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21. 发明申请

US20080071160A1 Displaying A Tracheobronchial Tree 审中-公开
标题翻译：显示气管支气管树
公开(公告)号：US20080071160A1
公开(公告)日：2008-03-20
申请号：US11570517
申请日：2005-06-15
申请人： Rafael Wiemker , Thomas Blaffert , Thomas Buelow , Steffen Renisch , Cristian Lorenz , Hans-Aloys Wischmann
发明人： Rafael Wiemker , Thomas Blaffert , Thomas Buelow , Steffen Renisch , Cristian Lorenz , Hans-Aloys Wischmann
IPC分类号： A61B5/04
CPC分类号： G06T11/206 , G06T7/12 , G06T7/62 , G06T2207/10072 , G06T2207/30028 , G06T2207/30061
摘要： The invention relates to automatically segmenting and displaying the tracheobronchial tree (400) and displaying clinical values (404) related to the segmented tracheobronchial tree (400).
摘要翻译：本发明涉及自动分割和显示气管支气管（400）并显示与分段的气管支气管结石（400）相关的临床值（404）。

22. 发明授权

US10380735B2 Image data segmentation 有权
公开(公告)号：US10380735B2
公开(公告)日：2019-08-13
申请号：US13637674
申请日：2011-03-16
申请人： Rafael Wiemker , Thomas Buelow , Daniel Bystrov , Torbjoern Vik , Heinrich Schulz
发明人： Rafael Wiemker , Thomas Buelow , Daniel Bystrov , Torbjoern Vik , Heinrich Schulz
IPC分类号： G06T7/00 , G06T7/12
摘要： A method for segmenting image data includes identifying a 2D boundary start position corresponding to tissue of interest in a cross-section of volumetric image data, wherein the start position is identified by a current position of a graphical pointer with respect to the cross-section, generating a preview 2D boundary for the tissue of interest based on the start position, displaying the preview 2D boundary superimposed over the cross-section, and updating the displayed preview 2D boundary if the position of the graphical pointer changes with respect to the cross-section.

23. 发明授权

US09406146B2 Quantitative perfusion analysis 有权
标题翻译：定量灌注分析
公开(公告)号：US09406146B2
公开(公告)日：2016-08-02
申请号：US13380610
申请日：2010-06-23
申请人： Rafael Wiemker , Thomas Buelow
发明人： Rafael Wiemker , Thomas Buelow
IPC分类号： G06K9/00 , G06T7/40 , G06T7/20 , G06T7/00
CPC分类号： G06T7/401 , G06T7/0016 , G06T7/20 , G06T7/41 , G06T2207/10096 , G06T2207/20104 , G06T2207/30104
摘要： A system is disclosed for quantitative analysis of perfusion images comprising image elements having intensity values associated therewith. The system comprises a frequency distribution computing subsystem (1) for computing a plurality of frequency distributions of the intensity values of at least part of the images. The system comprises a perfusion information extractor (2) for extracting information relating to perfusion from the plurality of frequency distributions. The perfusion information extractor (2) comprises a shift detector (3) for detecting a shift of the intensity values of the frequency distribution. The perfusion information extractor (2) is arranged for extracting the information relating to perfusion, based on the detected shift. A user interface element (8) enables a user to indicate a boundary between the core region and the rim region by a single degree of freedom. A vesselness subsystem (9) associates a vesselness value with an image element.
摘要翻译：公开了一种用于定量分析包括具有与其相关联的强度值的图像元素的灌注图像的系统。该系统包括用于计算至少部分图像的强度值的多个频率分布的频率分布计算子系统（1）。该系统包括用于从多个频率分布中提取与灌注相关的信息的灌注信息提取器（2）。灌注信息提取器（2）包括用于检测频率分布的强度值的偏移的移位检测器（3）。灌注信息提取器（2）被布置为基于检测到的移位来提取与灌注有关的信息。用户界面元件（8）使得用户能够通过单个自由度来指示核心区域和边缘区域之间的边界。容器子系统（9）将容器值与图像元素相关联。

24. 发明授权

US08892188B2 Identifying abnormal tissue in images of computed tomography 有权
标题翻译：识别计算机断层扫描图像中的异常组织
公开(公告)号：US08892188B2
公开(公告)日：2014-11-18
申请号：US11815973
申请日：2006-02-03
申请人： Thomas Buelow , Rafael Wiemker , Cristian Lorenz , Steffen Renisch , Thomas Blaffert
发明人： Thomas Buelow , Rafael Wiemker , Cristian Lorenz , Steffen Renisch , Thomas Blaffert
IPC分类号： A61B6/03 , G06T7/00 , G06K9/34 , A61B6/00
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/481 , A61B6/5217 , G06T5/50 , G06T7/10 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/10116 , G06T2207/30061 , G06T2207/30064 , G06T2207/30101
摘要： An imaging method for identifying abnormal tissue in the lung is provided, comprising the recording of slice images of the lung by means of X-ray radiation, recording of blood vessels, differentiation of blood vessels and abnormal tissue, segmentation of the abnormal tissue and display of the segmented abnormal tissue on an output device. In addition, a computer tomograph for identifying abnormal tissue in the lung is provided, having a radiation source for recording slice images of the lung and blood vessels by means of X-ray radiation, a computer unit for differentiating the blood vessels from the abnormal tissue and for segmenting the abnormal tissue, as well as an output device for displaying the segmented abnormal tissue. Furthermore, a computer program is provided for controlling a computer tomograph for an identification of abnormal tissue in the lung by means of a radiation source, designed to record slice images of the lung and blood vessels by means of X-ray radiation, to differentiate the blood vessels from abnormal tissue, to segment the abnormal tissue and to control an output device for displaying the abnormal tissue.
摘要翻译：提供了一种用于鉴定肺中异常组织的成像方法，包括通过X射线照射记录肺的切片图像，记录血管，血管和异常组织的分化，异常组织的分割和显示的输出装置上的分段异常组织。另外，提供了一种用于识别肺中的异常组织的计算机断层摄影机，具有用于通过X射线辐射记录肺和血管的切片图像的辐射源，用于将血管与异常组织分离的计算机单元并且用于分割异常组织，以及用于显示分段的异常组织的输出装置。此外，提供了一种计算机程序，用于通过辐射源来控制用于识别肺中的异常组织的计算机断层摄影机，其被设计成通过X射线辐射记录肺和血管的切片图像，以区分来自异常组织的血管，分割异常组织并控制用于显示异常组织的输出装置。

25. 发明授权

US08805044B2 Segmenting pulmonary arteries 有权
标题翻译：分段肺动脉
公开(公告)号：US08805044B2
公开(公告)日：2014-08-12
申请号：US12937289
申请日：2009-04-14
申请人： Thomas Buelow , Rafael Wiemker
发明人： Thomas Buelow , Rafael Wiemker
IPC分类号： G06K9/00
CPC分类号： G06T7/162 , G06T7/33 , G06T2207/10081 , G06T2207/20016 , G06T2207/20072 , G06T2207/30061 , G06T2207/30101
摘要： A method of identifying at least part of a pulmonary artery tree (402) comprises receiving (102) a bronchial tree structure (500) and receiving (104) a pulmonary vessel structure (400). A pair of a first bronchial segment (602) and a first vessel segment (604) is identified (106), wherein the first bronchial segment and the first vessel segment are adjacent with respect to position and orientation. The first vessel segment is identified (108) as arterial segment of the pulmonary artery tree. A spatial transformation is applied (110) such that the first bronchial segment and the first vessel segment substantially coincide (602′). Respective further vessel segments (606, 608) are identified (112) adjacent to bronchial segments (610, 612), wherein the bronchial segments are comprised in the bronchial tree.
摘要翻译：识别肺动脉树（402）的至少一部分的方法包括接收（102）支气管树结构（500）并接收（104）肺血管结构（400）。识别出一对第一支气管段（602）和第一血管段（604）（106），其中第一支气管区段和第一血管区段相对于位置和取向相邻。识别第一血管段（108）作为肺动脉树的动脉段。应用空间变换（110）使得第一支气管段和第一血管段基本上重合（602'）。识别与支气管段（610,612）相邻的另外的血管段（606,608），其中支气管段包括在支气管树中。

26. 发明授权

US08761470B2 Analyzing an at least three-dimensional medical image 有权
标题翻译：分析至少三维医学图像
公开(公告)号：US08761470B2
公开(公告)日：2014-06-24
申请号：US13126203
申请日：2009-10-19
申请人： Thomas Buelow
发明人： Thomas Buelow
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/60 , G06T2207/10096 , G06T2207/30068
摘要： A system for analyzing an at least three-dimensional medical image comprises a lesion detector (51) for identifying a lesion (4) represented by the image. A surface detector (52) identifies at least part of a surface (5) of an object represented by the image. Means (53) are provided for establishing an orientation of the lesion (4) with respect to at least part of the surface (5), based on an output of the lesion detector (51) and an output of the surface detector (52). A model fitter (54) fits a model (6) to the lesion (4). The means (53) for establishing an orientation of the lesion (4) comprises a lesion orientation detector (56) for computing an orientation value (α) indicative of an orientation of the model (6) with respect to at least part of the surface (5).
摘要翻译：用于分析至少三维医学图像的系统包括用于识别由图像表示的病变（4）的病变检测器（51）。表面检测器（52）识别由图像表示的物体的表面（5）的至少一部分。提供装置（53），用于基于病变检测器（51）的输出和表面检测器（52）的输出，相对于表面（5）的至少一部分建立病变部（4）的取向，。模型拟合器（54）适合于病变（4）的模型（6）。用于建立病变（4）的取向的装置（53）包括病变取向检测器（56），用于计算指示模型（6）相对于表面的至少一部分的取向的取向值（α）（5）。

27. 发明授权

US08718341B2 Synopsis of multiple segmentation results for breast lesion characterization 有权
标题翻译：乳腺病变特征的多个分割结果的概要
公开(公告)号：US08718341B2
公开(公告)日：2014-05-06
申请号：US13131140
申请日：2009-11-16
申请人： Thomas Buelow , Rafael Wiemker , Martin Bergtholdt , Lina Arbash Meinel
发明人： Thomas Buelow , Rafael Wiemker , Martin Bergtholdt , Lina Arbash Meinel
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/136 , G06T2207/10096 , G06T2207/30096
摘要： When characterizing a tumor or lesion as malignant or benign, a system (10) receives an image of the lesion volume (50), employs a processor (12) to perform a raw segmentation of the image, the results of which are stored to memory (14). Then processor then executes a hole-filling procedure to fill in dark areas in the image of the lesion representing necrotic tissue that absorbed little or no contrast agent, and optionally a leakage removal procedure to remove image voxels associated with non-lesion tissue, e.g., blood vessels, in which the contrast agent was present during imaging, to generate a complete lesion volume. A voxel analyzer (18) assesses a number of voxels included in the raw segmentation of the lesion image, and the final segmentation (e.g., after filling and optional leakage removal). A segmentation comparator (20) computes a ratio of dark area voxels related to necrotic tissue detected after the raw segmentation to total voxels detected in the final image segmentation. The ratio is then used to determine a likelihood of malignancy, with a higher ratio indicating a higher likelihood.
摘要翻译：当将肿瘤或病变描绘为恶性或良性时，系统（10）接收病变体积（50）的图像，使用处理器（12）执行图像的原始分割，其结果存储到存储器（14）。然后，处理器然后执行填充填充程序以填充代表坏死组织的损伤图像中的暗区域，其吸收很少或没有造影剂，以及可选地泄漏去除程序以去除与非损伤组织相关联的图像体素，在成像期间存在造影剂的血管，以产生完整的病变体积。体素分析器（18）评估包括在损伤图像的原始分割中的多个体素，以及最终分割（例如在填充和可选的泄漏移除之后）。分割比较器（20）计算与原始分割之后检测到的坏死组织相关的暗区域体素与在最终图像分割中检测到的总体素的比率。然后将该比率用于确定恶性肿瘤的可能性，其中较高的比率表明更高的可能性。

28. 发明申请

US20120207373A1 THREE-DIMENSIONAL ANALYSIS OF LESIONS REPRESENTED BY IMAGE DATA 有权
标题翻译：图像数据表示的三维分析
公开(公告)号：US20120207373A1
公开(公告)日：2012-08-16
申请号：US13502475
申请日：2010-10-21
申请人： Michael Grass , Eberhard Sebastian Hansis , Thomas Buelow , Klaus Erhard
发明人： Michael Grass , Eberhard Sebastian Hansis , Thomas Buelow , Klaus Erhard
IPC分类号： G06K9/00
CPC分类号： A61B6/502 , A61B6/025 , A61B6/466 , G06K9/00208 , G06K9/6221 , G06T7/0012 , G06T2207/10072 , G06T2207/30068
摘要： A system for three-dimensional analysis of lesions in image data is disclosed. It comprises a lesion detection subsystem (1) for detecting individual lesions and three-dimensional positions of the individual lesions, based on e.g. breast image data (301). It comprises a cluster detection subsystem (2) for detecting a cluster of lesions (302), based on three-dimensional position information of lesions, and associating at least some of the individual lesions with the cluster of lesions (302), based on the three-dimensional positions of the individual lesions. The cluster detection subsystem (2) is arranged for detecting the cluster of lesions (302), based on the three-dimensional positions of the individual lesions. It comprises a cluster analysis subsystem (3) for analyzing the cluster of lesions (302).
摘要翻译：公开了一种用于图像数据中病变三维分析的系统。它包括病变检测子系统（1），用于根据例如病毒检测子系统（1）检测个体病变和个体病变的三维位置。乳房图像数据（301）。其包括用于基于损伤的三维位置信息来检测病变群集（302）的簇检测子系统（2），并且基于所述病变群集（302）将至少一些个体病变与所述病变簇（302）相关联个体病变的立体位置。群体检测子系统（2）被设置为基于个体病变的三维位置来检测病变簇（302）。它包括用于分析病变簇（302）的聚类分析子系统（3）。

29. 发明申请

US20110194742A1 ONE-CLICK CORRECTION OF TUMOR SEGMENTATION RESULTS 审中-公开
标题翻译：一次性修正肿瘤分期结果
公开(公告)号：US20110194742A1
公开(公告)日：2011-08-11
申请号：US13123042
申请日：2009-10-06
申请人： Thomas Buelow , Rafael Wiemker
发明人： Thomas Buelow , Rafael Wiemker
IPC分类号： G06K9/00
CPC分类号： G06T7/11 , G06T2200/04 , G06T2200/24 , G06T2207/20092 , G06T2207/30096
摘要： When adjusting parameters of a segmentation protocol for segmenting a volume of interest in an anatomical image, a user selects a superparameter (50) that includes multiple internal parameters (52) for adjusting a raw segmentation of the volume interest. As a weight of the selected superparameter is adjusted, weights of the internal parameters associated with the superparameter are adjusted according to a superparameter segmentation adjustment algorithm (20). The volume of interest is iteratively re-segmented after each internal parameter adjustment, transparently to the user, until a predetermined amount of change has been effected in the volume of interest segmentation, at which time the re-segmented volume of interest is displayed to the user.
摘要翻译：当调整分割协议的参数以分解解剖图像中的感兴趣体积时，用户选择包括多个内部参数（52）的超参数（50），以调整体积兴趣的原始分割。当调整所选超参数的权重时，根据超参数分段调整算法（20）调整与超参数相关联的内部参数的权重。在每个内部参数调整之后，对用户透明地重新分段感兴趣的体积，直到感兴趣区段的体积中已经实现了预定量的变化，此时将重新分割的感兴趣体积显示给用户。

30. 发明申请

US20100260392A1 CONSISTENCY METRIC BASED IMAGE REGISTRATION 审中-公开
标题翻译：一致性公制图像注册
公开(公告)号：US20100260392A1
公开(公告)日：2010-10-14
申请号：US12746179
申请日：2008-12-12
申请人： Rafael Wiemker , Sven Kabus , Thomas Buelow , Roland Opfer
发明人： Rafael Wiemker , Sven Kabus , Thomas Buelow , Roland Opfer
IPC分类号： G06T7/00 , G06K9/60
CPC分类号： G06K9/32 , G06F19/321 , G06K2209/05 , G06T7/337 , G06T2207/10081 , G06T2207/30004
摘要： A method includes registering a first sub-portion of a first image with a corresponding second sub-portion of a second image, and registering the second sub-portion of the second image with a corresponding third sub-portion of the first image. The first sub-portion encompasses a first object of interest, and the third sub-portion encompasses a third object of interest. The method further includes reducing a size of the first sub-portion when the first and third objects of interest are substantially similar. The method further includes repeating the steps of registering the first sub-portion, registering the second sub-portion, and reducing the size of the first sub-portion until the first and third objects are not substantially similar.
摘要翻译：一种方法包括：将第一图像的第一子部分与第二图像的对应的第二子部分对齐，并且将第二图像的第二子部分与第一图像的对应的第三子部分进行登记。第一子部分包含第一感兴趣对象，第三子部分包含第三感兴趣对象。所述方法还包括当所述第一和第三感兴趣对象基本相似时减小所述第一子部分的大小。该方法还包括重复登记第一子部分，登记第二子部分以及减小第一子部分的大小，直到第一和第三对象基本不相似的步骤。

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