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21. 发明授权

US07008615B2 Delivery of anti-migraine compounds through an inhalation route 失效
标题翻译：通过吸入途径输送抗偏头痛化合物
公开(公告)号：US07008615B2
公开(公告)日：2006-03-07
申请号：US10735198
申请日：2003-12-12
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing lidocaine, verapamil, diltiazem, isometheptene, or lisuride that are used in inhalation therapy. In a method aspect of the present invention, lidocaine, verapamil, diltiazem, isometheptene, or lisuride is administered to a patient through an inhalation route. The method comprises: a) heating a composition of lidocaine, verapamil, diltiazem, isometheptene, or lisuride, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering lidocaine, verapamil, diltiazem, isometheptene, or lisuride through an inhalation route is provided which comprises: a) a thin coating of a lidocaine, verapamil, diltiazem, isometheptene, or lisuride composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送抗偏头痛化合物。具体地说，它涉及在吸入治疗中使用的含有利多卡因，维拉帕米，地尔硫卓，异月精或伊瑞沙德的气溶胶。在本发明的方法方面，通过吸入途径向患者施用利多卡因，维拉帕米，地尔硫卓，异月精或碘化is。该方法包括：a）加热利多卡因组合物，维拉帕米，地尔硫卓，异月精或黎西汀，形成蒸气; 和b）允许蒸气冷却，由此形成包含具有小于5％药物降解产物的颗粒的凝结气溶胶。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送利多卡因，维拉帕米，地尔硫卓，异月桂烯或碘化尿的试剂盒，其包括：a）利多卡因，维拉帕米，地尔硫卓，异月桂烯或碘化铱组合物的薄涂层以及b）用于将所述薄涂层分配为冷凝气溶胶的装置。

22. 发明授权

US06994843B2 Delivery of stimulants through an inhalation route 失效
标题翻译：通过吸入路线输送兴奋剂
公开(公告)号：US06994843B2
公开(公告)日：2006-02-07
申请号：US10815527
申请日：2004-04-01
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patient through an inhalation route. The method comprises: a) heating a thin coating of a stimulant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% stimulant degradation products. In a kit aspect of the present invention, a kit for delivering a stimulant through an inhalation route is provided which comprises: a) a thin coating of a stimulant drug and b) a device for dispensing said thin coating a stimulant as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送兴奋剂。具体地说，它涉及用于吸入治疗的含有兴奋剂的气溶胶。在本发明的方法方面，兴奋剂通过吸入途径输送给患者。该方法包括：a）在固体支持物上加热兴奋剂的薄涂层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％刺激性降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送兴奋剂的试剂盒，其包括：a）刺激性药物的薄涂层;以及b）用于将所述薄涂层分散为兴奋剂作为冷凝气溶胶的装置。

23. 发明授权

US06814955B2 Delivery of physiologically active compounds through an inhalation route 失效
公开(公告)号：US06814955B2
公开(公告)日：2004-11-09
申请号：US10154765
申请日：2002-05-23
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of physiologically active compounds through an inhalation route. Specifically, it relates to aerosols containing physiologically active compounds that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine. In a method aspect of the present invention, chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine; and, b) a device that forms a chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine containing aerosol from the composition, for inhalation by the mammal.

24. 发明授权

US06803031B2 Delivery of erectile dysfunction drugs through an inhalation route 失效
标题翻译：通过吸入路线输送勃起功能障碍药物
公开(公告)号：US06803031B2
公开(公告)日：2004-10-12
申请号：US10155703
申请日：2002-05-22
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an erectile dysfunction drug. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an erectile dysfunction drug, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an erectile dysfunction drug through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an erectile dysfunction drug; and, b) a device that forms an erectile dysfunction drug aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送勃起功能障碍药物。具体来说，它涉及含有用于吸入治疗的勃起功能障碍药物的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的勃起功能障碍药物的颗粒。在本发明的方法方面，勃起功能障碍药物通过吸入途径递送至哺乳动物。该方法包括：a）加热组合物，其中所述组合物包含至少5重量％的勃起功能障碍药物，以形成蒸汽; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径向哺乳动物递送勃起功能障碍药物的试剂盒，其包括：a）包含至少5重量％的勃起功能障碍药物的组合物; 和b）由组合物形成勃起功能障碍药物气雾剂的装置，用于哺乳动物的吸入。

25. 发明授权

US06780400B2 Delivery of antiemetics through an inhalation route 有权
标题翻译：通过吸入路线输送止吐药
公开(公告)号：US06780400B2
公开(公告)日：2004-08-24
申请号：US10150591
申请日：2002-05-17
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antiemetics through an inhalation route. Specifically, it relates to aerosols containing antiemetics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antiemetic. In a method aspect of the present invention, an antiemetic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antiemetic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antiemetic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antiemetic; and, b) a device that forms an antiemetic aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送止吐剂。具体地说，它涉及用于吸入治疗的含有止吐剂的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％止吐剂的颗粒。在本发明的方法方面，止吐剂通过吸入途径递送至哺乳动物。该方法包括：a）加热组合物，其中组合物包含至少5重量％的止吐剂，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径将止吐药输送到哺乳动物的试剂盒，其包含：a）包含至少5重量％止吐药的组合物; 和b）从所述组合物形成止吐雾气的装置，以供哺乳动物吸入。

26. 发明授权

US06740309B2 Delivery of compounds for the treatment of migraine through an inhalation route 失效
标题翻译：输送化合物用于通过吸入途径治疗偏头痛
公开(公告)号：US06740309B2
公开(公告)日：2004-05-25
申请号：US10154594
申请日：2002-05-23
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of a migraine headache drug through an inhalation route. Specifically, it relates to aerosols containing a migraine headache drug that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a migraine headache drug. In a method aspect of the present invention, a migraine headache drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a migraine headache drug, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a migraine headache drug through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of a migraine headache drug; and, b) a device that forms a migraine headache drug containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送偏头痛药物。具体地说，它涉及含有用于吸入治疗的偏头痛药物的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的偏头痛药物的颗粒。在本发明的方法方面，偏头痛药物通过吸入途径递送至哺乳动物。该方法包括：a）加热组合物，其中组合物包含至少5重量％的偏头痛头痛药物以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于将偏头痛药物通过吸入途径递送至哺乳动物的试剂盒，其包括：a）包含至少5重量％偏头痛头痛药物的组合物; 和b）一种由组合物形成含有气雾剂的偏头痛药物供哺乳动物吸入的装置。

27. 发明授权

US06740307B2 Delivery of &bgr;-blockers through an inhalation route 失效
标题翻译：通过吸入途径递送β受体阻滞剂
公开(公告)号：US06740307B2
公开(公告)日：2004-05-25
申请号：US10152652
申请日：2002-05-20
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of beta-blockers through an inhalation route. Specifically, it relates to aerosols containing atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of atenolol, pindolol, esmolol, propranolol, or metoprolol. In a method aspect of the present invention, one of atenolol, pindolol, esmolol, propranolol, or metoprolol is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of atenolol, pindolol, esmolol, propranolol, or metoprolol, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of atenolol, pindolol, esmolol, propranolol, or metoprolol; and, b) a device that forms a atenolol, pindolol, esmolol, propranolol, or metoprolol containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送β受体阻滞剂。具体地说，它涉及用于吸入治疗的含有阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的气溶胶。在本发明的组合物方面，气雾剂包含包含至少5重量％的阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的颗粒。在本发明的方法方面，将阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔中的一种通过吸入途径递送至哺乳动物。该方法包括：a）加热组合物，其中组合物包含至少5重量％的阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径向哺乳动物递送阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的试剂盒，其包含：a）包含至少5重量％的阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔; 和b）从组合物形成含有阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的气溶胶的装置，用于哺乳动物的吸入。

28. 发明授权

US06737043B2 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 有权
标题翻译：通过吸入途径递送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑
公开(公告)号：US06737043B2
公开(公告)日：2004-05-18
申请号：US10155373
申请日：2002-05-22
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , F24V30/00 , Y10S514/958
摘要： The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Specifically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of alprazolam, estazolam, midazolam or triazolam. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of alprazolam, estazolam, midazolam or triazolam, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of alprazolam, estazolam, midazolam or triazolam; and, b) a device that forms an alprazolam, estazolam, midazolam or triazolam containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑。具体来说，它涉及用于吸入治疗的含有阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的阿普唑仑，咪唑安定，咪达唑仑或三唑仑的颗粒。在本发明的方法方面，阿普唑仑，艾司唑仑，咪达唑仑或三唑仑通过吸入路线递送至哺乳动物。该方法包括：a）加热组合物，其中所述组合物包含至少5重量％的阿普唑仑，咪达唑仑或三唑仑，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径向哺乳动物递送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的试剂盒，其包含：a）包含至少5重量％的阿普唑仑，咪达唑仑，咪达唑仑或三唑仑和b）从该组合物形成含有阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的气溶胶以供哺乳动物吸入的装置。

29. 发明授权

US06716417B2 Delivery on nonsteroidal antiinflammatory drugs through an inhalation route 失效
标题翻译：通过吸入途径运送非甾体抗炎药物
公开(公告)号：US06716417B2
公开(公告)日：2004-04-06
申请号：US10155097
申请日：2002-05-23
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61R912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an NSAID. In a method aspect of the present invention, an NSAID is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an NSAID, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an NSAID; and, b) a device that forms an NSAID aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送非甾体抗炎药（NSAID）。具体地说，它涉及用于吸入治疗的含有NSAID的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的NSAID的颗粒。在本发明的方法方面，通过吸入途径将NSAID递送至哺乳动物。该方法包括：a）加热组合物，其中所述组合物包含至少5重量％的NSAID，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了用于通过吸入途径将NSAID递送至哺乳动物的试剂盒，其包含：a）包含至少5重量％的NSAID的组合物; 和b）从组合物形成NSAID气雾剂的装置，用于哺乳动物的吸入。

30. 发明授权

US08235037B2 Drug condensation aerosols and kits 有权
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US08235037B2
公开(公告)日：2012-08-07
申请号：US12117737
申请日：2008-05-08
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61M15/00 , A61K9/12 , A61K9/14 , H05B3/00
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

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