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21. 发明授权

US4292272A Multilayer analysis sheet for analyzing liquid samples 失效
标题翻译：用于分析液体样品的多层分析表
公开(公告)号：US4292272A
公开(公告)日：1981-09-29
申请号：US157737
申请日：1980-06-09
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01M3/04 , G01M3/20 , G01N31/22 , G01N33/52 , G01N21/84 , G01N33/50
CPC分类号： G01N33/525
摘要： A multilayer analysis sheet for analyzing liquid samples is described, comprising, in sequence, a light transmitting hydrophobic support having on one side thereof at least one layer containing at least one reagent in a binder and a liquid sample spreading layer made of fabric, which layers are laminated to form an integral unit together with the support, wherein said fabric has the ability to supply a liquid sample placed on the surface thereof to the reagent-containing layer at a substantially constant volume per unit area, which ability is conferred upon the fabric by rendering it hydrophilic; the multilayer analysis sheet can be economically manufactured without variations in quality, and improves the spreading capability of liquid samples.
摘要翻译：描述了用于分析液体样品的多层分析片，其中依次包括透光性疏水性支持体，其透光性疏水性支持体的一面上具有至少一层含有粘合剂中的至少一种试剂和由织物构成的液体样品扩散层，层叠以与支撑体一起形成整体单元，其中所述织物具有以每单位面积基本上恒定的体积供应将其表面上的液体样品供应到含有试剂的层的能力，该能力被赋予织物通过使其亲水; 可以经济地制造多层分析片而不产生质量变化，并提高液体样品的铺展能力。

22. 发明授权

US3951851A Process of producing aspirin-containing capsules 失效
标题翻译：生产含阿司匹林胶囊的方法
公开(公告)号：US3951851A
公开(公告)日：1976-04-20
申请号：US364478
申请日：1973-05-29
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
IPC分类号： A61K9/62 , A61K9/50 , A61K31/60 , B01J13/02
CPC分类号： A61K9/5047 , A61K31/60 , A61K9/5089 , Y10T428/2989
摘要： Process of producing aspirin-containing capsules which comprises (1) dispersing aspirin particles in a solution of a cellulose derivative in an organic solvent partially miscible with water; (2) adding the dispersion to an encapsulation medium comprising water containing organic solvent(s) partially miscible with water with or without aspirin; (3) stirring the mixture to form a fine dispersion of the aspirin; and (4) evaporating off the organic solvent to deposit the cellulose derivative around the aspirin particles.
摘要翻译：制备含阿司匹林胶囊的方法，其包括（1）将阿司匹林颗粒分散在纤维素衍生物在与水部分混溶的有机溶剂中的溶液中; （2）将分散体加入到包含含有有机溶剂的水的包封介质中，所述有机溶剂与或不与阿斯匹林部分混溶; （3）搅拌混合物形成阿司匹林的精细分散体; 和（4）蒸发掉有机溶剂以将纤维素衍生物沉积在阿司匹林颗粒周围。

23. 发明授权

US4631174A Multilayer chemical analysis member having an outer waterproof layer 失效
标题翻译：具有外防水层的多层化学分析构件
公开(公告)号：US4631174A
公开(公告)日：1986-12-23
申请号：US718976
申请日：1985-04-02
申请人： Asaji Kondo
发明人： Asaji Kondo
IPC分类号： G01N33/52
CPC分类号： G01N33/525 , Y10S435/805 , Y10S436/81
摘要： Chemical analysis sheets comprising a reagent layer, a porous spreading layer and a cover layer provided with a small opening are disclosed. The cover layer prevents rapid evaporation of moisture to ensure a complete reaction between the chemical reagent and the ingredient tested for.
摘要翻译：公开了包括试剂层，多孔扩散层和设置有小开口的覆盖层的化学分析片。覆盖层防止水分的快速蒸发，以确保化学试剂与被测试成分之间的完全反应。

24. 发明授权

US4356149A Multi-layer chemical analytical materials 失效
标题翻译：多层化学分析材料
公开(公告)号：US4356149A
公开(公告)日：1982-10-26
申请号：US165444
申请日：1980-07-02
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01N21/78 , C12Q1/58 , G01N31/22 , G01N33/52 , G01N33/62
CPC分类号： C12Q1/58 , G01N33/526 , Y10S435/805
摘要： A multi-layer chemical analytical material comprising a support, a reagent layer on the support and a spreading layer on the reagent layer wherein the reagent layer is composed of a hydrophilic binder and fine hydrophobic particles dispersed in the hydrophilic binder, said hydrophobic particles containing a reagent capable of directly or indirectly reacting with the component being analyzed to produce a color change.
摘要翻译：一种多层化学分析材料，包括载体，载体上的试剂层和试剂层上的扩散层，其中试剂层由亲水性粘合剂和分散在亲水性粘合剂中的细疏水性颗粒构成，所述疏水性颗粒含有能够直接或间接地与被分析的组分反应以产生颜色变化的试剂。

25. 发明授权

US4337222A Hemoglobin concentration determining article 失效
标题翻译：血红蛋白浓度测定篇
公开(公告)号：US4337222A
公开(公告)日：1982-06-29
申请号：US223062
申请日：1981-01-07
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01N33/72 , G01N31/22 , G01N33/52
CPC分类号： G01N33/525
摘要： A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area.
摘要翻译：一种血红蛋白浓度测定制品，其包含一体地设置在其上的不透水性支持体，依次是亲水性粘合剂层和具有亲水性表面的多孔扩散层，其中内部空隙或内部的表面是亲水性的和水不溶性，所述多孔扩散层构成为使得施加到其上的水性样品能够以每单位面积的基本上确定的体积扩散并结合在其中。

26. 发明授权

US3937798A Method of controlling hydrogen ion concentration by microcapsules 失效
标题翻译：通过微球控制氢离子浓度的方法
公开(公告)号：US3937798A
公开(公告)日：1976-02-10
申请号：US172535
申请日：1971-08-17
申请人： Masao Kitajima , Asaji Kondo
发明人： Masao Kitajima , Asaji Kondo
IPC分类号： B01J13/02 , B01J13/12 , B01J13/20 , B01J19/00 , G01N33/84 , C02B1/30
CPC分类号： B01J13/025 , B01J13/125 , G01N33/84
摘要： A method for controlling the hydrogen ion concentration of an aqueous solution is provided, which method comprises adding to an aqueous solution, microcapsules prepared by encapsulating an acid material with a polymer, which is dissolved in or swelled with water in an alkaline state only, and/or microcapsules prepared by encapsulating an alkaline material with a polymer, which is dissolved in or swelled with water in an acid state only, and adding an aqueous acid solution or an aqueous alkaline solution to the system.

27. 发明授权

US5177021A Element for immunoassay and process of using the same 失效
标题翻译：免疫的元素及其使用方法
公开(公告)号：US5177021A
公开(公告)日：1993-01-05
申请号：US25843
申请日：1987-03-16
申请人： Asaji Kondo
发明人： Asaji Kondo
IPC分类号： G01N31/22 , G01N33/52 , G01N33/543 , G01N33/94
CPC分类号： G01N33/54386 , G01N33/525 , G01N33/94 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： A dipping element for immunoassay or quantitative analysis of an immunoreactive analyte is disclosed having a first matrix having a carrier therein containing an immobilized antibody capable of an immunochemical reaction with a sample antigen. The immobilized antibody is not released into the aqueous liquid sample upon contact. The element further comprises a second matrix which contains labelled antigen which does dissolve in the aqueous liquid sample upon contact. On dipping, the marker-labelled antigen reacts with the immobilized antibody in competition with the antigen-antibody reaction between the analyte antigen and the immobilized antibody. if the analyte is an antibody, then the second matrix contains a marker labelled antibody and the first matrix contains an immobilized antigen. Methods for the quantitative analysis of an analyte antigen or antibody are also disclosed.
摘要翻译：公开了一种用于免疫反应性分析物的免疫测定或定量分析的浸渍元件，其具有含有载体的第一基质，其中含有能够与样品抗原进行免疫化学反应的固定化抗体。接触后固定的抗体不会释放到水性液体样品中。该元件还包括第二基质，其含有标记的抗原，其在接触时溶解在含水液体样品中。在浸渍时，标记标记的抗原与固定化的抗体反应，与分析物抗原和固定的抗体之间的抗原 - 抗体反应竞争。如果分析物是抗体，则第二基质含有标记标记抗体，第一基质含有固定化的抗原。还公开了分析物抗原或抗体的定量分析方法。

28. 发明授权

US4340565A Hematocrit value determining element 失效
标题翻译：血细胞比容值确定元件
公开(公告)号：US4340565A
公开(公告)日：1982-07-20
申请号：US221183
申请日：1980-12-29
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01N33/49 , G01N31/22 , G01N33/48 , G01N33/52 , G01N33/50
CPC分类号： G01N33/48 , G01N33/525
摘要： A hematocrit value determining element comprising, in one embodiment, a water-impermeable planar support having integrally provided thereon a hydrophilic porous spreading layer, the porous spreading layer being such that blood spreads therethrough depending upon the viscosity of the blood and, in a second embodiment, a hematocrit value determining element as described above and a binder layer provided between the planar support and the porous spreading layer.
摘要翻译：一种血细胞比容值确定元件，在一个实施方案中包括在其上整体设置有亲水性多孔扩散层的不透水平面支撑体，所述多孔扩散层使得血液通过其中的血液扩散，这取决于血液的粘度，并且在第二实施方案中，如上所述的血细胞比容值确定元件和设置在平面支撑体和多孔扩散层之间的粘合剂层。

29. 发明授权

US4328184A Test slide strip 失效
标题翻译：测试滑条
公开(公告)号：US4328184A
公开(公告)日：1982-05-04
申请号：US208680
申请日：1980-11-20
申请人： Asaji Kondo
发明人： Asaji Kondo
IPC分类号： B65H1/06 , B65H5/28 , G01N1/04 , G01N31/22 , G01N33/48 , G01N33/52 , G01N37/00 , G01N31/00 , B65D69/00
CPC分类号： G01N33/521 , Y10S206/82 , Y10S435/805
摘要： A plurality of test slides carrying thereon dry reagents for chemical analysis of fluid samples or a dry porous analysis layer are sandwiched and sealed between a continuous base sheet and a continuous cover sheet at equal intervals. A test slide strip having alternately slide holding portions and slide free portions along its length is thus produced. The spaces between the adjacent test slides are longer than the test slides, whereby the test slide strip can be folded in an accordion shape so that the slide holding portions and slide free portions are alternately superposed. The folded test slide strip is nested in a box like casing having a slot in one side wall thereof adjacent the bottom. The test slides are dispensed from the casing through the slot one by one in order by pulling the leading edge of the test slide strip.
摘要翻译：多个试验载玻片上载有用于流体样品或干多孔分析层的化学分析的干试剂，并以相等的间隔夹在连续的基片和连续覆盖片之间。因此产生具有交替地滑动保持部分并沿其长度滑动自由部分的测试滑动条。相邻测试滑块之间的空间比测试滑块长，由此测试滑动条可以折叠成折叠形状，使得滑动保持部分和滑动部分交替重叠。折叠的测试滑动条被嵌套在具有在其一个侧壁中的相邻底部的狭槽的盒状壳体中。通过拉动测试滑块的前缘，依次通过插槽从套管中分配测试滑块。

30. 发明授权

US4250010A Integrated ion selection electrode device 失效
标题翻译：集成离子选择电极装置
公开(公告)号：US4250010A
公开(公告)日：1981-02-10
申请号：US87855
申请日：1979-10-24
申请人： Asaji Kondo , Masao Kitajima , Isamu Hatanaka
发明人： Asaji Kondo , Masao Kitajima , Isamu Hatanaka
IPC分类号： G01N27/28 , G01N27/30
CPC分类号： G01N27/28
摘要： An ion selection electrode device for measuring concentrations of predetermined ions such as in biological samples in which measuring electrodes are disposed on a planar substrate with their active heads lying within a circle of small radius. A small sample of a liquid to be measured is dropped on and spreads over the circle contacting each electrode. In a preferred embodiment, two sets of electrodes are provided around adjacent circles on a single substrate, one for the sample and the other for a standard reference fluid. A dam separates the two liquids but electrical contact therebetween is provided by a porous bridge.
摘要翻译：一种离子选择电极装置，用于测量诸如生物样品中的预定离子的浓度，其中测量电极设置在平面基板上，其有源头位于小半径的圆周内。将待测量的液体的小样品滴落在与每个电极接触的圆上。在优选实施例中，在单个基板上围绕相邻圆周设置两组电极，一组用于样品，另一组用于标准参考流体。大坝分离两个液体，但是它们之间的电接触由多孔桥提供。

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