for applying electrical stimulation or drug infusion to nervous tissue of a patient to treat epilepsy, movement disorders, and other indications uses at least one implantable system control unit (SCU) (110), including an implantable signal/pulse generator (IPG) and one or more electrodes (152, 152′). The IPG is implanted in the mastoid area (143) of the skull (140) and communicates with at least one external appliance (230), such as a Behind-the-Ear (BTE) unit (100). In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：用于对患者的神经组织施加电刺激或药物输注以治疗癫痫，运动障碍和其它指征的系统和方法使用至少一个可植入系统控制单元（SCU）（110），其包括可植入信号/脉冲发生器 IPG）和一个或多个电极（152,152'）。将IPG植入颅骨（140）的乳突区域（143）中并与至少一个外部设备（230）（例如，耳后（BTE）单元）进行通信。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。

29. 发明申请

US20120119699A1 External Charger for an Implantable Medical Device Having at Least One Moveable Charging Coil 有权
标题翻译：具有至少一个可移动充电线圈的可植入医疗设备的外部充电器
公开(公告)号：US20120119699A1
公开(公告)日：2012-05-17
申请号：US13277522
申请日：2011-10-20
申请人： Rafael Carbunaru , Andrew DiGiore , Todd Whitehurst
发明人： Rafael Carbunaru , Andrew DiGiore , Todd Whitehurst
IPC分类号： H02J7/00
CPC分类号： H02J50/40 , A61N1/3787 , H01F38/14 , H02J7/0042 , H02J7/025 , H02J50/12 , H02J50/90
摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include design elements for mechanically manipulating the position of one or more charging coils within the external charger to customize the magnetic charging field as appropriate for the charger/implantable device environment. For example, a single charging coil may be moved within a housing of the external charger to direct the charging field of the coil towards the currently “coldest” implant, i.e., the implant with the lowest coupling to the external charger. The one or more charging coils may be mechanically manipulated within the external charger housing in a number of ways, including by using linear actuators, by inflatable bladders, or even by hand.
摘要翻译：公开了改进的用于对植入式医疗装置进行充电的外部充电器，并且对于多个这种装置的充电特别有用。各种实施例中的每一个都包括用于机械地操纵外部充电器内的一个或多个充电线圈的位置的设计元件，以适应充电器/可植入装置环境来定制磁充电场。例如，单个充电线圈可以在外部充电器的壳体内移动以将线圈的充电场引向当前“最冷”的植入物，即具有与外部充电器的最低耦合的植入物。一个或多个充电线圈可以以多种方式在外部充电器壳体内机械地操作，包括通过使用线性致动器，可膨胀气囊，或甚至手动操作。

30. 发明申请

US20080065183A1 Vagus nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：迷走神经刺激通过动作电位的单向传播
公开(公告)号：US20080065183A1
公开(公告)日：2008-03-13
申请号：US11935921
申请日：2007-11-06
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/08 , A61N1/36071 , Y10S128/903
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for vagus nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于迷走神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。

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