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21. 发明申请

US20060240505A1 Identification of Targets of Antimicrobial Compounds 审中-公开
标题翻译：鉴定抗菌化合物的目标
公开(公告)号：US20060240505A1
公开(公告)日：2006-10-26
申请号：US11427043
申请日：2006-06-28
申请人： Frank Fan , Yiping He , Jianzhong Huang , Xinhe Jiang , Damien McDevitt , Martin Rosenberg , Annemarie St. John
发明人： Frank Fan , Yiping He , Jianzhong Huang , Xinhe Jiang , Damien McDevitt , Martin Rosenberg , Annemarie St. John
IPC分类号： C12Q1/18 , C12N1/21 , C12N15/74
CPC分类号： C12Q1/6897 , C12N15/1034 , C12N15/74 , C12Q1/18 , C12Q1/689 , C12Q2531/113
摘要： A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.
摘要翻译：确定抗微生物化合物的细胞或遗传靶标的方法包括用诱导型启动子将细菌基因克隆到表达载体中，并确定克隆基因在细胞中的表达增加是否会导致对抗微生物化合物的抗性。此外，该方法可以包括将细菌菌株的每个基因并入具有诱导型启动子的表达载体，诱导，用抗微生物化合物处理，分离赋予细胞对该化合物有抗性的基因克隆，以及确定抗性基因的同一性通过各种方法，包括DNA微阵列和基因测序。

22. 发明申请

US20050070366A1 Method for predicting a golfer's ball striking performance 有权
公开(公告)号：US20050070366A1
公开(公告)日：2005-03-31
申请号：US10990147
申请日：2004-11-15
申请人： Scott Manwaring , Frank Fan , Peter Ligotti
发明人： Scott Manwaring , Frank Fan , Peter Ligotti
IPC分类号： A63B57/00 , A63B69/36
CPC分类号： A63B69/36 , A63B57/00 , A63B2069/3605
摘要： A system for a predicting golfer's performance is disclosed herein. The system inputs the pre-impact swing properties of a golfer, a plurality of mass properties of a first golf club, and a plurality of mass properties of a first golf ball into a rigid body code. Ball launch parameters are generated from the rigid body. The ball launch parameters, a plurality of atmospheric conditions and lift and drag properties of the golf ball are inputted into a trajectory code. This trajectory code is used to predict the performance of a golf ball if struck by the golfer with the golf club under the atmospheric conditions. The system can then predict the performance of the golf ball if struck by the golfer with a different golf club. The system of the present invention predicts the performance of the golf ball without the golfer actually striking the golf ball.

23. 发明授权

US09888999B2 Acellular dermal allografts and method of preparation 有权
公开(公告)号：US09888999B2
公开(公告)日：2018-02-13
申请号：US13389937
申请日：2010-01-04
申请人： James Forsell , Frank Fan
发明人： James Forsell , Frank Fan
IPC分类号： A61F2/10 , A01N1/02
CPC分类号： A61F2/105 , A01N1/0294
摘要： A method for preparing a sterilized human acellular dermal allograft where the dermal allograft is sterilized by irradiation and has a greatly reduced bio-burden and enzymatic and antigenic activity. This product line of allografts can be easily used by surgeons in soft tissue replacement or repair and has an extended shelf life, of up to at least about three years.

24. 外观设计

USD547463S1 Post anchor 有权
标题翻译：邮政锚
公开(公告)号：USD547463S1
公开(公告)日：2007-07-24
申请号：US29246356
申请日：2006-04-03
申请人： John Gross , Simon Walker , Frank Fan , Wei Min Zhu
设计人： John Gross , Simon Walker , Frank Fan , Wei Min Zhu

25. 发明申请

US20060141448A1 Whole cell assay 审中-公开
公开(公告)号：US20060141448A1
公开(公告)日：2006-06-29
申请号：US11354387
申请日：2006-02-15
申请人： Frank Fan , Yinduo Ji , Howard Kallender , Tong Li , Damien McDevitt
发明人： Frank Fan , Yinduo Ji , Howard Kallender , Tong Li , Damien McDevitt
IPC分类号： C12Q1/00 , C12Q1/68
CPC分类号： G01N33/5023 , C12N9/1096 , G01N33/5008
摘要： This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.

26. 发明申请

US20060102483A1 Hydrogel-driven micropump 失效
标题翻译：水凝胶驱动的微型泵
公开(公告)号：US20060102483A1
公开(公告)日：2006-05-18
申请号：US11262266
申请日：2005-10-28
申请人： Shih-Wei Chuang , Morris Liang , Frank Fan , Wae-Honge Chen
发明人： Shih-Wei Chuang , Morris Liang , Frank Fan , Wae-Honge Chen
IPC分类号： G01N27/447
CPC分类号： F04B43/043 , F04B19/006 , F04B19/24
摘要： A hydrogel-driven micropump, comprising: two fluid chambers; a fluid channel, connecting the two fluid chambers; a first substrate plate and a second substrate plate, which are glass wafers produced by micromechanical working, each having accommodation chambers which are filled in hydrogel which are placed next to the two fluid chambers and connected by inward extending bridges, with electric terminals leading to the accommodation chambers; a middle substrate, sandwiched between the first and second substrate plates and made by a bulk micromachining process, having separated accommodation chambers close to ends thereof. A separating block is placed between the accommodation chambers. The middle substrate between the first and second substrate plates forms a micropump body. All of the substrates are separated by membranes. The accommodation chambers for electrophoretic fluid are located between the membranes and the first and second substrate plates, respectively, and insulating material. An electrophoretic fluid channel is left between the membranes and the bridges. The fluid channel is placed within the middle substrate between the membranes. The first substrate plate has through holes from outside to the two fluid chambers, allowing fluid to be injected.
摘要翻译：一种水凝胶驱动的微型泵，包括：两个流体室; 连接两个流体室的流体通道; 第一衬底板和第二衬底板，其是通过微机械加工制造的玻璃晶片，每个具有容纳室，其被填充在靠近两个流体室并且通过向内延伸的桥连接的水凝胶中，电端子通向住宿室中间基板夹在第一和第二基板之间并通过本体微加工工艺制成，其接近其端部具有分离的容纳室。分离块放置在容纳室之间。第一和第二基板之间的中间基板形成微型泵体。所有的底物都被膜分离。用于电泳液体的容纳室分别位于膜与第一和第二基板之间以及绝缘材料之间。电泳流体通道留在膜和桥之间。流体通道被放置在膜之间的中间基板内。第一基板具有从外部到两个流体室的通孔，允许流体被注入。

27. 发明申请

US20050153310A1 Luciferase biosensor 有权
标题翻译：萤光素酶生物传感器
公开(公告)号：US20050153310A1
公开(公告)日：2005-07-14
申请号：US10957433
申请日：2004-10-01
申请人： Frank Fan , Martin Lewis , John Shultz , Keith Wood , Braeden Butler
发明人： Frank Fan , Martin Lewis , John Shultz , Keith Wood , Braeden Butler
IPC分类号： C07H21/04 , C12N5/06 , C12N9/02 , C12N9/06 , C12Q1/66 , C12Q1/68
CPC分类号： C12N9/0069 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C12Q1/66 , G01N2500/04
摘要： A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
摘要翻译：提供了一种环境敏感的报告蛋白的改良甲壳质萤光素酶蛋白。

28. 发明申请

US20130013068A1 Acellular Dermal Allografts And Method Of Preparation 有权
标题翻译：无细胞真皮同种异体移植物及其制备方法
公开(公告)号：US20130013068A1
公开(公告)日：2013-01-10
申请号：US13389937
申请日：2010-01-04
申请人： James Forsell , Frank Fan
发明人： James Forsell , Frank Fan
IPC分类号： A61F2/10
CPC分类号： A61F2/105 , A01N1/0294
摘要： A method for preparing a sterilized human acellular dermal allograft where the dermal allograft is sterilized by irradiation and has a greatly reduced bio-burden and enzymatic and antigenic activity. This product line of allografts can be easily used by surgeons in soft tissue replacement or repair and has an extended shelf life, of up to at least about three years.
摘要翻译：一种制备灭菌的无细胞真皮同种异体移植物的方法，其中皮肤同种异体移植物通过照射灭菌并且具有极大降低的生物负荷和酶和抗原活性。这种同种异体移植物产品线可以被外科医生轻易地用于软组织更换或修复，并具有长达至少约三年的延长保质期。

29. 发明授权

US07472874B2 Ground stake 有权
标题翻译：地面桩
公开(公告)号：US07472874B2
公开(公告)日：2009-01-06
申请号：US11279377
申请日：2006-04-11
申请人： John Gross , Simon Walker , Frank Fan , Wei Min Zhu
发明人： John Gross , Simon Walker , Frank Fan , Wei Min Zhu
IPC分类号： A45F3/44
CPC分类号： E04H12/2215
摘要： A ground stake for securing ropes or other fastening elements comprises a head portion with an elevated, textured surface and two or more extending flanges above a neck portion comprising recesses and a passageway. A plurality of elongated fins, at least a portion of which are tapered, depend from the base of the head portion and terminate in a truncated blunt end, providing a stronger tip while allowing clean penetration of the ground. One or more of the fins may comprise a stiffening rib to increase the rigidity of the fin. The elevated, textured surface provides increased impact resistance and prevents slippage of a pounding implement when the stake is being driven into the ground.
摘要翻译：用于固定绳索或其他紧固元件的接地桩包括具有升高的纹理表面的头部部分和在包括凹部和通道的颈部部分上方的两个或更多个延伸凸缘。其至少一部分呈锥形的多个细长翅片取决于头部的底部并终止于截头钝端，提供更强的尖端，同时允许地面的清洁穿透。一个或多个翅片可以包括加强肋，以增加翅片的刚度。升高的纹理表面提供增加的抗冲击性，并防止当桩被驱动到地面时打击工具的滑动。

30. 发明申请

US20070235616A1 POST ANCHOR 有权
标题翻译：后锚
公开(公告)号：US20070235616A1
公开(公告)日：2007-10-11
申请号：US11278647
申请日：2006-04-04
申请人： John Gross , Simon Walker , Frank Fan , Wei Zhu
发明人： John Gross , Simon Walker , Frank Fan , Wei Zhu
IPC分类号： A47B91/00
CPC分类号： E04H12/2269 , E04H12/2261
摘要： A post anchor for securing a support post for a structure comprises a base with four upstanding sidewalls forming a cavity into which a post is inserted, and means to secure the post inside the cavity. Interior ribs and exterior augmented corners resist deformation under pressure exerted by the post. Interior channels allow water to drain from inside the cavity toward a drain hole. The anchor post is slightly elevated relative to the ground, allowing air and water to circulate around the post and post anchor. The post anchor is made of a thermoplastic polymer which is given a textured surface, and may include an ultraviolet protection additive.
摘要翻译：用于固定用于结构的支撑柱的支柱锚固件包括具有四个直立侧壁的底座，其形成有一个柱体插入其中的空腔，以及将柱固定在空腔内的装置。内部肋骨和外部增强角抵抗由柱施加的压力下的变形。内部通道允许水从腔体内排出到排水孔。锚柱相对于地面略微升高，允许空气和水在柱子和柱锚之间循环。后锚由热塑性聚合物制成，其被赋予纹理表面，并且可以包括紫外线防护添加剂。

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