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    • 21. 发明授权
    • Predistorter for compensating for nonlinear distortion and method thereof
    • 用于补偿非线性失真的预失真器及其方法
    • US08421534B2
    • 2013-04-16
    • US13330986
    • 2011-12-20
    • Young Hoon KimGweon Do JoKwang Chun Lee
    • Young Hoon KimGweon Do JoKwang Chun Lee
    • H03F1/26
    • H03F1/3247H03F1/3258H03F3/189H03F3/24H03F2201/3212
    • The predistorter may include: a predistortion filter predistorting an input signal to provide an output signal; a predistortion output estimation unit estimating the characteristics of a nonlinear device based on a signal processed by the nonlinear device and the output signal, and calculating a desired output signal of the predistortion filter by using the estimated characteristics of the nonlinear device; and an adaptive algorithm driving unit comparing the output signal with the desired output signal to output an error as a comparison result, calculating a filter coefficient according to which the calculated error is minimized, and providing the calculated filter coefficient to the predistortion filter in order to update a filter coefficient of the predistortion filter.
    • 预失真器可以包括:预失真滤波器预失真输入信号以提供输出信号; 预失真输出估计单元,基于由所述非线性装置处理的信号和所述输出信号来估计所述非线性装置的特性,以及通过使用所述非线性装置的估计特性来计算所述预失真滤波器的期望输出信号; 以及自适应算法驱动单元,将输出信号与期望的输出信号进行比较以输出误差作为比较结果,计算滤波器系数,根据该滤波器系数计算误差最小化,并将计算的滤波器系数提供给预失真滤波器,以便 更新预失真滤波器的滤波器系数。
    • 23. 发明申请
    • OXALIPLATIN NANOPARTICLES AND METHOD FOR PREPARING SAME
    • OXALIPLATIN纳米颗粒及其制备方法
    • US20120177728A1
    • 2012-07-12
    • US13497208
    • 2010-09-20
    • Sung Jae LeeYoung Hoon KimSang Heon LeeKab Sig Kim
    • Sung Jae LeeYoung Hoon KimSang Heon LeeKab Sig Kim
    • A61K31/282A61K9/48B32B5/16A61K9/00A61P35/00B82Y40/00B82Y5/00
    • A61K9/146A61K9/0095A61K9/10A61K9/2027A61K9/4866A61K31/555A61K47/38Y10T428/2982
    • The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas.By providing oxaliplatin, which is currently available only in injection form for parenteral administration, in the form of a nanoparticle, the present invention allows for the development of orally administrable oxaliplatin which is stable against gastric acid and has improved bioavailability, thereby improving patient compliance through avoiding the inconvenience of injection and greatly reducing medical cost. Since the oxaliplatin nanoparticle can be prepared economically using a relatively inexpensive supercritical fluid producing facility, it can be prepared via a simple process with high yield in commercial scale.
    • 本发明涉及奥沙利铂的纳米粒子,其为水溶性活性物质,含有该纳米粒子的药物组合物,以及通过乳化脂质混合溶液制备口服奥沙利铂纳米粒子的方法,其中固体脂质和表面活性剂为 在其中混合奥沙利铂和特定共溶剂的混合物水溶液中混合,然后使用超临界流体气体除去固体脂质和助溶剂。 通过提供目前仅以注射用于肠胃外给药的奥沙利铂作为纳米颗粒的形式,本发明允许开发对胃酸稳定的可口服奥沙利铂,并且具有改善的生物利用度,从而通过 避免注射带来的不便,大大降低医疗成本。 由于奥沙利铂纳米颗粒可以使用相对便宜的超临界流体生产设备经济地制备,所以可以通过工业规模的高产率的简单方法制备。