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22. 发明授权

US07466132B2 Squid detected NMR and MRI at ultralow fields 失效
标题翻译：鱿鱼在超低场检测到核磁共振和核磁共振
公开(公告)号：US07466132B2
公开(公告)日：2008-12-16
申请号：US11740339
申请日：2007-04-26
申请人： John Clarke , Alexander Pines , Robert F. McDermott , Andreas H. Trabesinger
发明人： John Clarke , Alexander Pines , Robert F. McDermott , Andreas H. Trabesinger
IPC分类号： G01V3/00
CPC分类号： G01R33/326 , G01R33/0356 , G01R33/445
摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.
摘要翻译：核磁共振（NMR）信号在微量场中检测。随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。超低磁场中的MRI是基于超低场的NMR。应用梯度磁场，并根据检测到的NMR信号构建图像。

23. 发明授权

US07218104B2 Squid detected NMR and MRI at ultralow fields 有权
标题翻译：鱿鱼在超低场检测到核磁共振和核磁共振
公开(公告)号：US07218104B2
公开(公告)日：2007-05-15
申请号：US11534757
申请日：2006-09-25
申请人： John Clarke , Robert McDermott , Alexander Pines , Andreas Heinz Trabesinger
发明人： John Clarke , Robert McDermott , Alexander Pines , Andreas Heinz Trabesinger
IPC分类号： G01V3/00
CPC分类号： G01R33/326 , G01R33/0356 , G01R33/445
摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.
摘要翻译：核磁共振（NMR）信号在微量场中检测。随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。超低磁场中的MRI是基于超低场的NMR。应用梯度磁场，并根据检测到的NMR信号构建图像。

24. 外观设计

USD520643S1 Tool for laboratories 失效
标题翻译：实验室工具
公开(公告)号：USD520643S1
公开(公告)日：2006-05-09
申请号：US29205396
申请日：2004-05-13
申请人： John Clarke , Peter Le Feuvre , David Inder
设计人： John Clarke , Peter Le Feuvre , David Inder

25. 发明申请

US20060079958A1 Balloon expandable stent 有权
标题翻译：球囊扩张支架
公开(公告)号：US20060079958A1
公开(公告)日：2006-04-13
申请号：US11274158
申请日：2005-11-16
申请人： Peter Stratford , Alistair Taylor , Vincent O'Byrne , John Clarke , Denis Healy
发明人： Peter Stratford , Alistair Taylor , Vincent O'Byrne , John Clarke , Denis Healy
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relate to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译：本发明涉及一种安装在球囊导管上的球囊可扩张支架，整个组件被涂覆有凝聚聚合物涂层，其优选地基本上在圆周上基本上连续，更优选地，支架在气囊上的轴向长度。聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。

26. 发明申请

US20050247087A1 Wheel immobilizer 有权
标题翻译：车轮防盗器
公开(公告)号：US20050247087A1
公开(公告)日：2005-11-10
申请号：US10839223
申请日：2004-05-06
申请人： John Clarke
发明人： John Clarke
IPC分类号： B60R25/00 , B62D43/00 , B62H5/14
CPC分类号： B60R25/093 , Y10T70/40 , Y10T70/5765 , Y10T70/5841
摘要： An immobilization apparatus for a vehicle having a wheel with a tire. The apparatus comprises first and second elongated members having inner ends and outer ends. The inner ends are connected together and the outer ends are angularly spaced apart. There is an L-shaped clasp at each of the outer ends for grasping the tire. The clasps are rotatable about the outer ends. A third elongated member has an inner portion and an outer portion and is angularly spaced-apart from the first and second members. The inner portion is tubular and the outer portion of the third elongated member is telescopically received therein. The outer portion has an L-shaped clasp, and the outer portion is rotatable with respect to the inner portion. A locking mechanism secures the outer portion at a fixed telescopic position with respect to the inner portion of the third elongated member.
摘要翻译：一种具有带有轮胎的车轮的车辆的固定装置。该装置包括具有内端和外端的第一和第二细长构件。内端连接在一起，并且外端部成角度间隔开。在每个外端都有一个L形扣环，用于抓紧轮胎。夹子可绕外端旋转。第三细长构件具有内部部分和外部部分，并且与第一和第二构件成角度地间隔开。内部是管状的，并且第三细长构件的外部可伸缩地容纳在其中。外部具有L形扣环，并且外部部分可相对于内部部分旋转。锁定机构将外部部分固定在相对于第三细长构件的内部的固定的伸缩位置。

27. 发明授权

US06159444A NMR/MRI with hyperpolarized gas and high Tc SQUID 失效
标题翻译：具有超极化气体和高Tc SQUID的NMR / MRI
公开(公告)号：US06159444A
公开(公告)日：2000-12-12
申请号：US393406
申请日：1999-09-10
申请人： Klaus Schlenga , Ricardo E. de Souza , Annjoe Wong-Foy , John Clarke , Alexander Pines
发明人： Klaus Schlenga , Ricardo E. de Souza , Annjoe Wong-Foy , John Clarke , Alexander Pines
IPC分类号： G01R33/28 , G01R33/36 , A61B5/055
CPC分类号： G01R33/326 , G01R33/281 , Y10T436/24
摘要： A method and apparatus for the detection of nuclear magnetic resonance (NMR) signals and production of magnetic resonance imaging (MRI) from samples combines the use of hyperpolarized inert gases to enhance the NMR signals from target nuclei in a sample and a high critical temperature (Tc) superconducting quantum interference device (SQUID) to detect the NMR signals. The system operates in static magnetic fields of 3 mT or less (down to 0.1 mT), and at temperatures from liquid nitrogen (77K) to room temperature. Sample size is limited only by the size of the magnetic field coils and not by the detector. The detector is a high Tc SQUID magnetometer designed so that the SQUID detector can be very close to the sample, which can be at room temperature.
摘要翻译：用于检测核磁共振（NMR）信号和从样品产生磁共振成像（MRI）的方法和装置组合使用超极化惰性气体以增强样品中目标核和高临界温度的NMR信号（ Tc）超导量子干涉器件（SQUID）来检测NMR信号。该系统在3mT以下（低至0.1mT）的静态磁场和在液氮（77K）至室温的温度下工作。样品尺寸仅由磁场线圈的尺寸而不是由检测器限制。检测器是一种高Tc SQUID磁力计，设计使得SQUID检测器可以非常接近样品，可以在室温下。

28. 外观设计

USD434315S Filter pack clam shell package 失效
公开(公告)号：USD434315S
公开(公告)日：2000-11-28
申请号：US107152
申请日：1999-06-28
申请人： John Clarke
设计人： John Clarke

29. 发明授权

US4733182A Josephson junction Q-spoiler 失效
标题翻译：约瑟夫逊结Q-扰流板
公开(公告)号：US4733182A
公开(公告)日：1988-03-22
申请号：US844034
申请日：1986-03-25
申请人： John Clarke , Claude Hilbert , Erwin L. Hahn , Tycho Sleator
发明人： John Clarke , Claude Hilbert , Erwin L. Hahn , Tycho Sleator
IPC分类号： G01R33/035 , G01R33/08
CPC分类号： G01R33/0358
摘要： An automatic Q-spoiler comprising at least one Josephson tunnel junction connected in an LC circuit for flow of resonant current therethrough. When in use in a system for detecting the magnetic resonance of a gyromagnetic particle system, a high energy pulse of high frequency energy irradiating the particle system will cause the critical current through the Josephson tunnel junctions to be exceeded, causing the tunnel junctions to act as resistors and thereby damp the ringing of the high-Q detection circuit after the pulse. When the current has damped to below the critical current, the Josephson tunnel junctions revert to their zero-resistance state, restoring the Q of the detection circuit and enabling the low energy magnetic resonance signals to be detected.
摘要翻译：一种自动Q-扰流器，其包括连接在LC电路中的至少一个约瑟夫逊隧道结，用于使谐振电流流过。当在用于检测回转磁体粒子系统的磁共振的系统中使用时，照射粒子系统的高频能量的高能量脉冲将导致超过约瑟夫逊隧道结的临界电流，导致隧道结作用电阻器，从而在脉冲后抑制高Q检测电路的振铃。当电流衰减到临界电流以下时，约瑟夫逊隧道结回复到其零电阻状态，恢复检测电路的Q并使能够检测低能量磁共振信号。

30. 发明授权

US4599542A Linear beam tubes 失效
标题翻译：直线光束管
公开(公告)号：US4599542A
公开(公告)日：1986-07-08
申请号：US634484
申请日：1984-07-26
申请人： Robin C. M. King , Maurice Esterson , John Clarke
发明人： Robin C. M. King , Maurice Esterson , John Clarke
IPC分类号： H01J23/06 , H01J29/96 , H01J1/96 , H01J7/44
CPC分类号： H01J23/06
摘要： The invention provides a linear beam tube which may be protected against high voltage arcs between the cathode and anode of its electron gun by connecting to ground a limiting impedance in a series path from said anode. The anode is carried upon the end of a ceramic cylinder which is co-axially within a conical metallic member. The end of the ceramic cylinder remote from the anode is attached to one end of said conical metallic member, the other end of which is flanged, with the flange passing through the tube envelope to provide an external termination which may be connected to ground. Resistive material is deposited in a groove in the inner surface of said ceramic cylinder to form a deposited impedance which extends from the anode over the end of the ceramic cylinder, to the end of the conical metallic member and constitutes said limiting impedance.
摘要翻译：本发明提供了一种线性束管，其可以通过将来自所述阳极的串联路径中的限制阻抗连接到地来保护其抵抗其电子枪的阴极和阳极之间的高压电弧。阳极被承载在陶瓷圆柱体的一端，该陶瓷圆柱体在锥形金属构件内共同轴向。远离阳极的陶瓷圆柱体的端部附接到所述锥形金属构件的一端，其另一端是凸缘的，凸缘通过管壳，以提供可以连接到地面的外部端接件。电阻材料沉积在所述陶瓷圆柱体的内表面中的凹槽中以形成从陶瓷圆柱体的端部上的阳极延伸到锥形金属构件的端部并构成所述限制阻抗的沉积阻抗。

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