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21. 发明授权

US07040314B2 Aerosol generating devices and methods for generating aerosols suitable for forming propellant-free aerosols 有权
标题翻译：用于产生适于形成不含无推进剂的气溶胶的气溶胶的气溶胶产生装置和方法
公开(公告)号：US07040314B2
公开(公告)日：2006-05-09
申请号：US10653934
申请日：2003-09-04
申请人： Tung T. Nguyen , Christopher L. Irving , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
发明人： Tung T. Nguyen , Christopher L. Irving , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61M16/00
CPC分类号： A61K9/0078 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/02 , A61M15/025 , A61M2016/0027 , A61M2205/8206 , A61M2205/8237
摘要： Liquid aerosol formulations for generating aerosols include at least one high volatility carrier and a second component. In some embodiments, the liquid aerosol formulation is propellant free. An aerosol generating device generates an aerosol by passing liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor, which is mixed with air to form an aerosol. In some embodiments, particles of the aerosol consist essentially of the second component. The aerosol generator can be incorporated in a hand held inhaler. The aerosol can be delivered to a targeted portion of the lung using the inhaler.
摘要翻译：用于产生气溶胶的液体气溶胶制剂包括至少一种高挥发性载体和第二组分。在一些实施方案中，液体气溶胶制剂不含推进剂。气溶胶发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化为蒸汽而产生气溶胶，该蒸汽与空气混合以形成气溶胶。在一些实施方案中，气溶胶的颗粒基本上由第二组分组成。气溶胶发生器可以并入手持式吸入器中。气雾剂可以使用吸入器输送到肺的目标部分。

22. 发明授权

US07625548B2 Methods and apparatus for producing nanoscale particles 有权
标题翻译：制备纳米级颗粒的方法和装置
公开(公告)号：US07625548B2
公开(公告)日：2009-12-01
申请号：US12149604
申请日：2008-05-05
申请人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
发明人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61K47/06
CPC分类号： A61K31/137 , A61K9/0073 , A61K31/573 , A61K47/08 , A61K47/10 , A61M11/041 , A61M11/042 , A61M15/0025 , A61M15/025 , A61M2016/0021 , A61M2205/8206 , A61M2205/8237
摘要： Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand held inhaler, and can be delivered to a targeted portion of the lung using the inhaler. Composite controlled release particles of micron or nanoscale size can be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.
摘要翻译：用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。颗粒发生器可以并入手持式吸入器中，并且可以使用吸入器输送到肺的目标部分。可以通过使药物，控制释放剂和载液的溶液流过毛细管加热器来生产微米或纳米尺寸的复合控制释放颗粒。

23. 发明授权

US06715487B2 Dual capillary fluid vaporizing device 有权
标题翻译：双毛细管流体蒸发装置
公开(公告)号：US06715487B2
公开(公告)日：2004-04-06
申请号：US10430272
申请日：2003-05-07
申请人： Walter A. Nichols , Kenneth A. Cox , Tung Tien Nguyen
发明人： Walter A. Nichols , Kenneth A. Cox , Tung Tien Nguyen
IPC分类号： A61M1500
CPC分类号： A61M15/00 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2016/0024
摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol and includes first and second capillary tubes connected electrically in series by providing separate electrodes at the inlet ends of each capillary tube, and connecting the outlet ends of the capillary tubes by an electrical connection that connects the outlet ends both electrically and thermally. The capillary tubes are heated by the flow of electricity therethrough, and liquid flowing through the tubes is vaporized. The outlet ends of the capillary tubes are easily maintained at a temperature for optimizing aerosol generation since there is minimal heat loss through the connection connecting the outlet ends.
摘要翻译：一种流体蒸发装置，其用于将流体蒸发成气溶胶，并且包括通过在每个毛细管的入口端处提供分开的电极串联电连接的第一和第二毛细管，并且通过电连接连接毛细管的出口端，该电连接出口端部电气和热端都结束。毛细管由电流通过其加热，流过管的液体被蒸发。毛细管的出口端容易地保持在用于优化气溶胶产生的温度，因为通过连接出口端的连接件具有最小的热损失。

24. 发明授权

US06640050B2 Fluid vaporizing device having controlled temperature profile heater/capillary tube 有权
公开(公告)号：US06640050B2
公开(公告)日：2003-10-28
申请号：US09957026
申请日：2001-09-21
申请人： Walter A. Nichols , Kenneth A. Cox , Douglas D. McRae , Tung Tien Nguyen
发明人： Walter A. Nichols , Kenneth A. Cox , Douglas D. McRae , Tung Tien Nguyen
IPC分类号： F24F600
CPC分类号： A61M11/041 , A61M11/001 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2016/0021 , A61M2205/8206
摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol includes a capillary tube made from an electrically conductive material, an upstream electrode connected to the tube, and a downstream electrode connected to the tube and provided with an electrical resistivity sufficient to cause heating of the downstream electrode during operation to approximately the same temperature as the tube at the point of connection. The upstream and downstream electrodes connected to the capillary tube divide the tube into an initial feed section, a heated section, and a tip. A source of material to be volatilized is provided to the tube at the feed section, passes downstream into the heated section, is vaporized, and then exits from the tube through the tip. The temperature profile of the tube along the heated section is controlled by varying parameters to substantially eliminate any effect of the downstream electrode as a heat sink. These parameters may include the electrical resistivity of the downstream electrode, its cross-sectional area, and its length.

25. 发明授权

US09526808B2 Air freshening device 有权
标题翻译：空气清新装置
公开(公告)号：US09526808B2
公开(公告)日：2016-12-27
申请号：US12903419
申请日：2010-10-13
申请人： Christopher S. Tucker , Walter A. Nichols
发明人： Christopher S. Tucker , Walter A. Nichols
IPC分类号： A61L9/03 , A61L9/14
CPC分类号： A61L9/037 , A01M1/2077 , A61L9/02 , A61L9/14 , A61L2209/11 , A61L2209/135 , B05B1/24
摘要： An air freshening device includes a liquid supply operable to supply liquid fragrance material, a wick in contact with the liquid supply, a conductive mesh material operable to retain the liquid material in interstices thereof, and a power supply operable to apply voltage across the mesh material so as to heat the mesh material and the liquid fragrance material contained in interstices of the mesh material to a temperature sufficient to vaporize the liquid. The air freshening device is operable to substantially prevent deposition of the vaporized liquid material.
摘要翻译：空气清新装置包括可操作以供应液体香料的液体供应源，与液体供应源接触的芯，可操作以将液体材料保持在其间隙中的导电网状材料，以及可操作以跨网格材料施加电压的电源以便将网状材料的间隙中所含的网状材料和液体香料材料加热到足以使液体蒸发的温度。空气清新装置可操作以基本上防止蒸发的液体材料的沉积。

26. 发明授权

US08662479B2 Respiratory humidification system 有权
标题翻译：呼吸加湿系统
公开(公告)号：US08662479B2
公开(公告)日：2014-03-04
申请号：US13618494
申请日：2012-09-14
申请人： Walter A. Nichols , Christopher S. Tucker , Amit Limaye
发明人： Walter A. Nichols , Christopher S. Tucker , Amit Limaye
IPC分类号： B01F3/04
CPC分类号： A61M16/16 , A61M11/007 , A61M11/042 , A61M16/1075 , A61M16/147 , A61M16/164 , A61M2205/75
摘要： A respiratory humidification system having a capillary passage in communication with a ventilator, the ventilator adapted to deliver an air stream, a heater operable to at least partially vaporize water in the capillary passage, a pumping unit adapted to supply water to the capillary passage, wherein the water upon heating is at least partially vaporized to form an aerosol stream. The aerosol stream is combined with the air stream to form a humidified air stream.
摘要翻译：一种呼吸加湿系统，其具有与通气机连通的毛细管通道，所述呼吸机适于输送空气流，可操作以至少部分蒸发毛细管通道中的水的加热器，适于向毛细通道供水的泵送单元，其中加热时的水至少部分蒸发以形成气溶胶流。气溶胶流与空气流合并形成加湿空气流。

27. 发明授权

US07323207B2 Method and apparatus for fingerprint detection 有权
标题翻译：指纹检测方法和装置
公开(公告)号：US07323207B2
公开(公告)日：2008-01-29
申请号：US10532122
申请日：2003-10-21
申请人： Walter A. Nichols , Daniel Diefenbach
发明人： Walter A. Nichols , Daniel Diefenbach
IPC分类号： B05D7/00 , B05C5/02
CPC分类号： A61B5/1172
摘要： A portable apparatus for detecting latent fingerprints that discharges a vapor of a cyanoacrylate-containing solution. The apparatus comprises a reservoir for holding a liquid solution comprising cyanoacrylate, a valve for controlling the release of the solution through a capillary flow passage, and a power supply for heating the capillary flow passage and vaporizing the solution. When cyanoacrylate vapor contacts latent fingerprints, the fingerprints are rendered visible.
摘要翻译：一种用于检测放出含氰基丙烯酸酯溶液的蒸汽的潜在指纹的便携式设备。该装置包括用于保持包含氰基丙烯酸酯的液体溶液的储存器，用于控制通过毛细管流动通道释放溶液的阀，以及用于加热毛细管流动通道并蒸发溶液的电源。当氰基丙烯酸酯蒸气接触潜在指纹时，指纹便可见。

28. 发明授权

US4646763A Adjustable filter cigarette 失效
标题翻译：可调滤嘴香烟
公开(公告)号：US4646763A
公开(公告)日：1987-03-03
申请号：US799747
申请日：1985-11-19
申请人： Walter A. Nichols
发明人： Walter A. Nichols
IPC分类号： A24D1/04 , A24D3/04
CPC分类号： A24D3/041
摘要： A variable dilution cigarette, of the type having a filter with two relatively rotatable segments having slits in the plug wrapping and the tipping paper which rotate in and out of rotational registry to vary the dilution level, is provided which is insensitive to slight longitudinal misalignment of the slits. An array of longitudinal depressions is formed in one segment of the filter plug centered on the slit in the plug wrapping and ending short of both ends of the filter segment containing the slit. The depressions act as a plenum allowing the longitudinal flow of air between the slit in the tipping paper and the slit in the plug wrapping in case of longitudinal misalignment arising during use, but do not allow circumferential air flow when the slits are intentionally deregistered by relative rotation of the filter segments. Because the depressions do not reach the ends of the filter segment containing the slit, they do not allow any unwanted air into the filter.
摘要翻译：一种可变稀释香烟，其具有带有两个相对可旋转的片段的过滤器，该片段在塞子包装中具有狭缝，并且提供旋转登记中旋转和离开旋转注册表以改变稀释度的接装纸，其对轻微的纵向不对准不敏感狭缝。纵向凹陷的阵列形成在滤芯的一段中心于塞子包裹中的狭缝上，并且在包含狭缝的过滤段的两端不足。凹陷作为一个充气室，允许在使用期间出现纵向不对准的情况下允许在接装纸中的狭缝和塞子包装中的狭缝之间的空气的纵向流动，但是当狭缝有意地被相对地注销时，不允许周向空气流动过滤段的旋转。由于凹陷没有到达包含狭缝的过滤器段的端部，所以它们不允许任何不需要的空气进入过滤器。

29. 发明授权

US4313339A Rheometer and rheological measuring method 失效
标题翻译：流变仪和流变学测量方法
公开(公告)号：US4313339A
公开(公告)日：1982-02-02
申请号：US131745
申请日：1980-03-19
申请人： Walter A. Nichols , George L. Mathe
发明人： Walter A. Nichols , George L. Mathe
IPC分类号： G01N11/04
CPC分类号： G01N11/04
摘要： A rheometer of the extrusion plastometer type is provided with means for forcibly mechanically mixing the material to be tested within the chamber of the rheometer. The rheometer preferably includes a pair of telescopically arranged pistons which can be selectively coupled and uncoupled from one another so that one of them can serve as a mixing device. The pistons are coupled for unitary movement when discharging the material being tested.
摘要翻译：挤出塑性仪型流变仪设置有用于在流变仪的腔室内强制机械混合待测材料的装置。流变仪优选地包括一对可伸缩布置的活塞，其可以彼此选择性地联接和分离，使得它们中的一个可以用作混合装置。当排出被测试材料时，活塞连接成一体运动。

30. 发明申请

US20090267242A1 Respiratory humidification system 失效
标题翻译：呼吸加湿系统
公开(公告)号：US20090267242A1
公开(公告)日：2009-10-29
申请号：US12285913
申请日：2008-10-16
申请人： Walter A. Nichols , Christopher S. Tucker , Amit Limaye
发明人： Walter A. Nichols , Christopher S. Tucker , Amit Limaye
IPC分类号： A61M16/16 , A61M16/10
CPC分类号： A61M16/16 , A61M11/007 , A61M11/042 , A61M16/1075 , A61M16/147 , A61M16/164 , A61M2205/75
摘要： A respiratory humidification system having a capillary passage in communication with a ventilator, the ventilator adapted to deliver an air stream, a heater operable to at least partially vaporize water in the capillary passage, a pumping unit adapted to supply water to the capillary passage, wherein the water upon heating is at least partially vaporized to form an aerosol stream. The aerosol stream is combined with the air stream to form a humidified air stream.
摘要翻译：一种呼吸加湿系统，其具有与通气机连通的毛细管通道，所述呼吸机适于输送空气流，可操作以至少部分蒸发毛细管通道中的水的加热器，适于向毛细通道供水的泵送单元，其中加热时的水至少部分蒸发以形成气溶胶流。气溶胶流与空气流合并形成加湿空气流。

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