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21. 发明授权

US06404908B1 Method and system for fast detection of lines in medical images 失效
标题翻译：医学图像线路快速检测方法及系统
公开(公告)号：US06404908B1
公开(公告)日：2002-06-11
申请号：US09087245
申请日：1998-05-28
申请人： Alexander C. Schneider , Jimmy R. Roehrig
发明人： Alexander C. Schneider , Jimmy R. Roehrig
IPC分类号： G06K900
CPC分类号： G06K9/4609 , G06T7/12 , G06T2207/10116 , G06T2207/30068
摘要： A method an apparatus for detecting lines in medical images is disclosed, wherein a direction image array and a line image array are formed by filtering a digital image with a single-peaked filter, convolving the resultant array with second order difference operators oriented along the horizontal, vertical, and diagonal axes, and computing the direction image arrays and line image arrays as direct scalar functions of the results of the second order difference operations. Advantageously, line detection based on the use of four line operator functions along the horizontal, vertical, and diagonal directions in accordance with the preferred embodiments actually results in fewer computations than line detection based on the use of three line operator functions. In particular, because of the special symmetries involved, 3×3 second order difference operators may be effectively used. Moreover, the number of computations associated with the second order difference operations may be achieved with simple register shifts, additions, and subtractions, yielding an overall line detection process that is significantly less computationally intensive than prior art algorithms. Also according to a preferred embodiment, computational complexity is reduced by selecting a separable single-peaked filter, and sequentially convolving the digital image with the component kernels of the separable single-peaked filter.
摘要翻译：公开了一种用于检测医学图像中的线的方法，其中通过用单峰滤波器对数字图像进行滤波来形成方向图像阵列和线图像阵列，将得到的阵列与沿着水平面的二阶差分运算符进行卷积，垂直和对角轴，并计算方向图像阵列和线图像阵列作为二阶差分运算结果的直接标量函数。有利地，根据优选实施例，基于沿水平，垂直和对角线方向的四线操作者功能的线路检测实际上导致比基于使用三线操作员功能的线检测更少的计算。特别地，由于涉及特殊的对称性，可以有效地使用3×3的二阶差分运算符。此外，与二阶差分运算相关联的计算次数可以通过简单的寄存器移位，加法和减法来实现，产生的总线检测过程比现有技术的算法显着减少计算密集度。还根据优选实施例，通过选择可分离的单峰值滤波器，并且将数字图像与可分离单峰滤波器的分量粒子顺序卷积，来减少计算复杂度。

22. 发明授权

US6014452A Method and system for using local attention in the detection of abnormalities in digitized medical images 失效
标题翻译：在数字化医学图像检测异常中使用局部注意力的方法和系统
公开(公告)号：US6014452A
公开(公告)日：2000-01-11
申请号：US901541
申请日：1997-07-28
申请人： Wei Zhang , Harlan M. Romsdahl , Jimmy R. Roehrig
发明人： Wei Zhang , Harlan M. Romsdahl , Jimmy R. Roehrig
IPC分类号： G06T7/00 , G06K9/00 , A61B6/04 , G06K9/62
CPC分类号： G06K9/342 , G06T7/0012 , G06K2209/05
摘要： A method an system for using a local attention threshold to aid in the detection of clustered abnormalities in digitized medical images is disclosed. The local attention threshold is applied to locate spots within a predetermined distance from previously identified spots. More specifically, seed pixels are identified by applying a first seed threshold function to the output of a shift-invariant neural network and adaptive threshold. The seed pixels are then segmented into spots by applying a segmentation threshold function to each seed pixel. False-positive spots are removed using various techniques. Additional seed pixels are then identified by applying a local attention threshold to pixels within a predetermined distance to previously identified spots. The local attention threshold disclosed is less selective for pixels which are closer to the nearest spot than for pixels which are further from the nearest spot. The new seed pixels are then segmented into spots, and potential abnormalities are identified in the medical image based in part on the closeness of the identified spots.
摘要翻译：公开了一种使用局部关注阈值来辅助检测数字化医学图像中的聚类异常的方法。应用局部注意阈值来定位距离先前识别的点的预定距离内的点。更具体地，通过对移位不变神经网络和自适应阈值的输出应用第一种子阈值函数来识别种子像素。然后通过对每个种子像素应用分割阈值函数将种子像素分割成点。使用各种技术去除假阳性斑点。然后通过对与先前识别的点的预定距离内的像素应用局部注意阈值来识别附加种子像素。所公开的局部注意阈值对于距离最近的点更靠近最近的像素的像素的选择性较小。然后将新的种子像素分割成斑点，并且部分地基于识别的斑点的接近度在医学图像中识别潜在的异常。

23. 发明授权

US5815591A Method and apparatus for fast detection of spiculated lesions in digital mammograms 失效
公开(公告)号：US5815591A
公开(公告)日：1998-09-29
申请号：US676660
申请日：1996-07-10
申请人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
发明人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
IPC分类号： A61B6/00 , G06K9/32 , G06K9/46 , G06K9/56 , G06K9/00 , A61B6/04
CPC分类号： G06K9/4633 , G06K9/3233 , G06K9/4638 , G06K9/56 , A61B6/502 , G06K2209/05
摘要： A method and apparatus for the fast detection of spiculated lesions in a digital mammogram, the method for use in a computer aided diagnosis system for assisting a radiologist in identifying and recognizing the spiculations among a multiplicity of lines corresponding to standard fibrous breast tissue. A line and direction image is created from a digital mammogram, and a region of potential intersection for substantially every pixel in the digital mammogram image is determined. The region of potential intersection for each pixel is a predetermined pattern, such as a high aspect ratio rectangle or trapezoid, positioned around the pixel and rotated in a direction corresponding to direction information for that pixel. The regions of potential intersection are accumulated among the pixels to produce a cumulative array, and information in the cumulative array is processed for identifying spiculations in the digital mammogram.

24. 发明授权

US07769216B2 Facilitating comparison of medical images 有权
标题翻译：促进医学图像的比较
公开(公告)号：US07769216B2
公开(公告)日：2010-08-03
申请号：US11323939
申请日：2005-12-29
申请人： Takeshi Doi , Vilim Simcic , Jimmy R. Roehrig
发明人： Takeshi Doi , Vilim Simcic , Jimmy R. Roehrig
IPC分类号： G06K9/00
CPC分类号： G06F19/321 , G06F19/00 , G16H50/20
摘要： Facilitating viewer comparison of a plurality of medical images of at least one body part on a softcopy review workstation is described. First and second medical images are displayed such that the second medical image appears as a spatially registered underlay to the first medical image exposed through an aperture therein. The aperture comprises at least one edge that is viewer-manipulable in a back-and-forth manner so that the first and second medical images can be visually compared with minimal eye movement. For a temporal comparison embodiment, the first and second medical images comprise identical views of the same body part acquired at different times. For a cross-modality comparison embodiment, the first and second medical images are acquired substantially concurrently, or at different times, using different medical imaging modalities. For a bilateral comparison embodiment, the first and second images are corresponding views of two laterally corresponding body parts.
摘要翻译：描述了在软拷贝检查工作站上促进对至少一个身体部位的多个医学图像的观看者比较。显示第一和第二医疗图像，使得第二医疗图像作为空间注册的底层显示出通过其中的孔暴露的第一医疗图像。所述孔包括至少一个能够以往复方式观察者操纵的边缘，使得可以在视觉上比较第一和第二医学图像与最小的眼睛运动。对于时间比较实施例，第一和第二医学图像包括在不同时间获取的相同身体部位的相同视图。对于交叉模态比较实施例，使用不同的医学成像模式基本同时或不同时间获取第一和第二医学图像。对于双向比较实施例，第一和第二图像是两个横向对应的身体部分的对应视图。

25. 发明授权

US6075879A Method and system for computer-aided lesion detection using information from multiple images 有权
标题翻译：使用多幅图像信息进行计算机辅助病变检测的方法和系统
公开(公告)号：US6075879A
公开(公告)日：2000-06-13
申请号：US178901
申请日：1998-10-26
申请人： Jimmy R. Roehrig , Alexander C. Schneider , Shih-Ping Wang
发明人： Jimmy R. Roehrig , Alexander C. Schneider , Shih-Ping Wang
IPC分类号： G06F19/00 , G06T3/00 , G06T5/40 , G06T5/50 , G06T7/00 , H05G1/60 , G06K9/00
CPC分类号： G06F19/321 , G06F19/3406 , G06F19/345 , G06T7/0012 , H05G1/60 , G06T2207/30068 , Y10S128/922
摘要： A system, method, and computer program product for computer-aided detection of suspicious lesions in digital mammograms is described, wherein single-view feature vectors from a first digital mammogram are processed in a classification algorithm along with information computed from a plurality of related digital mammograms to assign an overall probability of suspiciousness to potentially suspicious lesions in the first digital mammogram. In one preferred embodiment, a greater probability of suspiciousness is determined where there are similar corresponding lesions in the first digital mammogram and in an alternate digital mammogram view of the same breast. In another preferred embodiment, a lesser probability of suspiciousness is found where there are symmetric lesions or structures located in the first digital mammogram and a digital mammogram of the opposite breast. In another preferred embodiment, a lesser probability of suspiciousness is found where there are similar lesions or structures located in the first digital mammogram and a digital mammogram of the same breast taken months or years earlier in time. In another preferred embodiment, the nipple location, which serves as a reference location point across different digital mammogram, is located using an algorithm that takes into account the chest wall, the skin line of the breast, and the general orientation of the fibrous breast tissue in the digital mammogram relative to the chest wall.
摘要翻译：描述了一种用于数字乳腺X线照片中可疑病变的计算机辅助检测的系统，方法和计算机程序产品，其中来自第一数字乳腺X线照片的单视图特征向量与分类算法一起被处理，以及从多个相关数字乳房X光检查图将第一次数字乳腺X线照片中的潜在可疑病变的整体可疑性分配给患者。在一个优选实施例中，确定在第一数字乳房X线照片和相同乳房的替代数字乳房X线照片视图中存在相似的相应损伤的可疑性的可能性更大。在另一个优选实施例中，发现存在位于第一数字乳房X线照片中的对称损伤或结构和相对乳房的数字乳房X线照片的可疑性较小的可能性。在另一个优选实施例中，发现在第一数字乳腺X线照片中存在类似的损伤或结构的同时存在数月或数年前同一乳房的数字乳腺X线照片的可疑性较小。在另一个优选实施例中，用作穿过不同数字乳腺X线照片的参考位置点的乳头位置使用考虑胸壁，乳房皮肤线以及纤维性乳房组织的总体取向的算法来定位在数字乳腺X线照相中相对于胸壁。

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