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21. 发明授权

US5980548A Transmyocardial revascularization system 失效
标题翻译：经心肌血运重建系统
公开(公告)号：US5980548A
公开(公告)日：1999-11-09
申请号：US958788
申请日：1997-10-29
申请人： Douglas G. Evans , John E. Nash
发明人： Douglas G. Evans , John E. Nash
IPC分类号： A61B17/00 , A61F2/02 , A61F2/82 , A61B17/34
CPC分类号： A61F2/82 , A61F2/2493 , A61B2017/00247 , A61B2018/00392
摘要： A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or nonresorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deployment instruments may make use of a stabilizing device to stabilize them during the procedure of inserting the inserts into the myocardium. A controller may also be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens can be achieved either by the inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
摘要翻译：一种经心肌血运重建系统，其包括由材料组成的多个插入物，以在心肌的组织中引发愈合反应，以及用于将插入物部署到心肌壁上的相关组件。插入件布置成设置在心肌壁中相应的腔或通道内。插入件可以采取各种形式，例如是实心构件，管状构件或多孔构件，并且可以是可再吸收的，部分可再吸收的或不可再吸收的。在一些实施例中，插入物被布置成在心肌壁中的通道内留在适当的位置，以产生多个流明，使得血液能够流过并流入相邻的毛细血管。根据所使用的特定部署仪器，这些展开装置被设置成从心内膜或心外膜刺穿心肌的组织以将插入物插入心肌。在将插入物插入心肌的过程中，展开装置可以利用稳定装置来稳定它们。还可以提供控制器作为系统的一部分，以协调部署仪器与心动周期的操作。腔的形成可以通过插入件或通过其它手段实现，例如刺穿尖端或形成器械的一部分的能量施加器。插入物可以包括一种或多种药物，生物活性剂，不透射线材料等。

22. 发明授权

US5922022A Bifurcated connector system for coronary bypass grafts and methods of use 失效
标题翻译：用于冠状动脉旁路移植物的分叉连接器系统和使用方法
公开(公告)号：US5922022A
公开(公告)日：1999-07-13
申请号：US2267
申请日：1997-12-31
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/06 , A61B17/08 , A61B17/11 , A61B17/12 , A61F2/06
CPC分类号： A61B17/0057 , A61B17/11 , A61B17/06 , A61B17/12009 , A61B2017/00004 , A61B2017/00243 , A61B2017/1107 , A61B2017/1135
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which the connector assembly is deployed by the deployment instrument. The connector assembly is at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures. Moreover, the system can be used to bypass of at least two coronary arteries by a common connection with the aorta utilizing at least two bypass grafts, a single upstream anastomosis connector, a pair of downstream anastomosis connectors, and a common bifurcated midstream anastomosis connector, for securement between the aorta and the coronary arteries.
摘要翻译：一种用于实现生物体内的天然血管，导管，内腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括连接器组件和用于将装置运送到容器，管道，管腔或管状器官内所需位置的展开仪器。该系统包括穿孔器 - 扩张仪器，以在容器，管道，管腔或管状器官的壁中形成开口，连接器组件通过展开器械展开。连接器组件至少部分地由可吸收材料形成，并且包括可移动构件，用于将其固定到与开口相邻的容器，管道，管腔或管状器官的组织。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。此外，该系统可以用于利用至少两个旁路移植物，单个上游吻合连接器，一对下游吻合连接器和一个共同的分叉中间吻合连接器与主动脉的共同连接来旁路至少两个冠状动脉，用于主动脉和冠状动脉之间的固定。

23. 发明授权

US5861004A Hemostatic puncture closure system including closure locking means and method of use 失效
标题翻译：止血止血系统包括闭锁装置和使用方法
公开(公告)号：US5861004A
公开(公告)日：1999-01-19
申请号：US921270
申请日：1997-08-29
申请人： Kenneth Kensey , John E. Nash , Douglas G. Evans
发明人： Kenneth Kensey , John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

24. 发明授权

US06872192B2 Tool for facilitating the connecting of a catheter or other tubular member onto a guide-wire without access to the ends of the guide-wire 有权
标题翻译：用于促进将导管或其它管状构件连接到导丝上而不进入导丝末端的工具
公开(公告)号：US06872192B2
公开(公告)日：2005-03-29
申请号：US10230312
申请日：2002-08-28
申请人： John E. Nash , Gregory Walters , Douglas G. Evans , David Szabo , Michael Paris
发明人： John E. Nash , Gregory Walters , Douglas G. Evans , David Szabo , Michael Paris
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09 , A61M25/16 , A61M25/18 , A61M29/02 , A61M39/00 , A61M5/178
CPC分类号： A61M25/0169 , A61M25/00 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/09041 , A61M29/02 , A61M2025/0177 , A61M2025/018 , A61M2025/0186 , A61M2025/09008 , A61M2025/09125 , A61M2025/1056 , A61M2025/1095
摘要： An attachment tool to facilitate the attachment of a catheter or similar elongated instrument to a guide-wire or other elongated guide member, without requiring access to either end of said wire or member. Said tool providing repeatable and reliable alignment of components to be attached, while being operated with a single hand. The tool further facilitates the attachment of a plurality of catheters or instruments to a single wire or member.
摘要翻译：连接工具，以便于将导管或类似的细长器械附接到导丝或其它细长的引导构件，而不需要接近所述线或构件的任一端。所述工具在单手操作的同时提供要附接的部件的可重复且可靠的对准。该工具进一步有助于将多个导管或器械附接到单个线或构件。

25. 发明授权

US06709427B1 Systems and methods for delivering agents into targeted tissue of a living being 有权
标题翻译：将药剂递送到生活目标组织中的系统和方法
公开(公告)号：US06709427B1
公开(公告)日：2004-03-23
申请号：US09368410
申请日：1999-08-05
申请人： John E. Nash , Douglas G. Evans , David M. Hoganson
发明人： John E. Nash , Douglas G. Evans , David M. Hoganson
IPC分类号： A61M3100
CPC分类号： A61B17/32037 , A61B17/320758 , A61B17/3478 , A61B18/14 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22038 , A61B2018/00208 , A61B2018/00291 , A61B2018/00392 , A61B2018/00839 , A61B2018/1861 , A61B2018/2005
摘要： The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
摘要翻译：该系统基本上包括用于进入生命体内的目标组织的递送系统，以及在心肌和其它选择组织中的选定位置处引入至少一种药剂。输送系统被布置成进入心脏的组织。可以在经腔，经胸和直接手术进入程序中使用一个或多个系统。在适当的情况下，例如在心室内进入的情况下，系统的部分可操纵以适当地定向装置。仪器可以刺穿心脏组织并产生从心内膜，心外膜或心脏血管延伸的通道。当使用组织穿透时，该装置可以包括控制穿透深度的特征。为了最大程度地减少通道通道的流出，设备可以扩大小的初始穿刺，后来在设备移除后收缩。当需要形成通道时，可以通过例如旋转尖端装置，加压流体喷射装置，振动器械和刺穿针状尖端装置来实现。该系统可以在该过程中利用某种形式的机械作用或能量的应用（例如电，声，热，光，加压流体，射频（RF），核）。机械作用或能量施加可能会影响距离设备一定距离的周围组织。递送到组织的药剂可以包括一种或多种药物，生物活性剂，不透射线材料等。

26. 发明授权

US06402767B1 Anastomosis connection system and method of use 有权
标题翻译：吻合连接系统及使用方法
公开(公告)号：US06402767B1
公开(公告)日：2002-06-11
申请号：US09519191
申请日：2000-03-06
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B1704
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2002/065
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes an anastomosis connector device and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The deployment device may include a dilator to facilitate the placement of the anastomosis device within the interior of the vessel, duct, lumen or other tubular organ. The anastomosis device is preferably formed of a resorbable material and is configured to minimize blood or other fluid turbulence therethrough. The device may include snap-connectors or other components for securing it to the tissue of the vessel, duct, lumen or tubular organ and hemostasis-inducing sealing rings to prevent blood leakage. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.
摘要翻译：一种用于实现生物体内的天然血管，管道，管腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括吻合连接器装置和用于将装置运送到血管，管道，管腔或管状器官内所需位置的展开装置。展开装置可以包括扩张器，以便于将吻合装置放置在血管，管道，管腔或其它管状器官内部。吻合装置优选地由可再吸收的材料形成并且被构造成使通过其中的血液或其它流体湍流最小化。该装置可以包括卡扣连接器或其它部件，用于将其固定到血管，管道，管腔或管状器官的组织，以及止血诱导密封环以防止血液渗漏。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。

27. 发明授权

US6063114A Connector system for vessels, ducts, lumens or hollow organs and methods of use 失效
标题翻译：用于血管，导管，腔或中空器官的连接器系统和使用方法
公开(公告)号：US6063114A
公开(公告)日：2000-05-16
申请号：US923682
申请日：1997-09-04
申请人： John E. Nash , Douglas G. Evans , David M. Hoganson
发明人： John E. Nash , Douglas G. Evans , David M. Hoganson
IPC分类号： A61B17/00 , A61B17/06 , A61B17/08 , A61B17/11 , A61B17/12 , A61F2/00
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/06 , A61B17/12009 , A61B2017/00004 , A61B2017/00243 , A61B2017/1107 , A61B2017/1135
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which the connector assembly is deployed by the deployment instrument. The connector assembly is at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.
摘要翻译：一种用于实现生物体内的天然血管，导管，内腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括连接器组件和用于将装置运送到容器，管道，管腔或管状器官内所需位置的展开仪器。该系统包括穿孔器 - 扩张仪器，以在容器，管道，管腔或管状器官的壁中形成开口，连接器组件通过展开器械展开。连接器组件至少部分地由可吸收材料形成，并且包括可移动构件，用于将其固定到与开口相邻的容器，管道，管腔或管状器官的组织。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。

28. 发明授权

US6045569A Hemostatic puncture closure system including closure locking means and methods of use 失效
标题翻译：止血止血系统包括闭锁锁定装置和使用方法
公开(公告)号：US6045569A
公开(公告)日：2000-04-04
申请号：US15190
申请日：1998-01-29
申请人： Kenneth Kensey , John E. Nash , Douglas G. Evans
发明人： Kenneth Kensey , John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

29. 发明授权

US07695483B2 Surgical connector systems and methods of use 失效
标题翻译：手术连接器系统和使用方法
公开(公告)号：US07695483B2
公开(公告)日：2010-04-13
申请号：US11849206
申请日：2007-08-31
申请人： John E. Nash , Douglas G. Evans , David M. Hoganson
发明人： John E. Nash , Douglas G. Evans , David M. Hoganson
IPC分类号： A61B17/08 , A61B17/04
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/06 , A61B17/12009 , A61B2017/00004 , A61B2017/00243 , A61B2017/1107 , A61B2017/1135
摘要： A system and method of use for effecting the bypass or other anastomosis, connection, or port in a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which a connector assembly may be deployed by the deployment instrument. The connector assembly may be at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the procedure, with or without the use of sutures.
摘要翻译：用于在生命体内的天然血管，导管，内腔或其他管状器官的一部分中实现旁路或其它吻合，连接或端口的系统和方法。该系统包括连接器组件和用于将装置运送到容器，管道，管腔或管状器官内所需位置的展开仪器。该系统包括穿孔器 - 扩张仪器，以在容器，管道，管腔或管状器官的壁中形成开口，连接器组件可以由展开仪器部署到该开口中。连接器组件可以至少部分地由可再吸收的材料形成，并且包括用于将其固定到与开口相邻的容器，管道，管腔或管状器官的组织的可移动构件。在使用或不使用缝合线的情况下，可以在装置中包括用于加速该程序的其它部件。

30. 发明授权

US07476234B2 Transmyocardial revascularization system and method of use 有权
公开(公告)号：US07476234B2
公开(公告)日：2009-01-13
申请号：US11076500
申请日：2005-03-09
申请人： Douglas G. Evans , John E. Nash
发明人： Douglas G. Evans , John E. Nash
IPC分类号： A61B17/34
CPC分类号： A61F2/82 , A61B2017/00247 , A61B2018/00392 , A61F2/2493
摘要： A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deployment instruments may make use of a stabilizing device to stabilize them during the procedure of inserting the inserts into the myocardium. A controller may also be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens can be achieved either by the inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.

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