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21. 发明授权

US5632272A Signal processing apparatus 失效
标题翻译：信号处理装置
公开(公告)号：US5632272A
公开(公告)日：1997-05-27
申请号：US320154
申请日：1994-10-07
申请人： Mohamed K. Diab , Esmaiel Kiani-Azarbayjany , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
发明人： Mohamed K. Diab , Esmaiel Kiani-Azarbayjany , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
IPC分类号： A61B5/0245 , A61B5/00 , A61B5/02 , A61B5/0215 , A61B5/145 , A61B5/1455 , A61B5/1464 , A61B6/00 , A61B8/00 , G06F17/00 , G06F19/00 , H04B1/12 , H04B3/46 , H04B17/00
CPC分类号： H04B1/123 , A61B5/14546 , A61B5/14551 , A61B5/4821 , A61B5/7214 , A61B5/7253 , A61B8/5276 , G06K9/0051 , A61B5/021 , A61B5/02154 , A61B5/024 , A61B5/029 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/14532 , A61B5/7257 , A61B6/00 , A61B8/00
摘要： The present invention involves method and apparatus for analyzing two measured signals that are modeled as containing primary and secondary portions. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, the present invention involves utilizing a transformation which evaluates a plurality of possible signal coefficients in order to find appropriate coefficients. Alternatively, the present invention involves using statistical functions or Fourier transform and windowing techniques to determine the coefficients relating to two measured signals. Use of this invention is described in particular detail with respect to blood oximetry measurements.
摘要翻译：本发明涉及用于分析被建模为包含主要和次要部分的两个测量信号的方法和装置。系数根据根据本发明定义的模型关联两个信号。在一个实施例中，本发明涉及利用评估多个可能的信号系数以便找到适当系数的变换。或者，本发明涉及使用统计功能或傅里叶变换和加窗技术来确定与两个测量信号有关的系数。关于血液测碘法测量，特别详细地描述了本发明的用途。

22. 发明授权

US5508304A Glucagon antagonists and methods relating thereto 失效
标题翻译：胰高血糖素拮抗剂及其相关方法
公开(公告)号：US5508304A
公开(公告)日：1996-04-16
申请号：US288875
申请日：1994-08-10
申请人： Robert R. West , Virender Labroo , James R. Piggott , Robert A. Smith , Patricia A. McKernan
发明人： Robert R. West , Virender Labroo , James R. Piggott , Robert A. Smith , Patricia A. McKernan
IPC分类号： A61K31/12 , A61K31/122 , A61K31/22 , A61K31/27 , C12P15/00 , A61K31/21
CPC分类号： A61K31/122 , A61K31/12 , A61K31/22 , A61K31/27 , C12P15/00
摘要： Glucagon antagonists and methods relating thereto are disclosed. The glucagon antagonists include skyrin and skyrin analogs, and serve to inhibit the stimulation of a glucagon-induced response pathway, such as the adenylate cyclase response pathway or the inositol phosphate response pathway. The glucagon antagonists may be used within therapeutic compositions to treat disease states associate with elevated glucose levels, including diabetes and hyperglycemia. The present invention also discloses a biologically pure culture of ATCC accession number 74200, as well as methods relating to the production of glucagon antagonists by cultivating the same in a nutrient medium and recovering the glucagon antagonist therefrom.
摘要翻译：公开了胰高血糖素拮抗剂及其相关方法。胰高血糖素拮抗剂包括天冬氨酸和天冬氨酸类似物，并且用于抑制胰高血糖素诱导的应答途径的刺激，例如腺苷酸环化酶应答途径或肌醇磷酸应答途径。胰高血糖素拮抗剂可用于治疗组合物内以治疗与升高的葡萄糖水平相关的疾病状态，包括糖尿病和高血糖。本发明还公开了ATCC保藏号74200的生物纯纯培养物，以及通过在营养培养基中培养并从其中回收胰高血糖素拮抗剂来产生胰高血糖素拮抗剂的方法。

23. 发明授权

US5408037A Methods for detecting glucagon antagonists 失效
标题翻译：检测胰高血糖素拮抗剂的方法
公开(公告)号：US5408037A
公开(公告)日：1995-04-18
申请号：US741931
申请日：1991-08-08
申请人： Robert A. Smith , James R. Piggott
发明人： Robert A. Smith , James R. Piggott
IPC分类号： C07K14/575 , C07K14/605 , C12N1/19 , C12N15/09 , C12N15/16 , C12P21/02 , C12R1/865 , G01N33/53 , A61K37/00 , C07K7/00
CPC分类号： C07K14/605
摘要： Methods for detecting glucagon antagonists through the use of recombinant DNA techniques are provided. Briefly, subsequent to the expression of glucagon analogs within suitable host cells, the analogs are exposed to a glucagon receptor coupled to a response pathway in the presence of native glucagon. A reduction in the stimulation of the response pathway resulting from the binding of the glucagon analog to the glucagon receptor relative to the stimulation of the response pathway by native glucagon alone indicates the presence of a glucagon antagonist. Glucagon antagonists identified and isolated through the methods are also provided.
摘要翻译：提供了通过使用重组DNA技术检测胰高血糖素拮抗剂的方法。简而言之，在合适的宿主细胞内表达胰高血糖素类似物之后，类似物暴露于在天然胰高血糖素存在下偶联至应答途径的胰高血糖素受体。由胰高血糖素类似物与胰高血糖素受体的结合引起的反应途径的刺激相对于单独的天然胰高血糖素刺激反应途径的降低表明存在胰高血糖素拮抗剂。还提供了通过该方法鉴定和分离的胰高血糖素拮抗剂。

24. 发明授权

US5162425A Fast curing rubber blend 失效
标题翻译：快速固化橡胶混合物
公开(公告)号：US5162425A
公开(公告)日：1992-11-10
申请号：US590260
申请日：1990-09-28
申请人： Paul H. Sandstrom , Emil M. Friedman , J. Dale Massie, II , Robert A. Smith
发明人： Paul H. Sandstrom , Emil M. Friedman , J. Dale Massie, II , Robert A. Smith
IPC分类号： C08L21/00
CPC分类号： C08L21/00 , C08L9/00 , C08L9/06
摘要： It is highly desirable to be able to cure rubbers quickly since the amount of energy required for the curing process is reduced and the number of articles that can be cured in a mold in a given time is increased. In other words, the cycle time needed to cure articles made from such a rubber is reduced and the throughput of a mold utilized in curing such a rubber is increased. Unfortunately, most attempts to accelerate the cure rate of rubber have resulted in the rubber having poor scorch safety. The present invention discloses a fast curing rubber blend having excellent scorch safety which comprises: (a) from 50 to 98 weight percent of at least one polydiene rubber, and (b) from 2 to 50 weight percent of at least one vinylpyridine copolymer comprised of repeat units which are derived from a diene monomer and vinylpyridine wherein from 1 to 75 weight percent of the repeat units in said copolymer are derived from vinylpyridine. The rubber blends of the present invention have unexpectedly been shown to have particular utility in improving tire tread traction.
摘要翻译：由于固化过程所需的能量的量减少并且在给定时间内可以在模具中固化的制品的数量增加，所以非常希望能够快速地固化橡胶。换句话说，固化由这种橡胶制成的制品所需的循环时间减少，并且用于固化这种橡胶的模具的生产量增加。不幸的是，大多数加速橡胶固化速度的尝试导致橡胶具有差的焦烧安全性。本发明公开了一种具有优异的焦烧安全性的快速固化橡胶共混物，其包括：（a）50至98重量％的至少一种聚二烯橡胶，和（b）2至50重量％的至少一种乙烯基吡啶共聚物，衍生自二烯单体和乙烯基吡啶的重复单元，其中所述共聚物中1至75重量％的重复单元衍生自乙烯基吡啶。本发明的橡胶混合物意外地被证明在改善轮胎胎面牵引力方面具有特别的用途。

25. 发明授权

US5057416A Supersecreting mutants of Saccharomyces cerevisiae 失效
标题翻译：超级酵母酿酒酵母突变体
公开(公告)号：US5057416A
公开(公告)日：1991-10-15
申请号：US273362
申请日：1988-11-18
申请人： Robert A. Smith , Margaret J. Duncan
发明人： Robert A. Smith , Margaret J. Duncan
IPC分类号： C07K14/61 , C12N5/00 , C12N9/64 , C12N9/72 , C12N15/62 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/865
CPC分类号： C12N15/625 , C07K14/61 , C12N15/81 , C12N9/6462 , C12N9/6481 , C12R1/865 , C12Y304/21073 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75
摘要： A screening procedure is provided which utilizes a milk clotting assay for selecting supersecreting yeast cells for obtaining high yields of desired polypeptide products.Supersecreting yeast cells are provided as filed with American Type Culture Collection.Final polypeptide products are obtained from mutant yeast strains which have been screened as to secreting properties with supersecreters then cultured to obtain high yields.
摘要翻译：提供了一种筛选程序，其利用凝乳分析法选择超滤酵母细胞以获得高产量的所需多肽产物。提供超级酵母细胞提供与美国典型培养物保藏中心。最终的多肽产物是从突变酵母菌株获得的，这些菌株已被筛选为用超分解器分泌特性，然后培养以获得高产率。

26. 发明授权

US5037761A Method of applying an automotive type oxygen sensor for use in an industrial process analyzer 失效
标题翻译：应用用于工业过程分析仪的汽车型氧传感器的方法
公开(公告)号：US5037761A
公开(公告)日：1991-08-06
申请号：US335605
申请日：1989-05-08
申请人： Daniel C. Barnett , John J. Fry , George R. Hall, II , David F. Ross , Robert A. Smith , Gordon D. Woolbert
发明人： Daniel C. Barnett , John J. Fry , George R. Hall, II , David F. Ross , Robert A. Smith , Gordon D. Woolbert
IPC分类号： F23N5/00 , G01N27/406
CPC分类号： F23N5/006 , G01N27/4067 , F02D41/1494 , Y10T436/208339 , Y10T436/218
摘要： An industrial process oxygen analyzer, and method of using same, incorporates an automotive oxygen sensor to minimize the criticalness of controlling heater temperature during operation. Higher sensor heater temperature, required to accommodate the automotive oxygen sensor, is achieved by application of higher supply voltage to the sensor heater. Current limiting of the heater supply circuit reduces stress on the sensor heater, even at the higher operating temperature.
摘要翻译：工业过程氧分析仪及其使用方法包括汽车氧传感器，以最小化操作期间控制加热器温度的关键性。通过向传感器加热器施加更高的电源电压来实现适应汽车氧传感器所需的更高的传感器加热器温度。即使在较高的工作温度下，加热器电路的电流限制也会降低传感器加热器的压力。

27. 发明授权

US4694057A Preparation of polymers containing pendant isocyanate groups and derivatives thereof by emulsion copolymerization 失效
标题翻译：通过乳液共聚制备含异氰酸酯侧基的聚合物及其衍生物
公开(公告)号：US4694057A
公开(公告)日：1987-09-15
申请号：US708840
申请日：1985-03-06
申请人： Robert A. Smith , Dane K. Parker , Howard A. Colvin , Arthur H. Weinstein , Dennis B. Patterson
发明人： Robert A. Smith , Dane K. Parker , Howard A. Colvin , Arthur H. Weinstein , Dennis B. Patterson
IPC分类号： C08F12/00 , C08F2/22 , C08F2/24 , C08F12/26 , C08F212/14 , C08F220/42 , C08F220/44 , C08F236/10 , C08G18/72
CPC分类号： C08G18/728 , C08F212/14
摘要： It has unexpectedly been discovered that 1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl) benzene(m-TMI) can be emulsion copolymerized with other monomers into useful polymers. For example, it has been found that m-TMI can be emulsion copolymerized with diene monomers to produce polymers which contain pendant isocyanate groups. Such pendant isocyanate groups are useful in a variety of applications. For instance, such pendant isocyanate groups can be utilized as sites to which chemical agents, such as antidegradants, can be bound to the polymer. Elastomers which contain such pendant isocyanate groups are of value since they can be crosslinked without employing sulfur. Elastomers of this type which contain pendant isocyanate groups can also potentially be thermo-reversibly crosslinked.
摘要翻译：意外地发现1-（1-异氰酸基-1-甲基乙基）-3-（1-甲基乙烯基）苯（m-TMI）可以与其它单体乳液共聚成有用的聚合物。例如，已经发现，m-TMI可以与二烯单体乳液共聚以制备含异氰酸酯侧基的聚合物。这种侧挂异氰酸酯基可用于各种应用。例如，这种异氰酸酯侧基可用作化学试剂如抗降解剂可以结合到聚合物上的位点。含有这种异氰酸酯侧基的弹性体是有价值的，因为它们可以交联而不使用硫。含有异氰酸酯侧基的这种类型的弹性体也可能是热可逆交联的。

28. 发明授权

US4253740A Liquid crystal materials and devices containing them 失效
标题翻译：液晶材料和含有它们的装置
公开(公告)号：US4253740A
公开(公告)日：1981-03-03
申请号：US940758
申请日：1978-09-08
申请人： Edward P. Raynes , Robert A. Smith
发明人： Edward P. Raynes , Robert A. Smith
IPC分类号： C09K19/42 , C09K19/44 , C09K19/46 , C09K19/48 , C09K19/50 , G02F1/13 , C09K3/34
CPC分类号： C09K19/42 , C09K19/48
摘要： A liquid crystal material having a low threshold voltage for use in displays comprises a mixture of at least three liquid cyrstal materials at least two of which are selected from the following compounds. ##STR1## or the above compounds where in a cyclo hexane ring is substituted for one of the benzene rings, where X is a short alkyl group C.sub.n H.sub.2n+1 and n is an even integer, or where X is a short alkoxy group C.sub.m H.sub.2m+1 and m is an odd integer.
摘要翻译：具有用于显示器的低阈值电压的液晶材料包括至少三种液态硅胶材料的混合物，其中至少两种液体材料选自下列化合物。或者上述化合物，其中在环己烷环中取代一个苯环，其中X是短烷基C n H 2n + 1，n是偶数整数，或其中X是短烷氧基 CmH2m + 1，m是奇整数。

29. 发明授权

US4185120A Topical treatment of fungal or yeast infections using p-tolyl diiodomethyl sulfone 失效
标题翻译：使用对甲苯基二碘甲基砜对真菌或酵母菌感染进行局部治疗
公开(公告)号：US4185120A
公开(公告)日：1980-01-22
申请号：US947328
申请日：1978-10-02
申请人： Robert A. Smith
发明人： Robert A. Smith
IPC分类号： A61K9/00 , A61K31/10 , A61K47/02
CPC分类号： A61K31/10 , A61K47/02 , A61K9/0014
摘要： By incorporating p-tolyl diiodomethyl sulfone into a topically acceptable base, the growth of yeast or fungi on the skin of warm-blooded animals can be alleviated, reversed or eliminated.
摘要翻译：通过将对甲苯基二碘甲基砜并入局部可接受的碱中，可以减轻，逆转或消除温血动物皮肤上酵母或真菌的生长。

30. 发明授权

US3976296A Magnetic game apparatus 失效
标题翻译：磁性游戏机
公开(公告)号：US3976296A
公开(公告)日：1976-08-24
申请号：US528724
申请日：1974-12-02
申请人： Robert A. Smith
发明人： Robert A. Smith
IPC分类号： A63F7/06
CPC分类号： A63F7/068
摘要： A game apparatus comprising a playing surface with a plurality of playing members on the surface. A ball member is adapted to move over the playing surface among the playing members with a magnetic element within the ball member. A rotatable surface located below the playing surface carries a plurality of second magnetic elements which exert magnetic forces on the magnetic element within the ball. The movement of the rotatable surface randomly positions the ball member on the playing surface and among the playing members.
摘要翻译：一种游戏装置，包括在表面上具有多个游戏部件的游戏面。球部件适于在球部件内部具有磁性元件在游戏部件之间移动。位于游戏表面下方的可旋转表面承载多个第二磁性元件，该第二磁性元件对球内的磁性元件施加磁力。可旋转表面的运动将球形件随机定位在演奏表面和演奏构件之间。

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