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    • 25. 发明申请
    • OPTICAL SPECTROSCOPY DEVICE FOR NON-INVASIVE BLOOD GLUCOSE DETECTION AND ASSOCIATED METHOD OF USE
    • 用于非侵入性血液葡萄糖检测的光学光谱仪和相关的使用方法
    • US20100252721A1
    • 2010-10-07
    • US12729886
    • 2010-03-23
    • Zhi Xu
    • Zhi Xu
    • G01J3/51F21V7/04F21V13/04
    • A61B5/1455A61B5/14532G01J3/02G01J3/0216G01J3/10G01J3/18G01J3/42G01J2003/1239G01N21/359
    • An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto-conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized.
    • 公开了一种用于集中光的装置和相关联的使用方法。 该装置包括具有前端,后端,内表面和外表面的第一外壁,内表面限定内部部分,内部具有前端和后端,以及光源, 内部部分。 第一外壁在后端具有开口,开口具有开口直径。 内部具有基本上截头圆锥形的形状,并且在开口处的截面直径等于开口直径,并且在前端附近的第二截面直径小于开口直径, 反光。 光通过孔和收集透镜或第二外壁穿过样品。 可以使用透射衍射光栅。
    • 30. 发明授权
    • Ultrasensitive spectrophotometer
    • 超声分光光度计
    • US06741348B2
    • 2004-05-25
    • US10135854
    • 2002-04-29
    • David W. LarsenZhi XuWayne Garver
    • David W. LarsenZhi XuWayne Garver
    • G01J340
    • G01J3/28G01J3/02G01J3/0224G01J3/0286G01J3/0291G01J3/42
    • The invention concerns improvements in spectrophotometry. Aspects of the invention may be used independently or together to increase the sensitivity of spectrophotometry. One aspect of the invention is a spectrophotometer detection circuit. In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing with a hollowed portion defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments. Many noise sources would not normally be considered in conventional spectrophotometry because the magnitude of particular noise sources dominates device performance.
    • 本发明涉及分光光度法的改进。 本发明的各方面可以独立地或一起使用来提高分光光度法的灵敏度。 本发明的一个方面是分光光度计检测电路。 在本发明的这个方面,在当前模式下,归因于参考和采样光束的电流被消除。 检测电路产生与电流差成比例的第一电压和与参考或采样光束之一成比例的第二电压。 两种电压均可用于同时测量和分析。 本发明的另一方面涉及热稳定性。 根据本发明,在壳体和光学系统部件之间建立导热性以促进平衡。 另一个优选实施例具有整体的实心金属外壳,其具有限定为安装和放置光学系统部件的中空部分。 识别和识别分光光度计中的重要噪声源形成本发明的一个方面,其有利于优选实施例中的特征和特征的组合。 常规分光光度法通常不会考虑许多噪声源,因为特定噪声源的大小主导器件性能。