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21. 发明授权

US07342040B2 5-fluorooxindole-3-carboxylic acid ester 失效
标题翻译： 5-氟羟吲哚-3-羧酸酯
公开(公告)号：US07342040B2
公开(公告)日：2008-03-11
申请号：US11093603
申请日：2005-03-30
申请人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
发明人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/34 , C07C201/12 , C07C205/56 , C07C255/41 , C07D209/32
摘要： A 5-fluorooxindole-3-carboxylic acid ester represented by a formula (2): wherein R1 is a group selected from the group consisting of an unsubstituted or substituted alkyl group having 1 to 10 carbon atoms, an unsubstituted or substituted cycloalkyl group having 3 to 7 carbon atoms, an aralkyl group having 7 to 10 carbon atoms or an aryl group having 6 to 14 carbon atoms.
摘要翻译：由式（2）表示的5-氟羟吲哚-3-羧酸酯：其中R 1是选自未取代或取代的碳原子数1〜10的烷基，具有3至7个碳原子的未取代或取代的环烷基，具有7至10个碳原子的芳烷基或具有6至14个碳原子的芳基。

22. 发明申请

US20070106083A1 Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same 有权
标题翻译：制备4-氨基四氢吡喃化合物及其酸式盐的合成中间体及其制备方法
公开(公告)号：US20070106083A1
公开(公告)日：2007-05-10
申请号：US10564709
申请日：2004-07-14
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
IPC分类号： C07D309/14
CPC分类号： C07D309/10 , C07D309/14
摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
摘要翻译：本发明涉及一种由式（2）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐由式（1）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，以及其制备方法准备一样

23. 发明申请

US20060287541A1 Method for producing nitrile compound, carboxylic acid compound or carboxylate compound 有权
标题翻译：腈化合物，羧酸化合物或羧酸酯化合物的制造方法
公开(公告)号：US20060287541A1
公开(公告)日：2006-12-21
申请号：US10572373
申请日：2004-09-17
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada
IPC分类号： C07D309/14
CPC分类号： C07C253/30 , C07C51/00
摘要： The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.
摘要翻译：本发明公开了一种制备由式（2）表示的腈化合物，羧酸化合物或羧酸酯化合物的方法：其中R表示氰基，羧基或酯基，R 1 R 2和R 2各自表示不参与反应的基团，其可以具有取代基，R 1和R 2， SUP>可以彼此组合以形成环，其包括使由式（1）表示的乙酸化合物：其中R，R 1和R 2，具有与上述相同的含义，在金属催化剂的存在下脱羧。

24. 发明申请

US20060270849A1 Process for producing pyrimidin-4-one compound 审中-公开
标题翻译：制备嘧啶-4-酮化合物的方法
公开(公告)号：US20060270849A1
公开(公告)日：2006-11-30
申请号：US10561042
申请日：2004-06-18
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , C07D239/90 , C07D239/91 , C07D471/04 , C07D495/04
摘要： A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions.
摘要翻译：通过使氨基芳基羧酸化合物与有机酸化合物在含氮原子化合物的存在下，在相对简单和适中的反应条件下反应，可以高收率地制备嘧啶-4-酮化合物。

25. 发明申请

US20050130995A1 Process for producing 4-aminoquinazoline compound 审中-公开
标题翻译： 4-氨基喹唑啉化合物的制备方法
公开(公告)号：US20050130995A1
公开(公告)日：2005-06-16
申请号：US10503664
申请日：2003-02-06
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda
IPC分类号： C07D239/88 , C07D239/94 , A61K31/517
CPC分类号： C07D239/88 , C07D239/94
摘要： A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
摘要翻译： 4-氨基喹唑啉衍生物可以通过以下步骤获得：将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应，然后使反应产物与由式R 5 -NH-R 6（R 5和R 6各自表示氢或任选地取代的烃基）在第二有机溶剂的存在下进行。

26. 发明授权

US06900335B2 Process for producing 5-fluorooxindole and for producing intermediates therefor 失效
标题翻译：制备5-氟羟吲哚的方法及其制备中间体
公开(公告)号：US06900335B2
公开(公告)日：2005-05-31
申请号：US10333316
申请日：2001-07-19
申请人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
发明人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
IPC分类号： C07C205/56 , C07C255/41 , C07D209/32 , C07D209/34
CPC分类号： C07D209/34 , C07C201/12 , C07C205/56 , C07C255/41 , C07D209/32
摘要： The present invention discloses a process for preparing 5-fluorooxindole represented by the formula (3): which comprises (A) a first step of cyclizing 2-(5-fluoro-2-nitrophenyl)malonic acid diester represented by the formula (1): wherein R1 and R2 may be the same or different from each other and each represents a group which does not participate in the reaction, under reductive conditions to form 5-fluorooxindole-3-carboxylic acid ester represented by the formula (2): wherein R1 has he same meaning as defined above, and (B) then, a second step of decarboxylating the 5-fluorooxindole-3-carboxylic acid ester, and a process for preparing its synthetic intermediates.
摘要翻译：本发明公开了一种制备式（3）表示的5-氟羟吲哚的方法：其包括（A）使由式（1）表示的2-（5-氟-2-硝基苯基）丙二酸二酯环化的第一步骤，：其中R 1和R 2彼此可以相同或不同，并且各自代表不参与反应的基团，在还原条件下形成5- 由式（2）表示的氟氧吲哚-3-羧酸酯：其中R 1具有与上述相同的含义，（B）然后，将5-氟羟吲哚-3 - 羧酸酯及其合成中间体的制备方法。

27. 发明申请

US20050080262A1 Process for producing quinazolin-4-one derivative 失效
标题翻译：喹唑啉-4-酮衍生物的制备方法
公开(公告)号：US20050080262A1
公开(公告)日：2005-04-14
申请号：US10502734
申请日：2003-01-28
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
IPC分类号： C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/88 , C07D239/90 , C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92 , C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/90
摘要： A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.
摘要翻译：制备具有下式的喹唑啉-4-酮化合物的方法：其中R 1，R 2，R 3和R 4各自表示不参与下述反应的基团，和 R 1，R 2，R 3和R 4可以组合在一起形成环]，其包括使具有下式的邻氨基苯甲酸衍生物：其中R 5是氢原子或烃基]与甲酸衍生物在羧酸铵存在下反应。

28. 发明授权

US06841681B2 Process for producing quinoline carboxyaldehyde derivative and intermediate thereof 失效
标题翻译：制备喹啉羧醛衍生物及其中间体的方法
公开(公告)号：US06841681B2
公开(公告)日：2005-01-11
申请号：US10468062
申请日：2002-02-14
申请人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Naoko Okada , Takashi Harada , Akira Nakamura , Hiroyuki Oda
发明人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Naoko Okada , Takashi Harada , Akira Nakamura , Hiroyuki Oda
IPC分类号： C07D215/14 , C07D215/54 , C07C225/22 , C07C255/17 , C07D215/12
CPC分类号： C07D215/14
摘要： 2-Cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carboxyaldehyde useful as a material for pharmaceutical products, can be obtained by reacting 3-cyclopropyl-3-oxopropanenitrile with 2-amino-4′-fluorobenzophenone to obtain 2-cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carbonitrile, and reducing it.
摘要翻译：可用作药物物质的2-环丙基-4-（4'-氟苯基）喹啉-3-甲醛可以通过3-环丙基-3-氧代丙腈与2-氨基-4'-氟二苯甲酮反应得到2- 环丙基-4-（4'-氟苯基）喹啉-3-腈，并还原。

29. 发明授权

US08318932B2 Process for producing 4-aminoquinazoline compound 失效
标题翻译： 4-氨基喹唑啉化合物的制备方法
公开(公告)号：US08318932B2
公开(公告)日：2012-11-27
申请号：US12400895
申请日：2009-03-10
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda
IPC分类号： C07D239/72
CPC分类号： C07D239/88 , C07D239/94
摘要： A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
摘要翻译： 4-氨基喹唑啉衍生物可以通过以下步骤获得：将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应，然后使反应产物与由在第二有机溶剂的存在下，式R5-NH-R6（R5和R6各自表示氢或任选取代的烃基）。

30. 发明申请

US20090209674A1 RESIN COMPOSITION FOR STEREOLITHOGRAPHY 有权
标题翻译：用于立体成像的树脂组合物
公开(公告)号：US20090209674A1
公开(公告)日：2009-08-20
申请号：US12304962
申请日：2007-06-15
申请人： Takashi Ito , Tsuneo Hagiwara , Kenji Hirotsu , Tadashi Murakami
发明人： Takashi Ito , Tsuneo Hagiwara , Kenji Hirotsu , Tadashi Murakami
IPC分类号： C08F2/46
CPC分类号： C08F2/50 , B33Y70/00 , C08G59/18 , C08L63/00 , G03F7/0037 , G03F7/038
摘要： Provided is a resin composition for stereolithography that absorbs little water and moisture over time in uncured state, maintains a low moisture absorption rate even under high humidity, and has high curing sensitivity, from which a stereolithography product excellent in the properties, such as dimensional accuracy, mechanical properties, and dimensional stability can be smoothly produced for reduced light irradiation time.The resin composition for stereolithography comprising an oxetane compound expressed by the general formula (I) below; (wherein R1 denotes an alkyl group having 1 to 5 carbon atoms, and R2 denotes an alkylene group having 2 to 10 carbon atoms that may contain an ether bond) in the proportion of from 3 to 60 mass % based on the total mass of the resin composition for stereolithography.
摘要翻译：提供一种用于立体光刻的树脂组合物，其在未固化状态下随时间吸收几乎没有水分和水分，即使在高湿度下也保持低吸湿率，并且具有高固化灵敏度，由此可以获得诸如尺寸精度的性能优异的立体光刻产品，可以平滑地产生机械性能和尺寸稳定性，以减少光照射时间。用于立体光刻的树脂组合物，其包含由下述通式（I）表示的氧杂环丁烷化合物; （其中R1表示具有1至5个碳原子的烷基，R2表示可含有醚键的具有2至10个碳原子的亚烷基），基于总重量的3至60质量％用于立体光刻的树脂组合物。

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