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21. 发明授权

US08636911B2 Process for MEMS scanning mirror with mass remove from mirror backside 有权
标题翻译：从镜面背面去除质量的MEMS扫描镜的工艺
公开(公告)号：US08636911B2
公开(公告)日：2014-01-28
申请号：US12924873
申请日：2010-10-07
申请人： Jun Chen , Guomin Mao , Tom Zhong , Wei Cao , Yee-Chung Fu , Chyu-Jiuh Torng
发明人： Jun Chen , Guomin Mao , Tom Zhong , Wei Cao , Yee-Chung Fu , Chyu-Jiuh Torng
IPC分类号： B81C1/00
CPC分类号： B81B3/0045 , B81B2201/042 , G02B26/0841
摘要： Two methods of fabricating a MEMS scanning mirror having a tunable resonance frequency are described. The resonance frequency of the mirror is set to a particular value by mass removal from the backside of the mirror during fabrication.
摘要翻译：描述制造具有可调共振频率的MEMS扫描反射镜的两种方法。反射镜的共振频率通过在制造期间从反射镜的背面质量去除而被设定为特定的值。

22. 发明授权

US08604053B2 TRPV1 antagonists 有权
标题翻译： TRPV1拮抗剂
公开(公告)号：US08604053B2
公开(公告)日：2013-12-10
申请号：US12579821
申请日：2009-10-15
申请人： Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
发明人： Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
IPC分类号： C07D405/12 , A61K31/4709
CPC分类号： C07D311/74 , C07D405/12
摘要： Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

23. 发明申请

US20130164216A1 BLADDER CANCER TUMOR MARKER, ANTIBODY AND USE THEREOF 有权
标题翻译：乳腺癌肿瘤标志物，抗体及其用途
公开(公告)号：US20130164216A1
公开(公告)日：2013-06-27
申请号：US13814446
申请日：2011-08-12
申请人： Chong Li , Zusen Fan , Honglian Zhang , Zhonghua Dai , Haidong Tang , Jun Chen
发明人： Chong Li , Zusen Fan , Honglian Zhang , Zhonghua Dai , Haidong Tang , Jun Chen
IPC分类号： C07K14/705 , G01N33/68 , C12N15/113 , C12Q1/48 , A61K39/395 , C07K16/30 , A61K47/48 , A61K51/10 , A61K45/06 , G01N33/574 , C12Q1/02
CPC分类号： C07K16/2842 , A61K39/39558 , A61K45/06 , A61K47/48607 , A61K47/6861 , A61K51/1093 , C07K14/70546 , C07K14/7055 , C07K16/3038 , C12N9/1051 , C12N15/1137 , C12Q1/025 , C12Q1/48 , C12Y204/01041 , G01N33/57484 , G01N33/57488 , G01N33/6854 , G01N2333/70546 , G01N2440/38
摘要： Provided in the present invention are an aberrantly glycosylated integrin, AG-α3β1, and use thereof as a bladder cancer marker. Also provided in the present invention are a hybridoma cell generating an anti-AG-α3β1 monoclonal antibody, a monoclonal antibody BCMab1 secreted by the same, and use of BCMab1 in the preparation of a medicament for the treatment of bladder cancer. Also provided in the present invention is use of inhibitors of GAL3ST2 and N-acetylgalactosaminyltransferase 1 in the preparation of a medicament for the treatment of bladder cancer.
摘要翻译：在本发明中提供了异常糖基化的整联蛋白AG-α3β1及其作为膀胱癌标志物的用途。本发明还提供了产生抗AG-α3β1单克隆抗体的杂交瘤细胞，由其分泌的单克隆抗体BCMab1，以及BCMab1在制备用于治疗膀胱癌的药物中的用途。本发明还提供了GAL3ST2和N-乙酰半乳糖胺基转移酶1的抑制剂在制备用于治疗膀胱癌的药物中的用途。

24. 发明申请

US20130161528A1 METHOD AND SYSTEM FOR AMPLITUDE DIGITIZATION OF NUCLEAR RADIATION PULSES 有权
标题翻译：核辐射脉冲放大器的方法和系统
公开(公告)号：US20130161528A1
公开(公告)日：2013-06-27
申请号：US13807765
申请日：2012-05-22
申请人： Yonggang Wang , Wensong Zhu , Jun Chen
发明人： Yonggang Wang , Wensong Zhu , Jun Chen
IPC分类号： G01T1/17
CPC分类号： G01T1/17
摘要： Disclosed are methods and systems for amplitude digitization of nuclear radiation pulses. The method includes: applying a constant fraction discrimination (CFD) timing process on a subject current signal and outputting a CFD timing signal; applying a shaping process on the subject current signal to obtain a subject shaped signal; comparing, from a time To, values taken at the same time by the subject shaped signal and a dynamic threshold signal, and taking a time Tot as an over-threshold time if the value of the dynamic threshold signal changes from less than the value of the subject shaped signal to not less than the value of the subject shaped signal at the time Tot, wherein a time length between the time To and the arrival time Td of the subject current signal is preset as ΔT; converting a time length between the time Td and the time Tot into a digital quantity as a digitized value of the amplitude of the nuclear radiation pulse; wherein for any two subject shaped signals having amplitudes Vot1 and Vot2, respectively, the dynamic threshold signal satisfies an equation Tot   2 - To Vot   2 = Tot   1 - To Vot   1 , Tot1 represents an over-threshold time for one of the subject shaped signals compared with the dynamic threshold signal, and Tot2 represents an over-threshold time for the other of the subject shaped signals compared with the dynamic threshold signal.
摘要翻译：公开了用于核辐射脉冲幅度数字化的方法和系统。该方法包括：对目标电流信号应用恒定分数判别（CFD）定时处理并输出CFD定时信号; 对被摄体电流信号施加整形处理以获得被摄体成像信号; 从时间To比较由对象整形信号和动态阈值信号同时获取的值，并且如果动态阈值信号的值从小于该阈值的值，则将时间Tot作为过阈值时间被摄体整形信号不小于在时间Tot处的被摄体成像信号的值，其中，被摄体电流信号的时间To与到达时间Td之间的时间长度被预设为DeltaT; 将时间Td和时间Tot之间的时间长度转换为数字量作为核辐射脉冲幅度的数字化值; 其中对于分别具有幅度Vot1和Vot2的任何两个被摄体成像信号，动态阈值信号满足等式Toten 2 2 - ToVoté2 2 = Tot 1 2 - Tot 1 Tot 1表示过阈值与动态阈值信号相比，对象成像信号之一的时间，Tot2表示与动态阈值信号相比的对象成形信号中的另一个的过阈值时间。

25. 发明授权

US08426407B2 Preparation of 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and salts thereof and their applications 失效
标题翻译： 1-（取代的芳基）-5-三氟甲基-2-（1H）吡啶酮化合物及其盐的制备及其应用
公开(公告)号：US08426407B2
公开(公告)日：2013-04-23
申请号：US13322152
申请日：2010-05-24
申请人： Gaoyun Hu , Lijian Tao , Jun Chen
发明人： Gaoyun Hu , Lijian Tao , Jun Chen
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4427 , A61K31/44 , C07D413/02 , C07D401/02 , C07D211/06 , C07D211/80
CPC分类号： C07D213/64
摘要： A 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and pharmaceutical acceptable salts, preparation methods and uses for preparing the drugs for treating fibrosis thereof.
摘要翻译： 1-（取代的芳基）-5-三氟甲基-2-（1H）吡啶酮化合物及其制备方法和用途，用于制备治疗纤维化的药物。

26. 发明申请

US20130056985A1 WIND-POWER GENERATION SYSTEM WITH OVER-SPEED PROTECTION AND METHOD OF OPERATING THE SAME 有权
标题翻译：具有超速保护的风力发电系统及其运行方法
公开(公告)号：US20130056985A1
公开(公告)日：2013-03-07
申请号：US13466493
申请日：2012-05-08
申请人： Yan-Song LU , Jun Chen , Xue-Xiao Luo
发明人： Yan-Song LU , Jun Chen , Xue-Xiao Luo
IPC分类号： H02P9/04
CPC分类号： F03D7/0272 , F03D7/0248 , F03D9/255 , H02H7/067 , Y02E10/723 , Y02E10/725
摘要： A wind-power generation system with an over-speed protection is disclosed. The system is provided to convert wind energy into mechanical energy by a wind turbine, and mechanical energy is converted into electric energy by the wind turbine driving a generator. Also, electric energy is delivered to a power grid. The wind-power generation system mainly includes an AC crowbar, a fuse, and a DC chopper. The AC crowbar or the DC chopper is provided to consume superfluous energy outputted from the generator, thus providing an over-load operation to brake the wind turbine when the wind turbine operates under a first stage over-speed operation. Finally, the generator is isolated from the generator-side converter by disconnecting the fuse when the wind turbine operates under a second stage over-speed operation.
摘要翻译：公开了具有超速保护的风力发电系统。该系统被提供用于通过风力涡轮机将风能转换成机械能，并且机械能通过驱动发电机的风力涡轮机转换成电能。此外，电能被输送到电网。风力发电系统主要包括交流撬棒，保险丝和直流斩波器。提供AC撬棍或DC斩波器以消耗从发电机输出的多余能量，从而当风力涡轮机在第一级超速操作下运行时，提供过载操作以制动风力涡轮机。最后，当风力发电机在第二级超速运行时，通过断开保险丝，发电机与发电机侧转换器隔离。

27. 发明申请

US20130041996A1 Method and system for managing personal network 有权
公开(公告)号：US20130041996A1
公开(公告)日：2013-02-14
申请号：US13640112
申请日：2011-03-18
申请人： Lizhe Yao , Jun Chen , Man Xie
发明人： Lizhe Yao , Jun Chen , Man Xie
IPC分类号： G06F15/173
CPC分类号： H04W24/00 , H04L41/12 , H04W4/203 , H04W8/04 , H04W60/00 , H04W60/06
摘要： The disclosure discloses a method for managing a Personal Network (PN), which includes: realizing a management for the PN by any one of management ways including establishing the PN, releasing the PN, adding a PN device in the PN and enabling the PN device to leave the PN or a combination thereof. The disclosure also discloses a system for managing a PN, which includes a management unit for realizing a management for the PN by any one of management ways including establishing the PN, releasing the PN, adding a PN device in the PN and enabling the PN device to leave the PN or a combination thereof. By adopting the method and system of the disclosure, the management for the PN consisting of a large number of PN devices can be realized.

28. 发明申请

US20130009621A1 LOW OFFSET, FAST RESPONSE VOLTAGE CONTROLLED CURRENT SOURCE AND CONTROLLING METHOD THEREOF 有权
标题翻译：低偏差，快速响应电压控制电流源及其控制方法
公开(公告)号：US20130009621A1
公开(公告)日：2013-01-10
申请号：US13529079
申请日：2012-06-21
申请人： Jun Chen
发明人： Jun Chen
IPC分类号： G05F1/10
CPC分类号： G05F1/561
摘要： The present invention relates to a low offset and fast response voltage controlled current source, controlling method, and a power supply thereof. In one embodiment, a voltage controlled current source can include: a clock signal generator, a first operational amplifier, an input offset eliminator, a sampling and holding circuit, and an output circuit. The input offset eliminator can receive a clock signal, an input voltage, and a feedback voltage, and can (i) store and then eliminate an input offset of the first operation amplifier, and generate an error signal in accordance with an error between the input and feedback voltages when the clock signal is active, and (ii) generate the error signal in accordance with the stored input offset and the error between the input and feedback voltages when the clock signal is inactive.
摘要翻译：本发明涉及一种低失调和快速响应电压控制电流源，控制方法及其电源。在一个实施例中，压控电流源可以包括：时钟信号发生器，第一运算放大器，输入偏移消除器，采样和保持电路以及输出电路。输入偏移消除器可以接收时钟信号，输入电压和反馈电压，并且可以（i）存储并消除第一运算放大器的输入偏移量，并且根据输入之间的误差产生误差信号和时钟信号有效时的反馈电压，以及（ii）当时钟信号无效时，根据存储的输入偏移和输入和反馈电压之间的误差产生误差信号。

29. 发明申请

US20120296937A1 METHOD AND DEVICE FOR SEARCHING PERSONAL NETWORK SERVICE 审中-公开
标题翻译：搜索个人网络服务的方法和设备
公开(公告)号：US20120296937A1
公开(公告)日：2012-11-22
申请号：US13522449
申请日：2010-12-24
申请人： Jun Chen , Lizhe Yao , Yan Lu
发明人： Jun Chen , Lizhe Yao , Yan Lu
IPC分类号： G06F17/30
CPC分类号： H04W4/20 , H04W4/203
摘要： A method and a device for searching a personal network service are provided. The method includes: obtaining a primary keyword used for searching a service content by a Personal Network Equipment (PNE), generating an auxiliary keyword according to configuration information of the PNE, transmitting the auxiliary keyword generated and the primary keyword to a personal network server; and searching the service content by the personal network server according to the auxiliary keyword and the primary keyword, and providing a search result to the PNE; or, obtaining a search result generated by performing a search by a personal network server according to a keyword used for searching a service content by a PNE, generating a filtering condition according to configuration information of the PNE, filtering the search result generated by the personal network server and providing the search result filtered to the PNE. By means of the method, the PNE can rapidly and effectively search the service content interested by a user, and a higher searching accuracy can be obtained.
摘要翻译：提供了一种用于搜索个人网络服务的方法和设备。该方法包括：获取由个人网络设备（PNE）搜索服务内容的主要关键字，根据PNE的配置信息生成辅助关键字，将生成的辅助关键字和主要关键字发送到个人网络服务器; 以及根据所述辅助关键词和所述主要关键字，由所述个人网络服务器搜索所述服务内容，并向所述PNE提供搜索结果; 或者通过根据用于通过PNE搜索服务内容的关键字，由个人网络服务器执行搜索而生成的搜索结果，根据PNE的配置信息生成过滤条件，过滤个人生成的搜索结果网络服务器，并将搜索结果提供给PNE。通过该方法，PNE可以快速，有效地搜索用户感兴趣的服务内容，可以获得更高的搜索精度。

30. 发明授权

US08309369B2 Detection system and method for high sensitivity fluorescent assays 有权
标题翻译：用于高灵敏度荧光测定的检测系统和方法
公开(公告)号：US08309369B2
公开(公告)日：2012-11-13
申请号：US13224174
申请日：2011-09-01
申请人： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
发明人： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , C08B37/006 , G01N21/6428 , G01N21/645 , G01N33/54373 , G01N2021/6439 , G01N2201/06113
摘要： This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked Ficoll molecule having a plurality of binding molecules and a plurality of fluorescent labels.
摘要翻译：本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。本发明还涉及一种使用具有小表面积（＆NlE; 5mm）的探针尖端和具有多个结合分子和多个荧光标记的高分子量聚合物（≥1MD）来检测液体样品中的分析物的方法。通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。本发明还涉及包含具有多个结合分子和多个荧光标记的交联Ficoll分子的荧光标记组合物。

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