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21. 发明授权

US5037497A Method of fabricating an array of recessed radially oriented bipolar electrodes 失效
标题翻译：凹陷径向取向双极电极阵列的制造方法
公开(公告)号：US5037497A
公开(公告)日：1991-08-06
申请号：US555242
申请日：1990-07-19
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61F11/04 , A61N1/05 , H04R25/00
CPC分类号： A61N1/0541 , A61F11/04
摘要： An array of electrodes, suitable for use as an auditory prosthesis, and a method for fabricating such an array, are disclosed. The array includes an electrode body formed from an electrically insulating flexible material, preferably at least one annulus of an electrically insulating flexible material which is formed separately from the body and adhered thereto, at least one electrode positioned concentrically about each of the at least one annulus or electrode body, with the surface of each electrode being recessed and being exposed.
摘要翻译：公开了适合用作听觉假体的电极阵列及其制造方法。阵列包括由电绝缘的柔性材料形成的电极体，优选地是电绝缘的柔性材料的至少一个环，其与主体分开形成并粘附到其上，至少一个电极同心地围绕至少一个环或电极体，每个电极的表面凹进并露出。

22. 发明授权

US09724514B2 Variation of neural stimulation parameters 有权
公开(公告)号：US09724514B2
公开(公告)日：2017-08-08
申请号：US12970237
申请日：2010-12-16
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36071
摘要： Techniques for varying stimulus parameters used in neural stimulation to improve therapy efficacy, minimize energy consumption, minimize undesired side effects, and minimize loss of therapeutic effectiveness due to physiologic tolerance to stimulation. Neural stimulation is provided having a stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode-firing pattern, and a set of electrode-firing-polarity conditions. At least one of the stimulation parameters is pseudo-randomly varied. A second stimulation parameter is changed based upon having pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship specifying how changes in the first parameter affect desirable values for the second parameter.

23. 发明授权

US4535785A Method and apparatus for determining the viability and survival of sensori-neutral elements within the inner ear 失效
标题翻译：用于确定内耳内的传感器中性元件的存活力和存活率的方法和装置
公开(公告)号：US4535785A
公开(公告)日：1985-08-20
申请号：US421992
申请日：1982-09-23
申请人： Christopher van den Honert , Paul H. Stypulkowski
发明人： Christopher van den Honert , Paul H. Stypulkowski
IPC分类号： A61B5/12 , A61F11/04 , A61N1/32 , A61N1/36 , A61B5/05
CPC分类号： A61B5/12 , A61F11/04 , A61N1/32 , A61N1/36032
摘要： A method and apparatus for diagnosing the extent of survival of the peripheral sensori-neural elements within the inner ear of a patient by stimulating the patient with one or more pair of electrical stimulus signals having a known amplitude and inter-signal delay, and by measuring the electrical activity within the nervous system of the patient which results from these stimulus signals and comparing the activity which results from the second stimulus signal with the activity which results from the first stimulus signal.
摘要翻译：一种用于通过用具有已知幅度和信号间延迟的一对或多对电刺激信号刺激患者来诊断患者内耳内的外周传感神经元的存活程度的方法和装置，以及通过测量由这些刺激信号产生的患者神经系统内的电活动，并将从第二刺激信号产生的活动与由第一刺激信号产生的活动进行比较。

24. 发明授权

US07815597B2 System and method of treating stuttering by neuromodulation 失效
标题翻译：通过神经调节治疗口吃的系统和方法
公开(公告)号：US07815597B2
公开(公告)日：2010-10-19
申请号：US11168604
申请日：2005-06-27
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61M31/00 , A61F5/58 , A61N1/34 , A61B5/04
CPC分类号： A61M5/14276 , A61F5/58 , A61M5/1723 , A61M2210/0693 , A61N1/32
摘要： Stuttering-treatment techniques using neural stimulation and/or drug delivery. One or more electrodes and/or a catheter are implanted adjacent to sites in the brain. A signal generator and the electrode deliver stimulation to a first site. A pump and the catheter deliver one or more therapeutic drugs to a second site. The first and second sites could be: the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, or other paramedian thalamic and midbrain nuclei. The stuttering treatment could be performed via periodic transcranial magnetic stimulation. A sensor, located near the patient's vocal folds, can be used for generating a signal responsive to activity of the patient's speech-producing muscles. A controller adjusts one or more stimulation parameters in response to the signal from the sensor.
摘要翻译：使用神经刺激和/或药物递送的口吃治疗技术。一个或多个电极和/或导管与脑中的位置相邻地植入。信号发生器和电极将刺激传递到第一部位。泵和导管将一种或多种治疗药物递送到第二部位。第一个和第二个位置可以是：补充运动区域，中心线路，背内侧核，外侧前额叶电路或其他辅助丘脑丘脑和中脑核。口吃治疗可以通过周期性经颅磁刺激进行。位于患者声带附近的传感器可用于产生响应患者产生语音的肌肉的活动的信号。控制器响应于来自传感器的信号调整一个或多个刺激参数。

25. 发明授权

US07632225B2 System and method of treating stuttering by neuromodulation 失效
标题翻译：通过神经调节治疗口吃的系统和方法
公开(公告)号：US07632225B2
公开(公告)日：2009-12-15
申请号：US11168600
申请日：2005-06-27
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61F5/58 , A61M5/1723 , A61M2210/0693 , A61N1/32
摘要： Stuttering-treatment techniques using neural stimulation and/or drug delivery. One or more electrodes and/or a catheter are implanted adjacent to sites in the brain. A signal generator and the electrode deliver stimulation to a first site. A pump and the catheter deliver one or more therapeutic drugs to a second site. The first and second sites could be: the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, or other paramedian thalamic and midbrain nuclei. The stuttering treatment could be performed via periodic transcranial magnetic stimulation. A sensor, located near the patient's vocal folds, can be used for generating a signal responsive to activity of the patient's speech-producing muscles. A controller adjusts one or more stimulation parameters in response to the signal from the sensor.
摘要翻译：使用神经刺激和/或药物递送的口吃治疗技术。一个或多个电极和/或导管与脑中的位置相邻地植入。信号发生器和电极将刺激传递到第一部位。泵和导管将一种或多种治疗药物递送到第二部位。第一个和第二个位置可以是：补充运动区域，中心线路，背内侧核，外侧前额叶电路或其他辅助丘脑丘脑和中脑核。口吃治疗可以通过周期性经颅磁刺激进行。位于患者声带附近的传感器可用于产生响应患者产生语音的肌肉的活动的信号。控制器响应于来自传感器的信号调整一个或多个刺激参数。

26. 发明授权

US06944497B2 System and method of treating stuttering by neuromodulation 失效
标题翻译：通过神经调节治疗口吃的系统和方法
公开(公告)号：US06944497B2
公开(公告)日：2005-09-13
申请号：US10001751
申请日：2001-10-31
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61F5/58 , A61M5/142 , A61M5/172 , A61N1/32 , A61N1/00
CPC分类号： A61M5/14276 , A61F5/58 , A61M5/1723 , A61M2210/0693 , A61N1/32
摘要： Stuttering-treatment techniques using neural stimulation and/or drug delivery. One or more electrodes and/or a catheter are implanted adjacent to sites in the brain. A signal generator and the electrode deliver stimulation to a first site. A pump and the catheter deliver one or more therapeutic drugs to a second site. The first and second sites could be: the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, or other paramedian thalamic and midbrain nuclei. The stuttering treatment could be performed via periodic transcranial magnetic stimulation. A sensor, located near the patient's vocal folds, can be used for generating a signal responsive to activity of the patient's speech-producing muscles. A controller adjusts one or more stimulation parameters in response to the signal from the sensor.
摘要翻译：使用神经刺激和/或药物递送的口吃治疗技术。一个或多个电极和/或导管与脑中的位置相邻地植入。信号发生器和电极将刺激传递到第一部位。泵和导管将一种或多种治疗药物递送到第二部位。第一个和第二个位置可以是：补充运动区域，中心线路，背内侧核，外侧前额叶电路或其他辅助丘脑丘脑和中脑核。口吃治疗可以通过周期性经颅磁刺激进行。位于患者声带附近的传感器可用于产生响应患者产生语音的肌肉的活动的信号。控制器响应于来自传感器的信号调整一个或多个刺激参数。

27. 发明授权

US07050856B2 Variation of neural-stimulation parameters 有权
公开(公告)号：US07050856B2
公开(公告)日：2006-05-23
申请号：US10044405
申请日：2002-01-11
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36071
摘要： Techniques for varying stimulus parameters used in neural stimulation to improve therapy efficacy, minimize energy consumption, minimize undesired side effects, and minimize loss of therapeutic effectiveness due to physiologic tolerance to stimulation. Neural stimulation is provided having a stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode-firing pattern, and a set of electrode-firing-polarity conditions. At least one of the stimulation parameters is pseudo-randomly varied. A second stimulation parameter is changed based upon having pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship specifying how changes in the first parameter affect desirable values for the second parameter.

28. 发明授权

US06275596B1 Open ear canal hearing aid system 失效
标题翻译：开放耳道助听器系统
公开(公告)号：US06275596B1
公开(公告)日：2001-08-14
申请号：US08781714
申请日：1997-01-10
申请人： Robert J. Fretz , Paul H. Stypulkowski , Richard T. Woods
发明人： Robert J. Fretz , Paul H. Stypulkowski , Richard T. Woods
IPC分类号： H04R2500
CPC分类号： H04R25/656 , H04R25/456 , H04R25/652 , H04R2225/63 , H04R2460/09
摘要： An open ear canal hearing aid system comprises an ear canal tube sized for positioning in an ear canal of a user so that the ear canal is at least partially open for directly receiving ambient sounds. The open ear canal hearing aid system further comprises a sound processor for amplifying received ambient sounds included within a predetermined frequency to produce processed sounds and for supplying said processed sounds to said ear canal tube.
摘要翻译：开放耳道助听器系统包括耳道管，其尺寸适于定位在使用者的耳道中，使得耳道至少部分地打开以直接接收环境声音。开放式耳道助听器系统还包括声音处理器，用于放大包含在预定频率内的接收到的环境声音，以产生经处理的声音，并将所述经处理的声音提供给所述耳道管。

29. 发明授权

US4961434A Array of recessed radially oriented bipolar electrodes 失效
标题翻译：嵌入式径向取向双极电极阵列
公开(公告)号：US4961434A
公开(公告)日：1990-10-09
申请号：US238553
申请日：1988-08-30
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61F11/04 , A61N1/05 , H04R25/00
CPC分类号： A61N1/0541 , A61F11/04
摘要： The invention provides an array of electrodes, suitable for use as an auditory prosthesis. The array comprises an electrode body formed from an electrically insulating flexible material, preferably at least one annulus of an electrically insulating flexible material which is formed separately from the body and adhered thereto, at least one electrode positioned concentrically about each of the at least one annulus or electrode body, with the surface of each electrode being recessed and being exposed. The invention also provides a method for fabricating such an electrode array.
摘要翻译：本发明提供一种适合用作听觉假体的电极阵列。该阵列包括由电绝缘柔性材料形成的电极体，优选地是电绝缘柔性材料的至少一个环，其与主体分开形成并粘附到其上，至少一个电极同心地围绕所述至少一个环或电极体，每个电极的表面凹进并露出。本发明还提供了一种用于制造这种电极阵列的方法。

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