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    • 22. 发明申请
    • OPTICAL WAVEGUIDE TYPE ANTIBODY CHIP AND METHOD OF MEASURING ANTIGEN CONCENTRATION
    • 光波导型抗体芯片和测量抗原浓度的方法
    • US20080227126A1
    • 2008-09-18
    • US12047670
    • 2008-03-13
    • Ikuo UematsuMasatoshi SakaiShingo Kasai
    • Ikuo UematsuMasatoshi SakaiShingo Kasai
    • G01N33/543
    • G01N33/54373Y10S435/808Y10S436/805Y10S436/807
    • An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt.
    • 光波导型抗体芯片包括在基板的主面上彼此相隔一定距离放置的透明基板,入射侧光学元件和发光侧光学元件,形成在基板的主面上的防水树脂膜 所述基板包括形成在所述光学元件之间的光波导层,所述防水树脂膜包括在其底部露出光波导层的反应孔和围绕所述反应孔的框状沟槽,矩形框状电池壁, 固定在防水树脂膜的沟槽中,并且形成能够与反应孔一起输注和排出样品溶液的电池,以及形成在反应孔底部的抗体固定层,抗体表面 固定层用至少缓冲剂和盐掩蔽。