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21. 发明申请

US20090060913A1 COMBINATION THERAPY WITH TYPE I AND TYPE II ANTI-CD20 ANTIBODIES 审中-公开
标题翻译：与I型和II型抗CD20抗体的联合治疗
公开(公告)号：US20090060913A1
公开(公告)日：2009-03-05
申请号：US12203321
申请日：2008-09-03
申请人： Thomas Friess , Christian Klein , Pablo Umana
发明人： Thomas Friess , Christian Klein , Pablo Umana
IPC分类号： A61K39/395 , A61P31/00
CPC分类号： A61K39/39558 , A61K2039/507 , C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56
摘要： The present invention is directed to a combination therapy involving a type I anti-CD20 antibody and a type II anti-CD20 antibody for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer.An aspect of the invention is a composition comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody.Another aspect of the invention is a kit comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody.Yet another aspect of the invention is a method for the treatment of a patient suffering from cancer comprising co-administering, to a patient in need of such treatment, a type I anti-CD20 antibody and a type II anti-CD20 antibody.
摘要翻译：本发明涉及涉及用于治疗患有癌症的患者，特别是CD20表达癌症的患者的I型抗CD20抗体和II型抗-CD20抗体的组合疗法。本发明的一个方面是包含I型抗CD20抗体和II型抗-CD20抗体的组合物。本发明的另一方面是包含I型抗CD20抗体和II型抗CD20抗体的试剂盒。本发明的另一方面是用于治疗患有癌症的患者的方法，包括向需要这种治疗的患者共同给予I型抗CD20抗体和II型抗-CD20抗体。

22. 发明申请

US20070283077A1 Memory and Memory Communication System 有权
标题翻译：内存和内存通信系统
公开(公告)号：US20070283077A1
公开(公告)日：2007-12-06
申请号：US11754854
申请日：2007-05-29
申请人： Christian Klein , Stefan Linz , Helmut Reinig
发明人： Christian Klein , Stefan Linz , Helmut Reinig
IPC分类号： G06F12/00
CPC分类号： G11C7/22 , G11C7/1045 , G11C7/1072
摘要： A memory system includes a selection element for selecting a selectable access rate from a plurality of access rates and a memory element for providing or for accepting data at the selectable access rate.
摘要翻译：存储器系统包括用于从多个访问速率中选择可选访问速率的选择元件和用于以可选择访问速率提供或接收数据的存储器元件。

23. 发明申请

US20050282250A1 Method for the recombinant production and purification of protein kinases 失效
标题翻译：蛋白激酶重组生产和纯化方法
公开(公告)号：US20050282250A1
公开(公告)日：2005-12-22
申请号：US11000867
申请日：2004-12-01
申请人： Hubert Hertenberger , Konrad Honold , Christian Klein , Petra Rueger
发明人： Hubert Hertenberger , Konrad Honold , Christian Klein , Petra Rueger
IPC分类号： C12N9/12 , C12N15/11 , C12P21/06
CPC分类号： C12N9/1205
摘要： A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.
摘要翻译：一种通过在微生物宿主细胞中表达编码所述激酶的核酸，重组产生和纯化选自酪氨酸蛋白激酶和丝氨酸/苏氨酸激酶的方法，形成含有所述激酶的包涵体，分离，增溶，变性和纯化所述激酶，其中所述纯化通过与疏水性吸附剂的疏水相互作用进行，其中至少70％的所述蛋白激酶不与所述吸附剂结合，并且不结合所述吸附剂的蛋白激酶被回收。

24. 发明授权

US6153192A Peptides with a characteristic antigenic determinant of .alpha.1-microglobulin 失效
标题翻译：具有α1-微球蛋白特征抗原决定簇的肽
公开(公告)号：US6153192A
公开(公告)日：2000-11-28
申请号：US96044
申请日：1993-07-22
申请人： Erhard Kopetzki , Christian Klein , Dieter Mangold , Werner Stock , Reiner Schlipfenbacher
发明人： Erhard Kopetzki , Christian Klein , Dieter Mangold , Werner Stock , Reiner Schlipfenbacher
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/00 , C07K16/06 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N31/22 , G01N33/53 , A61K39/00 , A61K38/00 , G01N33/566
CPC分类号： C07K16/18 , C07K16/06 , Y10S530/81 , Y10S530/812
摘要： A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 1 and 20 of human .alpha.1-microglobulin.An antibody according to the present invention is capable of specific binding to a peptide according to the present invention as well as to human .alpha.1-microglobulin.In order to determine human .alpha.1-microglobulin in a sample liquid by an immunoassay, the sample liquid is brought into contact simultaneously or sequentially with defined amounts of the components antibody and peptide whereby one of the components is labelled and the determination is carried out by means of this label.
摘要翻译：根据本发明的肽不超过40个氨基酸长，并且含有与人α1-微球蛋白的氨基酸144和183之间的氨基酸部分序列至少6个氨基酸长的序列或/和该序列与人α1-微球蛋白的氨基酸1和20之间的氨基酸部分序列至少6个氨基酸长。根据本发明的抗体能够与根据本发明的肽以及人α1-微球蛋白特异性结合。为了通过免疫测定法在样品液体中测定人α1-微球蛋白，将样品液体与定义量的组分抗体和肽同时或依次接触，由此其中一种组分被标记，并且测定由该标签的手段。

25. 发明授权

US5248620A Non-ionic block copolymers of propylene oxide and ethylene oxide 失效
标题翻译：丙烯氧化物和乙烯氧化物的非离子嵌段共聚物
公开(公告)号：US5248620A
公开(公告)日：1993-09-28
申请号：US720305
申请日：1991-06-25
申请人： Peter Sluka , Christian Klein , Hans-Werner Griesser , Uwe Kobold
发明人： Peter Sluka , Christian Klein , Hans-Werner Griesser , Uwe Kobold
IPC分类号： G01N33/531 , B01F17/42 , C08G65/30 , G01N33/543
CPC分类号： G01N33/54393 , C08G65/30 , Y10S435/962 , Y10S436/817 , Y10S436/826
摘要： The invention concerns a method for the determination of a partner in an immunological reaction based on an immunoassay in which one of the reaction partners is present in a solid phase, wherein a polyethylene oxidepolypropylene oxide block copolymer having the formula I ##STR1## is used as the surface-active agent in which a can have a value between 40 and 150 and b a value between 10 and 50, which is characterized in that a hydrophilic block copolymer composition having the formula I is used which in a 1 % aqueous solution (weight/volume) has a surface tension of at least 45 mN/m and in which the average molar ratio of ethylene oxide groups to propylene oxide groups (2a/b) in the composition is at least 5.8. In addition the invention comprises a reagent for carrying out the above method.
摘要翻译：本发明涉及一种基于其中一个反应配偶体存在于固相中的免疫测定法来确定免疫反应中的配偶体的方法，其中将具有式I的聚乙烯氧化聚环氧丙烷嵌段共聚物用作其中罐的值可以在40到150之间，ba值在10和50之间的表面活性剂，其特征在于使用具有式I的亲水性嵌段共聚物组合物，其在1％水溶液（重量/ 体积）具有至少45mN / m的表面张力，其中组合物中环氧乙烷基团与环氧丙烷基团的平均摩尔比（2a / b）为至少5.8。此外，本发明包括用于实施上述方法的试剂。

26. 发明授权

US09982036B2 Dual FC antigen binding proteins 有权
公开(公告)号：US09982036B2
公开(公告)日：2018-05-29
申请号：US13406411
申请日：2012-02-27
申请人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
发明人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
IPC分类号： C07K16/30 , C07K16/28 , C07K16/00 , C07K16/32
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/41 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.

27. 发明申请

US20180089131A1 PHYSICAL CONFIGURATION OF A DEVICE FOR INTERACTION MODE SELECTION 审中-公开
公开(公告)号：US20180089131A1
公开(公告)日：2018-03-29
申请号：US15275215
申请日：2016-09-23
申请人： Aaron Mackay Burns , Riccardo Giraldi , Christian Klein , Roger Sebastian Kevin Sylvan , John Benjamin George Hesketh , Scott G. Wade
发明人： Aaron Mackay Burns , Riccardo Giraldi , Christian Klein , Roger Sebastian Kevin Sylvan , John Benjamin George Hesketh , Scott G. Wade
IPC分类号： G06F13/40 , G06F9/445
CPC分类号： G06F13/4068 , G06F9/4411 , G06F9/44505
摘要： In various embodiments, methods and systems are provide for detecting a physical configuration of a device based on sensor data from one or more configuration sensors. The physical configuration includes a position of a first display region of the device with respect to a second display region of the device, where the position is physically adjustable. A configuration profile is selected from a plurality of configuration profiles based on the detected physical configuration of the device. Each configuration profile is a representation of at least one respective physical configuration of the device. An interaction mode corresponding to the selected configuration profile is activated, where the interaction mode includes a set of mode input/output (I/O) features available while the interaction mode is active. Device interfaces of the device are managed using at least some mode I/O features in the set of mode I/O features based on the activating of the interaction mode.

28. 发明授权

US09676845B2 Bispecific antigen binding proteins 有权
公开(公告)号：US09676845B2
公开(公告)日：2017-06-13
申请号：US12780971
申请日：2010-05-17
申请人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
发明人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
IPC分类号： A61K39/395 , C07K16/22 , C07K16/46
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

29. 发明授权

US09415090B2 VEGF-D/VEGFR2/3-mediated regulation of dendrites 有权
标题翻译： VEGF-D / VEGFR2 / 3介导的树突调节
公开(公告)号：US09415090B2
公开(公告)日：2016-08-16
申请号：US14122116
申请日：2012-06-01
申请人： Hilmar Bading , Daniela Mauceri , Christian Klein
发明人： Hilmar Bading , Daniela Mauceri , Christian Klein
IPC分类号： A61K38/04 , A61K38/18 , C07K14/52 , C12N15/113 , A61K48/00
CPC分类号： A61K38/1866 , A61K48/005 , C07K14/52 , C12N15/1136 , C12N2310/14 , C12N2310/531 , C12N2320/30
摘要： The present invention relates to methods for modulating, i.e. increasing or decreasing, the length and/or the complexity of the dendrites of a neuronal cell by influencing the amount of vascular endothelial growth factor D (VEGFD)-related signaling. The present invention further relates to methods for treating age- and/or disease-related cognitive dysfunctions, or for impairing the memory of a subject. Finally, the present invention relates to recombinant VEGFD (rVEGFD) for use in the treatment of age- and/or disease-related cognitive dysfunctions.
摘要翻译：本发明涉及通过影响血管内皮生长因子D（VEGFD）相关信号的量来调节，即增加或减少神经细胞的树突的长度和/或复杂性的方法。本发明还涉及用于治疗年龄和/或疾病相关的认知功能障碍或损害受试者记忆的方法。最后，本发明涉及用于治疗年龄和/或疾病相关的认知功能障碍的重组VEGFD（rVEGFD）。

30. 发明授权

US09391063B2 Under voltage tolerant clamp 有权
标题翻译：低电压钳位
公开(公告)号：US09391063B2
公开(公告)日：2016-07-12
申请号：US13114738
申请日：2011-05-24
申请人： Nickole Gagne , Gregory A. Maher , Christian Klein
发明人： Nickole Gagne , Gregory A. Maher , Christian Klein
IPC分类号： H02J7/00 , H01L27/02 , H01L27/06
CPC分类号： H01L27/0266 , H01L27/0629
摘要： An apparatus comprises an integrated circuit (IC) comprising an external IC connection, an IC substrate connection, a voltage clamp circuit and an under voltage circuit. The voltage of the IC substrate connection is set to a first voltage when a voltage of the external connection of the IC is within a normal operating voltage range. The voltage clamp circuit is configured to clamp the voltage supply of one or more circuits internal to the IC to within a normal operating voltage range when the voltage of the external IC connection exceeds the normal operating voltage range. The under voltage circuit is communicatively coupled to the clamp circuit and configured to set the voltage of the substrate to a second voltage when the voltage at the external IC connection of the IC is less than zero volts.
摘要翻译：一种装置包括集成电路（IC），其包括外部IC连接，IC基板连接，电压钳位电路和欠压电路。当IC的外部连接电压处于正常工作电压范围内时，IC基板连接的电压被设定为第一电压。电压钳位电路被配置为当外部IC连接的电压超过正常工作电压范围时，将IC内部的一个或多个电路的电压钳位在正常工作电压范围内。欠压电路通信地耦合到钳位电路并且被配置为当IC的外部IC连接处的电压小于零伏特时将衬底的电压设置为第二电压。

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